| |
| Prof
Ming Chiu FUNG
Address: |
Room EG07, Science Centre, CUHK (Off); |
| |
Room G95,
Science Centre, CUHK (Lab) |
| Phone: |
(852)
3943-6147 (Off); |
| |
(852)
3943-6391 (Lab) |
| Fax: |
(852)
2603-5646, (852) 2603-5745 |
| E-mail: |
mingchiufung@cuhk.edu.hk |
| Education |
| 1985 |
PhD
(Molecular Biology), The Australian National University, Australia |
| 1980 |
MPhil
(Biology), The Chinese University of Hong Kong, Hong Kong |
| 1978 |
BSc
(Biology), The Chinese University of Hong Kong, Hong Kong |
| Position |
| 2002 |
Professor (Dept of Biology, The Chinese University of Hong
Kong, Hong Kong) |
| 1992-2002 |
Associate
Professor (Dept of Biology, The Chinese University of Hong
Kong, Hong Kong) |
| 1988-1992 |
Research
Fellow (Molecular Haematology Group and Medical Molecular
Biology Group, The John Curtin School of Medical Research,
The Australian National University) |
| 1986-1988 |
Research
Associate (Department of Virology and Epidemidology, Baylor
College of Medicine, Houston, USA) |
|
Concurrent Position |
| Adjunct
professor of the Soochow University, China |
| Visiting
Professor of the First Military Medical University, China |
| Deputy
Chief Editor of the ¡§Journal of Tropical Medicine¡¨ |
| Editor
of the ¡§Chinese Journal of Parasitology and Parasitic Diseases¡¨ |
| Professional
Activities |
| Appointments
in the following Professional Organizations: |
| Chairman
of the Hong Kong Society for Immunology (2003-) |
| Organizing
Committee of the 11th Annual Conference 2003 of the Hong Kong
Institution of Science |
Organizing
member (the International Symposium on "Lymphocytes in
Health and Disease") (1995) |
Session
Moderator/Chairman (the International Symposium on "Hypertrophic
Scars") (1995) |
Council
member (the Hong Kong Society for Immunology 94/95, 99/01)
(1994-95, 1999-2001) |
Membership in the following Professional Organizations: |
| American
Society for Microbiology |
| Australian
Society for Biochemistry and Molecular Biology |
| Australian
Society for Immunology |
| Australian
Society for Medical Research |
| Australian
Society for Parasitology |
| Hong Kong
Society for Immunology |
| Hong Kong
Institution of Science |
Invited Speaker in the following Talk: |
| Soochow
University, Nanjing University and Sun Yat-Sen University on:
"DNA Vaccine" (Nov 2002) |
| The Hong
Kong Society for Immunology on: "Biology of Cytokines and
Cytokine Receptors" (1994) |
| The Institute
of Biology (Hong Kong Branch) on: "Genetic Engineering
in Medicine" (1994) |
| Research
Interests |
| |
From
Basic to Applied Haematology and Immunology |
| 1. |
Discovery
of a new drug for treating beta-haemoglobinopathies such as
beta-thalassemia and sickle cell anemia
(Patent pending, USA) |
| 2. |
Development
of a multi-epitopic DNA vaccine against Toxoplasma gondii
(Patent pending, China) |
| 3. |
Host-parasite
immunology of Schistosoma japonicum |
| 4. |
Cercariae
stage specific antigens |
| 5. |
Molecular
analysis of the acetylcholinesterase and phophatidylinositol
glycan-class N, potential drug targets |
| 6. |
Immunological
studies of the anti-inflammatory protein ¡V Sj16 |
| Representative
Publications |
| 1. |
Hu, S., Law, P.K., Lv, Z., Wu, Z., Fung, M.C. (2008) Molecular characterization of a calcium-binding protein SjCa8 from Schistosoma japonicum. Parasitology Research DOI: 10.1007/s00436-008-1090-5. |
| 2. |
Leung, P.S., Lee, Y.S., Tang, C.Y., Kung, W.Y., Chuang, Y.H., Chiang, B.L., Fung, M.C., Chu, K.H. (2008) Induction of Shrimp Tropomyosin-Specific Hypersensitivity in Mice. International Archives of Allergy and Immunology 147: 305-314. [Pub Med] |
| 3. |
Haritunians, T., Gueller, S., Zhang, L., Badr, R., Yin, D., Xing, H., Fung, M.C., Koeffler, H.P. (2008) Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells. Leukemia Research 32: 1366-1373. [Pub Med] |
| 4. |
Tang, H.L., Lung, H.L., Wu, K.C., Le, A.H., Tang, H.M., Fung, M.C. (2008) Vimentin supports mitochondrial morphology and organization. The Biochemical Journal 410: 141-146. [Pub Med] |
| 5. |
Lau, K.W., Ren, J., Fung, M.C., Woo, P.C., Yuen, K.Y., Chan, K.K., Qian, P.Y., Wong, P.K., Wu, M. (2007) Fangia hongkongensis gen. nov., sp. nov., a novel gammaproteobacterium of the order Thiotrichales isolated from coastal seawater of Hong Kong. International journal of systematic and evolutionary microbiology 57: 2665-2669. [Pub Med] |
| 6. |
Tsang, S.L., Leung, P.C., Leung, K.K., Yau, W.L., Hardy, M.P., Mak, N.K., Leung, K.N., Fung, M.C. (2007) Characterization of murine interferon-alpha 12 (MuIFN-alpha12): biological activities and gene expression. Cytokine 37: 138-149. [Pub Med] |
| 7. |
Li, S.Q., Fung, M.C., Reid, S.A., Inoue, N., Lun, Z.R. (2007) Immunization with recombinant beta-tubulin from Trypanosoma evansi induced protection against T. evansi, T. equiperdum and T. b. brucei infection in mice. Parasite immunology 29: 191-199. [Pub Med] |
| 8. |
Leung, K.N., Mak, N.K., Fung, M.C. (2005) Cytokines in the differentiation therapy of leukemia: from laboratory investigations to clinical applications. Critical Reviews in Clinical Laboratory Sciences 42: 473-514. [Pub Med] |
| 9. |
Yue, P.Y., Wong, D.Y., Ha, W.Y., Fung, M.C., Mak, N.K., Yeung, H.W., Leung, H.W., Chan, K., Liu, L., Fan, T.P., Wong, R.N. (2005) Elucidation of the mechanisms underlying the angiogenic effects of ginsenoside Rg(1) in vivo and in vitro. Angiogenesis 8: 205-216. [Pub Med] |
| 10. |
Fung, M.C., Sia, S.F., Leung, K.N., Mak, N.K. (2004) Detection of differential expression of mouse interferon-alpha subtypes by polymerase chain reaction using specific primers. Journal of Immunological Methods 284: 177-186 [Pub Med] |
| 11. |
Mak, N.K., Leung, C.Y., Wei, X.Y., Shen, X.L., Wong, R.N., Leung, K.N., Fung, M.C. (2004) Inhibition of RANTES expression by indirubin in influenza virus-infected human bronchial epithelial cells. Biochemical Pharmacology 67: 167-174 [Pub Med] |
| 12. |
Chen, X.G., Li, H., Peng, H.J., Shen, S.M., Fung, M.C. (2002) Construction and characterization of the cDNA library from Schistosoma japonicum cercariae. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 20: 39-41 [Pub Med] |
| 13. |
Mak,
N.K., Wong, R.N.S., Leung, K.N. and Fung,
M.C. (2002) ¡§Involvement of tumor necrosis factor
(TNF- ) in
arsenic trioxide induced apoptic cell death of murine myeloid
leukemia cells¡¨ Toxicology Letters 135, 79-87. |
| 14. |
Ming-Chiu
Fung,
Man-Tat Lau and Xiao-Guang Chen (2002) ¡§Expressed sequence
tags (ESTs) analysis of a Schistosoma japonicum cercariae
cDNA library¡¨ Acta Tropica 82:215-224. |
| 15. |
Simeonovic,
C.J., Townsend, M., Morris, C.F., Hapel, A.J., Fung,
M.C., Mann, D.A., Young, I.G., and Wilson, J.D. (1999)
¡§Immune mechanisms associated with the rejection of fetal
murine proislet allografts and pig proislet xenografts: Comparison
of intragraft cyokine mRNA profiles¡¨ Transplantion 67:963-971. |
| 16. |
Chan, S.C., Fung, M.C., Mak,
N.K. and Leung, K.N. (1997) Involvement of interleukin-1 in
the differentiation-inducing activity of tumor necrosis factor-a
on a murine myeloid leukemia (WEHI-3B JCS). International
Journal of Oncology 10:821-826. |
| 17. |
Mak,
N.K., Wong-Leung, Y.L., Chan, S.C., Wen, J., Leung, K.N. and
Fung, M.C. (1996) Isolation of
anti-leukemia compounds from Citrus reticulata. Life Sciences
58:1269-1276. |
| 18. |
Morris,
C.F., Simeonovic, C.J., Fung, M.C.,
Wilson, J.D. and Hapel, A.J. (1995) Intragraft expression
of cytokine transcripts during pig proislet xenograft rejection
and tolerance in mice. Journal of Immunology 154:2470-2482. |
| 19. |
Mak,
N.K., Fung, M.C., Leung, K.N.
and Hapel, A.J. (1993) Monocytic differentiation of a myelomonocytic
leukemic cell (WEHI-3B JCS) is induced by alpha-tumour necrosis
factor. Journal of Immunology 150:1-14. |
| 20. |
Zola,
H., Weedon, H., Thomson, G., Fung, M.C.,
Ingley, E. and Hapel, A.J. (1991) Expression of IL-2 receptor
p55 and p75 chains by human B lymphocytes: Effects of activation
and differentiation. Immunology 72:167-173. |
| 21. |
Ingley,
E., Cutler, R.L., Fung, M.C.,
Sanderson, C.L. and Young, I.G. (1991) Production and purification
of recombinant human interleukin 5 from yeast and baculovirus
expression systems. European Journal of Biochemistry
196:623-629. |
| 22. |
Fung,
M.C.,
Chiu, K.Y.M., Weber, T., Chang, T.W. and Chang, N.T. (1988)
Detection and purification of a recombinant human B lymphotropic
virus (HHV6) in the baculovirus expression system by limiting
dilution and DNA dot-blot hybridization. Journal of Virological
Methods 19:33-42. |
| 23. |
Campbell,
H.D., Ymer, S., Fung, M.C. and
Young, I.G. (1985) Cloning and nucleotide sequence of the
murine interleukin-3 gene. European Journal of Biochemistry
150:297-304. |
| 24. |
Hapel,
A.J., Fung, M.C., Johnson, R.M.,
Young, I.G. and Metcalf, D. (1985) Biological properties of
molecularly cloned and expressed murine interleukin-3. Blood
65:1453-1459. |
| 25. |
Fung,
M.C.,
Hapel, A.J., Ymer, S., Cohen, D.R., Johnson, R.M., Campbell,
H.D. and Young, I.G. (1984) Molecular cloning of cDNA for
murine interleukin-3. Nature 307: 233-237. |
Research
Grants
|
Research Grants Council (RGC) Earmarked Grants |
2001-2004 |
Cercariae
Stage Specific and Immunogenic Antigen of Schistosoma japonicum
- HK$696,000 (Collaborator: Dr XG Chen) |
1998-2000 |
Genetic
Immunization against Toxoplasma gondii - HK$645,000 (Collaborators:
Dr XG Chen and Dr KN Leung) |
| 1995-1996 |
Molecular
Cloning and Expression of the Helminth Excretory/Secretory
Antigen (an Interleukin-5 like Molecule)- HK$531,000 (Collaborator:
Dr Nai Ki Mak) |
| 1995-1996 |
Biochemical
and Immunological Characterization of Anti-leukemia drugs
Isolated from Citrus species - HK$531,000 (Collaborators:
Dr Nai Ki Mak, Dr YL Wong-Leung, and Dr Kwok Nam Leung) |
| 1994-1995 |
Studies
on Cardiovascular, Hepatoprotective and Cytokine Potentiating
Activities of the Cultured Mycelial Products of Selected Mushroom
Species - HK$743,000 (Collaborators: Dr VEC Ooi, Dr KW Chiu
and Dr ST Chang) |
Industrial Support Fund |
| 1995-1997 |
Biodegradation
of Indigo Dye (Cloning of Indigonase Gene and Obtaining a
Thermostable Indigonase) - HK$1,320,000 (Collaborators: Dr
Albert Y Chang, Dr Kai-Keung Mark, Dr Simon Kwong, Industry
Department and the Biotechnology Committee) |
WHO Directors's Initiative Fund
Research Grant |
| 1999-2000 |
Construction
of the cDNA Library for Schistosoma japonicum cercariae -
US$15,000 (Collaborators: Dr XG Chen, XH Zhou, H Li and HJ
Peng) |
Commonwealth AIDS Research Grant |
| 1991-1992 |
Effects
of Baculovirus Expressed HIV Glycoproteins on Haematopoesis
- Aus$ 119,508 (Collaborators: AJ Hapel, and HC O'Neil) |
National Health and Medical Research
Council |
| 1990-1992 |
The
Role of HIV Envelope Glycoproteins in Viral Interference and
Immunity - Aus$ 117,365 (Collaborator: AJ Hapel) |
Stanley Melbourne Bruce Fund |
| 1988 |
A
Strategy to Combat AIDS - Aus$ 7,000 (Collaborator: AJ Hapel) |
Hong Kong University Grant Council
(UGC) Direct Grants |
2001-2002 |
Interferon
Alpha Subtypes and Antiviral Drugs - HK 24,773 |
2001-2002 |
Cloning
and expressiogene encoding Sj16, an anti-inflammatory protein
from Schistosoma japonicum ¡V HK$20,207 |
| 1999-2000 |
Molecular
Analysis of Different Interferon Alpha Subtypes - HK$32,516 |
| 1998-1999 |
The
Role of Prostaglandin D Synthase and Prostaglandin D in JCS
Cell and Normal Bone Marrow Cell Differentiation - HK$53,107
(Collaborator: Dr NK Mak) |
| 1997-1998 |
Studies
of the Novel Genes Differentially Expressed during Myeloid
Cell Differentiation and Embryo Development - HK$33,875 |
| 1996-1997 |
Molecular
Cloning of the Chitinase Gene from a Local Fungal Strain -
HK$40,000 |
| 1995-1996 |
Isolation
of Chitinase Producing Soil Microbes and the Characterization
of the Chitinolytic Enzyme - HK$30,000 |
Direct Grants of the Research
Committee, CUHK |
| 1994-1995 |
Molecular
Mechanism of TNF-a Induced Myeloid Leukemia Cell Differentiation
- HK$53,000 |
| 1993-1994 |
Molecular
Analysis of the Immunoregulatory Effect of the Polysaccharide
Bound Protein Complex on the Cytokine Gene Expression - HK$65,000 |
| 1992-1993 |
Molecular
Cloning of the Interleukin-5 (a cytokine) Like Molecule from
the Helminth Parasite -- Taenia hydatigena (a tapeworm) and
Fasicola hepatica (a liver fluke) - HK$100,000 |
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