| |
| Prof
Liwen JIANG
Office: |
Room 384, Science Centre |
| Lab: |
Room LG101 & LG103, CSLB |
| Phone: |
(852)
3943-6388 (Off); |
| |
(852)
3943-6379 (Lab) |
| Fax: |
(852)
2603-5646, (852) 2603-5745 |
| E-mail: |
ljiang@cuhk.edu.hk |
| Education |
| 1996 |
PhD
Simon Fraser University, Canada |
| 1992 |
MSc University
of British Columbia, Canada |
| 1984 |
BSc South
China Agricultural University, China |
| Position |
| 8.2007-present |
Professor (Dept of Biology, CUHK) |
| 8.2004-7.2007 |
Associate Professor (Dept of Biology, CUHK) |
| 8.2000-7.2004 |
Assistant
Professor (Dept of Biology, CUHK) |
| 1996-2000 |
Research
Associate (Institute of Biological Chemistry, Washington State
University, USA) |
Membership in the following Professional
Organizations: |
| The American
Society for Plant Biologists |
| The American
Association for the Advancement of Science |
| The International Society for Seed Science |
| Research
Interest |
| 1.
Plant cell biology and molecular biology |
| 2.
Protein targeting and organelle biogenesis |
| 3.
Molecular characterization of plant prevacuolar compartments
|
| 4.
Molecular mechanism of protein degradation in germinating seeds |
| 5.
Plant biotechnology |
| Representative
Publications (* indicates PI and Corresponding Author): |
| 1. |
Miao, Y.S. and *Jiang, L. (2007) Transient expression of fluorescent fusion proteins in protoplasts of suspension cultured cells. Nature Protocols 2: 2348-2353. |
| 2. |
Lam, S.K., Tse, Y.C., Robinson, D.G and *Jiang, L. (2007) Tracking down the elusive early endosome. Trends in Plant Science 12: 497-505. |
| 3. |
Wang, J.Q., Li, Y.B., Lo, S.W., Hillmer, H., Sun, S.S.M., Robinson, D.G. and *Jiang, L. (2007) Protein mobilization in germinating mung bean seeds involves vacuolar sorting receptors and multivesicular bodies. Plant Physiology 143: 1628-1639. |
| 4. |
Lam, S.K., Siu, C.L., Hillmer, S., Jang, S., An, G., Robinson, D.G. and *Jiang, L. (2007) Rice SCAMP1 defines clathrin-coated, trans Golgi-located tubular vesicular structures as an early endosome in tobacco BY-2 cells. The Plant Cell 19: 296-319. |
| 5. |
Tse, Y.C., Lo, S.W., Hillmer, S., Dupree, P. and *Jiang, L. (2006) Dynamic response of prevacuolar compartments to Brefeldin A in plant cells. Plant Physiology 142: 1442-1459. |
| 6. |
Miao, Y., Yan, P.K., Kim, H., Hwang, I. and *Jiang, L. (2006) Localization of GFP fusions with the seven Arabidopsis vacuolar sorting receptors to prevacuolar compartments in tobacco BY-2 cells. Plant Physiology 142: 945-962. |
| 7. |
Mo, B.X., Tse, Y.C. and *Jiang, L. (2006) Plant prevacuolar/endosomal compartments. International Review of Cytology 253: 95-129. (cover article) |
| 8. |
Oliviusson, P., Heinzerling, L., Hillmer, S., Hinz, G., Tse, Y.C., Jiang, L. and Robinson, D.G. (2006) Plant retromer: localized to the prevacuolar compartment and microvesicles in Arabidopsis, may interact with vacuolar sorting receptors. The Plant Cell 18: 1239-1252. |
| 9. |
Wang,
J.Q., Miao, Y.S. and *Jiang, L.
(2006) Response to Gomord et al: Golgi-bypassing delivery of biopharmaceutical proteins
to protein storage vacuole in plant bioreactors. Trends
in Biotechnology 24: 147-149. |
| 10. |
Lo, S.W.
and *Jiang, L. (2006) Molecular
study of prevacuolar compartments in tobacco BY-2 cells. Biotechnology in
Agriculture and Forestry 58: 153-166. |
| 11. |
Oufattole,
M., Park, J.H., Poxleitner, M., Jiang,
L. . and Rogers, J.C. (2005) Selective membrane protein
internalization accompanies movement from ER to protein storage
vacuole. The Plant Cell 17: 3066-3080. |
| 12. |
Lam,
S.K., Tse, Y.C., *Jiang, L. ,
Oliviusson, P., Heinzerling, L., and Robinson, D.R. (2005)
Plant prevacuolar compartments and endocytosis. Plant
Cell Monographs 1: 37-61. |
| 13. |
Tse,
Y.C., Mo, B.X., Hillmer, S., Zhao,M., Lo,
S.W., Robinson, D.G., and *Jiang, L. (2004) Identification
of multivescular bodies as prevacuolar compartments in Nicotiana tabacum BY-2 cells. The Plant Cell 16: 672-693. |
| 14. |
Jin,
J.B., Bae,H., Kim, S.J., Go, C., Kim,D.H., Lee, Y.J., Tse,
Y.C., Jiang, L. and Hwang, I.
(2003) Arabidopsis dynamin-like proteins, ADL1C and ADL1E,
play a critical role in mitochondrial morphogenesis. The
Plant Cell 15: 2357-2369. |
| 15. |
Mo, B.X., Tse, Y.C. and *Jiang,
L. (2003) Organelle identification and proteomics in
plant cells. Trends in Biotechnology 21: 331-332. |
| 16. |
Sohn,
E.S., Kim, E.S., Zhao, M., Kim, S.J., Kim, H.R., Kim, Y.W.,
Lee, Y.J., Hillmer, S., Sohn, U., Jiang,
L., and Hwang, I. (2003) Rha1, an Arabidopsis Rab5
homolog, plays a critical role in the vacuolar trafficking
of soluble cargo proteins. The Plant Cell 15:1057-1070. |
| 17. |
*Jiang, L. and Rogers, J.C. (2003) Sorting of lytic enzymes in the plant Golgi apparatus. Annual Plant Review 9: 114-140. |
| 18. |
Jiang,
L., Erickson, A. and Rogers, J.C. (2002) Multivesicular bodies: a mechanism to package lytic and storage function in one organelle? Trends in Cell Biology 12: 362-367. |
| 19. |
Li, Y.B., Rogers, S.W., Tse, Y.C., Lo, S.W., Sun, S.S.M., Jauh, G.Y. and *Jiang, L. (2002) BP-80 and homologs are concentrated on post-Golgi, probable lytic prevacuolar compartments. Plant & Cell Physiology 43: 726-742. |
| 20. |
*Jiang,
L. and Sun, S.S.M. (2002) Membrane anchors for vacuolar
targeting: application in plant bioreactors. Trends in
Biotechnology 20: 99-102. (cover article) |
| 21. |
Jiang,
L.,
Phillips, T.E., Hamm, C.A., Drozdowicz, Y.M., Rea, P.A., Maeshima,
M., Rogers, S.W. and Rogers, J.C. (2001) The protein storage
vacuole: a unique compound organelle. The Journal of Cell
Biology 155: 991-1002. (journal highlight article) |
| 22. |
Jiang, L., Phillips, T.E., Rogers,
S.W. and Rogers, J.C. (2000) Biogenesis of the protein storage
vacuole crystalloid. The Journal of Cell Biology
150: 755-769. |
| 23. |
Jiang,
L.
and Rogers, J.C. (1999) Functional analysis of a Golgi-localized
Kex2p-like protease in tobacco suspension culture cells. The
Plant Journal 18: 23-32. |
| 24. |
Jiang,
L.
and Rogers, J.C. (1998) Integral membrane protein sorting
to vacuoles in plant cells: evidence for two pathways. The
Journal of Cell Biology 143: 1183-1199. (this article was featured in Trends in Cell Biology) |
| Research
Grants |
Research Grants Council (RGC) Earmarked
Grants |
| 2008-2010
|
Molecular characterization of plant endocytosis - HK$1,408,404 (as PI) |
| 2006-2008
|
The biology
of vacuolar sorting receptor proteins and their applications
in plant bioreactors - HK$1,446,465 (as Co-PI, PI, Prof. SSM
Sun) |
| 2003-2008
|
Biogenesis
of the compound protein storage vacuole - HK$2,394,000 (as
PI) |
| 2002-2005 |
Molecular
characterization of plant prevacuolar compartments - HK$1,387,580
(as PI) |
| 2001-2004 |
Sorting of proteins to the protein storgae vacuole in plant
cells - HK$1,154,000 (as PI, Co-I, Prof SSM Sun) |
CUHK Scheme C |
| 2006-2009 |
Molecular characterization of plant prevacuolar compartments - HK$1,086,000 (as PI) |
National Nature Science Foundation
of China (NSFC) |
| 2006-2008 |
Biogenesis
of protein storage vacuole and its application - RMB$400,000
(as PI; collaborator, Prof. ZF Xu) |
The National High Technology Research and Development Program of China (863 Program) |
| 2008-2010 |
Plant cells as bioreactors for pharmaceuticals - RMB$1,000,000 (50% of the fund as Co-I; PI, Prof. ZF Xu) |
France/Hong Kong Joint Research
Scheme |
| 2003-2004 |
Molecular
mechanism of plant prevacuolar compartments - HK$63,000 |
Germany/Hong Kong Joint Research Scheme |
| 2002-2003 |
Protein
sorting in the plant Golgi - HK$60,000 |
| 2007-2008 |
Structural characterization and proteomics of plant prevacuolar compartments - HK$60,000 |
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