| |
| Prof
Hon Ming LAM
Address: |
Room 298A, Science Centre, CUHK (Off); |
| |
Room 298,
Science Centre, CUHK (Lab) |
| Phone: |
(852)
3943-6336 (Off); |
| |
(852)
3943-8132 (Lab); |
| |
(852)
3943-8142 (AoE Lab) |
| Fax: |
(852)
2603-5646, (852) 2603-5745 |
| E-mail: |
honming@cuhk.edu.hk |
¡@
| Education |
| 1992 |
PhD
(Molecular Biology and Biochemistry), Northwestern University,
USA |
| 1987 |
MPhil
(Biology), The Chinese University of Hong Kong, Hong Kong |
| 1985 |
BSc (Biology),
The Chinese University of Hong Kong, Hong Kong |
| Position |
| 2009-present
|
Associate Program Director (Molecular Biotechnology Program, The Chinese University of Hong Kong) |
| 2002-present
|
Associate Professor (Dept of Biology, The Chinese University
of Hong Kong) |
| 1997-2001 |
Assistant
Professor (Dept of Biology, The Chinese University of Hong
Kong, Hong Kong) |
| 2008-present |
Associate Director (State Key Laboratory for Agrobiotechnology, The Chinese University of Hong Kong) |
| 2006-present |
Associate Director (Institute of Plant Molecular Biology & Agricultural Biotechnology, The Chinese University of Hong Kong) |
| 2006-present |
Deputy
Director (UGC Area of Excellence on Plant & Agricultural
Biotechnology Center, The Chinese University of Hong Kong) |
|
1999-2006
|
Deputy
Director (UGC Area of Excellence on Plant & Fungal Biotechnology
Center, The Chinese University of Hong Kong) |
| 2002-present |
Hostel
Warden (Daisy Li Hall, New Asia College, The Chinese University
of Hong Kong) |
| 2006-present |
Visiting Professor (Institute of Plant Sciences, Jilin University, China) |
| 2000-present
|
Visiting
Research Professor (Institute of Crop Sciences, Chinese Academy of Agricultural Sciences,
China) |
| Professional
Activities |
| Professional
Awards: |
| 2007 |
Second-Class Award for Science and Technology, Zhejiang Province, PRC: Establishment and Large Scale Application of an Efficient and Safe System for Transgenic Rice Technology. |
| 2004 |
Foreign Expert (2004 Program for Introducing Foreign Experts on Technology and Management, State Administration of Foreign Experts Affairs, P.R.C.) |
| 2001 |
Second-Class Award for Scientific and Technological Achievements, Beijing City, PRC: Research and Application of Salt Tolerance Study in Soybean. |
|
1999-2000, 2005-2006 |
Exemplary
Teaching Award (Faculty of Science, The Chinese
University of Hong Kong) |
| 1998 |
Most
Cordial Teacher Award (elected by students from Department
of Biology, The Chinese University of Hong Kong) |
| 1998 |
Award
of Excellence in Presentation (6th Pacific Rim Biotechnology
Conference and BioExpo '98) |
| 1992 |
Raymond
W Sarber Award (American Society for Microbiology) |
Editorial Board: |
| 2010-present |
Acta Agronomica Sinica |
| 2009-present |
Bulletin of Botany |
| 2006-present |
Soybean Bulletin |
Appointments in the following Professional
Organizations: |
| 2003-present |
Chairman, Curriculum Development Institute and Hong Kong Examinations and Assessment Authority Joint Committee on Integrated Science (Senior Secondary) |
| 2002-present |
Member (Crop Farming Sub-Committee of the Advisory Committee
on Agriculture and Fisheries, HKSAR) |
| 2001-present |
Elected
Council Member (Soybean Specialty Committee of The Crop Science Society
of China) |
| 2005-present |
Vice Secretariat (Soybean Specialty Committee of The Crop Science Society of China) |
| 2005-present |
Member of Academic Council, Beijing Sub-center of the National (China) Center for Soybean Improvement |
Co-inventor of the following US Patents:
|
1. |
Plant
nitrogen regulatory P-PII polypeptides (granted); Patent number:
6,822,079 (2004) |
2. |
Plant
nitrogen regulatory P-PII genes (granted); Patent number:
6,177,275 (2001) |
3. |
Plant
glutamate receptors (granted); Patent number: 5,824,867 (1998);
5,981,703 (1999); 5,959,174 (1999); 6,451,546 (2002) |
|
¡@
| Research
Interest |
1.
|
Functional genomics, molecular and biochemical studies of biotic and abiotic stresses in higher plants |
2.
|
Molecular studies and manipulation of amino acid metabolisms in higher plants |
| Representative
Publications |
1. |
Lam, H.-M., Xu, X., Liu, X., Chen, W., Yang, G., Wong, F.-L., Li, M.-W., He, W., Qin, N., Wang, B., Li, J., Jian, M., Wang, J., Shao, G., Wang, J., Sun, S.S.-M., and Zhang, G. (2010) Resequencing of 31 wild and cultivated soybean genomes identifies patterns of genetic diversity and selection. Nat. Genet. 42:1053-1059 (cover story). |
2. |
Cheung, M.-Y., Xue, Y., Zhou, L., Li, M.-W., Sun, S.S.-M. and Lam, H.-M. (2010) An ancient P-loop GTPase in rice is regulated by a higher plant-specific regulatory protein. J. Biol. Chem. 48:37359¡V37369. |
3. |
Liang, C., Tian, J., Lam, H.-M., Lim, B.-L., Yan, X. and Liao, H. (2010) Biochemical and molecular characterization of PvPAP3, a novel purple acid phosphatase isolated from common bean enhancing extracellular ATP utilization. Plant Physiol. 152:854-865. |
4. |
Liang, Z., Cheung, M.-Y., Zhang, Q., Lei, C.-L., Zhang, S.-H., Sun, S.S.-M. and Lam, H.-M. (2009) A novel simple extracellular leucine-rich repeat (eLRR) domain protein from rice (OsLRR1) enters the endosomal pathway and interacts with the hypersensitive induced reaction protein 1 (OsHIR1). Plant Cell Environ. 32:1804-1820. |
5. |
Lam, H.-M., Chang, R.-Z., Shao, G.-H., Liu, Z.-T. (2009) (eds.). Researches on Soybean Stress Tolerance in China. China Agriculture Press. 428p. |
6. |
Phang, T.-H., Shao, G.-H., Liao, H., Yan, X. and Lam, H.-M. (2009) High external phosphate (Pi) increases sodium ion uptake and reduces salt tolerance of ¡§Pi tolerant¡¨ soybean. Physiol. Plant. 135: 412-425. |
7. |
Cheung, M.-Y., Zeng, N.-Y., Tong, S.-W., Li, F.W.-Y., Xue, Y., Zhao, K.-J., Wang, C., Zhang, Q., Fu, Y., Sun, Z., Sun, S.S.-M. and Lam, H.-M. (2008) Constitutive expression of a rice GTPase activating protein induces defense responses. New Phytol. 179: 530-545. |
8. |
Li, F.W.-Y., Shao, G.-H. and Lam, H.-M. (2008) Ectopic expression of GmPAP3 alleviates oxidative damage caused by salinity and osmotic stresses. New Phytol. 178: 80-91. |
9. |
Cheung, M.-Y., Zeng, N.-Y., Tong, S.-W., Li, F.W.-Y., Zhao, K.-J., Zhang, Q., Sun, S.S.-M. and Lam, H.-M. (2007) Expression of a RING-HC protein from rice improves resistance to Pseudomonas syringae pv. tomato DC3000 in transgenic Arabidopsis thaliana. J. Exp. Bot. 58: 4147-4159. |
10. |
Wan, T.-F., Shao, G.-H. Shao, Shan, X.-C., Zeng, N.-Y., and Lam, H.-M. (2006) Correlation between AS1 gene expression and seed protein contents in different soybean (Glycine max [L.] Merr.) cultivars. Plant Biol. 8: 271-276. |
11. |
Li, W.-Y.F., Wong, F.-L., Tsai, S.-N., Phang, T.-H., Shao, G., and Lam, H.-M. (2006) Tonoplast located GmCLC1 and GmNHX1 from soybean enhance salt tolerance in transgenic Bright Yellow (BY)-2 cells. Plant Cell Environ. 29: 1122-1137. |
12. |
Wu, C., Ma, Q., Yam, K.-M., Cheung, M.-Y., Xu, Y., Han, T., Lam, H.-M., and Chong, K.-C. (2006). In situ expression of the GmNMH7 gene is photoperiod-dependent in a unique soybean (Glycine max [L.] Merr.) flowering reversion system. Planta 223: 725-735. |
13. |
Wong,
H.-K., Chan, H.-K., Coruzzi, G., and Lam,
H.-M. (2004) Correlation of ASN2 gene expression with
ammonium metabolism in Arabidopsis thaliana. Plant
Physiol. 134: 332-338. |
14. |
Liao,
H., Wong, F.-L., Phang, T.-H., Cheung, M.-Y., Li, W.-Y.F.,
Shao, G., Yan, X., and Lam, H.-M. (2003)
GmPAP3, a novel purple acid phosphatase-like gene in soybean
induced by NaCl stress but not phosphorus deficiency. Gene
318: 103-111. |
15. |
Lam,
H.-M.,
Wong, P., Chan, H.-K., Yam, K.-M., Chen, L., Chow, C.-M., and
Coruzzi, G. (2003) Expression of the ASN1 gene enhances nitrogen
status in seeds of Arabidopsis thaliana. Plant
Physiol. 132: 926-935. |
16. |
Chiu,
J., DeSalle, R., Lam, H.-M., Meisel,
L. and Coruzzi, G. (1999) Molecular evolution of glutamate
receptors: A primitive mechanism that existed before plants
and animals diverged. Mol. Biol. Evol.
16: 826-838. |
17. |
Lam, H.-M., Chiu, J., Hsieh, M.-H.,
Meisel, L., Oliveira, I.C., Shin, M. and Coruzzi, G. (1998)
Glutamate receptor genes in plants. Nature 396: 125-126.
|
18. |
Lam,
H.-M.,
Hsieh, M.-H. and Coruzzi, G. (1998) Reciprocal regulation of
distinct asparagine synthetase genes by light and metabolites
in Arabidopsis thaliana. Plant J. 16: 345-353. |
19. |
Hsieh,
M.-H., Lam, H.-M., Van de Loo F.J.
and Coruzzi, G. (1998) A PII-like protein in Arabidopsis:
putative role in nitrogen sensing. Proc. Nat. Acad. Sci. U.S.A. 23: 13965-13970. |
20. |
Lam,
H.-M.,
Coschigano, K., Oliveira, I.C., Melo-Oliveira, R. and Coruzzi,
G. (1996) The molecular-genetics of nitrogen assimilation
into amino acids in higher plants. Ann. Rev. Plant Biol. 47: 569-593. |
21. |
Lam,
H.-M.,
Coschigano, K., Schultz, C., Ngai, N., Oliveira, R., Hsieh,
M., Oliveira, I. and Coruzzi, G. (1995) Nitrogen assimilation
into amide amino acids in Arabidopsis thaliana. Plant
Cell 7: 887-898. |
22. |
Lam,
H.-M.,
Peng, S. and Coruzzi, G. (1994) Metabolic control of asparagine
synthetase gene expression in Arabidopsis thaliana. Plant
Physiol. 106: 1347-1357. |
23. |
Lam, H.-M. and Winkler, M.E. (1992)
Characterization of the complex pdxH-tyrS operon of Escherichia
coli K-12 and pleiotropic phenotypes caused by pdxH insertion
mutations. J. Bacteriol. 174:6033-6045. |
24. |
Lam,
H.-M.,
Tancula, E., Dempsey, W.B. and Winkler, M.E. (1992) Suppression
of insertions in the complex pdxJ operon of Escherichia coli K-12 by lon and other mutations. J. Bacteriol.
174: 1554-1567. |
25. |
Lam,
H.-M.
and Winkler, M.E. (1990) Metabolic relationship between pyridoxine
(vitamin B6) and serine biosynthesis in Escherichia coli
K-12. J. Bacteriol. 172: 6518-6528. |
| Research
Grants |
| Hong
Kong University Grant Council (UGC) Area of Excellence (AoE) |
| 2007-2010
|
Plant
and Agricultural Biotechnology - HK$25,000,000 (co-investigator
and deputy director) |
|
2000-2006
|
Plant
and Fungal Biotechnology - HK$38,823,000 (co-investigator
and deputy director) |
Research Grants Council (RGC) Earmarked
Grants and General Research Fund |
| 2011-2013 |
Using a unique recombinant inbred population and genomic sequencing information to map loci controlling important agronomic traits of soybean - HK$2,070,000 |
| 2010-2011 |
The Functional Roles of GmSAL1 in Enhancing Stress Tolerance Via Regulating the Basal Cytosolic Calcium Level - HK$869,124 |
| 2009-2010 |
The Roles of a Novel G Protein Binding Protein in Plant Defense Response - HK$990,465 |
| 2004-2006 |
Characterization and Functional Analysis of a Novel NaCl-Inducible Purple Acid Phosphatase-Like Gene - HK$939,968 |
| 2002-2004 |
Gene
Regulation in the Signal Transduction Pathways of Broad-Spectrum
Bacterial Blight Resistance Loci in Rice - HK$876,000 |
| 2000-2002 |
Sink-source
Relationship during Seed Development in Arabidopsis thaliana
- Molecular Regulation of Aspartate Family Amino Acids - HK$1,062,600 |
| 1999-2002 |
Molecular
and Biochemical Characterization of a Salt-tolerant Soybean
Variety - HK$709,500 |
| 1998-2001 |
Asparagine
Synthetase Genes: Their Roles in Plant Growth and Development
- HK$1,032,000 |
China GM Crops Initiative Fund |
| 2009-2010 |
Identification and Mechanistic Study of Genes Related to Crop Yield, Nutrition and Stress Tolerance ¡V RMB3,500,000 (project leader of the part on stress tolerance) |
Industrial Support Fund |
| 1998-2001 |
Production of High Value Pharmaceutical Proteins in Transgenic
Seeds - HK$5,292,000 (co-investigator and deputy co-ordinator) |
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