| |
| Prof
Yum Shing WONG
Address: |
Room G83, Science Centre, CUHK (Off); |
| |
Room G92,
Science Centre, CUHK (Lab) |
| Phone: |
(852)
2609-6389 (Off); |
| |
(852)
2609-6121 (Lab) |
| Fax: |
(852)
2603-5646, (852) 2603-5745 |
| E-mail: |
yumshingwong@cuhk.edu.hk |
| Education |
| PhD
(Plant Physiology and Biochemistry), University of California
at Davis |
| MPhil
(Biology), The Chinese University of Hong Kong |
| BSc (Biology),
The Chinese University of Hong Kong |
| Position |
| 1995-present
|
Associate Professor (Dept of Biology, The Chinese University
of Hong Kong)
|
| 1988-1995 |
Lecturer
(Dept of Biology, The Chinese University of Hong Kong)
|
| 1985-1988 |
Postdoctoral
Fellow (Dept of Biochemistry and Biophysics, University of
California at Davis)
|
| |
|
| Concurrent
Position |
| 2003-present |
Deputy
Director, UNIDO-CUHK Joint Centre for International Services
to Mushroom Biotechnology |
| 1995-present |
Director,
Research Laboratory for Food Protein Production |
| Professional
Activities |
| Membership
in the following Professional Organizations: |
| American
Society of Plant Biologists |
| Guangdong
Botanical Society, China |
| Institute
of Food Technologists, USA |
| Hong
Kong Food Science and Technology Association (Founding member) |
| Sigma
Xi, The Scientific Research Society, USA |
Awards |
| 2001 |
Science
Faculty Exemplary Teaching Award |
| 1990 |
Biology
Society Best Teacher Award |
| Research
Interest |
 1. Flavonoid antioxidants and their health-promoting effects |
| 2.
Bioactive compounds in algae and fungi |
| 3.
Development of natural food additives and supplements |
| 4.
Mode of action of narciclasine in plant growth and development |
| Representative
Publications |
| 1. |
Chen, T. and Wong, Y.S. (2008) Antioxidant and antiproliferative activities of selenium-containing phycocyanin from selenium-enriched Spirulina platensis. Journal of Agricultural and Food Chemistry. (in press) |
| 2. |
Chen, T., Zheng, W., Wong, Y.S., and Yang, F. (2008) Mitochondria-mediated apoptosis in human breast carcinoma MCF-7 cells induced by a novel selenadiazole derivative. Biomedicine and Pharmacotherapy 62: 77-84. |
| 3. |
Chen, T., Zheng, W., Wong, Y.S. and Yang, F. (2008) Selenium-induced changes in activities of antioxidant enzymes and contents of photosynthetic pigments in Spirulina platensis. Journal of Integrative Plant Biology 50: 40-48. |
| 4. |
Ho, T.S., Ho, Y.P., Wong, W.Y., Chiu, L.C.M., Wong, Y.S. and Ooi, V.E.C. (2007). Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A357 cells. Biomedicine and Pharmacotherapy 61: 578-587. |
| 5. |
Li, W.Y., Chiu, L.C., Lam, W.S., Wong, W.Y., Chan, Y.T., Ho, Y.P., Wong, E.Y., Wong, Y.S. and Ooi, V.E. (2007) Ethyl acetate extract of Chinese medicinal herb Sarcandra glabra induces growth inhibition on human leukemic HL-60 cells, associated with cell cycle arrest and up-regulation of pro-apoptotic Bax/Bcl-2 ratio. Oncology Reports 17: 425-31. |
| 6. |
Chen, T., Wong, Y.S. and Zheng, W. (2006) Purification and characterization of selenium- containing phycocyanin from selenium-enriched Spirulina platensis. Phytochemistry 67: 2424-2430. |
| 7. |
Chen,
T., Zheng, W., Wong, Y.S., Yan,
F. and Bai, Y. (2006) Accumulation of selenium in mixotrophic
culture of Spirulina platenis on glucose. Bioresource
Technology 97: 2260-2265. |
| 8. |
Chen, T., Zheng, W., Yang, F., Bai, Y. and Wong, Y.S. (2006) Mixotrophic culture of selenium enriched Spirulina platensis on acetate and the enhanced production of photosynthetic pigments and phycobiliprotein. Enzyme and Microbial Technology 39: 103-107. |
| 9. |
Zheng,
L., Wong, Y.S., Gao, Q.X., Pu,
X., Li, S.F. and Bi, Y.R. (2005) Antioxidative and antitumor
activities of the crude extracts of Pleurotus eryngii
var. nerbrodensis. Mycosystema 24: 71-78. |
| 10. |
Chang,
Q. and Wong, Y.S. (2004) Identification
of flavonoids in Hakmeitau beans (Vigna sinensis) by
high performance liquid chromatography-electrospray- mass spectrometry
(LC-ESI/MS). Journal of Agriculture and Food Chemistry
52: 6694-6699. |
| 11. |
Bi,
Y.R., Guo, J.K., Zhang, L.X. and Wong,
Y.S. (2003) Changes in some enzymes of microbodies and
plastid development in excised radish cotyledons: Effect of
narciclasine. Journal of Plant Physiology 160: 1041-1049. |
| 12. |
Bi,
Y.R., Zhang, L.X., Guo, J.K., Yung, K.H. and Wong,
Y.S. (2003) Narciclasine alters chloroplast membrane
structure and inhibits 5-aminolevulinic acid and chlorophyll
binding protein accumulation in wheat (Triticum aestivum)
leaves. New Zealand Journal of Crop and Horticultural Science
31: 335-343. |
| 13. |
Bi,
Y.R., Zhang, L.X., Guo, J.K., Yung, K.H. and Wong,
Y.S. (2003) Effect of NCS on enzyme activities in microbodies
and cell ultra-structure of excised radish cotyledons. Acta
Botanica Boreal-Occidentalia Sinica 23: 2049-2057. |
| 14. |
Bi, Y.R.,
Zhang, L.X., Guo, J.K., Wong, Y.S.
and Yung, K.H. (2003) The interaction of NCS with phytohormones.
Acta Botanica Boreal-Occidentalia Sinica 23: 867-874. |
| 15. |
Goh,
T.K. and Wong, Y.S. (1999) In
vivo and in vitro observations of Cercospora
mikaniacola from Hong Kong: morphology, microcycle conidiation,
and potential bio-control of Mikania weed. Fungal Science
14: 1-10. |
| 16. |
Bi,
Y.R., Yung, K.H. and Wong, Y.S.
(1998) Physiological effects of narciclasine from the muscilage
of Narcissus tazetta bulbs. Plant Science
135: 103-108. |
| 17. |
Chau,
C.F., Cheung, P.C.K. and Wong, Y.S.
( 1998) Hypocholesterolemic effects of protein concentrates
from three Chinese indigenous legume seeds. Journal of
Agricultural and Food Chemistry 46: 3698-3701. |
| 18. |
Chau,
C.F., Cheung, P.C.K. and Wong, Y.S.
(1998) Chemical composition of three underutilized legume
seeds grown in China. Food Chemistry 61: 505-509. |
| 19. |
Chau,
C.F., Cheng P.C.K. and Wong Y.S.
(1997) Effects of cooking on the content of amino acids and
antinutrients in three Chinese indigenous legume seeds.
Journal of the Science of Food and Agriculture 75: 447-452. |
| 20. |
Chau, C.F., Cheng P.C.K. and Wong, Y.S.
(1997) Functional properties of protein concentrates from
three Chinese indigenous legume seeds. Journal of Agricultural
and Food Chemistry 42: 2500-2503. |
| 21. |
Lam,
Y.H., Wong, Y.S., Wang, B., Wong,
R.N.S, Yeung, H.W. and Shaw, P.C. (1996) Use of trichosanthin
to reduce infection by turnip mosaic virus. Plant Science
114: 111-117. |
| 22. |
Tai,
V.W.F., Fung, P.H., Wong, Y.S.
and Shing, T.K.M. (1995) Kinetic studies on cyclophellitol
analogues - Mechanism-based inactivators. Biochemical and
Biophysical Research Communications 213: 175-180. |
| 23. |
Tai,
V.W.F., Fung, P.H., Wong, Y.S.
and Shing, T.K.M. (1994) Synthesis and glycosidase inhibitory
activity of cyclophellitol analogues. Tetrahedron:Asymmetry
5: 1353-1362. |
|
24. |
Goh,
T.K. and Wong, Y.S. (1994) Potential
biocontrol strategies of mikania weed in Hong Kong. Proceedings
of the Guangdong Botanical Society 7: 36-37. |
| 25. |
Leung,
P.C. and Wong, Y.S. (1994) The
calcium effect on benzyladenine-induced stimulation of chlorophyll
accumulation in excised cucumber cotyledons. Proceedings
of the Guangdong Botanical Society 7: 18-19. |
| 26. |
Wong,
Y.S.
and Wang, X. (1991) Biodegradation of tannins in spent coffee
grounds by Pleurotus sajor-caju PL27. World Journal
of Microbiology and Biotechnology 7: 573-574. |
| 27. |
Wong,
Y.S.,
McMichael, R.W. and Lagarias, J.C. (1989) Properties of a
polycation-stimulated protein kinase associated with purified
Avena phytochrome. Plant Physiology 91: 709-718. |
| 28. |
Wong,
Y.S.
and Lagarias, J.C. (1989) Affinity labeling of Avena
phytochrome with ATP analogs. Proceedings of the National
Academy of Science, USA 86: 3469-3473. |
| 29. |
Wong,
Y.S.,
Cheng, H.C., Walsh, D.A., and Lagarias, J.C. (1986) Phosphorylation
of Avena phytochrome in vitro as a probe of
light-induced conformational changes. Journal of Biological
Chemistry 261: 12089-12097. |
| 30. |
Wong,
Y.S.
and Castelfranco, P.A. (1985) Properties of Mg-protoporphyrin
IX monomethyl ester (oxidative) cyclase system. Plant
Physiology 79: 730-733. |
| 31. |
Wong,
Y.S.
, Castelfranco, P.A., Goff, D.A., and Smith, K.M. (1985) Intermediates
in the formation of the chlorophyll isocyclic ring. Plant
Physiology 79: 725-729. |
| 32. |
Wong,
Y.S.
and Castelfranco P.A. (1984) Resolution and reconstitution
of Mg-proto porphyrin IX monomethyl ester (oxidative) cyclase,
the enzyme system responsible for the formation of the chlorophyll
isocyclic ring. Plant Physiology 75: 658-661. |
| Research
Grants |
| Chief Executive's Community Project |
| 2006-2010 |
Construction of Food Composition Database for Nutrition Labeling (HK$ 17,770,000) (as co-Investigator)
|
| |
| Research
Grants Council (RGC) Earmarked Grants |
| 2002-2004 |
Isolation
and characterization of flavonoid antioxidants in Vigna
sinensis seeds (HK$ 780,000) |
| 1997-1999 |
Genetic
engineering of sweet protein mabinlin for increased stability
(HK$ 656,000) (as co-investigator) |
| 1992-1993 |
Isolation
and characterization of glycosidase inhibitors from mushrooms
(HK$ 150,000) |
Hong Kong Universities Grant Council
(UGC) - Area of Excellence on Plant & Fungal Biotechnology
Program |
| 2000-2003 |
Fermentative
production of Monascus metabolites (HK$ 700,000) (as co-investigator) |
Education Department Quality Education Fund |
| 2004-2006 |
Case-based
learning of high school science subjects to support learning
to learn (HK$2,820,000) (as co-investigator) |
| 2003-2005 |
Multi-school
collaboration in the information technology for Hong Kong flora
and vegetation (HK$1,938,000) (as co-investigator) |
| 2002-2003 |
A Web-based database and training for Hong Kong flora and
vegetation (HK$ 1,500,000) (as co-investigator) |
Industrial Support Fund |
| 1998-2002 |
Development
of over-the-counter pharmaceutical products based on local
medicinal plants. (HK$ 8,120,000) (as co-investigator) |
The Croucher Foundation Research
Grant |
| 1992-1994 |
Biological
detoxification of rapeseed meals by fungi (HK$ 400,000) |
CUHK Research Committee Direct
Grants |
| 2004 |
Absorption
and anticancer activities of flavonoids |
| 2003 |
Antiproliferative
effects of selected flavonoids |
| 2002 |
Study
on the biological activities of narciclasine |
| 2001 |
Evaluation
of Castanea mollissima pigment as natural food additive |
| 2000 |
The
effects of narciclasine on the greening of etiolated wheat
leaves |
| 1999 |
Free
radical scavenging activities and antioxidant properties of
plant flavonoids |
| 1998 |
Natural
antioxidants from legume seeds |
| 1997 |
An
evaluation of the nutritional value and potential food use
of some underutilized Asiatic pulses |
| 1996 |
Vigna
sinesis pigment as natural food colorant |
| 1995 |
Thermal
stability of staphylococcal enterotoxin and evaluation of
the renaturation process after thermal treatment |
| 1994 |
Studies
on post-harvest storage of straw mushroom |
| 1993 |
Selection
of potential fungal pathogen for biological control of Mikania
weed |
| 1991 |
Screening
of edible fungi for glucosinolate degradation |
| 1989 |
Recycling
of spent coffee grounds |
Private Funding |
| 1990-1992 |
Analysis
of staphylococcal enterotoxins in mushrooms (HK$ 150,000 Tak
Fat Trading Co, Hong Kong) |
| 1989-1991 |
Utilization
of spent coffee grounds for mushroom cultivation (US$ 15,000
Kraft-General Food Co, USA) |
|
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