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CUHK > Department of Biology > People: Teaching Staffs |
 
 
 

Prof Yum Shing WONG

Address:

Room G83, Science Centre, CUHK (Off);
  Room G92, Science Centre, CUHK (Lab)
Phone: (852) 2609-6389 (Off);
  (852) 2609-6121 (Lab)
Fax: (852) 2603-5646, (852) 2603-5745
E-mail: yumshingwong@cuhk.edu.hk

 

Education
PhD (Plant Physiology and Biochemistry), University of California at Davis
MPhil (Biology), The Chinese University of Hong Kong
BSc (Biology), The Chinese University of Hong Kong

Position
1995-present
Associate Professor (Dept of Biology, The Chinese University of Hong Kong)
1988-1995
Lecturer (Dept of Biology, The Chinese University of Hong Kong)
1985-1988
Postdoctoral Fellow (Dept of Biochemistry and Biophysics, University of California at Davis)
   
Concurrent Position
2008-present Adjunct Professor, Jinan University, China
2003-present Deputy Director, UNIDO-CUHK Joint Centre for International Services to Mushroom Biotechnology
1995-present Director, Research Laboratory for Food Protein Production

Professional Activities
Membership in the following Professional Organizations:
American Society of Plant Biologists
Guangdong Botanical Society, China
Institute of Food Technologists, USA
Hong Kong Food Science and Technology Association (Founding member)
Sigma Xi, The Scientific Research Society, USA

Awards
2001 Science Faculty Exemplary Teaching Award
1990 Biology Society Best Teacher Award

Research Interest
1. Phytochemicals with health-beneficial properties
2. Bioactive compounds from algae and fungi
3. Selenium-containing compounds with anticancer activity

Representative Publications
1. Zheng, L., Si, J. and Wong, Y.S. (2009) Ergosterol peroxide and 9,11-dehydroergosterol peroxide from Ganoderma lucidum mycelia suppress the growth of human breast adenocarcinoma MCF-7 cells. International Journal of Medicinal Mushrooms 11:249-253.
2. Chen, T., Wong, Y.S., Zheng, W. and Liu, J. (2009) Caspase- and p53-dependent apoptosis in breast carcinoma cells induced by a synthetic selenadiazole derivative. Chemico-Biological Interactions 180:54-60.
3. Kong, C., Lam, C., Chiu, L., Ooi, V.E.C., Sun, S.S.M. and Wong, Y.S. (2009) A rice polyphenol, cycloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis. Biochemical Pharmacology 77:1487-1496
4. Li, X.L., Xu, G., Chen, T., Wong, Y.S., Zhao, H.L., Fang, R.R., Gu, X.M., Tong, P.T.C. and Chan, J.C.N. (2009) Phycocyanin protects INS-1E pancrestic beta cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress modulating JNK and p38 mitogen-activated protein kinase pathways. The International Journal of Biochemistry and Cell Biology 41:1526-1535.
5. Chen, T. and Wong, Y.S. (2009) Selenocystine induces caspase-independent apoptosis in MCF-7 human breast carcinoma cells with involvement of p53 phosphorylation and reactive oxygen species generation. The International Journal of Biochemistry and Cell Biology 41:666-676.
6. Chen, T. and Wong, Y.S. (2009) Selenocystine induces reactive oxygen species-mediated apoptosis in human cancer cells. Biomedicine & Pharmacotherapy 63:105-113.
7. Chen, T. and Wong, Y.S. (2008) Selenocystine induces S-phase arrest and apoptosis in human breast adenocarcinoma MCF-7 cells by modulating the ERK and Akt phosphorylation. Journal of Agricultural and Food Chemistry 56:10574-10581.
8. Chen, T., Wong, Y.S., Zheng, W., Bai, Y. and Huang, L. (2008) Selenium nanoparticles fabricated in Undaria pinnatifida polysaccharide solutions induce mitochondria-mediated apoptosis in A375 human melanoma cells. Colloids and Surfaces B: Biointerfaces 67:26-31.
9. Chen, T. and Wong, Y.S. (2008) Selenocystine induces apoptosis of A375 human melanoma cells by activating ROS-mediated mitochondrial pathway and p53 phosphorylation. Cellular and Molecular Life Sciences 65:2763-2775.
10. Chen, T. and Wong, Y.S. (2008) In vitro antioxidant and antiproliferative activities of selenium-containing phycocyanin from selenium-enriched Spirulina platensis. Journal of Agricultural and Food Chemistry 56:4352–4358.
11.
Chen, T., Zheng, W., Wong, Y.S., and Yang, F. (2008) Mitochondria-mediated apoptosis in human breast carcinoma MCF-7 cells induced by a novel selenadiazole derivative. Biomedicine and Pharmacotherapy 62: 77-84.
12.
Chen, T., Zheng, W., Wong, Y.S. and Yang, F. (2008) Selenium-induced changes in activities of antioxidant enzymes and contents of photosynthetic pigments in Spirulina platensis. Journal of Integrative Plant Biology 50: 40-48.
13.
Ho, T.S., Ho, Y.P., Wong, W.Y., Chiu, L.C.M., Wong, Y.S. and Ooi, V.E.C. (2007). Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A357 cells. Biomedicine and Pharmacotherapy 61: 578-587.
14.
Li, W.Y., Chiu, L.C., Lam, W.S., Wong, W.Y., Chan, Y.T., Ho, Y.P., Wong, E.Y., Wong, Y.S. and Ooi, V.E. (2007) Ethyl acetate extract of Chinese medicinal herb Sarcandra glabra induces growth inhibition on human leukemic HL-60 cells, associated with cell cycle arrest and up-regulation of pro-apoptotic Bax/Bcl-2 ratio. Oncology Reports 17: 425-31.
15.
Chen, T., Wong, Y.S. and Zheng, W. (2006) Purification and characterization of selenium- containing phycocyanin from selenium-enriched Spirulina platensis. Phytochemistry 67: 2424-2430.
16.
Chen, T., Zheng, W., Wong, Y.S., Yan, F. and Bai, Y. (2006) Accumulation of selenium in mixotrophic culture of Spirulina platenis on glucose. Bioresource Technology 97: 2260-2265.
17.
Chen, T., Zheng, W., Yang, F., Bai, Y. and Wong, Y.S. (2006) Mixotrophic culture of selenium enriched Spirulina platensis on acetate and the enhanced production of photosynthetic pigments and phycobiliprotein. Enzyme and Microbial Technology 39: 103-107.
18.
Zheng, L., Wong, Y.S., Gao, Q.X., Pu, X., Li, S.F. and Bi, Y.R. (2005) Antioxidative and antitumor activities of the crude extracts of Pleurotus eryngii var. nerbrodensis. Mycosystema 24: 71-78.
19.
Chang, Q. and Wong, Y.S. (2004) Identification of flavonoids in Hakmeitau beans (Vigna sinensis) by high performance liquid chromatography-electrospray- mass spectrometry (LC-ESI/MS). Journal of Agriculture and Food Chemistry 52: 6694-6699.
20.
Bi, Y.R., Guo, J.K., Zhang, L.X. and Wong, Y.S. (2003) Changes in some enzymes of microbodies and plastid development in excised radish cotyledons: Effect of narciclasine. Journal of Plant Physiology 160: 1041-1049.
21.
Bi, Y.R., Zhang, L.X., Guo, J.K., Yung, K.H. and Wong, Y.S. (2003) Narciclasine alters chloroplast membrane structure and inhibits 5-aminolevulinic acid and chlorophyll binding protein accumulation in wheat (Triticum aestivum) leaves. New Zealand Journal of Crop and Horticultural Science 31: 335-343.
22.
Bi, Y.R., Zhang, L.X., Guo, J.K., Yung, K.H. and Wong, Y.S. (2003) Effect of NCS on enzyme activities in microbodies and cell ultra-structure of excised radish cotyledons. Acta Botanica Boreal-Occidentalia Sinica 23: 2049-2057.
23.
Bi, Y.R., Zhang, L.X., Guo, J.K., Wong, Y.S. and Yung, K.H. (2003) The interaction of NCS with phytohormones. Acta Botanica Boreal-Occidentalia Sinica 23: 867-874.

Research Grants
國家自然科學基金
2008-2011 含硒、碲藻藍蛋白的形態分析、抗腫瘤作用及機理研究 (Co-investigator, RMB 300,000)
 
Institute of Plant Molecular Biology & Agricultural Biotechnology Research Grant
2006-2010 Improvement of mineral nutrient contents in rice: iron and selenium (HK$ 1,200,000)
 
Chief Executive's Community Project
2006-2010 Construction of Food Composition Database for Nutrition Labeling (HK$ 17,770,000) (as co-Investigator)
 
Research Grants Council (RGC) Earmarked Grants
2002-2004
Isolation and characterization of flavonoid antioxidants in Vigna sinensis seeds (HK$ 780,000)
1997-1999
Genetic engineering of sweet protein mabinlin for increased stability (HK$ 656,000) (as co-investigator)
1992-1993
Isolation and characterization of glycosidase inhibitors from mushrooms (HK$ 150,000)

Hong Kong Universities Grant Council (UGC) - Area of Excellence on Plant & Fungal Biotechnology Program
2000-2003
Fermentative production of Monascus metabolites (HK$ 700,000) (as co-investigator)

Education Department Quality Education Fund
2004-2006 Case-based learning of high school science subjects to support learning to learn (HK$2,820,000) (as co-investigator)
2003-2005 Multi-school collaboration in the information technology for Hong Kong flora and vegetation (HK$1,938,000) (as co-investigator)
2002-2003
A Web-based database and training for Hong Kong flora and vegetation (HK$ 1,500,000) (as co-investigator)

Industrial Support Fund
1998-2002
Development of over-the-counter pharmaceutical products based on local medicinal plants. (HK$ 8,120,000) (as co-investigator)

The Croucher Foundation Research Grant
1992-1994 Biological detoxification of rapeseed meals by fungi (HK$ 400,000)

CUHK Research Committee Direct Grants
Over HK$1,500,000 since 1990
 

Private Funding

1990-1992
Analysis of staphylococcal enterotoxins in mushrooms (HK$ 150,000 Tak Fat Trading Co, Hong Kong)
1989-1991
Utilization of spent coffee grounds for mushroom cultivation (US$ 15,000 Kraft-General Food Co, USA)


 

Last updated: August 21, 2009

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