| |
| Prof
Yum Shing WONG
Address: |
Room G83, Science Centre, CUHK (Off); |
| |
Room G92,
Science Centre, CUHK (Lab) |
| Phone: |
(852)
2609-6389 (Off); |
| |
(852)
2609-6121 (Lab) |
| Fax: |
(852)
2603-5646, (852) 2603-5745 |
| E-mail: |
yumshingwong@cuhk.edu.hk |
| Education |
| PhD
(Plant Physiology and Biochemistry), University of California
at Davis |
| MPhil
(Biology), The Chinese University of Hong Kong |
| BSc (Biology),
The Chinese University of Hong Kong |
| Position |
| 1995-present
|
Associate Professor (Dept of Biology, The Chinese University
of Hong Kong)
|
| 1988-1995 |
Lecturer
(Dept of Biology, The Chinese University of Hong Kong)
|
| 1985-1988 |
Postdoctoral
Fellow (Dept of Biochemistry and Biophysics, University of
California at Davis)
|
| |
|
| Concurrent
Position |
| 2008-present |
Adjunct Professor, Jinan University, China |
| 2003-present |
Deputy
Director, UNIDO-CUHK Joint Centre for International Services
to Mushroom Biotechnology |
| 1995-present |
Director,
Research Laboratory for Food Protein Production |
| Professional
Activities |
| Membership
in the following Professional Organizations: |
| American
Society of Plant Biologists |
| Guangdong
Botanical Society, China |
| Institute
of Food Technologists, USA |
| Hong
Kong Food Science and Technology Association (Founding member) |
| Sigma
Xi, The Scientific Research Society, USA |
Awards |
| 2001 |
Science
Faculty Exemplary Teaching Award |
| 1990 |
Biology
Society Best Teacher Award |
| Research
Interest |
 1. Phytochemicals with health-beneficial properties |
| 2. Bioactive compounds from algae and fungi |
| 3. Selenium-containing compounds with anticancer activity |
| Representative
Publications |
| 1. |
Zheng, L., Si, J. and Wong, Y.S. (2009) Ergosterol peroxide and 9,11-dehydroergosterol peroxide from Ganoderma lucidum mycelia suppress the growth of human breast adenocarcinoma MCF-7 cells. International Journal of Medicinal Mushrooms 11:249-253. |
| 2. |
Chen, T., Wong, Y.S., Zheng, W. and Liu, J. (2009) Caspase- and p53-dependent apoptosis in breast carcinoma cells induced by a synthetic selenadiazole derivative. Chemico-Biological Interactions 180:54-60. |
| 3. |
Kong, C., Lam, C., Chiu, L., Ooi, V.E.C., Sun, S.S.M. and Wong, Y.S. (2009) A rice polyphenol, cycloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis. Biochemical Pharmacology 77:1487-1496 |
| 4. |
Li, X.L., Xu, G., Chen, T., Wong, Y.S., Zhao, H.L., Fang, R.R., Gu, X.M., Tong, P.T.C. and Chan, J.C.N. (2009) Phycocyanin protects INS-1E pancrestic beta cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress modulating JNK and p38 mitogen-activated protein kinase pathways. The International Journal of Biochemistry and Cell Biology 41:1526-1535. |
| 5. |
Chen, T. and Wong, Y.S. (2009) Selenocystine induces caspase-independent apoptosis in MCF-7 human breast carcinoma cells with involvement of p53 phosphorylation and reactive oxygen species generation. The International Journal of Biochemistry and Cell Biology 41:666-676. |
| 6. |
Chen, T. and Wong, Y.S. (2009) Selenocystine induces reactive oxygen species-mediated apoptosis in human cancer cells. Biomedicine & Pharmacotherapy 63:105-113. |
| 7. |
Chen, T. and Wong, Y.S. (2008) Selenocystine induces S-phase arrest and apoptosis in human breast adenocarcinoma MCF-7 cells by modulating the ERK and Akt phosphorylation. Journal of Agricultural and Food Chemistry 56:10574-10581. |
| 8. |
Chen, T., Wong, Y.S., Zheng, W., Bai, Y. and Huang, L. (2008) Selenium nanoparticles fabricated in Undaria pinnatifida polysaccharide solutions induce mitochondria-mediated apoptosis in A375 human melanoma cells. Colloids and Surfaces B: Biointerfaces 67:26-31. |
| 9. |
Chen, T. and Wong, Y.S. (2008) Selenocystine induces apoptosis of A375 human melanoma cells by activating ROS-mediated mitochondrial pathway and p53 phosphorylation. Cellular and Molecular Life Sciences 65:2763-2775. |
| 10. |
Chen, T. and Wong, Y.S. (2008) In vitro antioxidant and antiproliferative activities of selenium-containing phycocyanin from selenium-enriched Spirulina platensis. Journal of Agricultural and Food Chemistry 56:4352–4358. |
| 11. |
Chen, T., Zheng, W., Wong, Y.S., and Yang, F. (2008) Mitochondria-mediated apoptosis in human breast carcinoma MCF-7 cells induced by a novel selenadiazole derivative. Biomedicine and Pharmacotherapy 62: 77-84. |
| 12. |
Chen, T., Zheng, W., Wong, Y.S. and Yang, F. (2008) Selenium-induced changes in activities of antioxidant enzymes and contents of photosynthetic pigments in Spirulina platensis. Journal of Integrative Plant Biology 50: 40-48. |
| 13. |
Ho, T.S., Ho, Y.P., Wong, W.Y., Chiu, L.C.M., Wong, Y.S. and Ooi, V.E.C. (2007). Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A357 cells. Biomedicine and Pharmacotherapy 61: 578-587. |
| 14. |
Li, W.Y., Chiu, L.C., Lam, W.S., Wong, W.Y., Chan, Y.T., Ho, Y.P., Wong, E.Y., Wong, Y.S. and Ooi, V.E. (2007) Ethyl acetate extract of Chinese medicinal herb Sarcandra glabra induces growth inhibition on human leukemic HL-60 cells, associated with cell cycle arrest and up-regulation of pro-apoptotic Bax/Bcl-2 ratio. Oncology Reports 17: 425-31. |
| 15. |
Chen, T., Wong, Y.S. and Zheng, W. (2006) Purification and characterization of selenium- containing phycocyanin from selenium-enriched Spirulina platensis. Phytochemistry 67: 2424-2430. |
| 16. |
Chen,
T., Zheng, W., Wong, Y.S., Yan,
F. and Bai, Y. (2006) Accumulation of selenium in mixotrophic
culture of Spirulina platenis on glucose. Bioresource
Technology 97: 2260-2265. |
| 17. |
Chen, T., Zheng, W., Yang, F., Bai, Y. and Wong, Y.S. (2006) Mixotrophic culture of selenium enriched Spirulina platensis on acetate and the enhanced production of photosynthetic pigments and phycobiliprotein. Enzyme and Microbial Technology 39: 103-107. |
| 18. |
Zheng,
L., Wong, Y.S., Gao, Q.X., Pu,
X., Li, S.F. and Bi, Y.R. (2005) Antioxidative and antitumor
activities of the crude extracts of Pleurotus eryngii
var. nerbrodensis. Mycosystema 24: 71-78. |
| 19. |
Chang,
Q. and Wong, Y.S. (2004) Identification
of flavonoids in Hakmeitau beans (Vigna sinensis) by
high performance liquid chromatography-electrospray- mass spectrometry
(LC-ESI/MS). Journal of Agriculture and Food Chemistry
52: 6694-6699. |
| 20. |
Bi,
Y.R., Guo, J.K., Zhang, L.X. and Wong,
Y.S. (2003) Changes in some enzymes of microbodies and
plastid development in excised radish cotyledons: Effect of
narciclasine. Journal of Plant Physiology 160: 1041-1049. |
| 21. |
Bi,
Y.R., Zhang, L.X., Guo, J.K., Yung, K.H. and Wong,
Y.S. (2003) Narciclasine alters chloroplast membrane
structure and inhibits 5-aminolevulinic acid and chlorophyll
binding protein accumulation in wheat (Triticum aestivum)
leaves. New Zealand Journal of Crop and Horticultural Science
31: 335-343. |
| 22. |
Bi,
Y.R., Zhang, L.X., Guo, J.K., Yung, K.H. and Wong,
Y.S. (2003) Effect of NCS on enzyme activities in microbodies
and cell ultra-structure of excised radish cotyledons. Acta
Botanica Boreal-Occidentalia Sinica 23: 2049-2057. |
| 23. |
Bi, Y.R.,
Zhang, L.X., Guo, J.K., Wong, Y.S.
and Yung, K.H. (2003) The interaction of NCS with phytohormones.
Acta Botanica Boreal-Occidentalia Sinica 23: 867-874. |
| Research
Grants |
| 國家自然科學基金 |
| 2008-2011 |
含硒、碲藻藍蛋白的形態分析、抗腫瘤作用及機理研究 (Co-investigator, RMB 300,000) |
| |
| Institute of Plant Molecular Biology & Agricultural Biotechnology Research Grant |
| 2006-2010 |
Improvement of mineral nutrient contents in rice: iron and selenium (HK$ 1,200,000) |
| |
| Chief Executive's Community Project |
| 2006-2010 |
Construction of Food Composition Database for Nutrition Labeling (HK$ 17,770,000) (as co-Investigator) |
| |
| Research
Grants Council (RGC) Earmarked Grants |
| 2002-2004 |
Isolation
and characterization of flavonoid antioxidants in Vigna
sinensis seeds (HK$ 780,000) |
| 1997-1999 |
Genetic
engineering of sweet protein mabinlin for increased stability
(HK$ 656,000) (as co-investigator) |
| 1992-1993 |
Isolation
and characterization of glycosidase inhibitors from mushrooms
(HK$ 150,000) |
Hong Kong Universities Grant Council
(UGC) - Area of Excellence on Plant & Fungal Biotechnology
Program |
| 2000-2003 |
Fermentative
production of Monascus metabolites (HK$ 700,000) (as co-investigator) |
Education Department Quality Education Fund |
| 2004-2006 |
Case-based
learning of high school science subjects to support learning
to learn (HK$2,820,000) (as co-investigator) |
| 2003-2005 |
Multi-school
collaboration in the information technology for Hong Kong flora
and vegetation (HK$1,938,000) (as co-investigator) |
| 2002-2003 |
A Web-based database and training for Hong Kong flora and
vegetation (HK$ 1,500,000) (as co-investigator) |
Industrial Support Fund |
| 1998-2002 |
Development
of over-the-counter pharmaceutical products based on local
medicinal plants. (HK$ 8,120,000) (as co-investigator) |
The Croucher Foundation Research
Grant |
| 1992-1994 |
Biological
detoxification of rapeseed meals by fungi (HK$ 400,000) |
CUHK Research Committee Direct
Grants |
| Over HK$1,500,000 since 1990 |
| |
|
Private Funding |
| 1990-1992 |
Analysis
of staphylococcal enterotoxins in mushrooms (HK$ 150,000 Tak
Fat Trading Co, Hong Kong) |
| 1989-1991 |
Utilization
of spent coffee grounds for mushroom cultivation (US$ 15,000
Kraft-General Food Co, USA) |
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