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CUHK > Department of Biology > People: Teaching Staffs |
 
 
 

Prof Yum Shing WONG

Address:

Room G83, Science Centre, CUHK (Off);
  Room G92, Science Centre, CUHK (Lab)
Phone: (852) 2609-6389 (Off);
  (852) 2609-6121 (Lab)
Fax: (852) 2603-5646, (852) 2603-5745
E-mail: yumshingwong@cuhk.edu.hk

 

Education
PhD (Plant Physiology and Biochemistry), University of California at Davis
MPhil (Biology), The Chinese University of Hong Kong
BSc (Biology), The Chinese University of Hong Kong

Position
1995-present
Associate Professor (Dept of Biology, The Chinese University of Hong Kong)
1988-1995
Lecturer (Dept of Biology, The Chinese University of Hong Kong)
1985-1988
Postdoctoral Fellow (Dept of Biochemistry and Biophysics, University of California at Davis)
   
Concurrent Position
2003-present Deputy Director, UNIDO-CUHK Joint Centre for International Services to Mushroom Biotechnology
1995-present Director, Research Laboratory for Food Protein Production

Professional Activities
Membership in the following Professional Organizations:
American Society of Plant Biologists
Guangdong Botanical Society, China
Institute of Food Technologists, USA
Hong Kong Food Science and Technology Association (Founding member)
Sigma Xi, The Scientific Research Society, USA

Awards
2001 Science Faculty Exemplary Teaching Award
1990 Biology Society Best Teacher Award

Research Interest
1. Flavonoid antioxidants and their health-promoting effects
2. Bioactive compounds in algae and fungi
3. Development of natural food additives and supplements
4. Mode of action of narciclasine in plant growth and development

Representative Publications
1.
Chen, T. and Wong, Y.S. (2008) Antioxidant and antiproliferative activities of selenium-containing phycocyanin from selenium-enriched Spirulina platensis. Journal of Agricultural and Food Chemistry. (in press)
2.
Chen, T., Zheng, W., Wong, Y.S., and Yang, F. (2008) Mitochondria-mediated apoptosis in human breast carcinoma MCF-7 cells induced by a novel selenadiazole derivative. Biomedicine and Pharmacotherapy 62: 77-84.
3.
Chen, T., Zheng, W., Wong, Y.S. and Yang, F. (2008) Selenium-induced changes in activities of antioxidant enzymes and contents of photosynthetic pigments in Spirulina platensis. Journal of Integrative Plant Biology 50: 40-48.
4.
Ho, T.S., Ho, Y.P., Wong, W.Y., Chiu, L.C.M., Wong, Y.S. and Ooi, V.E.C. (2007). Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A357 cells. Biomedicine and Pharmacotherapy 61: 578-587.
5.
Li, W.Y., Chiu, L.C., Lam, W.S., Wong, W.Y., Chan, Y.T., Ho, Y.P., Wong, E.Y., Wong, Y.S. and Ooi, V.E. (2007) Ethyl acetate extract of Chinese medicinal herb Sarcandra glabra induces growth inhibition on human leukemic HL-60 cells, associated with cell cycle arrest and up-regulation of pro-apoptotic Bax/Bcl-2 ratio. Oncology Reports 17: 425-31.
6.
Chen, T., Wong, Y.S. and Zheng, W. (2006) Purification and characterization of selenium- containing phycocyanin from selenium-enriched Spirulina platensis. Phytochemistry 67: 2424-2430.
7.
Chen, T., Zheng, W., Wong, Y.S., Yan, F. and Bai, Y. (2006) Accumulation of selenium in mixotrophic culture of Spirulina platenis on glucose. Bioresource Technology 97: 2260-2265.
8.
Chen, T., Zheng, W., Yang, F., Bai, Y. and Wong, Y.S. (2006) Mixotrophic culture of selenium enriched Spirulina platensis on acetate and the enhanced production of photosynthetic pigments and phycobiliprotein. Enzyme and Microbial Technology 39: 103-107.
9.
Zheng, L., Wong, Y.S., Gao, Q.X., Pu, X., Li, S.F. and Bi, Y.R. (2005) Antioxidative and antitumor activities of the crude extracts of Pleurotus eryngii var. nerbrodensis. Mycosystema 24: 71-78.
10.
Chang, Q. and Wong, Y.S. (2004) Identification of flavonoids in Hakmeitau beans (Vigna sinensis) by high performance liquid chromatography-electrospray- mass spectrometry (LC-ESI/MS). Journal of Agriculture and Food Chemistry 52: 6694-6699.
11.
Bi, Y.R., Guo, J.K., Zhang, L.X. and Wong, Y.S. (2003) Changes in some enzymes of microbodies and plastid development in excised radish cotyledons: Effect of narciclasine. Journal of Plant Physiology 160: 1041-1049.
12.
Bi, Y.R., Zhang, L.X., Guo, J.K., Yung, K.H. and Wong, Y.S. (2003) Narciclasine alters chloroplast membrane structure and inhibits 5-aminolevulinic acid and chlorophyll binding protein accumulation in wheat (Triticum aestivum) leaves. New Zealand Journal of Crop and Horticultural Science 31: 335-343.
13.
Bi, Y.R., Zhang, L.X., Guo, J.K., Yung, K.H. and Wong, Y.S. (2003) Effect of NCS on enzyme activities in microbodies and cell ultra-structure of excised radish cotyledons. Acta Botanica Boreal-Occidentalia Sinica 23: 2049-2057.
14.
Bi, Y.R., Zhang, L.X., Guo, J.K., Wong, Y.S. and Yung, K.H. (2003) The interaction of NCS with phytohormones. Acta Botanica Boreal-Occidentalia Sinica 23: 867-874.
15.
Goh, T.K. and Wong, Y.S. (1999) In vivo and in vitro observations of Cercospora mikaniacola from Hong Kong: morphology, microcycle conidiation, and potential bio-control of Mikania weed. Fungal Science 14: 1-10.
16.
Bi, Y.R., Yung, K.H. and Wong, Y.S. (1998) Physiological effects of narciclasine from the muscilage of Narcissus tazetta bulbs. Plant Science 135: 103-108.
17.
Chau, C.F., Cheung, P.C.K. and Wong, Y.S. ( 1998) Hypocholesterolemic effects of protein concentrates from three Chinese indigenous legume seeds. Journal of Agricultural and Food Chemistry 46: 3698-3701.
18.
Chau, C.F., Cheung, P.C.K. and Wong, Y.S. (1998) Chemical composition of three underutilized legume seeds grown in China. Food Chemistry 61: 505-509.
19.
Chau, C.F., Cheng P.C.K. and Wong Y.S. (1997) Effects of cooking on the content of amino acids and antinutrients in three Chinese indigenous legume seeds. Journal of the Science of Food and Agriculture 75: 447-452.
20.
Chau, C.F., Cheng P.C.K. and Wong, Y.S. (1997) Functional properties of protein concentrates from three Chinese indigenous legume seeds. Journal of Agricultural and Food Chemistry 42: 2500-2503.
21.
Lam, Y.H., Wong, Y.S., Wang, B., Wong, R.N.S, Yeung, H.W. and Shaw, P.C. (1996) Use of trichosanthin to reduce infection by turnip mosaic virus. Plant Science 114: 111-117.
22.
Tai, V.W.F., Fung, P.H., Wong, Y.S. and Shing, T.K.M. (1995) Kinetic studies on cyclophellitol analogues - Mechanism-based inactivators. Biochemical and Biophysical Research Communications 213: 175-180.
23.
Tai, V.W.F., Fung, P.H., Wong, Y.S. and Shing, T.K.M. (1994) Synthesis and glycosidase inhibitory activity of cyclophellitol analogues. Tetrahedron:Asymmetry 5: 1353-1362.

24.

Goh, T.K. and Wong, Y.S. (1994) Potential biocontrol strategies of mikania weed in Hong Kong. Proceedings of the Guangdong Botanical Society 7: 36-37.
25.
Leung, P.C. and Wong, Y.S. (1994) The calcium effect on benzyladenine-induced stimulation of chlorophyll accumulation in excised cucumber cotyledons. Proceedings of the Guangdong Botanical Society 7: 18-19.
26.
Wong, Y.S. and Wang, X. (1991) Biodegradation of tannins in spent coffee grounds by Pleurotus sajor-caju PL27. World Journal of Microbiology and Biotechnology 7: 573-574.
27.
Wong, Y.S., McMichael, R.W. and Lagarias, J.C. (1989) Properties of a polycation-stimulated protein kinase associated with purified Avena phytochrome. Plant Physiology 91: 709-718.
28.
Wong, Y.S. and Lagarias, J.C. (1989) Affinity labeling of Avena phytochrome with ATP analogs. Proceedings of the National Academy of Science, USA 86: 3469-3473.
29.
Wong, Y.S., Cheng, H.C., Walsh, D.A., and Lagarias, J.C. (1986) Phosphorylation of Avena phytochrome in vitro as a probe of light-induced conformational changes. Journal of Biological Chemistry 261: 12089-12097.
30.
Wong, Y.S. and Castelfranco, P.A. (1985) Properties of Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase system. Plant Physiology 79: 730-733.
31.
Wong, Y.S. , Castelfranco, P.A., Goff, D.A., and Smith, K.M. (1985) Intermediates in the formation of the chlorophyll isocyclic ring. Plant Physiology 79: 725-729.
32.
Wong, Y.S. and Castelfranco P.A. (1984) Resolution and reconstitution of Mg-proto porphyrin IX monomethyl ester (oxidative) cyclase, the enzyme system responsible for the formation of the chlorophyll isocyclic ring. Plant Physiology 75: 658-661.

Research Grants
Chief Executive's Community Project
2006-2010 Construction of Food Composition Database for Nutrition Labeling (HK$ 17,770,000) (as co-Investigator)
 
Research Grants Council (RGC) Earmarked Grants
2002-2004
Isolation and characterization of flavonoid antioxidants in Vigna sinensis seeds (HK$ 780,000)
1997-1999
Genetic engineering of sweet protein mabinlin for increased stability (HK$ 656,000) (as co-investigator)
1992-1993
Isolation and characterization of glycosidase inhibitors from mushrooms (HK$ 150,000)

Hong Kong Universities Grant Council (UGC) - Area of Excellence on Plant & Fungal Biotechnology Program
2000-2003
Fermentative production of Monascus metabolites (HK$ 700,000) (as co-investigator)

Education Department Quality Education Fund
2004-2006 Case-based learning of high school science subjects to support learning to learn (HK$2,820,000) (as co-investigator)
2003-2005 Multi-school collaboration in the information technology for Hong Kong flora and vegetation (HK$1,938,000) (as co-investigator)
2002-2003
A Web-based database and training for Hong Kong flora and vegetation (HK$ 1,500,000) (as co-investigator)

Industrial Support Fund
1998-2002
Development of over-the-counter pharmaceutical products based on local medicinal plants. (HK$ 8,120,000) (as co-investigator)

The Croucher Foundation Research Grant
1992-1994 Biological detoxification of rapeseed meals by fungi (HK$ 400,000)

CUHK Research Committee Direct Grants
2004 Absorption and anticancer activities of flavonoids
2003 Antiproliferative effects of selected flavonoids
2002
Study on the biological activities of narciclasine
2001
Evaluation of Castanea mollissima pigment as natural food additive
2000
The effects of narciclasine on the greening of etiolated wheat leaves
1999
Free radical scavenging activities and antioxidant properties of plant flavonoids
1998
Natural antioxidants from legume seeds
1997
An evaluation of the nutritional value and potential food use of some underutilized Asiatic pulses
1996
Vigna sinesis pigment as natural food colorant
1995
Thermal stability of staphylococcal enterotoxin and evaluation of the renaturation process after thermal treatment
1994
Studies on post-harvest storage of straw mushroom
1993
Selection of potential fungal pathogen for biological control of Mikania weed
1991
Screening of edible fungi for glucosinolate degradation
1989
Recycling of spent coffee grounds

Private Funding
1990-1992
Analysis of staphylococcal enterotoxins in mushrooms (HK$ 150,000 Tak Fat Trading Co, Hong Kong)
1989-1991
Utilization of spent coffee grounds for mushroom cultivation (US$ 15,000 Kraft-General Food Co, USA)


 

Last updated: February 15, 2008

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