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photo of Prof. T.W. Dominic CHAN

陳德華教授

BSc(First Hons), PhD (University of Warwick, U.K.)
教授


location 香港中文大學 科學館163室
Phone No. (852) 3943-6260
Email (852) 2603-5057
Email twdchan@cuhk.edu.hk



擔任之職位

香港中文大學 
化學系教授

專業活動

香港質譜學會 (HKSMS)
2000–2002, 2005–2006 主席
1999–2000 副主席
1998 創辦會員
 
Member of the Editorial Advisory Board
  • European Journal of Mass Spectrometry
  • Journal of Chinese Mass Spectrometry Society
 
External Assessor for Grant Applications
  • HK Research Grants Council
  • HK Baptist University
  • Academic Sinica, Taiwan
 
Peer Reviewer for Research Papers
  • Journal of American Society for Mass Spectrometry
  • European Journal of Mass Spectrometry
  • Rapid Communication in Mass Spectrometry
  • Inorganic Chemistry Communication
 
Member of American Society for Mass Spectrometry
 
香港考試局
1998 香港高級程度會考 化學科 試卷主席
 
Organiser of Professional Activities
1998 Two-week Training Workshop on Mass Spectrometry and State-of-the-Art Mass Spectrometry Instruments for PRC Young Scientists
2006 The 4th International Uppsala Conference on Electron Capture and Dissociation Mass Spectrometry — Fundamental and Applications

榮譽和獎項

2002
香港中文大學 
理學院 
模範教學獎

研究興趣

  1. Development of new mass spectrometry interfaces:
    • MALDI interface for FTMS
    • Nanospray & nano-LC interface for FTMS
  2. Experimental and theoretical investigations of the novel mass spectrometry dissociation methods for structural analysis of proteins and DNA fragments
  3. Detection and characterization of bioactive polysaccharides from herbal medicines

現有空缺

We are looking for PhD students with research interest in mass spectrometry and will provide full financial support to the successful applicants. Applicants should apply with a resume, a transcript and a grade of English test (TOEFL or CET-6) to Prof. Chan at twdchan@cuhk.edu.hk.


研究資助/資金

總金額 (1994-2006: 1,448 萬港元)

2006
裘槎基金會:
Sponsorship of International Conference
HKD100,000
2006, 2004, 2003, 2000, 1998, 1996, 1995
香港特別行政區 
大學教育資助委員會 
研究用途補助金
2002
香港中文大學 
暑期研究資助
2002
Special Equipment Grants, 
The Chinese University of Hong Kong
2002, 1994
Direct Grants, 
The Chinese University of Hong Kong
1997, 1995
Industrial Support Fund, 
Department of Industry
1997
Joint HK/UK Research Scheme, 
British Council
1997
利希慎基金會
1997
One-time Support Funded Projects, 
The Chinese University of Hong Kong

研究合作

  • 美國 西雅圖 華盛頓大學
  • 瑞典 烏普薩拉大學
  • 英國 華威大學
  • 中華人民共和國 中國科學院
  • 中華人民共和國 北京大學
  • 中華人民共和國 清華大學
  • 香港 香港科技大學
  • 香港中文大學 中醫學院
  • 香港中文大學 醫學院

著作

  1. “Electron Caption Dissociation of Peptides Metalated with Alkaline Earth Metal Ions” J. Am. Mass Spectrom. 2006, 17. 757.
  2. “Analyses of Stemona Alkaloids in Stemona Tuberosa by Liquid Chromatography / Tandem Mass Spectrometry, Y. Zhou, R.-W. Jaing, P.-M. Hon, Y.-T. Xu, Y.-M. Chan, T.-W. D. Chan, H.-X. Xu, L.-S. Ding, P. P.-H. But, P.-C. Shaw, Rapid Commun. Mass Spectrom., 2006, 20, 1030.
  3. “Determination of molecular weight profile for a bioactive β-(13) polysaccharides -curdlan”, T.-W. D. Chan, P.K. Chan and K.Y. Tanf, Anal. Chim. Acta, 2006, 556, 226.
  4. “Facile disulfide bond cleavage in gaseous peptide and protein cations by 157-nm ultra-violet photo-dissociation”, Eva Y. M. Fung, Frank Kjeldsen, Oleg A. Silivra, T.-W. D. Chan and Roman A. Zubarev, Angew. Chem. Int. Ed., 2005, 44, 2.
  5. “Experimental and theoretical investigations of the loss of amino acid side chains in electron capture dissociation of model peptides”, Y. M. E. Fung and T.-W. D. ChanJ. Am. Soc. Mass Spectrom., 2005,16, 1523.
  6. “A modified internal lock-mass method for calibration of the product ions derived from sustained off-resonance irradiation collision-induced dissociation (SORI-CID) using a Fourier transform mass spectrometer (FTMS)” L. Duan and T.-W. D. Chan, Rapid Commun. Mass Spectrom., 2004, 18, 1286.
  7. “A comparative study of the collision induced dissociation and the electron capture dissociation of model peptides using ESI-FTMS” Y.M.E. Fung, L. Duan and T.-W. D. Chan, Euro. J. Mass Spectrom., 2004, 10, 449.
  8. “Analysis of a bioactive β-(1→3) polysaccharide (Curdlan) by using matrix-assisted laser desorption / ionization time-of-flight mass spectrometry (MALDI-TOFMS)” T.-W.D. Chan and K. Y. Tang, Rapid Commun. Mass Spectrom., 2003, 17, 1.
  9. “Accurate mass measurements for peptide and protein mixtures by using matrix-assisted laser desorption/ionization Fourier transform mass spectrometry (MALDI-FTMS)”, T.-W. D. Chan, L. Duan and T.-P. E. Sze, Anal. Chem., 2002, 74, 5282.
  10. “Optimization of Experimental Parameters for Electron Capture Dissociation of Peptides in a Fourier Transform Mass Spectrometer (FTMS)”, T.-W.D. Chan and W.H.H. Ip, J. Am. Soc. Mass Spectrom.,2002, 13, 1396.
  11. “A study of fast and metastable dissociations of adenine-thymine binary-based oligonucleotides by using positive-ion MALDI-TOF mass spectrometry”, T.-W. D. Chan, Y. M.E. Fung and Y. C. L. Li, J. Am. Soc. Mass Spectrom., 2002, 13, 1052.
  12. "Tetrapyrrole derivatives substituted with ferrocenylethynyl moieties. Synthesis and Electrochemical studies", K-W. Poon, W. liu, P-K. Chan. Q. Yang, T-W. D. Chan, T.C.W. Mak and D.K.P. Ng, J. Org. Chem., 2001, 66, 1553.
  13. "Antioxidative Glucosides from the fruits of Ligustrum lucidium", Z-D. He, P.P-H. But, T-W.D. Chan, H. Dong, H-X. Xu, C-P. Lau and H-D. Sun, Chem. Pharm. Bull, 2001, 49, 780.
  14. “Sequence analysis of peptides with biological activities using electrospray-Fourier transform ion cyclotron resonance mass spectrometry”, M. He, J. Xu, T-W. D. Chan and R.L.C. Lau, Chinese Science Bulletin, 2001, 46, 1281.
  15. "Effect of sample preparation methods on the analysis of dispersed polysaccharides by MALDI-TOF mass spectrometry, Rapid Commun. Mass Spectrom., 2000, 14, 1841.
  16. "Differentiation of enantiomers by using matrix-assisted laser desorption / ionization (MALDI) mass spectrometry", M.P. So, T.S.M. Wan and T-W.D. ChanRapid Commun. Mass Spectrom., 2000, 14, 692.
  17. "Differentiation and authentication of Panax ginsengPanax quinquefolius and ginseng products by using HPLC/MS", T-W.D. Chan, P.P.H. But, S.W. Cheng, I.M.Y. Kwok, F.W. Lau and H.X. Xu, Anal. Chem.,2000, 72, 1281.
  18. "Synthesis and structural characterization of highly chlorinated, brominated, iodinated, and methylated carbroane anions, H-1-CB9X9-, NH2-1-CB9X9- (X = Cl, Br, I), and H-1-CB9(CH3)9-", Inorg. Chem., 2000, 39, 3582.
  19. “Weakly coordinating nature of a carborane cage bearing different halogen atoms. Synthesis and structural characterization of icosahedral mixed halocarborane anions, 1-H-CB11Y5X6- (X, Y = Cl, Br, I)", Inorg. Chem., 2000, 39, 5851.
  20. "Time-of-flight effects in matrix-assisted laser desorption / ionization Fourier transform mass spectrometry", E.T-P. Sze and T-W.D. ChanRapid Commun. Mass Spectrom., 1999, 13, 1.
  21. "A novel non-metallized tip for electrospray mass spectrometry at nanoliter flow rate", K.W.Y. Fong and T-W.D. ChanJ. Am Mass Spectrom. Soc., 1999, 10, 72.
  22. "Highly Chlorinated, brominated, and iodinated icosahedral carbonane anions: 1-H-CB11X11-, 1-CH3-CB11-X11- (X = Cl, Br, I); 1-Br-CB11B11-", Z. Xie, C-W. Tsang, E.T-P. Sze, Q. Yang, T-W.D Chan and T.C.W. Mak, Inorg. Chem., 1998, 37, 6444.
  23. "Evaluation of ammonium salts as co-matrices for matrix-assisted laser desorption / ionization mass spectrometry of oligonucleotides", Y.C.L. Li, S-W. Cheng and T-W.D. ChanRapid Commun. Mass Spectrom., 1998, 12, 993.
  24. "Origins of proton in the generation of ions from polymers and peptides in matrix-assisted laser desorption / ionization", C.K.L. Wong, M.P. So and T-W.D. ChanEuro. Mass Spectrom., 1998, 4, 223.
  25. "Formulation of matrix solutions for use in matrix-assisted laser desorption / ionization (MALDI) of Biomoelcules", E.T.P. Sze, G. Wang and T-W.D. ChanJ. Am Mass Spectrom. Soc., 1998, 9, 166-174.
  26. "Cationization processes in matrix-assisted laser desorption / ionization mass spectrometry : Attachment of divalent and trivalent metal ions", C.K.L. Wong and T-W.D. ChanRapid Commun. Mass Spectrom., 1997, 11, 513-519.
  27. "Fourier Transform ion cyclotron resonance studies of Lanthanide(III) porphyrin-phthalocyanine heteroleptic sandwich complexes using electrospray ionization", R.L.C. Lau, J.Jiang, D.K.P. Ng and T-W.D. ChanJ. Am Mass Spectrom. Soc., 1997, 8, 161-169.
  28. "Sesquterpene lactones from Elephantopus scaber", P.P-H. But, P-M.Hon, T-W.D. Chan, T.C.W. Mak and C-T. Che; Phytochemistry, 1997, 44, 113-116.
  29. "Synthesis, spectroscopic and electrochemical properties of substituted bis(phthalocyaninato)lanthanide(III) complexes", J. Jiang, R.C.W. Liu, T.C.W. Mak, T-W.D. Chan and D.K.P. Ng, Polyhedron, 1997, 16, 515-520.
  30. "Synthesis and spectroscopic properties of heteroleptic sandwich-type (phthalocyaninato)(porphyrinato)lanthanide(III) complexes", J. Jiang, R.L.C. Lau, T-W.D. Chan, T.C.W. Mak and D.K.P. Ng; Inorg. Chim Acta,  1997, 255, 59-64.
  31. "Mass spectra of hydrazo, azo and azoxy compound", T-W.D. Chan and S.W. Tam, in The Chemistry of Hydrazo, Azo and Azoxy Groups, vol. 2, edited by S. Patai, John Wiley, & Sons Ltd., Chichester, 1997, Chap. 4, pp. 105-135.
  32. "Dendritic models of redox proteins: X-ray photoelectron spectroscopy and cyclic voltammetry studies of dendritic bis(terpyridine) iron(II) complexes", H-F Chow, Y-K. I Chan, T-W. D Chan and R.W.M. Kwok; Chem. Eur. J.,  1996, 2, 133
  33. "Positive-ion electrospray mass spectra for a number of polypeptides and proteins", M. He, J. Xu, T-W.D. Chan and R.L.C. Lau;  Rapid Commun. Mass Spectrom., 1996, 10, 987-902.
  34. "Use of ammonium halides as co-matrices for matrix-assisted laser desorption / ionization studies of oligonucleotides", S-W. Cheng and T-W.D. Chan; Rapid Commun. Mass Spectrom., 1996, 10, 907-910.
  35. "Fourier transform ion cyclotron resonances studies of terpyridine-based polyether dendrimers and their iron(II) metallocomplexes by liquid secondary ion mass spectrometry", R.L.C. Lau, T-W. D. Chan, I.Y-K. Chan and H.F. Chow; Euro. Mass Spectrom., 1995, 1, 371-380.
  36. "Initial velocities of positive and negative protein molecule-ions produced in matrix-assisted ultraviolet laser desorption using a liquid matrix", T-W.D. Chan, I. Thomas, A.W. Colburn and P.J. Derrick; Chem. Phys. Lett., 1994, 222, 579.
  37. "Design considerations in energy resolved time-of-flight mass spectrometry", A.E. Giannakopulos, D.J. Reynolds, T-W.D. Chan, A.W. Colburn and P.J. Derrick; Int. J. Mass Spectrom. Ion Phys., 1994, 131, 67.
  38. "Threshold fluences for production of positive and negative ions in matrix-assisted laser desorption / ionisation using liquid and solid matrices", P.Y. Yau, T-W. D. Chan, P.G. Cullis, A.W. Colburn and P.J. Derrick; Chem. Phys. Lett., 1993, 202, 93.
  39. "Suppression of matrix-ions in ultraviolet laser desorption: Scanning electron microscopy and Raman spectroscopy of the solid sample", T-W.D. Chan, A.W. Colburn, P.J. Derrick, D.J. Derek and M. Bowden; Org. Mass Spectrom., 1992, 27, 188.
  40. "Matrix-assisted laser desorption / ionization using a liquid matrix: Formation of high-mass cluster ions from proteins", T-W.D. Chan, A.W. Colburn and P.J. Derrick; Org. Mass Spectrom., 1992, 27, 53.
  41. "Matrix-assisted ultraviolet laser desorption: Suppression of the matrix peaks", T-W.D. Chan, A.W. Colburn and P.J. Derrick; Org. Mass Spectrom., 1991, 26, 342.
  42. "Computer-controlled activation of 25µm diameter tungsten wire for field desorption", T-W. D. Chan, A.W. Colburn and P.J. Derrick; Int. J. Mass Spectrom. and Ion Phys., 1991, 107, 491.