Prof. CHAN, Ho Yin Edwin
| Address: | Rm. 509B, Mong Man Wai Building, CUHK (Office) |
| Rm. 509, Mong Man Wai Building, CUHK (Lab) | |
| Phone: | (852)-31634021 (Off) / (852)-2609-8032 (Lab) |
| Fax: | (852)-26037732 |
| E-mail: | hyechan@cuhk.edu.hk |
Education
| 1999 | Ph.D. in Genetics, University of Cambridge, UK |
| 1995 | B.Sc. (Hons) Biochemistry, The Chinese University of Hong Kong, Hong Kong |
Position
| 2008-present | Associate Professor (Department of Biochemistry, The Chinese University of Hong Kong, Hong Kong) |
| 2002-2008 | Assistant Professor (Department of Biochemistry, The Chinese University of Hong Kong, Hong Kong) |
| 1999-2001 | Wellcome Trust International Travelling Research Fellow (University of Pennsylvania, USA) |
| Concurrent Position | |
| 2009-Present | Deputy Director, M.Sc. Programme in Biochemical and Biomedical Sciences (The Chinese University of Hong Kong, Hong Kong) |
| 2005-Present | Warden, Postgraduate Halls, The Chinese University of Hong Kong, Hong kong |
Professional Activities
| 2007 - Present | Scientific Advisory Board member, Society for Research on the Cerebellum |
| 2006 - Present | Treasurer, Hong Kong Society of Biochemistry and Molecular Biology |
| 1997 - Present | Member, Genetics Society of America |
Research Interest
| 1. Nucleolar function and nuclear trafficking. |
| 2. Genetic intervention of degenerative brain diseases. |
| 3. Drosophila models of human disease. |
Representative Publications
| 1. | Chan, C.M., Tsoi, H., Chan, W.M., Zhai, S., Wong, C.O., Yao, X., Chan, W.Y., Tsui, S.K.W., and Chan, H.Y.E.* (2009) The ion channel activity of the SARS-Coronavirus 3a protein is linked to its pro-apoptotic function. Int. J. Biochem. & Cell Biol. (in press) |
| 2. | Lee, F.K.M., Wong, A.K.Y., Lee, Y.W., Wan, O.W. Chan, H.Y.E.*,and Chung, K.K.K.* (2009) Neuroprotection against alpha-synuclein-induced toxicity by targeting the ubiquitin proteasomal pathway. Journal of Neurochemistry (in press) * denotes corresponding author |
| 3. | Mugat, B., Parmentier, M.L., Bonneaud, N., Chan, H.Y.E., and Maschat, F. (2008) Protective role of Engrailed in a Drosophila model of Huntington"s disease. Hum. Mol. Genet. 17, 3601-3616. |
| 4. | Lam, W., Chan, W.M., Lo, T.W., Wong, A.K.Y., Wu, C.C. and Chan, H.Y.E. (2008) Human receptor for activated protein kinase C1 associates with polyglutamine aggregates and modulates polyglutamine toxicity. Biochem. Biophys. Res. Comm. 377, 714-719. |
| 5. | Wong, S.L.A., Chan, W.M. and Chan, H.Y.E. (2008) SDS-insoluble polyglutamine oligomers are involved in neuronal degeneration. FASEB J. 22, 3348-3357. |
| 6. | Chan, W.M., Shaw, P.C. and Chan, H.Y.E. (2007) A green fluorescent protein-based reporter for protein import studies in Drosophila cells. Fly 1, 340-342. |
| 7. | Huen, N.Y.M., Wong, S.L.A. and Chan, H.Y.E. (2007) Transcriptional malfunctioning of heat shock protein gene expression in spinocerebellar ataxias. The Cerebellum. (Invited review) 6, 111-117. |
| 8. | Chan, C.M., Ma, C.W., Chan, W.Y. and Chan, H.Y.E. (2007) The SARS-Coronavirus Membrane protein induces apoptosis through modulating the Akt survival pathway. Arch. Biochem. Biophys. 459, 197-207. (Featured on the cover of the issue) |
| 9. | Chau KW, Chan WY, Shaw PC, Chan HYE. (2006) Biochemical investigation of Tau protein phosphorylation status and its solubility properties in Drosophila. Biochem Biophys Res Commun.346(1):150-9. |
| 10. | Wong, S.L.A., Chen, Y.W., Chan, C.M. , Chan, C.S.M., Chan, P.K.S., Chui, Y.L.,Fung, K.P., Waye, M.M.Y., Tsui, S.K.W. and Chan, H.Y.E. (2005) In vivo functional characterization of the SARS Coronavirus 3a protein in Drosophila.Biochem. Biophy. Res. Comm. 337, 720-729. |
| 11. | Huen, N.Y.M. and Chan, H.Y.E. (2005) Dynamic regulation of molecular chaperone gene expression in polyglutamine disease. Biochem. Biophy. Res. Comm. 334, 1074-1084. |
| 12. | Law, P.T.W., Wong, C.H., Au, T.C.C., Chuck, C.P., Kong, S.K., Chan, P.K.S.,To, K.F., Lo, A.W.I., Chan, J.Y.W., Suen, Y.K., Chan, H.Y.E., Fung, K.P.,Waye, M.M.Y., Sung, J.J.Y., Lo, Y.M.D., Tsui, S.K.W. (2005) The 3a protein of severe acute respiratory syndrome-coronavirus induces apoptosis in Vero E6 cells. J. Gen. Virol. 86, 1921-1930 |
| 13. | Kusano, A., Staber, C., Chan, H.Y.E. and Ganetzky, B. (2003) Closing the (Ran)GAP on Segregation distortion in Drosophila. BioEssays 25, 108-115. |
Research Grants
| Research Grants Council (RGC) Earmarked Grants | |
| 2009-2011 | Probing the nuclear transport role of the mutant polyglutamine domain in neurodegeneration – HK$929,247 |
| 2004-2007 | Nucleocytoplasmic transport and polyglutamine toxicity: A cellular genetic study – HK$1,265,677 |
| 2003-2006 | Genetic and proteomic studies of chaperone-mediated suppression of polyglutamine toxicity in Drosophila – HK$1,203,000 |
| Research Fund for Control of Infectious Diseases | |
| 2009-2011 | Deciphering the pro-apoptotic function of the SARS-CoV Membrane protein – HK$741,448 |
| 2004-2006 | Molecular and Genetic Characterization of the SARS Coronavirus Auxiliary Protein X1 in Drosophila – HK$675,144 |
| Cure Huntington’s Disease Initiative, USA | |
| 2009-2010 | Using the 3B5H10 Monoclonal Antibody to Investigate Huntingtin Oligomer and Toxicity in vivo – HK$444,149 |
© 2009. All Rights ReservedCell and Molecular Biology Programme, The Chinese University of Hong Kong