Prof. GE, Wei
| Address: | Room E109, Science Centre, CUHK (Off); |
| Room G93, Science Centre, CUHK (Lab) | |
| Phone: | (852) 2609-6145 (Off) / (852) 2609-6121 (Lab) |
| Fax: | 852) 2603-5646, (852) 2603-5745 |
| E-mail: | weige@cuhk.edu.hk |
Education
| 1993 | PhD (Reproductive Physiology), University of Alberta, Canada |
| 1985 | MSc (Genetics and Developmental Biology), Academia Sinica, China |
| 1982 | BSc (Experimental Zoology), Nanjing University, China |
Position
| 2004-present | Professor (Dept of Biology, The Chinese University of Hong Kong, Hong Kong) |
| 1999-2004 | Associate Professor (Dept of Biology, The Chinese University of Hong Kong, Hong Kong) |
| 1995-1999 | Assistant Professor (Dept of Biology, The Chinese University of Hong Kong, Hong Kong) |
| 1994-1995 | Postdoctoral Fellow (Dept of Developmental Biology, National Institute for Basic Biology, Japan) |
| 1993 | Postdoctoral Fellow (Dept of Biological Sciences, University of Alberta, Canada) |
Research Interest
| 1. Reproductive physiology and molecular endocrinology |
| 2. Growth factors in the development and function of the brain-pituitary-gonad (BPG) axis |
| 3. Endocrine and paracrine regulation of ovarian functions |
| 4. Molecular biology of gonadotropins and their receptors |
Representative Publications
| 1. | Ge, W. (2005) Intrafollicular paracrine communication in the zebrafish ovary: The state of the art of an emerging model for the study of vertebrate folliculogenesis. Molecular and Cellular Endocrinology 237:1-10. (Invited At-the-Cutting-Edge review) |
| 2. | Kwok, H.-F., So, W.-K., Wang, Y. and Ge, W. (2005) Zebrafish gonadotropins and their receptors: I. Cloning and characterization of zebrafish follicle-stimulating hormone and luteinizing hormone receptors (Fshr and Lhr) - Evidence for their distinct functions in follicle development. Biology of Reproduction 72:1370-81. |
| 3. | So, W.-K., Kwok, H.-F. and Ge, W. (2005) Zebrafish gonadotropins and their receptors: II. Cloning and characterization of zebrafish follicle-stimulating hormone (FSH) and luteinizing hormone (LH) subunits - Their spatial-temporal expression patterns and receptor specificity. Biology of Reproduction 72:1382-96. |
| 4. | Ge, W. (2005) Activin and its receptors in fish reproduction. In: Melamed, P. and Sherwood, N. (eds) Hormones and their receptors in fish reproduction. World Scientific Publishing Co., Singapore, pp. 128-154. (invited book chapter) |
| 5. | Lau, M.-T. and Ge, W. (2005) Cloning of Smad2, Smad3, Smad4 and Smad7 from the goldfish pituitary and evidence for their involvement in activin regulation of goldfish FSHβ promoter activity. General and Comparative Endocrinology. (in press). |
| 6. | Wang, Y. and Ge, W. (2004) Developmental profiles of activin βA, βB and follistatin expression in the zebrafish ovary - evidence for their differential roles during sexual maturation and ovulatory cycle. Biology of Reproduction 71: 2056-2064. |
| 7. | Wang, Y. and Ge, W. (2004) Cloning of epidermal growth factor (EGF) and EGF receptor (EGFR) from the zebrafish ovary and its potential roles in the regulation of ovarian activin/follistatin system. Biology of Reproduction 71: 749-760. |
| 8. | Yuen, C.W. and Ge, W. (2004) Follistatin suppresses FSH but increases LH expression in the goldfish-Evidence for an activin-mediated autocrine/paracrine system in fish pituitary. General and Comparative Endocrinology 135: 108-115. |
| 9. | Wang, Y., Wong, A.O.L. and Ge, W. (2003) Cloning, regulation of mRNA expression and function of a new isoform of pituitary adenylate cyclase-activating polypeptide (PACAP) in the zebrafish ovary. Endocrinology 144: 4799-4810. |
| 10. | Wang, Y. and Ge, W. (2003) Spatial expression patterns of activin and its signaling system in the zebrafish ovarian follicle - evidence for paracrine action of activin on the oocytes. Biology of Reproduction 69: 1998-2006. |
| 11. | Wang, Y. and Ge, W. (2003) Gonadotropin regulation of follistatin expression in the cultured ovarian follicle cells of zebrafish, Danio rerio. General and Comparative Endocrinology 134: 308-315. |
| 12. | Wang, Y. and Ge, W. (2003) Involvement of cyclic adenosine 3',5'-monophosphate in the differential regulation of activin A and B expression by gonadotropin in the zebrafish ovarian follicle cells. Endocrinology 144: 491-499. |
| 13. | Wang, Y. and Ge, W. (2002) Cloning of zebrafish ovarian carbonyl reductase-like 20 -hydroxysteroid dehydrogenase and characterization of its spatial and temporal expression. General and Comparative Endocrinology 127:209-216. |
| 14. | Pang, Y.F. and Ge, W. (2002) Epidermal growth factor (EGF) and transforming growth factor- (TGF-) promote zebrafish oocyte maturation in vitro: potential role of the ovarian activin regulatory system. Endocrinology 143:47-54. |
| 15. | Pang, Y.F. and Ge, W. (2002) Gonadotropin and activin enhance maturational competence of the oocytes in the zebrafish, Danio rerio. Biology of Reproduction 66:259-265. |
| 16. | Pang, Y.F. and Ge, W. (2002) Gonadotropin regulation of activin A and activin type II receptor expression in the ovarian follicle cells of the zebrafish, Danio rerio. Molecular and Cellular Endocrinology 188:195-205. |
| 17. | Ge, W. (2000) Roles of activin regulatory system in fish reproduction. Canadian Journal of Physiology and Pharmacology 78:1077-1085. |
| 18. | Pang, Y.F. and Ge, W. (1999) Activin stimulation of zebrafish oocyte maturation in vitro and its potential role in mediating gonadotropin-induced oocyte maturation. Biology of Reproduction 61:987-992. |
| 19. | Yam, K.M., Yu, K.L. and Ge, W. (1999) Molecular cloning and characterization of goldfish activin A subunit cDNA. Molecular and Cellular Endocrinology 154:45-54. |
Research Grants
| Research Grants Council (RGC) Earmarked Grants | |
| 2006-2008 | Functional analysis of pituitary-gonadal axis in the zebrafish – Why do fish need two gonadotropins, and what is the physiological relevance of FSH? - $1,397,914 |
| 2005-2007 | Intrafollicular communication in the zebrafish ovary – roles of GDF-9 from the oocyte in orchestrating follicle development - $1,321,920 |
| 2002-2004 | Epidermal growth factor (EGF) in the ovary of zebrafish - how is it related to the ovarian activin system in controlling oocyte development? - $876,000 |
| 2001-2003 | Activin system in the pituitary: how important is it in the differential expression of fish FSH and LH? - $699,600 |
| 1999-2001 | Transcriptional regulation of gonadotropin-I and II (GTH-I and II) genes in the goldfish by activin - functional analysis of cis-acting elements that mediate activin stimulation of GTH-I and inhibition of GTH-II in the goldfish, Carassius auratus - HK$789,000 |
| 1996-1998 | Activin regulation of pituitary gonadotropin gene expression and oocyte development in the goldfish, Carassius auratus - HK$865,000 |
| Strategic Grants | |
| 2000-2004 | Strategies for the improvement of marine fish and shrimp culture: a molecular biological approach - HK$500,000 (co-investigator) |
Awards
| 2003 | The VC’s Exemplary Teaching Award, The Chinese University of Hong Kong |
| 2003 | Exemplary Teaching Award, Faculty of Science, The Chinese University of Hong Kong |
| 2001 | Exemplary Teaching Award, Faculty of Science, The Chinese University of Hong Kong |
| 1996 |
Biology Society Best Lecturer Award, Department of Biology, The Chinese University of Hong Kong. |
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