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Prof. TSANG, Suk Ying Faye
Address: Rm.607, Mong Man Wai Building, CUHK (Office)
  Rm 610, Mong Man Wai Building, CUHK (lab)
Phone: (852) 26961020 (Off) / (852) 26096054 (Lab)
Fax: (852) 26037732
E-mail: fayetsang@cuhk.edu.hk
Education
2003 Ph.D. in Physiology, The Chinese University of Hong Kong, Hong Kong
1999 BSc (First Class Honors), The Chinese University of Hong Kong, Hong Kong
Position
2006-present Assistant Professor (Department of Biochemistry, The Chinese University of Hong Kong, Hong Kong)
 
2005-2006 Postdoctoral Fellow (Stem Cell Institute, University of California, USA)
2003-2005 Postdoctoral Fellow (Department of Medicine, Division of Cardiology, Johns Hopkins University, USA)
 
Concurrent Position
2008-present Investigator of the State Key Laboratory in Agrobiotechnology (The Chinese University of Hong Kong, Hong Kong)
 
Research Interest
1.
Basic biology of embryonic stem cells and their cardiac derivatives:
  a. Mechanisms controlling cardiac differentiation of embryonic stem cells.
  b. Maintenance of the pluripotent characteristic of embryonic stem cells.
2. Derivatives of human embryonic stem cells for therapeutic purposes.
3. Ion channels and cardiovascular physiology.
Representative Publications
1. Lam CK, Zhang Z, Yu H, Tsang SY, Huang Yu, and Chen ZY. (2008) Apple polyphenols inhibit plasma CETP activity and reduce the ratio of non-HDL to HDL cholesterol. Mol Nutr Food Res. 52:950-8.
2. Wong CM, Yung LM, Leung FP, Tsang SY, Au CL, Chen ZY, Yao X, Cheng CHK, Gollasch M, Lau CW, and Huang Y. (2008) Raloxifene protects endothelial cell function against oxidative stress. Brit J Pharmacol. 155:326-34.
3. Law SK, Ng SY, Leung CFP, Huang Y, and Tsang SY. (2008) Role of reactive oxygen species (ROS) in cardiac differentiation of embryonic stem cells. International Society for Stem Cell Research. P.392.
4. Wong CM, Tsang SY, Yao X, Chan CL, and Huang Y. (2008) Differential effects of estrogen and progesterone on potassium channels expressed in Xenopus oocytes. Steroids. 73:272-9.
5. Chin CH, Ng SY, Law SK, Leung CSL, and Tsang SY. (2008) Role of voltage-gated potassium channels in maintaining the characteristics of embryonic stem cells. International Society for Stem Cell Research. P.398
6. Law SK, Ng SY, Leung CSL, and Tsang SY. (2008) Directed differentiation of embryonic stem cells into cardiac lineage. Association of Chinese Geneticists in America (ACGA) - Hong Kong Society of Medical Genetics (HKSMG) International Conference on Genetics and Genomic Medicine.
7. Tsang SY. (2008) Embryonic stem cell-derived cardiomyocytes for therapy: how close are we? International Journal of Cardiology 125 Suppl 1: S26.
8. Leung FP, Tsang SY, Wong CM, Yung LM, Chan YC, Leung HS, Yao XQ, Huang Y (2007) Raloxifene, tamoxifen and vascular tone. Clinical and Experimental Pharmacology and Physiology. 34:809-13.
9. (2007) Ion channels and embryonic stem cells. IEEE-nanomed. P.90.
10. Tsang SY.Moore JC, Huizen RV, Chan CWY, and Li RA (2007) Ectopic expression of systemic RNA interference defective protein (SID-1) in embryonic stem cells. Biochem Biophys Res Commun. 357:480-6.
11. Tsang SY*, Yao XQ, Chan HY, Chan FL, Leung CSL, Yung LM, Au CL, Chen ZY, Laher I, Huang Y (2007) Tamoxifen and estrogen attenuate enhanced vascular reactivity induced by estrogen deficiency in rat carotid arteries. Biochemical Pharmacology. 73:1330-9. (*corresponding author)
12. Wong CM, Yao X, Au CL, Tsang SY, Fung KP, Laher I, Vanhoutte PM, Huang Y (2006) Raloxifene restores endothelial function in aging ovariectomized female rats.Vascul Pharmacol. 44:290-8..
13. Tsang SY, Moore JC, Chan CWY, Li RA (2006) Functional consequences of overexpressing the gap junction connexin 43 in the cardiogenic potential of human embryonic stem cells. Submitted.
14. Xue T, Cho HC, Akar FG, Tsang SY, Jones SP, Marbán E, Tomaselli GF and Li RA (2005) Functional integration of electrically-active cardiac derivatives from genetically-engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: Insights into the development of cell-based pacemakers. Circulation 111:11-20.
15. Moore JC, Laake LW, Braam SR, Xue T, Tsang SY, Ward D, Passier R, Tertoolen LL, Li RA, and Mummery LC (2005) Human Embryonic Stem Cells: Genetic Manipulation on the Way to Cardiac Cell Therapies. Reproductive Toxicology 20:377-91.
16. Wang G, Xue T, Tsang SY, Huizen HV, Wong J, Lai KW, Ye Z, Cheng L, Au K, Zhang J, Li GR, Lau CP, Li RA and Tse HF (2005) Electrophysiological properties of pluripotent human and mouse embryonic stem cells. Stem Cells 23:1526-34.
17. Tsang SY, Tsushima RG, Tomaselli GF, Li RA and Backx PH (2005) A multifunctional aromatic residue in the external pore vestibule of Na+ channels contributes to the local anesthetic receptor. Molecular Pharmacology 67(2):424-434.
18. Azene ME, Sang D, Tsang SY and Li RA (2005) Pore-to-gate coupling of HCN-channels revealed by a pore variant that contributes to gating but not permeation. Biochem Biophys Res Commun. 327:1131-42.
19. Tsang SY, Lesso H and Li RA (2004) Critical intra-linker interactions of HCN1-encoded pacemaker channels revealed by interchange of S3-S4 determinants. Biochem Biophys Res Commun. 322:652-8.
20. Tsang SY, Yao XQ, Essin K, Wong CM, Chan FL, Gollasch M and Huang Y (2004) Raloxifene relaxes rat cerebral arteries in vitro and inhibits L-type voltage-sensitive Ca2+ channels. Stroke 35:1709-14
21. Tsang SY, Lesso H and Li RA (2004) Dissecting the structural and functional roles of the S3-S4 linker of pacemaker (HCN) channels by systematic length alterations. Journal of Biological Chemistry 279:43752-9.
22. Tsang SY, Yao XQ, Chan FL, Wong CM, Chen ZY, Laher I and Huang Y (2004) Estrogen and tamoxifen modulate cerebrovascular tone in ovariectomized female rats. Hypertension 44:1-5.
23. Verlohren S, Dubroyska G, Tsang SY, Essin K, Luft FC, Huang Y and Gollasch M (2004) Visceral periadventitial adipose tissue regulates arterial tone of small mesenteric arteries. Hypertension 44:271-6.
24. Huang Y, Wong CM, Lau CW, Yao XQ, Tsang SY, Su YL and Chen ZY (2004) Inhibition of nitric oxide/cyclic GMP-mediated relaxation by purified flavonoids, baicalin and baicalein, in rat aortic rings. Biochemical Pharmacology 67:787-794.
25. Tsang SY, Yao XQ, Wong CM, Chan FL, Chen ZY and Huang Y (2004) Differential regulation of K+ and Ca2+ channel gene expression by chronic treatment with estrogen and tamoxifen in rat aorta. European Journal of Pharmacology 483:155-162.
26. HUANG Yu; CHAN Leung Franky; LAU Chi Wai; CHEN Zhenyu; HE Guo Wei; TSANG Suk Ying and YAO Xiaoqiang. (2003) Urocortin-Induced Relaxations of the Rat Coronary Artery. EDHF 2002 ed. by Paul M. Vanhoutte. pp.87-92. USA: Taylor and Francis Group.
27. Tsang SY; YAO Xiaoqiang; WONG C. M.; AU Chak Leung; CHEN Zhen Yu and HUANG Yu. (2003) Role of Na+-Ca2+ Exchanger to Pinacidil-induced Relaxation in the Rat Mesenteric Artery. British Journal of Pharmacology vol.138 no.3, pp.453-460.
28. Tsang SY, Wong CM, Yao XQ, Chan FL and Huang Y (2003) Estrogen and endothelial nitric oxide. Current Topics in Pharmacology 7:155-161.
29. Wartenberg M, Budde P, Marees M, Grunheck F, Tsang SY, Huang Y, Chen ZY, Hescheler J and Sauer H (2003) Inhibition of tumor-induced angiogenesis and matrix-metalloproteinase expression in confrontation cultures of embryoid bodies and tumor spheroids by plant ingredients used in traditional chinese medicine. Laboratory Investigation 83:87-98.
30. TSANG Suk Ying; YAO Xiaoqiang; CHAN Hoi Yun; WONG Chi Ming; CHEN Zhen Yu; AU Chak Leung and HUANG Yu. (2003) Contribution of K+ Channels to Relaxation Induced by 17β-Estradiol but Not by Progesterone in Isolated Rat Mesenteric Artery Rings. Journal of Cardiovascular Pharmacology ed. by PM Vanhoutte. vol.41 no.1, pp.4-13.
31. HUANG Yu; TSANG Suk Ying; YAO Xiaoqiang; LAU Chi Wai; SU Ya Lau and CHEN Zhenyu. (2002) Baicalin-Induced Vascular Response in Rat Mesenteric Artery: Role of Endothelial Nitric Oxide. Clinical and Experimental Pharmacology and Physiology vol.29 no.8 pp.721
32. TSANG Suk Ying; YAO Xiaoqiang; CHAN Hoi Yun; CHEN Zhenyu; WONG Chi Ming and HUANG Yu. (2002) Effect of 17βEstradiol Exposure on Vasorelaxation Induced by K+ Channel Openers and Ca2+ Channel Blockers. Pharmacology 1st ed. vol.65, pp.26-31.
33. Yao X, He GW, Chan FL, Lau CW, Tsang SY, Chen ZY and Huang Y (2002) Endothelium-dependent and -independent coronary relaxation induced by urocortin. Journal of Cardiac Surgery 17:347-349.
34. Chan HY, Yao XQ, Tsang SY, Bourreau JP, Chan FL and Huang Y (2002) Isoprenaline amplifies 17βestradiol-mediated vasorelaxation: role of endothelium and cyclic AMP. Cardiovascular Research 53:627-633.
35. Lohn M, Muzzulin U, Essin K, Tsang SY, Kirsch T, Litteral J, Waldron P, Conrad H, Klugbauer N, Hofmann F, Haller H, Luft GC, Huang Y and Gollasch M (2002) Cilnidipine is a novel slow-acting blocker of vascular L-type calcium channels that does not target protein kinase C. Journal of Hypertension 20:885-893.
36. Chan HY, Yao XQ, Tsang SY, Chan FL, Lau CW and Huang Y (2001) Different role of endothelium / nitric oxide in 17β-estradiol- and progesterone- induced relaxtion in rat arteries. Life Sciences 69:1609-1617.
37. HUANG Yu; CHAN Leung Franky; LAU Chi Wai; TSANG Suk Ying; HE Guo Wei; CHEN Zhenyu and YAO Xiaoqiang. (2001) Urocortin-Induced Endothelium-Dependent Relaxation of Rat Coronary Artery: Role of Nitric Oxide and K+ Channels. British Journal of Pharmacology vol.135 no.6 pp.1467-1476.
38. Tsang, S.Y.; CHEN Zhenyu; YAO Xiaoqiang and HUANG Hai. (2000) Potentiating Effects on Contractions by Purified Baicalin and Baicalein in the Rat Mesenteric Artery. Journal of Cardiovascular Pharmacology vol.36 no.2 pp.263-269.
39. Huang Y, Yao XQ, Tsang SY, Lau CW and Chen ZY (2000) Role of endothelium / nitric oxide in vascular response to flavonoids and epicatechin. Acta Pharmacologica Sinica 21:1119-1124.
40. Chen ZY, Su YL, Bi YR, Tsang SY and Huang Y (2000) Effect of baicalein and acetone extract of Scutellaria baicalensis on canola oil oxidation. Journal of American Oil Chemists Society 77:73-78.
41. Tsang, S.Y., Chen, Z.Y., Yao, X.Q., and Huang, Y. (2000) Inhibition of nitric oxide-mediated response by purified baicalin and baicalein in rat arteries.FASEB J. 14:A493.
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Cell and Molecular Biology Programme, The Chinese University of Hong Kong