Dr. Kelvin CK Cheng is the scientific officer in charge of the Molecular Haematology services, Prince of Wales Hospital. His main research focuses on the identification and characterization of novel genetic/epigenetic aberrations in acute myeloid leukaemia, a lethal blood cancer in adults and children.

Cheng CK, Wong TH, Wan TS, Wang AZ, Chan NP, Chan NC, Li CK, Ng MH (2018) RUNX1 upregulation via disruption of long-range transcriptional control by a novel t(5;21)(q13;q22) translocation in acute myeloid leukemia. Mol Cancer. 17:133.

Cheng CK, Wang AZ, Wong TH, Wan TS, Cheung JS, Raghupathy R, Chan NP, Ng MH (2017) FNDC3B is another novel partner fused to RARA in the t(3;17)(q26;q21) variant of acute promyelocytic leukemia. Blood. 129:2705-9.

Cheng CK, Chan NP, Wan TS, Lam LY, Cheung CH, Wong TH, Ip RK, Wong RS, Ng MH (2016) Helicase-like transcription factor is a RUNX1 target whose downregulation promotes genomic instability and correlates with complex cytogenetic features in acute myeloid leukemia. Haematologica.101:448-57.

Wong WS, Wong HF, Cheng CK, Chang KO, Chan NP, Ng MH, Wong KF (2015) Congenital sideroblastic anaemia with a novel frameshift mutation in SLC25A38. J Clin Pathol. 68:249-51.

Cheng CK, Kwan TK, Cheung CY, Ng K, Liang P, Cheng SH, Chan NP, Ip RK, Wong RS, Lee V, Li CK, Yip SF, Ng MH (2013) A polymorphism in the 3'-untranslated region of the NPM1 gene causes illegitimate regulation by microRNA-337-5p and correlates with adverse outcome in acute myeloid leukemia. Haematologica. 98:913-7.

Cheng CK, Li L, Cheng SH, Ng K, Chan NP, Ip RK, Wong RS, Shing MM, Li CK, Ng MH (2011) Secreted-frizzled related protein 1 is a transcriptional repression target of the t(8;21) fusion protein in acute myeloid leukemia. Blood. 118:6638-48.

Cheng CK, Li L, Cheng SH, Lau KM, Chan NP, Wong RS, Shing MM, Li CK, Ng MH (2008) Transcriptional repression of the RUNX3/AML2 gene by the t(8;21) and inv(16) fusion proteins in acute myeloid leukemia. Blood. 112:3391-402.

Wong RS, Cheng CK, Chan NP, Cheng SH, Wong WS, Lau KM, Cheng G, Ng MH (2008)JAK2 V617F mutation is associated with increased risk of thrombosis in Chinese patients with essential thrombocythaemia. Br J Haematol. 141:902-4.