Jesse Chung Sean Pang （彭頌先）

BSc, MSc (McGill University, Canada)

Research interests

• Elucidation of microRNA deregulation in human brain cancers
• Functional characterization of cancer-related genes in gliomas
• Identification of prognostic biomarkers for glioma patients

Publication list:

Li KK, Pang JC, Ching AK, Wong CK, Kong X, Wang Y, Zhou L, Chen Z, Ng HK. miR-124 is frequently down-regulated in medulloblastoma and is a negative regulator of SLC16A1.Human Pathology [Epub ahead of print]

Pang JC, Kwok WK, Chen Z, Ng HK (2009) Oncogenic role of microRNAs in brain tumors.Acta Neuropathologica 117:599-611. [Review]

Huang J, Pang J, Watanabe T, Ng HK, Ohgaki H (2009) Whole genome amplification for array comparative genomic hybridization using DNA extracted from formalin-fixed, paraffin-embedded histological sections.Journal of Molecular Diagnostics11:109-16.

Li KK, Pang JC, Chung NY, Ng YL, Chan NH, Zhou L, Poon WS, Ng HK (2007) EMP3 overexpression is associated with oligodendroglial tumors retaining chromosome arms 1p and 19q.International Journal of Cancer120:947-50.

Pang JC, Chung NY, Chan NH, Poon WS, Thomas T, Ng HK (2006) Rare mutation of PIK3CA in meningiomas.Acta Neuropathologica111:284-5.

Liu Y, Pang JC, Dong S, Mao B, Poon WS, Ng HK (2005) Aberrant CpG island hypermethylation profile is associated with atypical and anaplastic meningiomas.Human Pathology36:416-25.

Pang JC, Chang Q, Chung YF, Teo JG, Poon WS, Zhou LF, Kong X, Ng HK (2005) Epigenetic inactivation of DLC-1 in supratentorial primitive neuroectodermal tumor.Human Pathology36:36-43.

Chan KC, Chan AT, Leung SF, Pang JC, Wang AY, Tong JH, To KF, Chan LY, Tam LL, Chung NY, Zhang J, Lo KW, Huang DP, Lo YM (2005) Investigation into the origin and tumoral mass correlation of plasma Epstein-Barr virus DNA in nasopharyngeal carcinoma.Clinical Chemistry51:2192-5.

Dong Z, Pang J, Ng MH, Poon WS, Zhou L, Ng HK (2004) Identification of two contiguous minimally deleted regions on chromosome 1p36.31-p36.32 in oligodendroglial tumours.Bristish Journal of Cancer 91:1105-11.

Lo AK, Huang DP, Lo KW, Chui YL, Li HM, Pang JC, Tsao SW (2004) Phenotypic alterations induced by the Hong Kong-prevalent Epstein-Barr virus-encoded LMP1 variant (2117-LMP1) in nasopharyngeal epithelial cells.International Journal of Cancer109:919-25.

Chang Q, Pang JC, Li KK, Poon WS, Zhou L, Ng HK (2005) Promoter hypermethylation profile of RASSF1A, FHIT, and sFRP1 in intracranial primitive neuroectodermal tumors.Human Pathology 36:1265-72.

Tong CY, Hui AB, Yin XL, Pang JC, Zhu XL, Poon WS, Ng HK (2004) Detection of oncogene amplifications in medulloblastomas by comparative genomic hybridization and array-based comparative genomic hybridization.Journal of Neurosurgery 100:187-93.

Chang Q, Pang JC, Li J, Hu L, Kong X, Ng HK (2004) Molecular analysis of PinX1 in medulloblastomas. International Journal of Cancer 109:309-14.

Pang JC, Dong Z, Zhang R, Liu Y, Zhou LF, Chan BW, Poon WS, Ng HK (2003) Mutation analysis of DMBT1 in glioblastoma, medulloblastoma and oligodendroglial tumors. International Journal of Cancer 105:76-81.

Yin XL, Pang JC, Ng HK (2002) Identification of a region of homozygous deletion on 8p22-23.1 in medulloblastoma. Oncogene 21:1461-8.

Dong ZQ, Pang JC, Tong CY, Zhou LF, Ng HK (2002) Clonality of oligoastrocytomas. Human Pathology 33:528-35.

Dong S, Pang JC, Hu J, Zhou LF, Ng HK (2002) Transcriptional inactivation of TP73 expression in oligodendroglial tumors. International Journal of Cancer 98:370-5.

Hu J, Pang JC, Tong CY, Lau B, Yin XL, Poon WS, Jiang CC, Zhou LF, Ng HK (2002) High-resolution genome-wide allelotype analysis identifies loss of chromosome 14q as a recurrent genetic alteration in astrocytic tumours. British Journal of Cancer 87:218-24.

Tian XX, Pang JC, Zheng J, Chen J, To SS, Ng HK (2002) Antisense epidermal growth factor receptor RNA transfection in human glioblastoma cells down-regulates telomerase activity and telomere length.British Journal of Cancer86:1328-32.

Yin XL, Hui AB, Pang JC, Poon WS, Ng HK (2002) Genome-wide survey for chromosomal imbalances in ganglioglioma using comparative genomic hybridization.Cancer Genetics and Cytogenetics134:71-6.

Ke C, Poon WS, Ng HK, Lai FM, Tang NL, Pang JC (2002) Impact of experimental acute hyponatremia on severe traumatic brain injury in rats: influences on injuries, permeability of blood-brain barrier, ultrastructural features, and aquaporin-4 expression.Experimental Neurology178:194-206.

Ma SL, Ng HK, Baum L, Pang JC, Chiu HF, Woo J, Tang NL, Lam LC (2002) Low-density lipoprotein receptor-related protein 8 (apolipoprotein E receptor 2) gene polymorphisms in Alzheimer's disease.Neuroscience Letters 332:216-8.

Chan BC, To KF, Pang JC, Chung YF, Lo KW, Tong JH, Huang DW, Lim PL, Chui YL (2002) Generation of monoclonal antibodies against Hong Kong nasopharyngeal carcinoma-associated Epstein-Barr virus latent membrane protein 1 (LMP1).International Journal of Cancer 102:492-8.

Dong SM, Pang JC, Poon WS, Hu J, To KF, Chang AR, Ng HK (2001) Concurrent hypermethylation of multiple genes is associated with grade of oligodendroglial tumors. Journal of Neuropathology and Experimental Neurology 60:808-16.

Ching AK, Li PS, Li Q, Chan BC, Chan JY, Lim PL, Pang JC, Chui YL (2001) Expression of human BRE in multiple isoforms. Biochememical and Biophysical Research Communications 288:535-45.

Yin XL, Pang JC, Liu YH, Chong EY, Cheng Y, Poon WS, Ng HK (2001) Analysis of loss of heterozygosity on chromosomes 10q, 11, and 16 in medulloblastomas. Journal of Neurosurgery 94:799-805.

Tong CY, Zheng PP, Pang JC, Poon WS, Chang AR, Ng HK (2001) Identification of novel regions of allelic loss in ependymomas by high-resolution allelotyping with 384 microsatellite markers. Journal of Neurosurgery 95:9-14.

Ke C, Poon WS, Ng HK, Pang JC, Chan Y (2001) Heterogeneous responses of aquaporin-4 in oedema formation in a replicated severe traumatic brain injury model in rats. Neuroscience Letters 301:21-4.

Cheng Y, Pang JC, Ng HK, Ding M, Zhang SF, Zheng J, Liu DG, Poon WS (2000) Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas. Histopathology 37:437-44.

Zheng PP, Pang JC, Hui AB, Ng HK (2000) Comparative genomic hybridization detects losses of chromosomes 22 and 16 as the most common recurrent genetic alterations in primary ependymomas. Cancer Genetics and Cytogenetics 122:18-25.

Yin XL, Pang JC, Hui AB, Ng HK (2000) Detection of chromosomal imbalances in central neurocytomas by using comparative genomic hybridization. Journal of Neurosurgery 93:77-81.

Di Tomaso E, Pang JC, Lam HK, Tian XX, Suen KW, Hui AB, Hjelm NM (2000) Establishment and characterization of a human cell line from paediatric cerebellar glioblastoma multiforme. Neuropathology and Applied Neurobiology 26:22-30.

Lam PY, Di Tomaso E, Ng HK, Pang JC, Roussel MF, Hjelm NM (2000) Expression of p19INK4d, CDK4, CDK6 in glioblastoma multiforme. British Journal of Neurosurgery 14:28-32.

Chong EYY, Pang JCS, Ko CW, Poon WS, Ng HK (2000) Telomere length and telomerase catalytic subunit expression in non-astrocytic gliomas. Pathology Research and Practice 196:691-9.

Tong CY, Ng HK, Pang JC, Hu J, Hui AB, Poon WS (2000) Central neurocytomas are genetically distinct from oligodendrogliomas and neuroblastomas. Histopathology 37:160-5.

Preckel T, Fung-Leung WP, Cai Z, Vitiello A, Salter-Cid L, Winqvist O, Wolfe TG, Von Herrath M, Angulo A, Ghazal P, Lee JD, Fourie AM, Wu Y, Pang J, Ngo K, Peterson PA, Fruh K, Yang Y (1999) Impaired immunoproteasome assembly and immune responses in PA28-/- mice. Science 286:2162-5.

Tian XX, Pang JC, To SS, Ng HK (1999) Restoration of wild-type PTEN expression leads to apoptosis, induces differentiation, and reduces telomerase activity in human glioma cells. Journal of Neuropathology and Experimental Neurology 58:472-9.

Tian XX, Chan JY, Pang JC, Chen J, He JH, To TS, Leung SF, Ng HK (1999) Altered expression of the suppressors PML and p53 in glioblastoma cells with the antisense-EGF-receptor. British Journal of Cancer 81:994-1001.

Cheng Y, Ng HK, Ding M, Zhang SF, Pang JC, Lo KW (1999) Molecular analysis of microdissected de novo glioblastomas and paired astrocytic tumors. Journal of Neuropathology and Experimental Neurology 58:120-8.

Cheng Y, Ng HK, Zhang SF, Ding M, Pang JC, Zheng J, Poon WS (1999) Genetic alterations in pediatric high-grade astrocytomas. Human Pathology 30:1284-90.

Hui AB, Pang JC, Ko CW, Ng HK (1999) Detection of chromosomal imbalances in growth hormone-secreting pituitary tumors by comparative genomic hybridization. Human Pathology 30:1019-23.

Tong CY, Ng HK, Pang JC, Hui AB, Ko HC, Lee JC (1999). Molecular genetic analysis of non-astrocytic gliomas. Histopathology 34:331-41.

Li Y, Chambers J, Pang J, Ngo K, Peterson PA, Leung WP, Yang Y (1999) Characterization of the mouse proteasome regulator PA28b gene. Immunogenetics 49:149-57.

Tian XX, Lam PY, Chen J, Pang JC, To SS, Di-Tomaso E, Ng HK (1998) Antisense epidermal growth factor receptor RNA transfection in human malignant glioma cells leads to inhibition of proliferation and induction of differentiation. Neuropathology and Applied Neurobiology 24:389-96.

Fung-Leung WP, Surh CD, Liljedahl M, Pang J, Leturcq D, Peterson PA, Webb SR, Karlsson L (1996) Antigen presentation and T cell development in H2-M-deficient mice. Science 271:1278-81.

Fung-Leung WP, De Sousa-Hitzler J, Ishaque A, Zhou L, Pang J, Ngo K, Panakos JA, Chourmouzis E, Liu FT, Lau CY (1996) Transgenic mice expressing the human high-affinity immunoglobulin (Ig) E receptor alpha chain respond to human IgE in mast cell degranulation and in allergic reactions. Journal of Experimental Medicine 183:49-56.

Pang J, Taylor GR, Munroe DG, Ishaque A, Fung-Leung WP, Lau CY, Liu FT, Zhou L (1993) Characterization of the gene for the human high affinity IgE receptor (Fc epsilon RI) alpha-chain. Journal of Immunology 151:6166-74.

Zhou L, Pang J, Munroe DG, Lau C (1993) A human retinoic acid receptor gamma isoform is homologous to the murine retinoic acid receptor gamma 7. Nucleic Acids Research 21:2520.

Zhou L, Otulakowski G, Pang J, Munroe DG, Capetola RJ, Lau C (1992) Quantitation of human cellular retinoic acid-binding protein II (CRABP-II) RNA from cultured human skin fibroblast cells and human skin biopsies treated with retinoic acid. Nucleic Acids Research 20:6215-20.

Pang JC, Du RP, Bingham H, Juranka P, Chan VL (1989) Imbalance of purine nucleotides in alanosine-resistant baby hamster kidney cells. Somatic Cell and Molecular Genetics 15:101-11.

Please also see my recent publications at PubMed

E-mail : jessepang@cuhk.edu.hk