Ho-keung NG（吳浩強）

MB ChB (Edin.), MD, FRCPath, FRCPA, FCAP, FFPathRCPI, MIAC, FHKC Path

As a neuropathologist, my interest lies in diseases of the nervous system. We have active research programs on the molecular genetics of brain tumors, especially medulloblastomas and oligodendroglioma. We are interested in how alteration of the genetic components of cells, for example mutation or deletion of tumor suppressor genes, can cause cancer. Some of the cancers in the nervous system also occur in families. We are also interested in how alteration of cancer genes may stop tumors from growing. For these investigations, we use a variety of techniques. We look at whole chromosomes, specific segments of chromosomes of interest, the expression of the genes in terms of their protein products, as well as the sequence of cancer genes. We are also interested in the use of stem cells in the treatment of strokes.

We are a research team including doctors from other disciplines, as well as laboratory scientists and graduate students, on both MPhil and PhD programs.

Recent Publications from the group:

Ho CYS, Murnane JP, Yeung AKY, Ng HK, Lo AWI. Telomere acquired distinct heterochromatin characteristics during siRNA-induced RNAi in mouse cells. Current Biology, in press

Fong SP, Tsang KS, Chan ABW, Lu G, Poon WS, Li K, Baum LW, Ng HK. Trophism of neural progenitor cells to enbryonic stem cells : neural induction and transplantation in a mouse ischemic stroke model. Journal of Neuroscience Research 2007 Jul;85(9):1851-62

Li KK, Pang JC, Chung NY, Ng YL, Chan NH, Zhou L, Poon WS, Ng HK. EMP3 overexpression is associated with oligodendroglial tumors retaining chromosome arms 1p and 19q. International Journal Cancer. 2007; 120:947-50

Cheng SH, Ng MH, Lau KM, Liu HS, Chan JC, Hui AB, Lo KW, Jiang H, Hou J, Chu RW, Wong WS, Chan NP, Ng HK. 4q loss is potentially an important genetic event in MM tumorigenesis : identification of a tumor suppressor gene regulated by promoter methylation at 4q13.3 platelet factor 4. Blood 2007; 109:2089-99

Hui AB, Takano H, Lo KW, Kuo WL, Lam CN, Tong CY, Chang Q, Gray JW, Ng HK. Identification of a novel homozygous deletion region at 6q23.1 in medulloblastomas using high-resolution array comparative genomic hybridization analysis. Clin Cancer Res. 2005; 11:4707-16

Dong Z, Pang JS, Ng MH, Poon WS, Zhou L, Ng HK. Identification of two contiguous minimally deleted regions on chromosome 1p36.31-p36.32 in oligodendroglial tumours. Br J Cancer. 2004;91:1105-11

Dong SM, Pang JCS, Hu J, Zhou LF, Ng HK. Transcriptional inactivation of TP73 expression in oligodendroglial tumors. International Journal of Cancer 2002; 98:370-375

Yin XL, Pang JCS, Ng HK. Identification of a region of homozygous deletion on 8p22-23.1 in medulloblastoma. Oncogene 2002; 21:1461-1468

Please visit my Laboratory

Please also see my recent publications at PubMed

E-mail : hkng@cuhk.edu.hk