MB ChB; MD(CUHK); FRCPath (UK)

Dr. Margaret Ng is a hematopathologist, who is interested in research on the molecular genetics of hematopoietic malignancies, particularly multiple myeloma and childhood leukemia, and immunogenetics in cancer susceptibility. The molecular hematology laboratory located just next to the routine hematology laboratory, has also provided a comprehensive molecular testing service on the diagnosis and monitoring of blood cancers, genotyping of thalassaemia and thrombophilia and FISH evaluation on cytogenetic abnormalities of various hematological diseases. A few on-going projects funded by RGC, RFCID, KCF and NSFC are in progress.

On-going projects:

Elucidation of molecular mechanisms of thrombospondin (TSP-1)-induced cell growth inhibition in childhood acute lymphoblastic leukemia

Study of minimal residual disease (MRD) in Hong Kong Chinese children with acute lymphoblastic leukemia (ALL)

Immunogenetic Study of Nasopharyngeal Carcinoma in Hong Kong Chinese

Immunogenetics and viral genotyping of Hong Kong hepatitis B virus carriers forthe increased risk of hepatocellular carcinoma

Determination of the clinical and biological significances of platelet factor 4 (PF4), a tumor suppressor gene encoding an angiogenesis inhibitor and regulated by promoter methylation at 4q13.3 in multiple myeloma

Recent Publication from the group:

Cheng CK, Li L, Cheng SH, Lau KM, Chan NPH, Wong RSM, Tsang KS, Shing MMK, Li CK, Ng MHL. Transcriptional repression of the RUNX3/AML2 gene by the t(8;21) and inv(16) fusion proteins in acute myeloid leukemia. Blood 2008 Oct 15;112(8):3391-402. Epub 2008 Jul 28.

Wong RSM, Cheng CK, Chan NPH, Cheng SH, Wong WS, Lau KM, Cheng G, Ng MHL. JAK2 V617F mutation is associated with increased risk of thrombosis in Chinese patients with essential thrombocythaemia. Br J Haematol 141(6):902-904, 2008

Lau KM, Cheng SH, Lo KW, Lee SKW, Woo JKS, van Hasselt CA, Ng MH. Increase in circulating Foxp3+CD4+CD25high regulatory T-cells in nasopharyngeal carcinoma patients. Br J Cancer 96(4):617-22, 2007

Man CBL, Kwan P, Baum L, Yu E, Lau KM, Cheng SH, Ng MHL. Association between HLA–B*1502 allele and antiepileptic drug-induced cutaneous reactions in Chinese. Epilepsia 48(5)-1015-8, 2007

Cheng SH, Ng MH, Lau KM, Liu HS, Chan JC, ABY Hui, Lo KW, Jiang H, Hou J, Chu R, Wong WS, Chan NPH, Ng HK. 4q loss is potentially an important genetic event in MM tumorigenesis: identification of a tumor suppressor gene regulated by promoter methylation at 4q13.3, platelet factor 4. Blood 109(5):2089-99, 2007

Wong WS, Cheng CK, Lau KM, Chan NPH, Shing MMK, Cheng SH, Chik KW, Li CK, Ng MHL. Clonal evolution of 8p11 stem cell syndrome in a 14-year-old Chinese boy: A review of literature of t(8;13) associated myeloproliferative diseases. Leuk Res. 31(2):235-8, 2007

Ng MH, Lau KM, Hawkins BR, Chik KW, Chan NPH, Wong WS, Tsang KS, Shing MMK, Li CK. HLA-B67 may be a male-specific HLA marker of susceptibility to relapsed childhood ALL in Hong Kong Chinese: A retrospective analysis on 53 transplant candidates (1989-2003). Ann Hematol 85(8):534-41, 2006

Cheng Y, Cheng G, Chui CH, Lau FY, Chan PK, Ng MH, Wong A, Sung JJY, Wong RSM. ABO blood group and susceptibility to SARS. JAMA 293(12):1450-1. 2005

Ng MH, Lau KM, Cheng SH, Li L, Chan WY, Hui PK, Zee B, Leung CB, Sung JJY. Association of HLA genotypes (HLA-B703 and HLA-DRB1*0301) with genetic susceptibility and resistance to the development of Severe Acute Respiratory Syndrome (SARS). J Infect Dis 190:515-518, 2004

E-mail : margaretng@cuhk.edu.hk