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Ka-fai TO¡]§ù®a½÷¡^
MB ChB (CUHK), FRCPA, FHKCPath, FHKAM(Path)
Research interests:
- Common Asian Cancer, in particular nasopharyngeal carcinoma and the potential application of molecular bio-markers.
- Pathology related to Helicobacter- pylori associated gastritis.
- Renal pathology, in particular IgA glomerulonephritis.
- Paediatric pathology with current studies related to sudden infant death syndrome.
- Current interest in Infectious pathology.
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Recent Publications from the group:
Lo KW, To KF, Huang DP. Focus on nasopharyngeal carcinoma. Cancer Cell. 2004;5:423-8.
To KF, Tong JHM, Chan PKS, Au FWL, Chim SSC, Chan KCA, Cheung JLK, Liu EYM, Tse GMK, Lo AWI, Lo YMD, Ng HK. Tissue and cellular tropisms of the coronavirus associated with Severe Acute Respiratory Syndrome ¡V an in-situ hybridization study of fatal cases. J Pathol. 2004;202:157-63.
Tong JH, Tsang RK, Lo KW, Woo JK, Kwong J, Chan MW, Chang AR, van Hasselt CA, Huang DP, To KF. Quantitative Epstein-Barr virus DNA analysis and detection of gene promoter hypermethylation in nasopharyngeal (NP) brushing samples from patients with NP carcinoma. Clin Cancer Res. 2002;8:2612-9.
Chan MWY, Chan LW, Tang NLS, Tong JHM, Lo KW, Lee TL, Cheung HY, Wong WS, Chan PSF, Lai FMM, To KF . Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients. Clinical Cancer Res. 2002;8:464-470.
Lee TL, Leung WK, Chan MWY, Ng EKW, Tong JHM, Lo KW, Chung SCS, Sung JJY, To KF . Detection of gene promoter hypermethylation in the tumor and serum of patients with gastric carcinoma. Clin Cancer Res. 2002;8:1761-6.
To KF, Leung WK, Lee TL, Yu J, Tong JH, Chan MW, Ng EK, Chung SC, Sung JJ. Promoter hypermethylation of tumor-related genes in gastric intestinal metaplasia of patients with and without gastric cancer. Int J Cancer. 2002;102:623-8.
Chan FKL, To KF, Wu JCY, Yung MY, Leung WK, Kwok T, Hui Y, Chan HLY, Chan CSY, Hui E, Woo J, Sung JJY. Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: a randomized trial. Lancet 2002;359:9-13.
Mac-Moune Lai F , S zeto CC , Choi PCL , L i PKT , T ang NLS , Chow KM , L ui SF , Wong TYH , Ho KKL , To KF. Primary IgA Nephropathy with Low Histological Grade and Disease Progression : Is there a ¡§ Point of No Return ¡¨ ? Am J Kidney Dis , 2002;39:401-6.
To KF, Chan PK, Chan KF, Lee WK, Lam WY, Wong KF, Tang NL, Tsang DN, Sung RY, Buckley TA, Tam JS, Cheng AF. Pathology of fatal human infection associated with avian influenza A H5N1 virus. Journal of Medical Virology 2001;63:242-246.
Chan AS, To KF, Lo KW, Mak KF, Pak W, Chiu B, Tse GM, Ding M, Li X, Lee JC, Huang DP. High frequency of chromosome 3p deletion in histologically normal nasopharyngeal epithelia from southern Chinese. Cancer Research 2000;60:5365-5370.
To KF, Choi PC, Szeto CC, Li PK, Tang NL, Leung CB, Wang AY, Ho KK, Wong TY, Lui SF, Lai F. Outcome of IgA Nephropathy in Adults Graded by Chronic Histological Lesions. American J Kidney Dis 2000;35:392-400.
Please also see my recent publications at PubMed
E-mail : kfto@cuhk.edu.hk