Prof. William K.K. Wu
BSc (Hons), MMedSc (Distinction), MPhil, PhD, FRCPath, FRCP (Edin), FRCPS (Glasg)

Associate Professor (Non-clinical)

Department of Anaesthesia and Intensive Care
The Chinese University of Hong Kong

Principal Investigator
State Key Laboratory of Digestive Diseases & Li Ka Shing Institute of Health Sciences
The Chinese University of Hong Kong

Research Interests
Cancer Biology and Genomics; Sepsis and ICU-related Infections; Pain Mechanism; Autophagy; Microbiome; Evolutionary Medicine


For details about citations arising from my publications and links to online versions of some of the publications, refer to: (Researcher ID: A-3277-2009)

(^equal contribution; *corresponding author)

  • Sun X, Liu Y, Huang Z, Xu W, Hu W, Yi L, Liu Z, Chen H, Zeng J, Liu X, Chen H, Yu J, Chan FKL, Ng SC, Wong SH, Wang MH, Gin T, Joynt GM, Hui DSC, Zou X, Shu Y, Cheng CHK, Fang S*, Luo H*, Lu J*, Chan MTV*, Zhang L*, Wu WKK* (2022) SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1. Cell Death Differ doi: 10.1038/s41418-021-00916-7. [Online ahead of print]
  • Chan H, Li Q, Wang X, Liu Y, Hu W, Zeng J, Xie, C, Kwong NYK, Ho IHT, Liu X, Chen H, Yu J, Ko H, Chan RCY, Ip M, Gin T, Cheng ASL, Zhang L, Chan MTV*, Wong SH*, Wu WKK* (2022) Vitamin D3 and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome acidification. Autophagy doi: 10.1080/15548627.2021.2016004. [Online ahead of print]
  • Sun X, Yu J, Wong SH, Chan MTV*, Zhang L*, Wu WKK* (2022) SARS-CoV-2 targets the lysosome to mediate airway inflammatory cell death. Autophagy doi: 10.1080/15548627.2021.2021496. [In press]
  • Xu W, Liu Y, Zou X, Luo H, Wu W, Xia J, Chan MTV*, Fang S*, Shu Y*, Wu WKK*, Zhang L* (2022) Hypozincemia in COVID-19 patients correlates with stronger antibody response. Front Immunol 12:785599.
  • Xu D, Ma X, Sun C, Han J, Zhou C, Chan MTV, Wu WKK (2022) Circular RNAs in intervertebral disc degeneration: An updated review. Front Mol Biosci 8:781424.
  • Lam S, Zhang J, Yang K, Chu LC, Zhu W, Tang W, Chan FKL, Chan PKS, Wu WKK, Ng SC (2022) Modulation of gut microbiota impacts diet- and drug-induced alopecia in mice. Gut doi: 10.1136/gutjnl-2021-326320. [Online ahead of print]
  • Guo CLT, Wong SH, Lau LHS, Lui RNS, Mak JWY, Tang RSY, Yip TCF, Wu WKK, Wong GLH, Chan FKL, Lau JYW, Sung JJY (2022) Timing of endoscopy for acute upper gastrointestinal bleeding: A territory-wide cohort study. Gut doi: 10.1136/gutjnl-2020-323054. [Online ahead of print]
  • Sugimura N, Li Q, Chu ESH, Lau HCH, Fong W, Liu W Liang C, Nakatsu G, Su ACY, Coker OO, Wu WKK, Chan FKL, Yu J (2022) Lactobacillus gallinarum modulates the gut microbiota and produces anti-cancer metabolites to protect against colorectal tumorigenesis. Gut doi: 10.1136/gutjnl-2020-323951. [Online ahead of print]
  • Coker OO, Liu C, Wu WKK, Wong SH, Jia W, Sung JJY, Yu J (2022) Altered gut metabolites and microbiota interactions are implicated in colorectal carcinogenesis and can be non-invasive diagnostic biomarkers. Microbiome [In press]
  • Niu JY, Yin IX, Wu WKK, Li QL, Mei ML, Chu CH (2022) Efficacy of the dual-action GA-KR12 peptide for remineralising initial enamel caries: an in vitro study. Clin Oral Investig doi: 10.1007/s00784-021-04210-1. [Online ahead of print]