Prof. William K.K. Wu
BSc (Hons), MMedSc (Distinction), MPhil, PhD, FRCPath, FRCP (Edin), FRCPS (Glasg)

Associate Professor (Non-clinical)

Department of Anaesthesia and Intensive Care
The Chinese University of Hong Kong

Principal Investigator
State Key Laboratory of Digestive Diseases & Li Ka Shing Institute of Health Sciences
The Chinese University of Hong Kong

Research Interests
Cancer Biology and Genomics; Sepsis and ICU-related Infections; Pain Mechanism; Autophagy; Microbiome; Evolutionary Medicine


For details about citations arising from my publications and links to online versions of some of the publications, refer to: (Researcher ID: A-3277-2009)

(^equal contribution; *corresponding author)

  • Li Q, Hu W, Liu WX, Zhao LY, Huang D, Liu XD, Chan H, Zhang Y, Zeng JD, Coker OO, Kang W, Ng SSM, Zhang L, Wong SH, Gin T, Chan MTV*, Wu JL*, Yu J*, Wu WKK* (2021) Streptococcus thermophilus inhibits colorectal tumorigenesis through secreting beta-galactosidase. Gastroenterology doi: 10.1053/j.gastro.2020.09.003. [Epub ahead of print]
  • Li Z, Li X, Shen J*, Tan H, Rong T, Lin Y, Feng E, Chen Z*, Jiao Y, Liu G, Zhang L, Chan MTV, Wu WKK* (2021) Bioinformatic analysis of SMN1-ACE/ACE2 interactions hinted at a potential protective effect of spinal muscular atrophy against COVID-19-induced lung injury. Brief Bioinform doi: 10.1093/bib/bbaa285. [Epub ahead of print]
  • Huang D, Wang X, Liu Y, Huang Z, Hu X, Hu W, Li Q, Chan H, Zou Y, Ho IHT, Wang Y, Cheng ASL, Kang W, To KF, Wang MHT, Wong SH, Yu J, Gin T, Zhang Q, Li Z, Shen J, Zhang L, Chan MTV*, Liu X*, Wu WKK* (2021) Multi-omic analysis suggests tumor suppressor genes evolved specific promoter features to optimize cancer resistance. Brief Bioinform doi: 10.1093/bib/bbab040. [Epub ahead of print]
  • Fang S, Zhang L, Liu Y, Xu W, Wu W, Huang Z, Wang X, Liu H, Sun Y, Zhang R, Peng B, Liu X, Sun X, Yu J, Chan FKL, Ng SC, Wong SH, Wang MHT, Gin T, Joynt GM, Hui DSC*, Feng T*, Wu WKK*, Chan MTV*, Zou X*, Xia J* (2021) Lysosome activation in peripheral blood mononuclear cells and prognostic significance of circulating LC3B in COVID-19. Brief Bioinform doi: 10.1093/bib/bbab043. [Epub ahead of print]
  • Li Z, Li X, Xu D, Chen X, Li S, Zhang L, Chan MTV, Wu WKK (2021) An update on the roles of circular RNAs in osteosarcoma. Cell Prolif 54(1):e12936.
  • Klionsky DJ, ..., Wu WKK, et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy doi: 10.1080/15548627.2020.1797280. [Epub ahead of print]
  • Kang W, Zhang J, Huang T, Zhou Y, Wong CC, Chan RCK, Dong Y, Wu F, Zhang B, Wu WKK, Chan MWY, Cheng ASL, Yu J, Wong N, Lo KW, To KF (2021) NOTCH3, a crucial target of miR-491-5p/miR-875-5p, promotes gastric carcinogenesis by upregulating PHLDB2 expression and activating Akt pathway. Oncogene doi: 10.1038/s41388-020-01579-3. [Epub ahead of print]
  • Kang X, Zhang R, Kwong TNY, Wu WKK, Sung JJY, Yu J, Lui RNS, Wong SH (2021) Serrated neoplasia in the colorectum: gut microbiota and molecular pathways. Gut Microbes 13(1):1-12.
  • Niu JY, Yin IX, Wu WKK, Li QL, Mei ML, Chu CH (2021) Antimicrobial peptides for the prevention and treatment of dental caries: A concise review. Arch Oral Biol 122:105022.
  • Cao L, Lou J, Zhao S, Chan RWY, Chan M, Wu WKK, Chong MKC, Zee BCY, Yeoh EK, Wong SYS, Chan PKS, Wang MH (2021) In silico prediction of influenza vaccine effectiveness by sequence analysis. Vaccine doi: 10.1016/j.vaccine.2021.01.006. [Epub ahead of print]
  • Ng YL, Lo CK, Lee KH, Xie X, Kwong TNY, Ip M, Zhang L, Yu J, Sung JJY, Wu WKK, Wong SH, Kwok KW (2021) Development of an open-access and explainable machine learning prediction system to assess the mortality and recurrence risk factors of Clostridioides difficile infection patients. Adv Intell Syst 3(1):2000188.

  • Joynt GM, Wu WKK (2020) Understanding COVID-19: What dose viral RNA load really mean? Lancet Infect Dis 20(6):635-636.
  • Xia X^, Wu WKK^, Wong SH^, Liu D, Kwong TNY, Nakatsu G, Yan PS, Chuang YM, Chan MWY, Coker OO, Chen Z, Yeoh YK, Zhao L, Wang X, Cheng WY, Chan MTV, Chan PKS, Sung JJY, Wang MH, Yu J (2020) Bacteria pathogens drive host colonic epithelial cell promoter hypermethylation of tumor suppressor genes in colorectal cancer. Microbiome 8(1):108.
  • Ho J, Chan H, Liang Y, Liu X, Zhang L, Li Q, Zhang Y, Zeng J, Ugwu FN, Ho IHT, Hu W, Yau JCW, Wong SH, Wong WT, Ling L, Cho CH, Gallo RL, Gin T, Tse G, Yu J, Chan MTV*, Leung CCH*, Wu WKK* (2020) Cathelicidin preserves intestinal barrier function in polymicrobial sepsis. Crit Care 24(1):47.
  • Kong KY, Kwong TNY, Chan H, Wong K, Wong SSY, Chaparala AP, Chan RCY, Zhang L, Sung JJY, Yu J, Hawkey PM, Ip M, Wu WKK*, Wong SH* (2020) Biological characteristics associated with virulence in Clostridioides difficile ribotype 002 in Hong Kong. Emerg Microbes Infect 9(1):631-638.
  • Wang K, Liu X, Liu Q, Ho IHT, Wei X, Yin T, Zhan Y, Zhang W, Zhang W, Chen B, Gu J, Tan Y, Zhang L, Chan MTV, Wu WKK*, Du B*, Xiao J* (2020) Hederagenin potentiated cisplatin- and paclitaxel-mediated cytotoxicity by impairing autophagy in lung cancer cells. Cell Death Dis 11(8):611.
  • Wu WKK*, Yue J* (2020) Autophagy in host-microbe interactions. Semin Cell Dev Biol 101:1-2.
  • Hu W, Chan H, Lu L, Wong KT, Wong SH, Li MX, Gang XZ, Cho CH, Gin T, Chan MTV*, Wu WKK*, Zhang L* (2020) Autophagy in intracellular bacterial infection. Semin Cell Dev Biol 101:41-50.
  • Li Z, Li X, Shen J, Zhang L, Chan MTV, Wu WKK (2020) Emerging roles of non-coding RNAs in scoliosis. Cell Prolif 53(2):e12736.
  • Ho IHT, Chan MTV, Wu WKK*, Liu X* (2020) Spinal microglia-neuron interactions in chronic pain. J Leuko Biol 108(5):1575-1592.
  • Li CKH, Xu Z, Ho J, Lakhani I, Liu Y, Bazoukis G, Liu T, Wong WT, Cheng SH, Chan MTV, Zhang L, Gin T, Wong MCS, Wong I, Wu WKK*, Zhang Q*, Tse G* (2020) Association of NPAC score with survival after acute myocardial infarction. Atherosclerosis 301:30-36.
  • Yu X, Wang M, Li L, Zhang L, Chan MTV, Wu WKK (2020) MicroRNAs in atopic dermatitis: a systematic review. J Cell Mol Med 24(11):5966-5972.
  • Li Z, Ma J, Lin Y, Shen J, Wu Z, Chan MTV, Wu WKK (2020) Embryonic gene expression altered by maternal exposure to air pollution in rats. Environ Sci Pollut Res 27(25):31699-31705.
  • Li Z, Xu D, Chen X, Li S, Chan MTV, Wu WKK (2020) LINC01133: an emerging tumor-associated long non-coding RNA in tumor and osteosarcoma. Environ Sci Pollut Res 27(26):32467-32473.
  • Li Z, Huang C, Yang B, Hu W, Chan MTV, Wu WKK (2020) Emerging roles of long non-coding RNAs in osteonecrosis of the femoral head. Am J Transl Res 12(9):5984-5991.
  • Wong SH, Teoh JYC, Leung CH, Wu WKK, Yip BHK, Wong MCS, Hui DSC (2020) COVID-19 and public interest in face mask. Am J Resp Crit Care Med 202(3):453-455.
  • Coker OO, Wu WKK, Wong SH, Sung JJY, Yu J (2020) Altered gut archaea composition and interaction with bacteria are associated with colorectal cancer. Gastroenterology 159(4):1459-1470.e5.
  • Zhang J, Wong CC, Leung KT, Wu F, Zhou Y, Tong JHM, Chan RCK, Li H, Wang Y, Yan H, Liu L, Wu WKK, Chan MWY, Cheng ASL, Yu J, Wong N, Lo KW, To KF, Kang W (2020) FGF18-FGFR2 signaling triggers the activation of c-Jun-YAP1 axis to promote carcinogenesis in a subgroup of gastric cancer patients and indicates translational potential. Oncogene 39(43):6647–6663.
  • Turan A, Artis AS, Hanline C, Saha P, Masheshwari K, Kurz A, Devereaux PJ, Duceppe E, Patel A, Tiboni M, Ruetzler K, Pearse R, Chan MTV, Wu WKK, Srinathan S, Garg A, Sapsford R, Sessler DI (2020) Preoperative vitamin D concentration and cardiac, renal, and infectious morbidity after noncardiac surgery. Anesthesiology 132(1):121-130.
  • Chen Z, Wong PY, Ng CWK, Lan L, Fung S,  Li JW, Cai L, Lei P, Mou Q, Wong SH, Wu WKK,  Li RJ, Meehan K, Lui VWY, Chow C, Lo WK, Chan ABW, Boon SS, Lau EHL, Yeung Z, Chan KCA, Wong EWY, Cheng ASL,  Yu J, Chan PKS, Chan JYK (2020) Intersection between oral microbiota, host gene methylation and patient outcomes in head and neck squamous cell carcinoma. Cancers 12(11): 3425.
  • Liu YZ, Chu R, Lee A, Gomersall CD, Zhang L, Gin T, Chan MTV, Wu WKK, Ling L (2020) A surveillance method to identify patients with sepsis from electronic health records in Hong Kong: a single centre retrospective study. BMC Infect Dis 20(1):652.
  • Hu W, Zhang L, Wu WKK, Cho CH (2020) Involvement of autophagy in antibacterial actions of vitamin D in Helicobacter pylori infection: abridged secondary publication. Hong Kong Med J 26 Suppl 4:26-28.

  1. Ho IHT, Liu X, Zou Y, Liu T, Hu W, Chan H, Tian Y, Zhang Y, Li Q, Kou S, Chan CS, Gin T, Cheng C, Wong SH, Yu J, Zhang L, Wu WKK*, Chan MTV* (2019) A novel peptide interfering with proBDNF-sortilin interaction alleviates chronic inflammatory pain. Theranostics 9(6):1651-1665.
  • Ho J, Li X, Zhang L, Liang Y, Hu W, Yau JCW, Chan H, Gin T, Chan MTV*, Tse G*, Wu WKK* (2019) Translational genomics in pancreatic ductal adenocarcinoma: a review with re-analysis of TCGA dataset. Semin Cancer Biol 55:70-77.
  • Wong SH*, Wu WKK* (2019) Cancer genomics: From benchtop to bedside. Semin Cancer Biol 55:iii-iv.
  • Hu W, Zhang L, Li MX, Shen J, Liu XD, Xiao ZG, Wu DL, Ho IHT, Wu JCY, Cheung CKY, Zhang YC, Lau AHY, Ashktorab H, Smoot DT, Fang EF, Chan MTV, Gin T*, Gong W*, Wu WKK*, Cho CH* (2019) Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through PDIA3 receptor in gastric epithelial cells. Autophagy 15(4):707-725.
  • Li Z, Li X, Chen X, Li S, Ho IHT, Liu X, Chan MTV, Wu WKK (2019) Emerging roles of long non-coding RNAs in neuropathic pain. Cell Prolif 52(1):e12528.
  • Li Z, Chen X, Xu D, Li S, Chan MTV, Wu WKK (2019) Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration. Cell Prolif 52(6):e12704.
  • Chen X, Chan H, Zhang L, Liu X, Ho IHT, Zhang X, Ho J, Hu W, Tian Y, Kou S, Chan CS, Yu J, Wong SH, Gin T, Chan MTV*, Sun X*, Wu WKK* (2019) The phytochemical polydatin ameliorates non-alcoholic steatohepatitis by restoring lysosomal function and autophagic flux. J Cell Mol Med 23(6):4290-4300.
  • Sun X, Ng TTH, Sham KWY, Zhang L, Chan MTV, Wu WKK*, Cheng CHK* (2019) Bufalin, a traditional Chinese medicine compound, prevents tumour formation in two murine models of colorectal cancer. Cancer Prev Res (Phila) 12(10):653-666.
  • Ng TH, Sham KWY, Xie CM, Ng SSM, To KF, Tong JHM Liu WYZ, Zhang L, Chan MTV, Wu WKK*, Cheng CHK* (2019) Eukaryotic elongation factor-2 kinases expression is an independent prognostic factor in colorectal cancer. BMC Cancer 19(1):649. 
  • NeuroVISION Investigators (2019) Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study. Lancet 394(10203):1022-1029.
  • Chan MTV, Wang CY, Seet E, Tam S, Lai HY, Chew EFF, Wu WKK, Cheng BCP, Lam CKM, Short TG, Hui DSC, Chung F; for the Postoperative vascular complications in unrecognized Obstructive Sleep Apnea (POSA) Study Investigators (2019) Association of unrecognized obstructive sleep apnea with postoperative cardiovascular events in patients undergoing major noncardiac surgery. JAMA 321(18):1788-1798.
  • Coker OO, Nakatsu G, Dai Z, Wu WKK, Chen Z, Ng SC, Wong SH, Chan FKL, Sung JJY, Yu J (2019) Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer. Gut 68(4):654-662. 
  • Xing R, Zhou Y, Yu J, Yu Y, Nie YZ, Luo W, Yang C, Xiong T, Wu WKK, Li Z, Bing Y, Lin S, Zhang Y, Hu Y, Li L, Han L, Yang C, Huang S, Huang, S, Zhou R, Li J, Wu K, Fan D, Tang G, Zou J, Zhu Z, Ji J, Fang X, Lu Y (2019) Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer. Nat Commun 10(1):2037.
  • Tian Y, Yang B, Qiu W, Hao Y, Zhang Z, Yang B, Li N, Cheng S, Lin Z, Rui YC, Cheung OKW, Yang W, Wu WKK, Cheung YS, Lai PBS, Luo J, Sung JJY, Chen R, Wang HY, Cheng ASL, Yang P (2019) ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy. Nat Commun 10(1):3391.
  • Zhang Y, Zhang L, Yang L, Vong CI, Chan KF, Wu WKK, Kwong TNY, Lo NWS, Ip M, Wong SH, Sung JJY, Chiu PWY, Zhang L (2019) Real-time tracking of fluorescent magnetic spore-based microrobots for remote detection of C. diff toxins. Sci Adv 5(1):eaau9650.
  • Li Z, Li X, Bi J, Chan MTV, Wu WKK, Shen J (2019) Melatonin protected against the detrimental effects of microRNA-363 in a rat model of vitamin A-associated congenital spinal deformities: Involvement of Notch signaling. J Pineal Res 66(3):e12558.
  • Wang X, Wu WKK, Gao J, Li Z, Dong B, Lin X, Li Y, Li Y, Gong J, Qi C, Peng Z, Yu J, Shen L (2019) Autophagy inhibition enhances PD-L1 expression in gastric cancer. J Exp Clin Cancer Res 38(1):140.
  • Zeng JD, Wu WKK, Wang HY, Li XX (2019) Serine and one-carbon metabolism, a bridge that links mTOR signaling and DNA methylation in cancer. Pharmacol Res 149:104352.
  • Wong J, Chopra J, Chiang LLW, Liu T, Ho J, Wu WKK, Tse G, Wong SH (2019) The role of connexins in gastrointestinal diseases. J Mol Biol 431(4):643-652.
  • Li Z, Ho IHT, Li X, Xu D, Wu WKK, Chan MTV Li S, Liu X (2019) Long non-coding RNAs in the spinal cord injury: Novel spotlight. J Cell Mol Med 23(8):4883-4890.
  • Li Z, Ma J, Li X, Chan MTV, Wu WKK, Wu Z, Shen J (2019) Aberrantly expressed long non-coding RNAs in air pollution-induced congenital defects. J Cell Mol Med 23(11):7717-7725.
  • Li Z, Ma J, Bi J, Guo H, Chan MTV, Wu WKK, Wu Z, Shen J (2019) MicroRNA signature of air pollution exposure-induced congenital defects. J Cell Physiol 234(10):17896-17904.
  • Konstantatos AH, Zhong T, Paul E, Tsang S, Tian S, Liu M, Liang Y, Tian Y, Qiao S, Wu WKK, Chan MTV (2019) Effect of cultural background and healthcare environment on postoperative opioid requirement. Can J Anesth 66(3):309-317.
  • Li Z, Ma J, Shen J, Chan MTV, Wu WKK, Wu Z (2019) Differentially expressed circular RNAs in air pollution-exposed rat embryos. Environ Sci Pollut Res 26(33):34421-34429.
  • Sun R, Xia X, Chong KC, Zee BC, Wu WKK, Wang MH (2019) wtest: an integrated R package for genetic epistasis testing. BMC Med Genomics 12(Suppl 9):180. 
  • Ren Z, Li Z, Li S, Sheng L, Xu D, Chen X, Wu WKK, Chan MTV, Ho J (2019) Local infiltration with cocktail analgesics during 2 level lumbar spinal fusion surgery: Study protocol of a randomized controlled trial. Medicine (Baltimore) 98(19):e15526.
  • Yuan M, Zhang Z, Tse G, Feng X, Korantzopoulos P, Letsas KP, Yan BP, Wu WKK, Zhang H, Li G, Liu T, Xia Y (2019) Association of cancer and the risk of developing atrial fibrillation: A systematic review and meta-analysis. Cardiol Res Pract 2019:8985273.
  • Li CKH, Sang T, Chan CP, Gong M, Liu Y, Jesuthasan A, Li G, Liu T, Lam MHS, Wu WKK, Chan MTV, Liu FZ, Chen C, Ho J, Xia Y, Tse G; International Health Informatics Study (IHIS) Network (2019) Anesthesia use in catheter ablation for atrial fibrillation: A systematic review and meta-analysis of observational studies. Heart Asia 11:e011155.
  • Ng C, Li H, Wu WKK, Wong SH, Yu J (2019) Genomics and metagenomics of colorectal cancer. J Gastrointest Oncol 10(6):1164-1170
  • Kwong TNY, Wu WKK, Wong SH (2019) Reply. Gastroenterology 156(1):292.

  • Wang X^, Li X^, Zhang L^, Wong SH, Wang MHT, Tse G, Dai RZW, Nakatsu G, Coker OO, Chen Z, Ko H, Chan JYK, Liu T, Cheng CHK, Cheng ASL, To KF, Plewczynski D, Sung JJY, Yu J, Gin T*, Chan MTV*, Wu WKK* (2018) Oncogenes expand during evolution to withstand somatic amplification. Ann Oncol 29(11):2254-2260.
  • Li X^, Xu W^, Kang W, Wong SH, Wang M, Zhou Y, Fang X, Zhang X, Yang H, Wong CH, To FK, Chan SL, Chan MTV, Sung JJY, Wu WKK*, Yu J* (2018) Genomic analysis of liver cancer unveils novel driver genes and distinct prognostic features. Theranostics 8(6):1740-1751.
  • Tian Y, Liu X, Jia M, Yu H, Lichtner P, Shi Y, Meng Z, Kou S, Ho IHT, Jia B, Cheng BCP, Lam CKM, Tsang S, Wong SH, Yu J, Cheng CHK, Gin T#, Wu WKK#, Chen Z#, Chan MTV#; Persistent Pain After Surgery Study Investigators (2018) Targeted genotyping identifies susceptibility locus in brain-derived neurotrophic factor gene for chronic postsurgical pain. Anesthesiology 128(3):587-597. (#joint senior authorship)
  • Zhang L^, Hu W^, Cho CH, Chan FK, Yu J, Ross Fitzgerald J, Cheung CK, Xiao ZG, Shen J, Li LF, Li MX, Wu JC, Ling TK, Chan JY, Ko H, Tse G, Ng SC, Yu S, Wang MH, Gin T, Ashktorab H, Smoot DT, Wong SH*, Chan MTV*, Wu WKK* (2018) Reduced lysosomal clearance of autophagosomes promotes survival and colonization of Helicobacter pylori. J Pathol 244(4):432-444.
  • Wang X^, Zhang X^, Chu ESH, Chen X, Kang W, Wu F, To KF, Wong VWS, Chang HLY, Chan MTV, Sung JJY, Wu WKK*, Yu J* (2018) Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis. FASEB J 32(1):37-51.
  • Li Z^, Jiang C^, Li X^, Wu WKK^, Chen X, Zhu S, Ye C, Chan MTV, Qian W (2018) Circulating microRNA signature of steroid-induced osteonecrosis of the femoral head. Cell Prolif 51(1):e12418.
  • Liu T, Shi Y, Chan MTV, Peng G, Zhang Q, Sun X, Zhu Z, Xie Y, Sham KWY, Li J, Liu X, Ho IHT, Gin T, Lu Z, Wu WKK*, Cheng CHK* (2018) Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish. Transl Psychiatry 8(1):232.
  • Wu WKK^, Sun R^, Zuo T^, Tian Y^, Zheng Z, Ho J, Wu JCY, Chan FKL, Chan MTV, Yu J, Wong SH*, Wang MH*, Ng SC* (2018) A novel susceptibility locus in MST1 and gene-gene interaction network for Crohn’s disease in the Chinese population. J Cell Mol Med 22(4):2368-2377.
  • Yu X, Zheng H, Chan MTV, Wu WKK (2018) Nova1 acts as an oncogene in melanoma via regulating FOXO3a expression. J Cell Mol Med 22(5):2622-2630.
  • Zhang L^, Zhang Y^, Wong SH^, Law PTY, Zhao S, Yu J, Chan MTV*, Wu WKK* (2018) Common deregulation of seven biological processes by microRNAs in gastrointestinal cancers. Sci Rep 8:3287.
  • Tse G, Li KHC, Li G, Liu T, Wong SH, Bazoukis G, Wong WT, Chan MTV, Wong MCS, Letsas K, Chan CP, Chan YS, Wu WKK (2018) Higher dispersion measures of conduction and repolarization in type 1 compared to non-type 1 Brugada syndrome patients: an electrocardiographic study from a single centre. Front Cardiovasc Med 5:132.
  • Tipoe TL, Wu WKK*, Chung L, Gong M, Dong M, Liu T, Roever L, Ho J, Wong MCS, Chan MTV, Tse G*, Wu JCY*, Wong SH* (2018) Plasminogen activator inhibitor-1 for predicting sepsis severity and mortality outcomes: a systematic review and meta-analysis. Front Immunol 9:1218.
  • Tse G, Gong M, Lei M, Wong CW, Bazoukis G, Chan MTV, Wong MCS, Letsas K, Baranchuk AM, Yan GX, Liu T, Wu WKK (2018) Predictive value of Tpeak – Tend indices for adverse outcomes in acquired QT prolongation: a meta-analysis. Front Physiol 9:1226.
  • Lee YT, Gong M, Chau A, Wong WT, Bazoukis G, Wong SH, Lampropoulos K, Xia Y, Li G, Wong MCS, Liu T, Wu WKK*, Tse G*; International Health Informatics Study (IHIS) Network (2018) Pentraxin-3 as a marker of sepsis severity and predictor of mortality outcomes: A systematic review and meta-analysis. J Infect 76(1):1-10.
  • Li KHC, Gong M, Li G, Baranchuk A, Liu T, Wong MCS, Jesuthasan A, Lai RWC, Lai JCL, Lee APW, Bayés-Genis A, De la Espriella R, Sanchis J, Wu WKK*, Tse G*, Nuńez J* (2018) Cancer Antigen-125 and outcomes in acute heart failure: a systematic review and meta-analysis. Heart Asia 10:e011044.
  • Yu X, Zheng H, Tse G, Zhang L, Wu WKK (2018) CASC2: an emerging tumor-suppressing long non-coding RNA in human cancers and melanoma. Cell Prolif 51(6):e12506.
  • Li Z, Li X, Chen C, Li S, Shen J, Tse G, Chan MTV, Wu WKK (2018) Long non-coding RNAs in nucleus pulposus cell function and intervertebral disc degeneration. Cell Prolif 51(5):e12483.
  • Yu X, Zheng H, Tse G, Chan MTV, Wu WKK (2018) Long non-coding RNAs in melanoma. Cell Prolif 51(4):e12457.
  • Li Z, Shen J, Chan MTV, Wu WKK (2018) The long non-coding RNA SPRY4-IT1: an emerging player in tumorigenesis and osteosarcoma. Cell Prolif 51(4):e12446.
  • Li Z, Li X, Jiang C, Qian W, Tse G, Chan MTV, Wu WKK (2018) Long non-coding RNAs in rheumatoid arthritis. Cell Prolif 51(1):e12404.
  • Li Z, Yang B, Weng X, Tse G, Chan MTV, Wu WKK (2018) Emerging roles of microRNAs in osteonecrosis of the femoral head. Cell Prolif 51(1):e12405.
  • Yu X, Zheng H, Chan MTV, Wu WKK (2018) Immune consequences induced by photodynamic therapy in non-melanoma skin cancers: a review. Environ Sci Pollut Res 25(21):20569-20574.
  • Wu WKK, Zhang L, Chan MTV (2018) Autophagy, NAFLD and NAFLD-related HCC. In: Obesity, Fatty Liver and Liver Cancer, Adv Exp Med Biol pp. 127-138 Singapore: Springer
  • Zhang L, Hu W, Ho J, Fitzgerald RJ, Gin T, Chan MTV, Wu WKK (2018) Antimicrobial peptides in the host-microbiota homeostasis. In: Antimicrobial Peptides in Gastrointestinal Diseases pp. 23-33 Elsevier 
  • Nakatsu G, Zhou H, Wu WKK, Wong SH, Coker OO, Dai Z, Li X, Szeto CH, Sugimura N, Lam TYT, Yu ACS, Wang X, Chen Z, Wong MCS, Ng SC, Chan MTV, Chan PKS, Chan FKL, Sung JJY, Yu J (2018) Alterations in enteric virome associate with colorectal cancer and survival outcomes. Gastroenterology 155(2):529-541.e5.
  • Kwong TNY, Wang X, Nakatsu G, Chow TC, Tipoe T, Dai RZW, Tsoi KKK, Wong MCS, Tse G, Chan MTV, Chan FKL, Ng SC, Wu JCY, Wu WKK, Yu J, Sung JJY, Wong SH (2018) Bacteremia from specific microbiota are associated with subsequent colorectal cancer diagnosis. Gastroenterology 155(2):383-390.e8.
  • Coker OO, Dai ZW, Nie Y, Zhao G, Cao L, Nakatsu G, Wu WKK, Wong SH, Chen Z, Sung JJY, Yu J (2018) Mucosal microbiome dysbiosis in gastric carcinogenesis. Gut 67(6):1024-1032.
  • Huang T, Zhou Y, Zhang J, Wong CC, Li W, Kwan JSH, Yang R, Chan AKY, Dong Y, Wu F, Zhang B, Cheung AHK, Wu WKK, Cheng ASL, Yu J, Wong N, Kang W, To KF (2018) SRGAP1, a crucial target of miR-340 and miR-124, functions as a potential oncogene in gastric tumorigenesis. Oncogene 37(9):1159-1174.
  • Li D, Zhou Y, Yu J, Yu H, Xia Y, Zhang L, Wu WKK, Zeng Z, Yao R, Cao Y (2018) Evaluation of a novel prognostic score based on thrombosis and inflammation in patients with sepsis: a retrospective cohort study. Clin Chem Lab Med 56(7):1182-1192.
  • Tse G, Du YM, Chan YWF, Liu T, Li G, Bazoukis G, Letsas K, Wu WKK, Tian XY, Wong WT (2018) Quantification of beat-to-beat variability of action potential durations in Langendorff-perfused mouse hearts. Front Physiol 9:1578.
  • Li Z, Chen C, Lin Y, Li X, Tan H, Chan MTV, Wu WKK, Zhan S, Cao Q, Shen J (2018) A novel probe for measuring tissue bioelectrical impedance to enhance pedicle screw placement in spinal surgery. Am J Transl Res 10(7):2205-2212.
  • Li Z, Jiang C, Ye C, Zhu S, Chen X, Wu WKK, Qian W (2018) miR-10a-5p, miR-99a-5p and miR-21-5p are steroid-responsive circulating microRNAs. Am J Transl Res 10(5):1490-1497.
  • To KKW, Wu WKK, Loong HHF (2018) PPARgamma agonists sensitize PTEN-deficient resistant lung cancer cells to EGFR tyrosine kinase inhibitors by inducing autophagy. Eur J Pharmacol 823:19-26.
  • Mrkobrada M, Chan MTV, Cowan D, Spence J, Campbell D, Wang CY, Torres D, Malaga G, Sanders RD, Brown C, Sigamani A, Szczeklik W, Dmytriw AA, Agid R, Smith EE, Hill MD, Sharma M, Sharma M, Tsai S, Mensinkai A, Sahlas DJ, Guyatt G, Pettit S, Copland I, Wu WKK, Yu SCH, Gin T, Loh PS, Ramli N, Siow YL, Short TG, Waymouth E, Kumar J, Dasgupta M, Murkin J, Fuentes M, Ortiz-Soriano V, Lindroth H, Simpson S, Sessler D, Devereaux PJ (2018) Rationale and design for the detection and neurological impact of cerebrovascular events in noncardiac surgery patients cohort evaluation (NeuroVISION) study: a prospective international cohort study. BMJ Open 8:e021521.
  • Sun R, Weng H, Men R, Xia X, Chong KC, Wu WKK, Zee BCY, Wang MHT (2018) Gene-methylation epistatic analyses via the W-test identifies enriched signals of neuronal genes in patients undergoing lipid-control treatment. BMC Proc 12(Suppl 9):53.
  • Lakhani I, Gong M, Wong WT, Bazoukis G, Lampropoulos K, Wong SH, Wu WKK, Wong MCS, Ong KL, Liu T, Tse G (2018) Fibroblast growth factor 21 in cardio-metabolic disorders: a systematic review and meta-analysis. Metabolism 83:11-17.
  • Tse G, Gong M, Wong SH, Wu WKK, Bazoukis G, Lampropoulos K, Wong WT, Xia Y, Wong MCS, Liu T, Woo J (2018) Frailty and clinical outcomes in advanced heart failure patients undergoing left ventricular assist device implantation: a systematic review and meta-analysis. J Am Med Dir Assoc 19(3):255-261.e1.
  • Tse G, Wong CW, Gong M, Wong WT, Bazoukis G, Wong SH, Li G, Wu WKK, Tse LA, Lampropoulos K, Xia YL, Liu T, Baranchuk A; International Health Informatics Study (IHIS) Network (2018) Predictive value of inter-atrial block for new onset or recurrent atrial fibrillation: a systematic review and meta-analysis. Int J Cardiol 250:152-156.
  • Tse G, Gong M, Li G, Wong SH, Wu WKK, Wong WT, Roever L, Lee APW, Lip GYH, Wong MCS, Liu T (2018) Genotype-guided warfarin dosing versus conventional dosing strategies: a systematic review and meta-analysis of randomized controlled trials. Br J Clin Pharmacol 84(9):1868-1882
  • Li KHC, Dong M, Gong M, Bazoukis G, Wong SH, Li G, Wu WKK, Vassiliou VS, Wong MCS, Letsas KP, Du Y, Yan BP, Chan YS, Xia Y, Liu T, Tse G (2018) Atrial fibrillation recurrence and peri-procedural complication rates in nMARQ versus conventional ablation techniques: a systematic review and meta-analysis. Front Physiol 9:544.
  • Ho J, Ngai SPC, Wu WKK, Hou WH (2018) Association between daily life experience and psychological well-being in people living with non-psychotic mental disorders: protocol for a systematic review and meta-analysis. Medicine (Baltimore) 97(4):e9733.
  • Tse G, Gong M, Wong CW, Chan C, Georgopoulos S, Chan YS, Yan BP, Li G, Whittaker P, Ciobanu A, Ali-Hasan-Al-Saegh S, Wong SH, Wu WKK, Bazoukis G, Lampropoulos K, Wong WT, Tse LA, Baranchuk AM, Letsas KP, Liu T; International Health Informatics Study (IHIS) Network (2018) Total cosine R-to-T for predicting ventricular arrhythmic and mortality outcomes: A systematic review and meta-analysis. Ann Noninvasive Electrocardiol 23(2):e12495. 
  • Li KHC, Ho JCS, Recaldin B, Gong M, Ho J, Li G, Liu T, Wu WKK, Wong MCS, Xia Y, Dong M, Tse G; International Health Informatics Study (IHIS) Network (2018) Acute cellular rejection and infection rates in alemtuzumab versus traditional induction therapy agents for lung and heart transplantation: a systematic review and meta-analysis. Transplant Proc 50(10):3723-3731.
  • Cheung A, Gong M, Bellanti R, Ali-Hasan-Al-Saegh S, Li G, Roig E, Nunez J, Stamos TD, Yilmaz MB, Hakki K, Wu WKK, Wong SH, Wong WT, Bazoukis G, Lampropoulos K, Tse LA, Zhao J, Lip GYH, Baranchuk A, Wong MCS, Liu T, Tse G (2018) Cancer antigen-125 and atrial fibrillation risk: a systematic review with meta-analysis. Heart Asia 10(1):e010970.
  • Tse G, Bazoukis G, Roever L, Liu T, Wu WKK, Wong MCS, Baranchuk A, Korantzopoulos P, Asvestas D, Letsas KP (2018) T-wave indices and atherosclerosis. Curr Atheroscler Rep 20(11):55.
  • Leung CS, Lu S, Li J, Wu WKK, Lui KO (2018) Deciphering the role of microRNAs in regulation of immune surveillance, self-tolerance and allograft transplantation. Curr Stem Cell Res Ther 13(5):336-344.