Professor Dennis Lo
Professor Rossa Chiu
Professor Nelson Tang
Professor Allen K C Chan
Professor Chun Kwok Wong
Professor Yiu-Loon Chui
Professor Hao Sun
Professor Peiyong Jiang
Professor Kathy Lui
Professor Ping Yuan
Ms Elena Lo
Professor Christopher Lam
Professor Nirmal Panesar
Dr Michael H M Chan
Dr Liz Yuen
Ping Yuan 袁平
Assistant Professor 助理教授
I obtained my Ph.D. degree from The National University of Singapore in 2004. During my Ph.D. training, I was appointed as a Visiting Research Fellow and worked in the Department of Pathology in Brigham & Women's Hospital, Harvard Medical School, USA in 2001. Thereafter, I was a Research Associate in the Department of Molecular Biology in Princeton University from 2004 to 2006 and a Postdoctoral Research Fellow in Genome Institute of Singapore from 2006 to 2010. In 2010, I was appointed as an Assistant Professor in the Department of Chemical Pathology and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong.
Research Interests:
My research interests lie in the mechanism studies and practical applications of stem cells, especially pluripotent stem cells. My research topics include:
Discover novel interplays between the transcription factors and epigenetic modifiers in stem cells with functional genomics and molecular biology methods;
Identify genes that drive lineage specific differentiation in pluripotent stem cells; and
Derive the disease specific induced pluripotent stem cells (iPS cells) and exploit their applications on drug screening and cell therapy.
Selected Publications:
Li, P., Ma, X., Adams, I. and Yuan, P.* A tight control of Rif1 by Oct4 and Smad3 is critical for mouse embryonic stem cell stability, Cell death and disease, (2015),6: e1588; doi:10.1038/cddis.2014.551
Yuan, P.*, Ma, X. Endothelial cell facilitated cardiac repair: progress and challenge. Current Stem Cell Research and Therapy, (2014), 9(5), 415-423
Chan, L.J., Wang, W., Yeung, W.W., Deng, Y., Yuan, P., and Mak, K.K., Hedgehog signaling induces osteosarcoma development through Yap1 and H19 overexpression. Oncogene, (2014), 33 (40):4857-66
Li, P., Chen, Y., Mak, K.K., Wong, C., Wang, C.C. and Yuan, P.* Functional role of Mst1/Mst2 in embryonic stem cell differentiation. PLoS ONE, (2013), 8(11):e79867
Li, P., Chen, Y., Meng, X., Kwok, K.Y., Huang, X., Choy, K.W., Wang, C.C., Lan, H. and Yuan, P.* Suppression of malignancy by Smad3 in mouse embryonic stem cell formed teratoma. Stem Cell Reviews and Reports, (2013), 9 (5), 709-720
Han, J., Yuan, P., Yang, H., Zhang, J., Yay, J., Soh, B.S., Li, P., Lim, S.L., Orlov, Y., Luftkin, T., Ng, H.H., Tam, W.L. and Lim, B. Tbx3 improves the germ-line competency of induced pluripotent stem cells. Nature (2010), 463(7284), 1096-1100
Yuan, P.#, Han, J.#, Guo, G., Orlov, Y.L., Huss, M., Loh, Y.H., Clarke, N., Robson, P., Lim, Bing. and Ng, H.H. Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells. Genes & Development (2009), 23(21), 2507-2520 (#Equal first author)
Chen, X., Han, X., Yuan, P., Fang, F., Huss, M., Vega, V.B., Wong, E., Orlov, Y.L., Zhang, W., Jiang, J., Loh, Y.H., Yeo, H.C., Yeo, Z.X., Narang, V., Govinfarajan, K.R., Leong, B., Shahab, A., Ruan, Y., Bourque, G., Sung, W.K., Clarke, N.D., Wei, C.L. and Ng, H.H. Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells. Cell, (2008), 133, 1106-1117
Saxena, S.#, Yuan, P.#, Dhar, S.K.#, Senga, T., Takeda, D., Robinson, H., Kornbluth, S., Swaminathan, K. and Dutta, A. A dimerized coiled coil domain and an adjoining part of Geminin interact with two sites on Cdt1 for replication inhibition. Molecular Cell, (2004), 15(2), 245-258 (#Equal first author)
Yuan, P., Jedd, G., Kumaran, D., Swaminathan, S., Chua, N.H. and Swaminathan, K. A HEX-1 crystal lattice required for Woronin body function in Neurosporal Crassa. Nature Structural & Molecular Biology, (2003), 10(4), 264 -270
The Chinese University of Hong Kong