Professor Dennis Lo
Professor Rossa Chiu
Professor Nelson Tang
Professor Allen K C Chan
Professor Chun Kwok Wong
Professor Yiu-Loon Chui
Professor Hao Sun
Professor Peiyong Jiang
Professor Kathy Lui
Professor Ping Yuan
Ms Elena Lo
Professor Christopher Lam
Professor Nirmal Panesar
Dr Michael H M Chan
Dr Liz Yuen
Yiu-Loon Chui 崔耀隆
Associate Professor 副教授
1979 - 1982 BSc Pharmacology, University College London, UK
1982 - 1986
Certificate of Post-Experience Module in Immunology, and PhD, Royal Postgraduate Medical School, University of London, UK, in Transplantation Immunology with Prof J Richard Batchelor, Editor-in-Chief of Transplantation
2006 - 2008 PGCert and MSc (Distinction), University of Oxford, UK, in Bioinformatics (part-time)
Positions Held:
1985 - 1986 Research Officer, Dept. Immunology, Royal Postgraduate Medical School, University of London, UK
1986 - 1990 1851 Exhibition Research Fellowship and Croucher Foundation Fellowship, MRC Laboratory of Molecular Biology, Cambridge, UK, with Dr. César Milstein FRS, Nobelist (1984)
1990 - 1991 Scientific Staff, MRC Laboratory of Molecular Biology, Cambridge, UK
Since 1991 Lecturer, Associate Professor, Chinese University of Hong Kong, HK
Dr Chui teaches immunology and conducts tutorials on molecular biology and cancer immunotherapy to Years 1 to 3 medical students. His current research interest is mainly on apoptosis and immunology of cancer. Please email Dr Chui for details and opportunity for research.
Research Interests:
My current main research topic is on the functional and molecular role of a protein called "BRE". BRE, brain and reproductive organ-expressed, is an evolutionarily highly conserved protein of no identifiable functional domains and family member within the same species. It is now known to function in both cytoplasmic and nuclear compartments. In the nucleus, BRE is part of the BRCA1-A complex involved in DNA repair. BRE may regulate the deubiquitinase activity of BRCC36. In the cytosol, BRE binds to the cytoplasmic region of TNF-R1 and Fas, as well as the death-inducing signaling complex (DISC) during apoptotic induction, and down-regulates apoptotic response. Over-expression of BRE has been reported in human hepatocellular carcinoma and esophageal carcinoma. Immortalised human cell lines also uniformly express high levels of BRE regardless of the tissue origin of these cell lines. Transgenic expression of BRE in mouse livers attenuated acute fulminant hepatitis induced by anti-Fas antibody, and promoted diethylnitrosamine-induced liver tumorigenesis. Thus, BRE through its DNA repair and anti-apoptotic activities may enhance tumor survival.
Selected publication list for the recent 5 years:
Chui YL, Ching AK, Chen S, Yip FP, Rowlands DK, James AE, Lee KK, Chan JY. BRE over-expression promotes growth of hepatocellular carcinoma. Biochem Biophys Res Commun. 2010 Jan 15;391(3):1522-5. Epub 2009 Dec 24. PubMed PMID: 20035718.
Chan JY, Li L, Miao J, Cai DQ, Lee KK, Chui YL. Differential expression of a novel gene BRE (TNFRSF1A modulator/BRCC45) in response to stress and biological signals. Mol Biol Rep. 2010 Jan;37(1):363-8. PubMed PMID: 19757177.
Xu W, Zhang X, Chen W, Fok KL, Rowlands DK, Chui YL, Chan HC. Immunization with Bin1b decreases sperm motility with compromised fertility in rats. Fertil Steril. 2009 Jan 7. [Epub ahead of print] PubMed PMID: 19135192.
Chen HB, Pan K, Tang MK, Chui YL, Chen L, Su ZJ, Shen ZY, Li EM, Xie W, Lee KK. Comparative proteomic analysis reveals differentially expressed proteins regulated by a potential tumor promoter, BRE, in human esophageal carcinoma cells. Biochem Cell Biol. 2008 Aug;86(4):302-11. PubMed PMID: 18756325.
Leung WK, Wu KC, Wong CY, Cheng AS, Ching AK, Chan AW, Chong WW, Go MY, Yu J, To KF, Wang X, Chui YL, Fan DM, Sung JJ. Transgenic cyclooxygenase-2 expression and high salt enhanced susceptibility to chemical-induced gastric cancer development in mice. Carcinogenesis. 2008 Aug;29(8):1648-54. Epub 2008 Jul 7. PubMed PMID: 18611916.
Yu J, Wu CW, Chu ES, Hui AY, Cheng AS, Go MY, Ching AK, Chui YL, Chan HL, Sung JJ. Elucidation of the role of COX-2 in liver fibrogenesis using transgenic mice. Biochem Biophys Res Commun. 2008 Aug 8;372(4):571-7. Epub 2008 May 27. PubMed PMID: 18503750.
Chan BC, Ching AK, To KF, Leung JC, Chen S, Li Q, Lai PB, Tang NL, Shaw PC, Chan JY, James AE, Lai KN, Lim PL, Lee KK, Chui YL. BRE is an antiapoptotic protein in vivo and overexpressed in human hepatocellular carcinoma. Oncogene.
2008 Feb 21;27(9):1208-17. Epub 2007 Aug 20. PubMed PMID: 17704801.
Yu J, Hui AY, Chu ES, Cheng AS, Go MY, Chan HL, Leung WK, Cheung KF, Ching AK, Chui YL, Chan KK, Sung JJ. Expression of a cyclo-oxygenase-2 transgene in murine liver causes hepatitis. Gut. 2007 Jul;56(7):991-9. Epub 2006 Dec 5. PubMed PMID: 17148503.
Lo AK, Lo KW, Tsao SW, Wong HL, Hui JW, To KF, Hayward DS, Chui YL, Lau YL, Takada K, Huang DP. Epstein-Barr virus infection alters cellular signal cascades in human nasopharyngeal epithelial cells. Neoplasia. 2006 Mar;8(3):173-80. PubMed PMID: 16611410; PubMed Central PMCID: PMC1578522.
Tang MK, Wang CM, Shan SW, Chui YL, Ching AK, Chow PH, Grotewold L, Chan JY, Lee KK. Comparative proteomic analysis reveals a function of the novel death receptor-associated protein BRE in the regulation of prohibitin and p53 expression and proliferation. Proteomics. 2006 Apr;6(8):2376-85. PubMed PMID:16518872.
Wan J, Zhang W, Wu L, Bai T, Zhang M, Lo KW, Chui YL, Cui Y, Tao Q, Yamamoto M, Akira S, Wu Z. BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway. Mol Cell Biol. 2006 Jan;26(2):448-56. PubMed PMID: 16382137; PubMed Central PMCID: PMC1346911.
Wong SL, Chen Y, Chan CM, Chan CS, Chan PK, Chui YL, Fung KP, Waye MM, Tsui SK, Chan HY. In vivo functional characterization of the SARS-Coronavirus 3a protein in Drosophila. Biochem Biophys Res Commun. 2005 Nov 18;337(2):720-9. Epub 2005 Sep 26. PubMed PMID: 16212942.
Shan SW, Tang MK, Cai DQ, Chui YL, Chow PH, Grotewold L, Lee KK. Comparative proteomic analysis identifies protein disulfide isomerase and peroxiredoxin 1 as new players involved in embryonic interdigital cell death. Dev Dyn. 2005 Jun;233(2):266-81. PubMed PMID: 15858817.
Chan BC, Li Q, Chow SK, Ching AK, Liew CT, Lim PL, Lee KK, Chan JY, Chui YL. BRE enhances in vivo growth of tumor cells. Biochem Biophys Res Commun. 2005 Jan 14;326(2):268-73. PubMed PMID: 15582573.
The Chinese University of Hong Kong