Faculty
Margaret IP
Paul KS CHAN
Mamie HUI
Zigui CHEN
Christopher KC LAI
Rita WY NG
Xiao YANG
Siaw Shi BOON
Sishuo WANG
Research, Administrative and Honorary Staff
Elite Alumni Microbiologists
Hospital Staff
Department Photo Album
 
 
 
 
 
 
Faculty > Rita WY NG
Personal information
Name Rita Wai Yin NG
Academic / Professional Qualifications MBChB (CUHK), MRCP (UK), FRCPath (UK), FHKCPath, FHKAM (Pathology)
Academic title & affiliations Assistant Professor (Clinical), Department of Microbiology, Faculty of Medicine, Chinese University of Hong Kong
Email ritang@cuhk.edu.hk
Current Appointments
(Including honorary appointments)
  • Assistant Professor (Clinical), Department of Microbiology, Faculty of Medicine, Chinese University of Hong Kong
  • Honorary Associate Consultant in Microbiology, New Territories East Cluster, Hong Kong Hospital Authority
  • Elite Alumni Microbiologist, Department of Microbiology, Faculty of Medicine, Chinese University of Hong Kong
  • Assessor of Hong Kong Accreditation Service (HKAS)
 
Research
ORCID ORCID iD iconorcid.org/ 0000-0003-4966-3350
Google Scholar https://scholar.google.com/citations?user=ZuthZZMAAAAJ&hl=zh-TW
Research interest
1.
Microbiome
2.
Clinical microbiology & infectious diseases
3.
Infection control
 
 
Research Grants
  1. The role of gut microbiome in attention deficit hyperactivity disorder (ADHD) and its response to methylphenidate: A Southern Chinese study
    Early Career Scheme (ECS) / University Grants Committee (Hong Kong)
    Principle Investigator
  2. Early biomarkers in SARS-CoV-2 infection: correlation with short/medium/long-term clinical outcomes, and implications on acute patient management and long-term medical and health care
    Food and Health Bureau (Hong Kong)
    Co-Investigator
 
Publications (All)
  1. Ng RWY, Sze RKH, Chong KC, Zhao S, Ling L, Lui G, Leung ASY, Yeung ACM, Ho WCS, Wong MCS, Chen Z, Boon SS, Hui DSC, Chan PKS. Effectiveness of mRNA and inactivated COVID-19 vaccines: a test-negative study in an infection-naïve Hong Kong population. J Infect. 2023 May 26;S0163-4453(23)00298-0. DOI: 10.1016/j.jinf.2023.05.020
  2. Ng RWY, Dharmaratne P, Wong S, Hawkey P, Chan PKS, Ip Margaret. Revisiting the donor screening protocol of faecal microbiota transplantation (FMT): a systematic review. Gut. 2023 May 4;gutjnl-2023-329515. DOI: 10.1136/gutjnl-2023-329515
  3. Cheung MK, Ng RWY, Lai CKC, Zhu C, Au ETK, Yau JWK, Li C, Wong HC, Wong BCK, Kwok KO, Chen Z, Chan PKS. Lui GCY, Ip Margaret. Alterations in faecal microbiome and resistome in Chinese international travellers: a metagenomics analysis. J Travel Med. 2023 Mar 2;taad027. DOI: 10.1093/jtm/taad027.
  4. Gao X, Chan PKS, Wong KCY, Ng RWY, Yeung ACM, Lui GCY, Ling L, Hui DSC, Huang D, Wong CK. Characterization of METRNβ as a novel biomarker of Coronavirus disease 2019 severity and prognosis. Front Immunol. 2023 Jan 31;14:1111920. DOI: 10.3389/fimmu.2023.1111920. eCollection 2023
  5. Cheung MK, Tong SLY, Wong MCS, Chan JYK, Ip Margaret, Hui M, Lai CKC, Ng RWY, Ho WCS, Yeung ACM, Chan PKS, Chen Z. Extent of Oral-Gut Transmission of Bacterial and Fungal Microbiota in Healthy Chinese Adults. Microbiol SpectR 2023 Jan 10;e0281422. DOI: 10.1128/spectrum.02814-22
  6. Ng RWY, Boon SS, Chen Z, Ho WCS, Fung KSC, Wong BKC, Yeung ACM, Wong MCS, Chan PKS. A cohort study on long-lasting cross-clade memory immunity following SARS-CoV-1 infection in 2003. JAMA Netw Open 2022 Dec 1;5(12):e2247723. DOI: 10.1001/jamanetworkopen.2022.47723
  7. Lai CKC, Cheung MK, Lui G, Ling L, Chan JYK, Ng RWY, Chan HC, Yeung ACM, Ho WCS, Boon SS, Chan PKS, Chen Z. Limited Impact of SARS-CoV-2 on the Human Naso-Oropharyngeal Microbiota in Hospitalized Patients. Microbiol SpectR. 2022 Dec 21;10(6):e0219622. DOI: 10.1128/spectrum.02196-22
  8. Lai CKC, Lui G, Wei Y, Chong KC, Chen Z, Ling L, Ng RWY, Boon SS, Ho WCS, Yeung ACM, Hui DSC, Chan PKS. Remdesivir reduced upper respiratory tract SARS-CoV-2 viral RNA concentration in COVID-19 patients who developed pneumonitis. J Infect. 2022 Aug 31;S0163-4453(22)00513-8. DOI: 10.1016/j.jinf.2022.08.031
  9. Chen Z, Ng RWY, Lui G, Ling L, Chow C, Yeung ACM, Boon SS, Wang M, Chan K, Chan RWY, Hui DSC, Chan PKS. Profiling of SARS-CoV-2 subgenomic RNAs in clinical specimens. Microbiol SpectR. 2022 Apr 27;10(2):e0018222. DOI: 10.1128/spectrum.00182-22
  10. Chan RWY, Chan KCC, Lui G, Tsun JGS, Chan KYY, Yip JSK, Liu S, Yu MWL, Ng RWY, Chong KKL, Wang MH, Chan PKS, Li AM, Lam HS. Mucosal Antibody Response to SARS-CoV-2 in Paediatric and Adult Patients: A Longitudinal Study. Pathogens. 2022 Mar 24;11(4):397. DOI: 10.3390/pathogens11040397
  11. Ng RWY, Wong CK, Lui G, Tso EYK, Chen Z, Tsang OTY, Boon SS, Lai CKC, Fung KSC, Yeung ACM, Ho WCS, Hui DSC, Chan PKS, Chan JMC. Case series of HIV SARS-CoV-2 co-infection in Chinese adults. J Clin Virol Plus. 2022 Feb;2(1):100062. DOI: 10.1016/j.jcvp.2022.100062
  12. Ling L, Chen Z, Lui G, Wong CK, Wong WT, Ng RWY, Tso EYK, Fung KSC, Chan V. Yeung ACM, Hui DSC, Chan PKS. Longitudinal Cytokine Profile in Patients With Mild to Critical COVID-19. Front Immunol. 2021 Dec 6;12:763292. DOI: 10.3389/fimmu.2021.763292
  13. Zhu C, Li C, Lai CKC, Ng RWY, Chau S, Wong KT, Lo NWS, Barua N, Yang Y, Liyanapathirana V, Hui M, Lai RWM, Fung KSC, Tsang DNC, Ip Margaret. Longitudinal Genomic Characterization of Carbapenemase-producing Enterobacteriaceae (CPE) Reveals Changing Pattern of CPEs Isolated in Hong Kong Hospitals. Int J Antimicrob Agents. 2021 Nov;58(5):106430. DOI: 10.1016/j.ijantimicag.2021.106430
  14. Yau YK, Mak JWY, Lui RNS, Ng RWY, Cheung KCY, Li AYL, Ching JYL, Chin ML, Lau LHS, Chan FKL, Chan PKS, Ng SC. High prevalence of extended-spectrum beta-lactamase organisms and the COVID-19 pandemic impact on donor recruitment for fecal microbiota transplantation in Hong Kong. United European Gastroenterol J. 2021 Nov;9(9):1027-1038 DOI: 10.1002/ueg2.12160
  15. Boon SS, Wong MCS, Ng RWY, Leung DTM, Chen Z, Lai CKC, Ho WCS, Huang J, Wong BKC, Fung KSC, Chan PKS. Seroprevalence of Unidentified SARS-CoV-2 Infection in Hong Kong During 3 Pandemic Waves. JAMA Netw Open. 2021 Nov 1;4(11):e2132923. DOI: 10.1001/jamanetworkopen.2021.32923
  16. Lai CKC, Lui G, Chen Z, Cheung YY, Cheng KC, Leung ASY, Ng RWY, Cheung JLK, Yeung ACM, Ho WCS, Chan KC, Hui DSC, Tsang DNC, Chan PKS. Comparison of Self-collected Mouth Gargle with Deep-throat Saliva Samples for the diagnosis of COVID-19: Mouth gargle for diagnosis of COVID-19. J Infect. 2021 Oct;83(4):496-522. DOI: 10.1016/j.jinf.2021.07.012
  17. Boon SS, Xia C, Wang MH, Yip KL, Luk HY, Li S, Ng RWY, Lai CKC, Chan PKS, Chen Z. Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using in Silico Approach. mBio. 2021 Oct 26;12(5):e0268721. DOI: 10.1128/mBio.02687-21
  18. Subramanian R, Liyanapathirana V, Barua N, Sun R, Wang MH, Ng RWY, Nelson EAS, Hui DSC, Ip Margaret. Persistence of Pneumococcal Serotype 3 in Adult Pneumococcal Disease in Hong Kong. Vaccines (Basel) 2021 Jul 7;9(7):756. DOI: 10.3390/vaccines9070756
  19. Zuo T, Liu Q, Zhang F, Yeoh YK, Wan Y, Zhan H, Lui G, Li AYL, Cheung CP, Chen N, Lv W, Ng RWY, Tso EYK, Fung KSC, Chan V, Ling L, Joynt G, Hui DSC. Chan FKL, Chan PKS. Ng SC. Temporal landscape of human gut RNA and DNA virome in SARS-CoV-2 infection and severity. Microbiome 2021 Apr 14;9(1):91. DOI: 10.1186/s40168-021-01008-x
  20. Yeoh YK , Zuo T, Lui G, Zhang F, Liu Q, Li AYL, Chung ACK, Cheung CP, Tso EYK, Fung KSC, Chan V, Ling L, Joynt G, Hui DSC, Chow KM , Ng SSS, Li TCM, Ng RWY, Yip TCF, Wong GLH , KL Chan FKL , Wong CK, Chan PKS, Ng SC. Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19. Gut 2021 Apr;70(4):698-706. DOI: 10.1136/gutjnl-2020-323020
  21. Lai CKC, Ng RWY, Leung SSY, Hui M, Ip M. Overcoming the rising incidence and evolving mechanisms of antibiotic resistance by novel drug delivery approaches - An overview. Adv Drug Deliv Rev. 2021 Feb;181:114078. DOI: 10.1016/j.addr.2021.114078
  22. Wong MCS, Wong ELY, Huang J, Cheung AWL, Law K, Chong KC, Ng RWY, Lai CKC, Boon SS, Lau JTF, Chen Z, Chan PKS. Acceptance of the COVID-19 vaccine based on the health belief model: A population-based survey in Hong Kong. Vaccine 2021 Feb 12;39(7):1148-1156. DOI: 10.1016/j.vaccine.2020.12.083
  23. Chen Z, Chong KC, Wong MCS, Boon SS, Huang J, Wang MH, Ng RWY, Lai CKC, Chan PKS. A global analysis of replacement of genetic variants of SARS-CoV-2 in association with containment capacity and changes in disease severity. Clin Microbiol Infect. 2021 Jan 30;27(5):750-757. DOI: 10.1016/j.cmi.2021.01.018.
  24. Lai CKC, Chen Z, Lui G, Ling L, Li T, Wong MCS, Ng RWY, Tso EYK, Ho T, Fung KSC, Ng ST, Wong BKC, Boon SS, Hui DSC, Chan PKS. Prospective study comparing deep-throat saliva with other respiratory tract specimens in the diagnosis of novel coronavirus disease (COVID-19). J Infect Dis. 2020 Oct 13;222(10):1612-1619. DOI: 10.1093/infdis/jiaa487.
  25. Wong MCS*, Ng RWY*, Chong KC, Lai CKC, Huang J, Chen Z, Boon SS, Chan PKS. Stringent containment measures without complete city lockdown to achieve low incidence and mortality across two waves of COVID-19 in an international city, Hong Kong. BMJ Glob Health 2020 Oct;5(10):e003573. DOI: 10.1136/bmjgh-2020-003573. [*co-first authors]
  26. Lui G, Lai CKC, Chen Z, Tong SLY, Ho WCS, Yeung ACM, Boon SS, Ng RWY, Chan PKS. SARS-CoV-2 RNA detection on disposable wooden chopsticks, Hong Kong. Emerg Infect Dis. 2020 Sep; 26(9): 2274–2276. DOI: 10.3201/eid2609.202135
  27. Wong MCS, Huang J, Lai CKC, Ng RWY, Chan FKL, Chan PKS. Detection of SARS-CoV-2 RNA in fecal specimens of patients with confirmed COVID-19: a meta-analysis. J. Infect 2020 Aug; 81(2): e31–e38. DOI: 10.1016/j.jinf.2020.06.012
  28. Lai CKC, Ng RWY, Wong MCS, Chong KC, Yeoh YK, Chen Z, Chan PKS. Epidemiological characteristics of the first 100 cases of Coronavirus Disease 2019 (COVID-19) in Hong Kong SAR China, a city with a stringent containment policy. Int J Epidemiol. 2020 Aug 1;49(4):1096-1105. DOI: 10.1093/ije/dyaa106.
  29. Ng RWY, Fung Erik, Lui LT, Chan PKS. Metabolomic profiling of COVID-19 patients in Hong Kong: a preliminary analysis. European Congress of Clinical Microbiology and Infectious Diseases 2023. Poster number 03556
  30. Ng RWY, Sapugahawatte DN, Dharmaratne P, Ip Margaret. Association between maternal antibiotic exposure and collateral effects related to microbiome changes in young children: A systematic review. Microbiome Interactions in Health and Disease 2022. Poster number 48
  31. Ng RWY, Lui G, Wong CK. Ling L, Chen Z, Wong WT, Tso EYK, Fung KSC, Chan V. Yeung ACM, Hui DSC, Chan PKS. Cytokine profile in COVID-19 patients. Health Research Symposium 2021; poster number 67
  32. Ng RWY. Bloodstream Infections by Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae in Paediatric Oncology Patients: Epidemiology and Clinical Outcome. 12th Western Pacific Congress on Chemotherapy and Infectious Diseases 2010; poster board number 28