B.Sc (Hons), Ph.D.
FRCPath (UK), FIBMS (UK), MIBiol, CBiol (UK)
 

Adjunct Associate Professor
Scientific Officer (Medical), Hospital Authority
e-mail: lingt@cuhk.edu.hk
Telephone Number: (852)2632-2307
FAX Number: (852) 2645-1256
 

Clinical Microbiology and Antimicrobials


Early in the antibiotic era, a number of prominent clinicians and scientists felt that antimicrobial agents would eliminate bacterial infections as a major cause of human morbidity and mortality. As we now know, that false sense of security had a relatively short duration. This actually has developed an ongoing battle between bacteria (other microorganisms) that develop resistance to antimicrobial agents and scientists who developing new and potent antimicrobial agents. Research in antimicrobial agents include:

Evaluate new systems for antimicrobial susceptibility testing

  • Study the efficacy of new anti-infective agents
  • Develop methods for detecting antimicrobial resistance mechanisms in hospital pathogens
  • Improve clinical microbiology laboratory standards
  • To develop and apply new methodologies in the clinical microbiology services
  • Appoint as quality manager t o improve the quality management system of the clinical Microbiology services
  1. Ling, T.K.W., Liu, Z.K. and Cheng, A.F.B. (2003). Evaluation of the VITEK 2 System for rapid direct identification and susceptibility testing of gram-negative bacilli from positive blood cultures. Journal of Clinical Microbiology 41: 4705-4707.

  2. Liu, Z.K., Ling, T.K.W., and Cheng, A.F.B. (2005). Evaluation of the BD Phoenix Automated Microbiology System for identification and antimicrobial susceptibility testing of common clinical isolates. Medical Principles and Practice. 14: 250-4.

  3. Ling, T.K.W. and Lee, C.C. (2005). In-vitro activity of telithromycin against respiratory tract pathogens in comparison with other antimicrobial agents. Chemotherapy. 51: 182-185.

  4. Ling, T.K.W., Ying, C.M., Lee, C.C. and Liu, Z.K. (2005). Comparison of antimicrobial resistance of Acinetobacter baumannii clinical isolates from Shanghai and Hong Kong. Medical Principles and Practice. 14: 338-41.

  5. Ling, T.K.W., Xiong, J.H., Yu, Y.S., Lee, C.C., Ye, H.F., Hawkey, P.M. and the MK0826 China Study group (2006). Multicenter antimicrobial susceptibility survey of Gram- negative bacteria isolated from patients with community-acquired infections in the People’s Republic of China. Antimicrobial Agents and Chemotherapy. 50: 374-378.

  6. Ying, C.M., Ling, T.K.W., Lee, C.C., Ling, J.M. (2006) Characterization of carbapenem-resistant Acinetobacter baumannii in Shanghai and Hong Kong. Journal of Medical Microbiology. 55:799-802.

  7. Wang B., Xu J.S., Wang C.X ., Mi Z.H., Pu Y.P., Hui M., Ling T .K .W., Chan C.Y. (2006) Antimicrobial susceptibility of Neisseria gonorrhoeae isolated in Jiangsu Province, China, with a focus on fluoroquinolone resistance. Journal of Medical Microbiology. 55: 1251-1255.

  8. Xu L, Evans J, Ling T, Nye K, Hawkey P. (2007). Rapid genotyping of CTX-M extended-spectrum {beta}-lactamases by Denaturing High-Performance Liquid Chromatography (dHPLC). Antimicrobial Agents and Chemotherapy. 51:1446-1454.

  9. Lee C.C., Lee V.W., Chan F.K., Ling T.K. (2008) Levofloxacin-resistant Helicobacter pylori in Hong Kong. Chemotherapy. 54:50-53.

  10. Tam FC, Ling TK, Wong KT, Leung DT, Chan RC, Lim PL. (2008). The TUBEX test detects not only typhoid-specific antibodies but also soluble antigens and whole bacteria. J Med Microbiol. 57:316-23.