MBBS (HK), MSc (Virology) (Lond),
MD (CUHK), FRCPath, FHKCPath, FHKAM (Pathology)

 
Professor
e-mail: paulkschan@cuhk.edu.hk
Telephone Number: (852)2632-2301
FAX Number: (852)2647-3227
 

Clinical Virology


1. Viral Oncology

To study the epidemiology and pathogenesis of viral infections that are associated with human cancers. Our present lines of research include the role of novel human herpesviruses (human herpesvirus types six, seven and eight) in the development of human cancers; the molecular mechanisms of human papillomaviruses in causing cervical cancer; the potential clinical applications of using human papillomavirus DNA detection in screening and post-treatment surveillance for cervical cancer.

2. Viral Epidemiology

To study viral infections at a population level. Our recent studies include the disease impact and seasonal variation of rotavirus (the most important cause of diarrhoea in infants) and respiratory syncytial virus (the most important cause of lower respiratory tract in young children).

3. Opportunistic Viral Infections

To study the clinical presentations, rapid diagnostic methods and pathogenesis of viral infections that attack immunocompromised patients. Our recent research mainly concentrates on the clinical significance of human herpesvirus six, human herpesvirus seven, human herpesvirus eight and TT virus in bone marrow and renal transplant recipients.

  1. Human papillomavirus: oncogenesis, immunology and epidemiology
  2. Opportunistic viral infection and transplantation
  3. Emerging viral infections
  4. Antiviral compound development
  1. Chan PKS, Li CK, Chik KW, Lee V, Shing MMK, Ng KC, Cheung JLK, Fok TF, Cheng AF. Rick factors and clinical consequences of human herpesvirus 7 infection in paediatric haematopoietic stem cell transplant recipients. Journal of Medical Virology 2004; 72: 668-674.

  2. Chan PKS, To KF, Wu A, Tse GMK, Chan KF, Lui SF, Sung JJY, Tam JS, Tomlinson B. Human metapneumovirus-associated atypical pneumonia and SARS. Emerging Infectious Diseases 2004; 10: 497-500.

  3. Chan PKS, Ng KC, Chan RCW, Lam RKY, Chow VCY, Hui M, Wu A, Lee N, Yap HY, Cheng FWT, Sung JJY, Tam JS. Immunofluorescence assay for serologic diagnosis of SARS. Emerging Infectious Diseases 2004; 10: 530-532.

  4. Chan PKS, Ip M, Ng KC, Chan RCW, Wu A, Lee N, Rainer TH, Joynt GM, Sung JJY, Tam JS. Severe acute respiratory syndrome-associated coronavirus infection. Emerging Infectious Diseases 2003; 9: 1453-1454.

  5. Chan PKS, Tam JS, Lam CW, Chan E, Wu A, Li CK, Buckley TA, Ng KC, Joynt GM, Cheng FWT, To KF, Lee N, Hui DSC, Cheung JLK, Chu I, Liu E, Chung SSC, Sung JJY. Detection of human metapneumovirus from patients with severe acute respiratory syndrome. Emerging Infectious Diseases 2003; 9: 1058-1063.

  6. Chan PKS, Li CK, Chik KW, Shing MMK, Lee V, Ng KC, Lam CW, Cheung JLK, Cheng AF. Genetic Variations of Glycoproteins B and H of Human Herpesvirus 7 in Hong Kong. Journal of Medical Virology 2003; 71:429-433.

  7. Chan PKS, Lam CW, Cheung TH, Li WWH, Lo KWK, Chan MYM, Cheung JLK, Cheng AF. Association of human papillomavirus type 58 variant with the risk of cervical cancer. Journal of National Cancer Institute 2002; 94: 1249-1253.

  8. Chan PKS, Lam CW, Cheung TH, Li WWH, Lo KW, Chan MY, Cheung JL, Xu LY, Cheng AF. Human papillomavirus 16 intratypic variant infection and risk for cervical neoplasia in Southern China. Journal of Infectious Diseases 2002; 186: 696-700.

  9. Chan PKS. Outbreak of avian influenza A (H5N1) virus infection in Hong Kong in 1997. Clinical Infectious Diseases 2002; 34 (Suppl 2): S58-64.

  10. Chan PKS, Chang AR, Cheung JLK, Chan DPC, Xu LY, Tang NLS, Cheng AF. Determinants of cervical human papillomavirus infection: differences between high and low oncogenic risk types. Journal of Infectious Diseases 2002; 185: 28-35.