Biography

Dr Choy graduated in biomedical sciences from University of Bradford, UK and obtained his M(Med)Sc degree from the University of Birmingham, UK. He completed his PhD in molecular genetics in 1999 at the CUHK, followed by postdoctoral research at the Department of Ophthalmology & Visual Sciences at CUHK and the Institute of Molecular & Cell Biology in Singapore.

In the Department of Obstetrics & Gynaecology, Dr Choy serves as an Associate Professor and the Deputy Director of the Prenatal Genetic Diagnosis Centre. He has mentored 2 Master and 1 PhD students. Dr Choy was bestowed the Action for Vision Young Researcher of the Year Award, The Mr. IK Ho visiting Scholar and the Global Scholarship Programme for Research Excellence – CNOOC Grants.

Research interests

His current research covers (1) molecular mechanism of normal and pathological neuro-retinal biology, including retinoblastoma, (2) molecular and bioinformatics research of novel genes and proteins in eye development and their clinical implications, and (3) the development of the microarray based Comparative Genomic Hybridization platform for prenatal diagnosis. His research is currently supported by the Hong Kong Research Grants Council, Action for Vision Ophthalmic Research Grant, Agilent Research Grant and industrial collaborators including GlaxoSmithKline and Affymetrix.
 

Representative publications

1. Lau CS, Yu CB, Wong HK, Fan D, Mak HT, Wong KW, Lam DS, Pang CP, Choy KW. Allelic imbalance at 13q31 is associated with reduced GPC6 in Chinese with sporadic retinoblastoma. Br J Ophthalmol. 2009 Sep 1. [Epub ahead of print] PMID: 19726429.

2. Ng LW, Yip SK, Wong HK, Yam GH, Liu YM, Lui WT, Wang CC, Choy KW. Adipose-derived stem cells from pregnant women show higher proliferation rate unrelated to estrogen. Hum Reprod. 2009;24:1164-70.

3. Choy KW; Wang CC; Ogura A; Lau TK; Rogers MS; Ikeo K; Gojobori T; Lam DSC; Pang CP “Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes”, Physiological Genomics 2006;25:9-15

4. Choy KW, Lee TC, Cheung KF, Fan DSP, Lo KW, Beaverson KL Abramson DH, Lam DSC, Yu CBO, Pang CP. Clinical implications of promoter hypermethylation in RASSF1A and MGMT in retinoblastoma. Neoplasia 2005;7:200-6.

5. Choy KW, Pang C.P., Fan DSP, Lee T.C., Wang J. H., Abramson D.H., Lo K. W., To K.F., Yu C.B.O., Beaverson K.L., and Lam D.S.C. Genomic instability and hMLH1 promoter methylation in human retinoblastoma. Invest Ophthalmol Vis Sci 2004;45:3404-9.

6. Choy KW, Pang CP, Yu CBO, Wong HL, Ng JSK, Fan DSP, Lo KW, Chai JTY, Wang JH, Fu WL and Lam DSC. Loss of heterozygosity and mutations are the major mechanisms of Rb1 gene inactivation in Chinese with sporadic retinoblastoma. Hum Mutat. 2002;20:408.