Biography and Research interests
Chi-Chao Chan, an American board certified ophthalmologist, was born in Chengdu, China. After her graduation from Chungzhan Medical College (Sun Yat-sen University) in China in 1967, she received a B.A. and a M.D. degree from Johns Hopkins University in 1972 and 1975, respectively. She completed her Ophthalmology Residency at Stanford University Medical Center. Subsequently, she finished two post-doctoral trainings in Ophthalmic Pathology at the Wilmer Ophthalmological Institute with W. Richard Green (1979-1982), and Clinical Ocular Immunology at the National Eye Institute (NEI) with Robert B. Nussenblatt (1982-1985). Since 1992, Dr. Chan has been the Chief of the Immunopathology Section, Laboratory of Immunology; and since 1999, she has also served as the Head of the NEI Histology Core. Her clinical activities include ophthalmic pathology and uveitis. Her research interests are molecular pathology, experimental pathology, immunopathology, and ocular immunology. She is an author and co- author of 496 articles in peer reviewed journals, 41 book chapters, and one textbook. Currently her research focuses on age-related macular degeneration, ocular inflammation, and primary intraocular lymphoma. She is presently on the Editorial Boards of 12 medical journals, including British Journal of Ophthalmology (Section Editor), Current Eye Research and Investigative Ophthalmology & Visual Sciences.

Representative publications
1. X. Ding, M. Patel, C.C. Chan: Molecular pathology of age-related macular degeneration. Prog Ret Eye Res 2008 Nov 6 [Epub ahead of print].
2. J. Tuo, C.M. Bojanowski, M. Zhou, D. Shen, R.J. Ross, K.I. Rosenberg, D. J. Cameron, C. Yin, J.A. Kowalak, Z. Zhuang, K. Zhang, C.C. Chan: Murine Ccl2/Cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Invest Ophthalmol Vis Sci 48:3827-3836, 2007.
3. J. Tuo, B. Ning, C.M. Bojanowski, Z.N. Lin, R.J. Ross, G.F. Reed, D. Shen, X. Jiao, M. Zhou, E.Y. Chew, F.F. Kadlubar, C.C. Chan: Synergic effect of polymorshisms in ERCC6 5' flanking region and complement factor H on age-related macular degeneration predisposition. Proc Natl Acad Sci USA 103:9256-9261, 2006.
4. J. Tuo, B. Smith, C.M. Bojanowski, A.D. Meleth, I. Gery, K. Csaky, E.Y. Chew, C.C. Chan: The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration. FASEB J 18:1297-1299, 2004.
5. C.C. Chan: Molecular pathology of primary intraocular lymphoma. Tranas Am Ophthalmol Soc 101:275-292, 2003.
6. D.F. Shen, Z. Zhuang, P. LeHoang, R. Böni, S. Zheng, R.B. Nussenblatt, C.C. Chan: Utility of microdissection and polymerase chain reaction for the detection of immunoglobulin gene rearrangement and translocation in primary intraocular lymphoma. Ophthalmology 105:1664-1669, 1998.
7. C.C. Chan, S.M. Whitcup, D. Solomon, R.B. Nussenblatt: Interleukin-10 in the vitreous of patients with primary intraocular lymphoma. Am J Ophthalmol 120:671-673, 1995.
8. C.C. Chan, Q. Li: Immunopathology of uveitis. Br J Ophthalmol 82:91-96, 1998.
9. C.C. Chan, R.B. Nussenblatt, L.S. Fujikawa, A.G. Palestine, G. Stevens, Jr., L.M. Parver, M.W. Luckenbach, T. Kuwabara: Sympathetic Ophthalmia: Immunopathological findings. Ophthalmology 93:690-695, 1986.
10. C.C. Chan, M. Mochizuki, A.G. Palestine, D. BenEzra, I. Gery, R.B. Nussenblatt: Kinetics of T-lymphocyte subsets in the eyes of Lewis rats with experimental autoimmune uveitis. Cell Immunol 96:430-434, 1985.