Mr Chi Wai LAU

• Jiang M, Ding H, Huang Y, Cheng CK, Lau CW, Xia Y, Yao X, Wang L, Huang Y (2023) Thioridazine protects against disturbed flow-induced atherosclerosis by inhibiting RhoA/YAP-mediated endothelial inflammation. Acta Pharmacologica Sinica 44(10):1977-1988.

• Kang L, Yi J, Lau CW, He L, Chen Q, Xu S, Li J, Xia Y, Zhang Y, Huang Y, Wang L (2023) AMPK-dependent YAP inhibition mediates the protective effect of metformin against obesity-associated endothelial dysfunction and inflammation. Antioxidants 2023,12(9):1681 (16 pages)

• Luo JY, Cheng CK, Gou L, He L, Zhao L, Zhang Y, Wang L, Lau CW, Chen AF, Huang Y (2023) Induction of KLF2 by exercise activates eNOS to improve vasodilatation in diabetic mice. Diabetes 72(9):1330-1342

• Ding H, Jiang M, Lau CW, Luo J, Chan AM, Wang L, Huang Y (2023) Curaxin CBL0137 inhibits endothelial inflammation and atherogenesis via suppression of Src-YAP signaling axis. British Journal of Pharmacology 180(8):1168-1185

• Wang C, Wu Y, Li Y, Zhang Y, Fung YK, Tong KK, Lau CW, Xiang L, Kwan KM, You LR, Huang Y, Tian XY (2023) Smad4-mediated angiogenesis facilitates beiging of white adipose tissue in mice. iScience 26(3):106272 (17 pages),

• Cheng CK, Lin X, Pu Y, Tse KYJ, Wang Y, Zhang CL, Cao X, Lau CW, Huang J, He L, Luo JY, Shih YT, Wan S, Ng CF, Wang L, Ma CWR, JJ Chiu, Chan TF, Tian XY & *Huang Y (2023) SOX4 is a novel phenotypic regulator of endothelial cells in atherosclerosis revealed by single-cell analysis. Journal of Advanced Research 43:187-203. 

• Huo M, Cao X, Zhang H, Lau CW, Hong H, Chen FM, Huang Y, Chawla A & Tian XY (2022) Loss of Myeloid Bmal1 Exacerbates Hypertensive Vascular Remodelling Through Interaction with STAT6 in Mice. Cardiovascular Research 118(13):2859-2874

• Luo JY, Cheng CK, He L, Pu Y, Zhang Y, Lin X, Xu A, Lau CW, Tian XY, Ma RCW, Jo H & *Huang Y (2022) Endothelial UCP2 is a mechanosensitive suppressor of atherosclerosis. Circulation Research 131(5):424-441.

• Zhang H, Dong J, Lau CW, Wei Y & *Huang Y (2022) Berberine reverses nitroglycerin tolerance through suppressing PKCa activity in vascular smooth muscle cells. Cardiovascular Drugs and Therapy 36(4):633-643

• Zhang H, Xiang L, Huo M, Wu Y, Yu M, Lau CW, Tian D, Gou L, Huang Y, Luo JY, Wang L, Song W, Huang J, Cai Z, Chen S, Tian XY & *Huang Y (2022)  Branched-chain amino acid supplementation Impairs Insulin Sensitivity and Promotes Lipogenesis During Exercise in Diet-Induced Obese Mice. Obesity (Silver Spring). 30(6):1205-1218.

• Cheng CK, Shang W, Liu J, Cheang WS, Wang Y, Xiang L, Lau CW, Luo JY, Ng CF, *Huang Y, *Wang L (2022) Activation of AMPK/miR-181b Axis Alleviates Endothelial Dysfunction and Vascular Inflammation in Diabetic Mice. Antioxidants 11(6):1137 (17 pages)

• Zhao L, Zhang CL, He L, Chen QH, Liu L, Kang L, Liu J, Luo JY, Gou L, Qu D, Song W, Lau CW, Ko H, Mok VCT, Tian XY, Wang L & *Huang Y (2022) Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Reducing Mitochondrial ROS-mediated eNOS Monomerization. Diabetes 71(5):1099-1114. doi: 10.2337/db21-0660

• Wu Y, Tang X, Lee S, Hong H, Cao X, Lau CW, Liu B, Chawla A, Ma RCW, Huang Y, Lui KO, Tian XY (2022).Endothelial PPARδ facilitates the post-ischemic vascular repair through interaction with HIF1α. Theranostics 12(4):1855-1869.

• Teoh YCJ, Tian XY, Wong YPC, Lau CW, Cheng CK, Tang WLV, Chan CKR, Huang Y & Ng CF (2022) Endothelial dysfunction after androgen deprivation therapy and the possible underlying mechanisms. Prostate 82(1):13-25.

• Liu J, Zhang Y, Qu D, Zhang H, Wang L, Lau CW, Han JY, Pingcuo D, *Huang Y & Liu L (2021) Salvianolic acid B ameliorates vascular endothelial dysfunction through the inhibition of bone morphogenetic protein 4 in diabetic mice. Life Sciences 286:120039.

• Cheng CK, Luo JY, Lau CW, Cho WCS, Ng CF, Ma RCW, Tian XY & *Huang Y (2021) A GLP-1 analog lowers ER stress and enhances protein folding to ameliorate homocysteine-induced endothelial dysfunction. Acta Pharmacological Sinica 42(10):1598-1609.

• Huang J, Pu Y, Zhang H, Xie L, He L, Zhang C, Cheng CK, Huo Y, Wan S, Chen S, Huang Y, Lau CW, Wang L, Xia Yin, Huang Y & Luo JY (2021) Endothelial KLF2 mediates the suppressive effect of laminar flow on vascular calcification by inhibiting BMP/SMAD1/5 signaling. Circulation Research 129(4):e87-e100.

• Xiang L, Nie J, Wang L, Wang Y, Shi J, Wei J, Lau CW, Cai ZW & Huang Y (2021) Integrated metabolomics analysis of the effect of PPARd agonist GW501516 on catabolism of BCAAs and carboxylic acids in diabetic mice. Chinese Chemical Letters 32(7):2197-2202.

• Cheng CK, Wang C, Shang W, Lau CW, Luo JY, Wang L & Huang Y (2021) A high methionine and low folate diet alters glucose homeostasis and gut microbiome. Biochemistry and Biophysics Reports 24 (March 2021): article 100921

• Cheng CK, Luo JY, Lau CW, Chen ZY, Tian XY & Huang Y (2020) Pharmacological Basis and New Insights of Resveratrol Action in the Cardiovascular System. British Journal of Pharmacology 177(6):1258-1277.

• Qu D, Wang L, Huo M, Song W, Lau CW, Xu J, Xu A, Yao X, Chiu JJ, Tian XY & Huang Y (2020) Focal TLR4 activation mediates disturbed flow-induced endothelial inflammation. Cardiovascular Research 116(1):226-236. doi: 10.1093/cvr/cvz046.

• Qu D, Huo M, Wang L, Lau CW, Tian XY & Huang Y (2019) Nilotinib activates endothelial TLR4 to exacerbate atherosclerosis. bioRxiv (Cold Spring Harbor Laboratory), doi: https://doi.org/10.1101/2019.12.14.876599

• Cheang WS, Wong WT, Wang L, Cheng CK, Lau CW, Ma RCW, Xu A, Wang N, *Huang Y & *Tian XY (2019) Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor δ. Pharmacological Research 139:384-394.

• Liang C, Zhang Y, Zhuo D, Lo CY, Yu L, Lau CW, Kwan YW, Tse G, Huang Y & Yao X (2018) Endothelial cell transient receptor potential channel C5 (TRPC5) is essential for endothelium-dependent contraction in mouse carotid arteries. Biochemical Pharmacology 159:11-24.

• Zhang H, Liu J, Qu D, Wang L, Wong CM, Lau CW, Huang Y, Wang YF, Huang H, Xia Y, Xiang L, Cai Z, Liu P, Wei Y, Yao X, Ma RCW & *Huang Y (2018) Serum exosomes mediate delivery of arginase 1 as a novel mechanism for endothelial dysfunction in diabetes. Proceedings of the Academy of National Sciences USA 115(29):E6927-E6936.

• Gou L, Zhao L, Song W, Wang L, Liu J, Zhang H, Huang Y, Lau CW, Yao XQ, Tian XY, Wong WT, Luo JY & Huang Y (2017) Inhibition of miR-92a suppresses oxidative stress and improves endothelial function by upregulating heme oxygenase-1 in db/db mice. Antioxidants & Redox Signaling 28(5):358-370.

• Ling WC, Liu J, Lau CW, Murugan DD, Mustafa MR & Huang Y (2017) Treatment with salvianolic Acid B restores endothelial function in angiotensin II-induced hypertensive mice. Biochemical Pharmacology 136 (2017):76-85.

• Wong CM, Au CL, Tsang SY, Lau CW, Yao X, Cai Z, Chung AC (2017) Role of inducible nitric oxide synthase in endothelium-independent relaxation to raloxifene in rat aortas. British Journal of Pharmacology 174(8):718-733.

• Cheang WS, Wong WT, Zhao L, Xu J, Wang L, Lau CW, Chen ZY, Ma RCW, Xu A, Wang N, Tian XY & Huang Y (2017) PPARδ Is required for exercise to attenuate endoplasmic reticulum stress and endothelial dysfunction in diabetic mice. Diabetes 66(2):519-528.

• Wang L, Luo JY, Li B, Tian XY, Chen LJ, Huang Y, Liu J, Deng D, Lau CW, Wan S, Ai D, Mak KL, Tong KK, Kwan KM, Wang N, Chiu JJ, Zhu Y & Huang Y (2016) Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature 540:579-581. Commented in Nature News and Views, Nature 540:531-532.

• Leung SB, Zhang H, Lau CW, Lin ZX (2016) Attenuation of blood pressure in spontaneously hypertensive rats by acupuncture was associated with reduction oxidative stress and improvement from endothelial dysfunction. Chinese Medicine 2016 Aug 30;11(1):38. doi: 10.1186/s13020-016-0110-0.

• Choy KW, Mustafa MR, Lau YS, Liu J, Murugan D, Lau CW, Wang L, Zhao L & Huang Y (2016) Paeonol protects against endoplasmic reticulum stress-induced endothelial dysfunction via AMPK/PPARd signalling pathway. Biochemical Pharmacology 116:51-62.

• Leung FP, Yung LM, Ngai CY, Cheang WS, Tian XY, Lau CW, Zhang Y, Liu J, Chen ZY, Bian ZX, Yao X & Huang Y (2016) Chronic black tea consumption improves endothelial function in ovariectomized rats. European Journal of Nutrition 55(5):1963-1972.

• Tian XY, Wong WT, Lau CW, Wang YX, Cheang WS, Liu J, Lu Y, Huang H, Xia Y, Chen ZY, Mok CSD, Lau CM & Huang Y (2016) Melamine impairs renal and vascular function in rats. Scientific Reports 6:28041

• Zhang H, Liu J, Qu D, Wang L, Luo JY, Lau CW, Liu P, Gao Z, Tipoe, GL, Lee HK, Ng CF, Ma RCW, Yao X & Huang Y (2016) Inhibition of miR-200c restores endothelial function in diabetic mice through suppression of COX-2. Diabetes 65(5):1196-1207 with Commentary Diabetes 65(5):1152-1154.

• Hu W, Zhang Y, Wang L, Lau CW, Xu J, Luo JY, Gou L, Yao XY, Chen ZY, Ma RCW, Tian XY & Huang Y (2016) Bone morphogenic protein 4-Smad induced upregulation of platelet-derived growth factor AA impairs endothelial function. Arteriosclerosis, Thrombosis and Vascular Biology 36(3):553-560.

• Dharmani Devi M*, Lau YS, Lau CW, Mohd Rais M & Huang Y (2015) Angiotensin 1-7 protects against angiotensin II-induced endoplasmic reticulum stress and endothelial dysfunction via Mas receptor. PLoS One 2015 Dec 28;10(12):e0145413.

• Sun Y, Lau CW, Jia Y, Li Y, Wang W, Ran J, Li F, Huang Y, Zhou H & Yang B (2016) Functional inhibition of urea transporter UT-B enhances endothelial-dependent vasodilation and lowers blood pressure via L-arginine-endothelial nitric oxide synthase-nitric oxide pathway. Scientific Reports 2016 Jan 7;6:18697. doi: 10.1038/srep18697.

• Zhang Y, Liu J, Luo JY, Tian XY, Cheang WS, Xu J, Lau CW, Wang L, Wong WT, Wong CM, Lan HY, Yao XQ, Raizada MK & Huang Y (2015) Upregulation of angiotensin (1-7)-mediated signaling preserves endothelial function through reducing oxidative stress in diabetes. Antioxidants & Redox Signaling 23(11):880-892 with Cover Image of the Issue.

• Cheang WS, Ngai CY, Tam YY, Tian XY, Wong WT, Zhang Y, Lau CW, Chen ZY, Bian ZX, Huang Y & Leung FP (2015) Black tea protects against hypertension-associated endothelial dysfunction through alleviation of endoplasmic reticulum stress. Scientific Reports 5:10340

• Wu XL, Cheang WS, Zhang DM, Li Y, Lau CW, Wang GC, Huang Y & Ye WC (2014) Antagonism of Ca2+ influx via L-type Ca2+ channels mediates the vasorelaxant effect of Catharanthus roseus--derived vindorosine in rat renal artery. Planta Medica 80(18)1672-1677.

• Qu D, Liu J, Lau CW & Huang Y (2014) Differential mechanisms for insulin-induced relaxation in mouse posterior tibial arteries and main mesenteric arteries. Vascular Pharmacology 63(3):173-177.

• Ni X, Wong SL, Lau CW, Shi X, Wong CM, Cai Y & Huang Y (2014) Tetramethylpyrazine protects against hydrogen peroxide-provoked endothelial dysfunction in isolated rat aortic rings: implications for antioxidant therapy of vascular diseases. Evidence-Based Complementary and Alternative Medicine Volume 2014 (2014), Article ID 627181, 10 pages

• Gao Z, Zhang H, Liu J, Lau CW, Liu P, Chen ZY, Lee HK, Tipoe GL, Ho HM, Yao X & Huang Y (2014) Cyclooxygenase-2-dependent oxidative stress mediates palmitate-induced impairment of endothelium-dependent relaxations in mouse arteries. Biochemical Pharmacology 91(4):474-481

• Liu L, Liu J, Tian XY, Wong WT, Lau CW, Xu A, Xu G, Ng CF, Yao X, Gao Y & Huang Y (2014) Uncoupling protein-2 up-regulation and oxidative stress inhibition mediate DPP-4 inhibition-induced restoration of endothelial function in hypertension. Antioxidants & Redox Signaling 21(11):1571-1581

• Qu D, Liu J, Lau CW & Huang Y (2014) Interleukin-6 in diabetes and cardiovascular complications. British Journal of Pharmacology 171(15):3595-3603

• Wang Y, Dong J, Liu P, Lau CW, Gao Z, Zhou D, Tang J, Ng CF & Huang Y (2014) Ginsenoside Rb3 attenuates oxidative stress and preserves endothelial function in hypertension. British Journal of Pharmacology 171(13):3171-3181

• Cheang WS, Tian XY, Wong WT, Lau CW, Lee ST; Chen ZY, Yao X, Wang N & Huang Y (2014) Metformin protects endothelial function in diet-Induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway. Arteriosclerosis, Thrombosis and Vascular Biology 34(4):830-6

• Zhang Y, Liu J, Tian XY, Wong WT, Chen Y, Wang L, Luo JY, Cheang WS, Lau CW, Kwan KM, Wang N, Yao X & Huang Y (2014) Inhibition of bone morphogenic protein-4 restores endothelial function in db/db diabetic mice. Arteriosclerosis, Thrombosis and Vascular Biology 34(1):152-159

• Lau YS, Tian XY, Mustafa MR, Murugan D, Liu J, Zhang Y, Lau CW & Huang Y (2013) Boldine improves endothelial function in diabetic db/db mice through inhibiting angiotensin II-mediated BMP4 oxidative stress cascade. British Journal of Pharmacology 170(6):1190-1198

• Chan GHH, Law BYK, Chu JMT, Yue KKM, Jiang ZH, Lau CW, Huang Y, Chan SW, Yue P & Wong R (2013) Ginseng extracts restore high-glucose induced vascular dysfunctions by altering triglyceride metabolism and down-regulation of atherosclerosis-related genes. Evidence-Based Complementary and Alternative Medicine 2013(2013):797310

• Dong J, Wong SL, Lau CW, Liu J, Wang YX, He ZD, Ng CF, Chen ZY, Yao X, Xu A, Ni X, Wang H & Huang Y (2013) Calcitriol restores renovascular function in estrogen-deficient rats through downregulation of cyclooxygenase-2 and the thromboxane-prostanoid receptor. Kidney International 84(1):54-63 with Commentary 2013;84(1):9-11.

• Yung LM, Tian XY, Wong WT, Leung FP, Yung LH, Chen ZY, Lau CW, Yao YX & Huang Y (2013) Chronic cranberry juice consumption restores cholesterol profiles and improves endothelial function in ovariectomized rats. European Journal of Nutrition 52(3):1145-1155

• Leung SB, Zhang H, Lau CW, Huang Y & Lin Z (2013) Salidroside improves homocysteine induced endothelial dysfunction by reducing oxidative stress.Evidence-Based Complementary and Alternative Medicine 2013(2013):679635

• Yang C, Chen ZY, Wong SL, LIU J, Liang YT, Lau CW, Lee HK, Huang Y & Tsang SY (2013) b-Sitosterol oxidation products attenuate vasorelaxation through increasing reacitive oxygen species and cyclooxygenase-2. Cardiovascular Research 97(3):520-532.

• Bi CWC, Xu L, Tian XY, Liu J, Lau CW, Zheng KYZ, Lau DTW, Choi RCY, Dong TTX, Huang Y, Tsim KWK (2012) Fo Shou San, an ancient Chinese herbal decoction, protects endothelial function through increasing endothelial nitric oxide synthase activity. PLoS One 7(12):e51670.

• Dong J, Wong SL, Lau CW, Lee, HK, Ng CF, Zhang L, Yao X, Chen ZY, Vanhoutte PM & Huang Y (2012) Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress. European Heart Journal 33(23):2980-2990.

• Zhang DM, Li Y, Cheang WS, Lau CW, Lin SM, Zhang QL, Yao N, Wang Y, Wu X, Huang Y & Ye WC (2012) Cajaninstilbene acid relaxes rat renal arteries: roles of Ca2+ antagonism and protein kinase C-dependent mechanism. PLoS One 7(10):e47030.

• Liu L, Liu J, Wong WT, Tian XY, Lau CW, Wang YX, Xu G, Pu Y, Zhu Z, Xu A, Lam KSL, Chen ZY, Ng CF, Yao X & Huang Y (2012) Dipeptidyl peptidase inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism. Hypertension 60(3):833-841.

• Yuen CY, Wong SL, Lau CW, Tsang SY, Xu A, Zhu Z, Ng CF, Kong SK, Lee HK, Yao X & Huang Y (2012) From skeleton to cytoskeleton: Osteocalcin transforms vascular fibroblasts to myofibroblasts via angiotensin II and Toll-like receptor 4. Circulation Research 111:e55-e66.

• Chan YC, Leung FP, Tian XY, Yung LM, Lau CW, Chen ZY, Yao X, Laher I & Huang Y (2012) Raloxifene improves vascular reactivity in pressurized septal coronary arteries of ovariectomized hamsters fed cholesterol diet. Pharmacological Research 65(20):182-188.

• Tian XY, Wong WT, Leung FP, Zhang Y, Wang YX, Lee HK, Ng CF, Chen ZY, Yao X, Au CL, Lau CW, Vanhoutte PM, Cooke JP & Huang Y (2012) Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin F2a impairs endothelial function in renovascular hypertensive rats Antioxidants & Redox Signaling 16(4):363-373,

• Tian XY, Wong WT, Xu A, Chen ZY, Lu Y, Liu L, Lee VWY, Lau CW, Yao X & Huang Y (2011) Rosuvastatin improves endothelial function of db/db mice: Role of angiotensin II type 1 receptors and oxidative stress. British Journal of Pharmacology 164(b):598-606.

• Wong WT, Tian XY, Xu A, Jun Y, Lau CW, Hoo RLC, Wang Y, Lee VWY, Lam KSL, Vanhouttee PM & Huang Y (2011) Adiponectin is required for PPARg-mediated improvement of endothelial function in diabetic mice. Cell Metabolism 14(1):104-115.

• Wong SL, Lau CW, Wong WT, Xu A, Au CL, Ng CF, Ng SSM, Gollasch M, Yao X, Huang Y (2011) Pivotal role of PKCδ in angiotensin II-induced endothelial cyclooxygenase-2 expression: A link to vascular inflammation. Arteriosclerosis, Thrombosis and Vascular Biology 31(5):1169-1176.

• Yu S, Wong SL, Lau CW, Huang Y, Yu CM (2011) Oxidized LDL at low concentration promotes in vitro angiogenesis and activates nitric oxide synthase through PI3K/Akt/eNOS pathway in human coronary artery endothelial cellsBiochemical and Biophysical Research Communications 407(1):44-48.

• Yuen CY, Wong WT, Tian XY, Wong SL, Lau CW, Yu J, Tomlinson B, Yao X & Huang Y (2011) Telmisartan inhibits vasoconstriction via PPARγ-dependent expression and activation of endothelial nitric oxide synthase. Cardiovascular Research 90(1):122-129

• Yung LM, Wong WT, Tian XY, Leung FP, Chen ZY, Lau CW, Yao X & *Huang Y (2011) Inhibition of renin-angiotensin system reverses endothelial dysfunction and oxidative stress during estrogen deficiency in ovariectomized rats. PloS One 6(3):e17437.

• Zhang DE, Lin SM, Lau CW, Yiu A, Wang J, Li Y, Fan CL, *Huang Y, Ye WC (2010) Anemoside A3-induced relaxation in rat renal arteries: role of endothelium and Ca2+ channel inhibition. Planta Medica 76(16):1814-1819.

• Cheang WS, Wong WT, Shen B, Lau CW, Tian XY, Tsang SY, Yao X, Chen ZY, *Huang Y (2010) 4-Aminopyridine-sensitive K+ channels contributes to NaHS-induced membrane hyperpolarization and relaxation in the rat coronary artery. Vascular Pharmacology 53(3-4):94-98.

• Chan YC, Leung FP, Wong WT, Tian TY, Yung LM, Lau CW, Tsang SY, Yao Y, Chen ZY, *Huang Y (2010) Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent eNOS activation. Arteriosclerosis, Thrombosis and Vascular Biology 30(5):992-999.

• Liu CQ, Wong SL, Leung FP, Tian XY, Lau CW, Lu LM, Yao X, Chen ZY, T Yao & *Huang Y (2010) Phosphodiesterase inhibition ameliorates prostanoid TP receptor-mediated impairment of vasorelaxation induced by cyclic AMP-elevating dilator. European Journal of Pharmacology 632(1):45-51.

• Liu CQ, Leung FP, Wong SL, Lau CW, Wong WT, Lu L, Yao X, Yao T & *Huang Y (2009) Thromboxane prostanoid receptor activation impairs endothelial nitric oxide-dependent vasorelaxations: the role of Rho kinase. Biochemical Pharmacology 78(4):374-381.

• Wang Y, Huang Y, Lam KSL, Li Y, Ye H, Lau CW, Vanhoutte P, Xu A (2009) Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via AMP-activated protein kinase and eNOS. Cardiovascular Research 82(3):484-492.

• Wong CW, Yung LM, Leung FP, Tsang SY, Au CL, Chen ZY, Yao X, Cheng HK, Lau CW, Gollasch M & *Huang Y (2008) Raloxifene protects endothelial cells against oxidative stress. British Journal of Pharmacology 155(3):326-334.

• Liu CQ, Leung FP, Lee WY, Lau CW, Yao Y, Lu Limin & *Huang Y (2008) Prevention of nitroglycerin tolerance in vitro by T0156, a selective phosphodiesterase type 5 inhibitor. European Journal of Pharmacology 590(1-3):250-254.

• Zhong JC, *Huang Y, Yung LM, Lau CW, Leung FP, Wong WT & Yu XY (2007) The novel peptide apelin regulates intrarenal artery tone in diabetic mice. Regulatory Peptides 144:109-114.

• Chan YC, Leung FP, Yao X, Lau CW, Vanhoutte PM & Huang Y. (2007) Raloxifene modulates pulmonary vascular reactivity in spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology 49(6):355-361.

• Zhong JX, Yu XY, Huang Y, Yung LM, Lau CW & Lin SG (2007) Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice. Cardiovascular Research 74(3):388-395. With Editorial Commentary “Apelin and vascular dysfunction in type 2 diabetes” Cardiovasc Res 2007;74(3):339-340

• Leung FP, Yao X, Lau CW, Ko WH, Lu L & Huang Y (2005) Raloxifene relaxes rat intrarenal arteries by inhibiting Ca2+ influx. American Journal of Physiology – Renal Physiology 289:F137-F144.

• Chan YC, Leung FP, Yao X, Lau CW, Vanhoutte PM & Huang Y (2005) Raloxifene relaxes rat pulmonary arteries and veins: roles of gender, endothelium and antagonism of Ca2+ influx. Journal of Pharmacology and Experimental Therapeutics 312(3): 1266-1271.

• Chan YC, Yao X, Lau CW, Chan FL, He GW, Bourreau JP & Huang Y (2004) The relaxant effect of urocortin in the rat pulmonary resistance artery. Regulatory Peptides 121(1-3):11-18.

• Lau CW, Chan YC, Yao XQ, Chan FL, Chen ZY & Huang Y (2004) Nickel inhibits urocortin-induced relaxation in the rat pulmonary artery. European Journal of Pharmacology 488(1-3):169-172.

• Lau CW, Chen ZY, Wong CM, Yao XQ, He DZ, Xu HX & Huang Y (2004) Attenuation of endothelium-mediated relaxation by acteoside in rat aorta: role of endothelial [Ca2+]i and nitric oxide-cyclic GMP pathway. Life Sciences 75(10):1149-1157.

• Huang Y, Wong CM, Lau CW, Yao, XQ, Tsang SY, Su YL & Chen, Z.Y. (2004) Inhibition of nitric oxide/cyclic GMP-mediated relaxation by purified flavonoids, baicalin and baicalein, in rat aortic rings. Biochemical Pharmacology 67(4):787-794.

• Huang Y, Yao X, Lau CW, Chan YC, Tsang SY & Chan FL (2004) Urocortin and cardiovascular protection. Acta Pharmacologica Sinica 25(3):257-265.

• Huang Y, Chan FL, Lau CW, Tsang SY, Chen ZY, He GW & Yao XQ. (2003) Role of cAMP and Ca2+-actyivated K+ channels in endothelium-independent relaxation by urocortin in the rat coronary artery. Cardiovascular Research 57(3): 824-833.

• Yao XQ, He GW, Chan FL, Lau CW, Tsang SY, Chen ZY & Huang Y. (2002) Endothelium-dependent and –independent coronary relaxation induced by urocortin. Journal of Cardiac Surgery 17(4):347-349.

• Huang Y, Tsang SK, Yao XQ, Lau CW, Su YL & Chen ZY. (2002) Baicalin-induced vascular response in rat mesenteric artery: role of endothelial nitric oxide. Clinical and Experimental Pharmacology and Physiology 29(8):721-724.

• Ko WH, Law WI, Yin YC, Yue GGL, Lau CW, Chen ZY & Huang Y. (2002) Stimulation of chloride secretion by baicalein in isolated rat distal colon. American Journal of Physiology Gastrointestinal and Liver Physiology 282(3):G508-G518.

• Huang Y, Chan FL, Lau CW, Tsang SK, He GW, Chen ZY & Yao XQ. (2002) Urocortin-induced endothelium-dependent relaxation of rat coronary artery: role of nitric oxide and K+ channels. British Journal of Pharmacology 135(6):1467-1476.

• Tam WY, Chen ZY, He ZD, Yao XQ, Lau CW & Huang Y. (2002) Enhancement of contraction of rat mesenteric artery by acteoside: role of endothelial nitric oxide. Journal of Natural Products 65(7):990-995.

• Chen ZY, Yao XQ, Chan FL, Lau CW & Huang Y. (2002) (-)Epicatechin induces and modulates endothelium-dependent relaxation in the isolated rat mesenteric artery rings. Acta Pharmacologica Sinica 23(12):1188-1192 (Invited article)

• Wong YF, Huang Y, Hen ZD, Lau CW & Chen ZY. (2001) Relaxing effects of Ligustrum purpurascens extract and purified acteoside in rat aortic rings. Planta Medica 67(5):317-321.

• Huang Y, Pai R, Lau CW, Chan FL, Chen ZY & Yao XQ. (2001) Modulatory effect of protein kinase C on contractility of rat vas deferens. Pharmacology 62(1): 2-9

• He ZD, Huang Y, Yao XQ, Lau CW, Law WI & Chen ZY. (2001) Purification of phenylethanoids from Brandisia hancei and the antiproliferative effects on aortic smooth muscle. Planca Medica 67 (6): 520-522.

• Wang ZT, Lau CW, Chen FL, Yao XQ, Chen ZY, He ZD & Huang Y. (2001) Vasorelaxant effects of alpinetin and cardamonin from Alpinia blepharocalyx K. Schum. Journal of Cardiovascular Pharmacology 37(5):596-606.

• Chen HY, Yao XQ, Tsang SY, Chan FL, Lau CW & Huang Y. (2001) Different role of endothelium/nitric oxide in 17s-estradiol and progesterone-induced relaxation in rat arteries. Life Sciences 69(14):1609-1617.

• Huang Y, Bourreau JP, Chan HY, Lau CW, Wong WT & Yao XQ. (2001) Inhibitory effect of tetrabutylammonium ions on endothelium/nitric oxide-mediated vasorelaxation. Life Sciences 69(14):1661-1672.

• Lau CW, Yao XQ, Chen ZY, Ko WH & Huang Y. (2001) Cardiovascular effects of berberine. Cardiovascular Drug Reviews 19(3)-234-244.

• Ko WH, Yao XQ, Lau CW, Law WY, Chen ZY, Ho WKK & Huang Y. (2000) Vasorelaxant and antiproliferative effect of berberine. European Journal of Pharmacology 399:187-196.

• Huang Y, Yao XQ, Chan FL, Lau CW, Chen NWK & Chen ZY. (2000) Abolition of endothelium-dependent relaxation in the rat aorta by tetraoctylammonium ions. Naunyn-Schmiedeberg’s Archives of Pharmacology 362 (2):152-159.

• Huang Y, Yao XQ, Lau CW, Chan FL, Chan NWK, Cheng YM & Chen ZY. (2000) Role of endothelium in thapsigargin-induced arterial responses in rat aorta. European Journal of Pharmacology 392:51-59.

• Huang Y, Yao XQ, Tsang SY, Lau CW & Chen ZY. (2000) Role of endothelium in vascular response to flavonoids and epicatechins. Acta Pharmacologica Sinica 21(12): 1119-1124. Special issue “Traditional Herbal Medicine Research”

• Chen Z, Su YL, Lau CW, Law WI & Huang Y. (1999) Endothelium-dependent contraction and direct relaxation induced by baicalein in rat mesenteric artery. European Journal of Pharmacology 374:41-47.

• Huang Y, Chan NWK, Lau CW, Yao XQ, Chan FL & Chen ZY. (1999) Involvement of endothelium/nitric oxide in vasorelaxation induced by purified green tea (-)epicatechin. Biochimica et Biophysica Acta 1427:322-328.

• Huang Y, Lau CW, Chan FL & Yao X. (1999) Contribution of nitric oxide and K+ channel activation to vasorelaxation of isolated rat aorta by procaine. European Journal of Pharmacology 367:231-237.

• Huang Y, Lau CW, Chan NWK, Yao XQ & Chan FL. (1998) Prejunctionally mediated inhibition of neurotransmission by isoprenaline in rat vas deferens. Life Sciences 63(23) 2107-2113.

• Huang Y & Lau CW. (1998) Unique effect of tetrapentylammonium ions on sympathetic transmission in rat vas deferens. Journal of Autonomic Pharmacology 18:189-194.

• Huang Y, Zhang AQ, Lau CW & Chen ZY. (1998) Vasorelaxant effects of purified green tea epicatechin derivatives in rat mesenteric artery. Life Sciences 63: 275-283.

• Kwok KH, Lau CW, Chan NWK & Huang Y. (1998) Contractile and relaxant effects of tetrapentylammonium ions in isolated rat mesenteric artery. Pharmacology 57: 188-195.

• Huang Y, Kwok KH, Chan NWK, Lau CW & Chen ZY. (1998) Role of endothelium and K+ channel in dobutamine-induced relaxation in rat mesenteric artery. Clinical and Experimental Pharmacology and Physiology 25:405-411

• Huang Y, Lau CW & Ho IHM. (1997) Involvement of ATP-sensitive K+ channels in inhibitory effect of calcitonin gene-related peptide on neurotrnasmission in rat vas deferens. European Journal of Pharmacology 327:209-214

• Huang Y, Lau CW. & Ho IHM. (1997) NS 1619 activates K+ channels in the rat vas deferens. European Journal of Pharmacology 325:21-27

• Huang Y & Lau CW. (1997) Inhibitory effect of amitriptyline on contraction of the rat isolated trachea. Pharmacology 54:312-318

• Huang Y & Lau CW. (1997) Differential effects of pinacidil, cromakalim and NS 1619 on electrically evoked contractions in rat vas deferens. Acta Pharmacologica Sinica 18:293-298