Professor Wei GE
| Address | (Office): |
N6-5027, University of Macau |  |
||
(Lab): |
N22-2037, University of Macau | ||||
| Phone | (Office/Lab): |
(853) 8822 4556 | |||
| Fax | (853) 8822 2314 | ||||
| weige@um.edu.mo | |||||
| Web | https://fhs.um.edu.mo/staff/academic-staff/wei-ge |
Education
| 1993 | Ph.D. | University of Alberta, Canada | |
| 1985 | M.Sc. | Academia Sinica, China | |
| 1982 | B.Sc. | Nanjing University, China |
Position
- Vice Rector (Research), University of Macau
- Chair Professor and Director of Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau
Research Interests
- Zebrafish as a model for aging, human diseases and drug discovery
- Endocrine regulation of reproduction by the reproductive and growth axes
- Intra-follicular paracrine/autocrine communication network in the ovary
- Impacts of environmental endocrine-disrupting chemicals (EDCs) on reproduction and public health
Representative Publications
- Qin, M., Zhang, Z., Song, W., Wong, W.-L., Chen, W. and *Ge, W. 2018 Roles of Figla/figla in juvenile ovary development and follicle formation during zebrafish gonadogenesis. Endocrinology (in press)
- Zhang, Y., Zhang, Z. and *Ge, W. 2018 An efficient platform for generating somatic point mutations with germline transmission in the zebrafish by CRISPR/Cas9-mediated knock-in. Journal of Biological Chemistry 293:6611
- Lu, H., Cui, Y., Jiang, L. and *Ge, W. 2017 Functional analysis of nuclear estrogen receptors (nERs) in zebrafish reproduction by genome editing approach. Endocrinology 158:2292–2308
(#This article received a special coverage by the journal with a news and commentary article: Endocrinology 2017; 158:2082-2083) - Wong, Q.W.-L., Sun, M.-A., Lau, S.-W., Parsania, C., Zhou, S., Zhong, S. and *Ge, W. 2017 Identification and characterization of a specific 13- miRNA expression signature during follicle activation in the zebrafish ovary. Biology of Reproduction 98:42-53
- Chen, W., Lau, S.-W., Fan, Y., Wu, R.S.S. and *Ge W. 2017 Juvenile exposure to bisphenol a promotes ovarian differentiation but suppresses its growth – potential involvement of pituitary follicle-stimulating hormone. Aquatic Toxicology 193:111-121
- Chen, W., Liu, L. and *Ge W. 2017 Expression analysis of growth differentiation factor 9 (Gdf9/gdf9), anti-Müllerian hormone (Amh/amh) and aromatase (Cyp19a1a/cyp19a1a) during gonadal differentiation of the zebrafish, Danio rerio. Biology of Reproduction 96:401-13
- Lau, E.S.-W., Zhang, Z., Qin, M. and *Ge W. 2016 Knockout of zebrafish ovarian aromatase gene (cyp19a1a) by TALEN and CRISPR/Cas9 leads to all-male offspring due to failed ovarian differentiation. Scientific Reports 6:37357
- Zhang, Z., Lau, S.-W., Zhang, L. and *Ge W. 2015 Disruption of zebrafish follicle-stimulating hormone receptor (fshr) but not luteinizing hormone receptor (lhcgr) gene by TALEN leads to failed follicle activation in females followed by sexual reversal to males. Endocrinology 156:3747-3762
(#This article received a special coverage by the journal with a news and commentary article: Endocrinology 2015; 156:3490-3493) - Yao, K. and *Ge W. 2015 Differential Regulation of Kit Ligand A (kitlga) Expression in the Zebrafish Ovarian Follicle Cells – Evidence for the Existence of a Cyclic Adenosine 3', 5' Monophosphate-Mediated Binary Regulatory System During Folliculogenesis. Molecular and Cellular Endocrinology 402:21-31
- Zhang, Z., Zhu, B. and *Ge W. 2015 Genetic Analysis of Zebrafish Gonadotropin (FSH and LH) Functions by TALEN-mediated Gene Disruption. Molecular Endocrinology 29:76-98