Professor Xiaoqiang YAO

	Address	(Office):	224A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK
		(Lab):	224-225, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK
	Phone	(Office):	(852) 3943 6877
		(Lab):	(852) 3943 5735
	Fax		(852) 2603 5123
	Email		yao2068@cuhk.edu.hk
	Web		http://ihome.cuhk.edu.hk/ ~b887763

 

 

 

 

 

 

 

 

 

 

Education

	1991	Ph.D.	The State University of New York at Buffalo, USA
	1992	M.Phil.	Chinese Academy of Sciences
	1981	B.Sc.	Hangzhou University, China

 

 

 

Position

• Professor, School of Biomedical Sciences, The Chinese University of Hong Kong

 

Research Interests

• Protein trafficking
• Patch clamp and ion channel study
• Identification of a voltage-gated channel in human and plant endosome

 

Representative Publications

• Ma X, Cai Y, He D, Zou C, Zhang P, Lo CY, Xu Z, Chan FL, Shan Y, Chen Y, Zhu R, Lei J, Jin J and *Yao X. (2012) Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells. Proceedings of the National Academy of Sciences of the U.S.A. 109: 16282-16287.
• Du J, Wong WY, Sun L, Huang Y and *Yao X. (2012) Protein kinase G regulates flow-induced Ca2+ entry in M1-CCD cells. Journal of the American Society of Nephrology 23: 1172-1180.
• Ma X, Qiu S, Luo JH, Ma Y, Ngai CY, Shen B, Wong CO, Huang Y and *Yao X. (2010) Functional role of TRPV4-TRPC1 complex in flow-induced Ca2+ influx. Arteriosclerosis, Thrombosis, and Vascular Biology 30: 851-858.
• Kwan HY, Shen B, Ma X, Kwok YC, Huang Y, Man YB, Yu S and *Yao X. (2009) TRPC1 Associates With BKCa Channel to Form a Signal Complex in Vascular Smooth Muscle Cells. Circulation Research 104: 670-678.
• Cheng KT, Leung YK, Shen B, Kwan HY, Kwok YC, Wong CO, Ma X, Huang Y and *Yao X. (2008) CNGA2 channels mediate adenosine-induced Ca2+ influx in vascular endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology28: 913-918.
• *Yao X and Garland CJ. (2005) Recent development in endothelial cell TRP channels. Circulation Research (Invited Review) 97: 853-863.
• Kwan HY, Huang Y and *Yao X. (2004) Regulation of canonical transient receptor potential channel isoforms 3 (TRPC3) by protein kinase G. Proceedings of the National Academy of Sciences of the U.S.A. 101: 2625-2630.
• Kwan HY, Leung PC, Huang Y and *Yao X. (2003) Depletion of intracellular Ca2+ stores sensitizes the flow-induced Ca2+ influx in rat endothelial cells. Circulation Research 92: 286-292.
• *Yao X and Huang Y (2003) From nitric oxide to endothelial cytosolic Ca, a negative feedback control. Trends in Pharmacological Sciences 24: 263-266.
• *Yao X, Kwan HY, Chan FL, Chan NWK and Huang Y. (2000) A protein kinase G-sensitive channel mediates flow-induced Ca2+ entry in endothelial cells. FASEB Journal 14: 932-938.

 

Research Grants as PC/PI

• 2014-2021, Research Grants Council (RGC) Areas of Excellence Scheme (AoE) Grant “Center for organelle biogenesis and function”, HK$47,250,000;
• 2011-2014, Research Grants Council (RGC) GRF Grant “TRPV4-C1-P2 complex: assembly and function”, HK$1,265,000;
• 2011-2013, RGC GRF Grant “Role of TRPC5-related channels in mechanosensing of aortic arch baroreceptor”, HK$1,380,000;
• 2011-2016, RGC Theme-based Research Scheme “Cell-Based Heart Regeneration”, HK$60,000,000;
• 2010-2012, RGC GRF Grant “Functional Role of Endothelial TRPV4-TRPC1 Complex in Vascular Tone Control”, HK$1,086,40.

 

Professional Activities

• Co-Editor-in-Chief: The Open Circulation and Vascular Journal (Current).
• Editor-in-Chief: The Open Circulation and Vascular Journal (2008-2011)
• Editorial Broad: Frontiers in Pharmacology of Ion Channel and Channelopathies (current) and Frontiers in Vascular and Smooth Muscle Pharmacology (current)
• Reviewer: Hong Kong RGC Earmarked Grant, Wellcome Trust of the United Kingdom, Portuguese Foundation for Science and Technology, Diabetes UK grant