The contributions of language pathways in white matter to linguistic and cognitive processing after mild traumatic brain injury
Fan-Pei Gloria Yang 杨梵孛

Abstract 摘要
Research on patients with mild traumatic brain injury (mTBI) has reported that discourse-level impairments are associated with decreased global cognitive functioning. The global cognitive disorganization potentially emerges from poor connectivity across nodes comprising dispersed cortical networks. A likely source of this functional disconnectivity in mTBI is a post-trauma deterioration in the white matter integrity. In mTBI patients and matched controls, we used diffusion tensor tractography (DTI) to compare the integrity of inter-hemispheric commissural, limbic, and association fibers. Relative to controls, patients showed lower fractional anisotropy (FA) and higher mean diffusivity (MD) values in a majority of tracts. Decreases in fiber count, volume and density suggest a large-scale white matter deterioration not restricted to language tracts. FA of several tracts correlated with performance of a language judgment task. These suggest that the abnormalities in the integrity of inter- and intra-hemispheric tracts are related to linguistic deficits in these patients.


Subject Keywords 主题词

Diffusion tensor imaging (DTI) 扩散张量造影 Traumatic brain injury (TBI) 创伤性脑伤 White matter 白质 Linguistic processing 语言处理 Fasciculus 神经纤维束

Journal of Chinese Linguistics vol.48, no.2 (June 2020): 488-516
Copyright © 2020 Journal of Chinese Linguistics. All rights reserved.

Article 文章

<< Back 返回

Readers 读者