Dr. Dajiang Guo completed his Bachelor of Medicine at Sun Yat-sen University in Guangzhou, China. He then went to University of Glasgow in UK and finished his Master of Research in Biomedical Sciences with first class. Afterward, he received his PhD from University of Sydney in Australia in 2020. In the same year, Dr. Guo joined the Wistar Institute and the University of Pennsylvania for postdoctoral study, focusing on epigenetic regulators in cancer progression. From 2022, he moved Weill Cornell Medicine as a research associate investigating genome architecture in carcinogenesis. He joined Department of Anatomical and Cellular Pathology of CUHK in 2024 as a research assistant professor.

 

Award and Honour
2021 Ann and Sol Schreiber Mentored Investigator Award, OCRA (Postdoc Fellowship, $75,000)
2016 - 2019 International Postgraduate Research Scholarship, Australia (tuition fee $40,000 p.a.)
2016 - 2019 Australian Postgraduate Award, Australia ($26,532 p.a.)
2016 Most outstanding presentation Award, University of Sydney ($200)
2014 Graduation with distinction, University of Glasgow
2013 Scottish Saltire Scholarship, United Kingdom (tuition fee £2,000)
2008 Daiichi-Sankyo Corporation Medical Scholarship, China (¥1,500)
2008 First class student prize, Sun Yat-sen University, China (¥2,000)

Professional Service
2016 Member, Molecular and Experimental Pathology Society of Australia (MEPSA)
2016 Member, Sydney Catalyst
2018 Member, American Association of Cancer Research (AACR)
2022 Member, American Society of Hematology (ASH)

ORCID: 0000-0001-5856-5854

Carol M. McMenemy, Dajiang Guo, Jean A Quinn, David A Greenhalgh (2024). 14-3-3σ/Stratifin and p21 limit AKT-related malignant progression in skin carcinogenesis following MDM2-associated p53 loss. Molecular carcinogenesis. 2024; 1-15.

Dajiang Guo, Russell Jurek, Kimberley A Beaumont, Danae S Sharp, Sioh-Yang Tan, Anna Mariana, Timothy W Failes, Abigail K Grootveld, Nayan D Bhattacharyya, Tri Giang Phan, Greg M Arndt, Rohit Jain, Wolfgang Weninger, Shweta Tikoo (2023). Invasion-Block & S-MARVEL: A High-content screening platform identifies ATM kinase as a modulator of melanoma invasion and metastasis. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2023 Nov 21;120(47): e2303978120. PMID: 37963252.

Jianhuang Lin*, Dajiang Guo*, Heng Liu*, Wei Zhou, Chen Wang, Iris Müller, Andrew Kossenkov, Ronny Drapkin, Benjamin Bitler, Kristian Helin, and Rugang Zhang (2021). SETDB1-TRIM28 complex suppresses antitumor immunity. Cancer immunology research, 2021 Dec;9(12):1413-1424. DOI: 10.1158/2326-6066.CIR-21-0754. *Co-first author.

Jianhuang Lin, Heng Liu, Takeshi Fukumoto, Joseph Zundell, Qingqing Yan, Chih-Hang Anthony Tang, Shuai Wu, Wei Zhou, Dajiang Guo, Sergey Karakashev, Chih-Chi Andrew Hu, Kavitha Sarma, Andrew V. Kossenkov, Rugang Zhang (2021). Targeting the IRE1a/XBP1s pathway suppresses CARM1-expressing ovarian cancer. Nature communications, 2021 Sep 7;12(1):5321. DOI: 10.1038/s41467-021-25684-3. PMID: 34493732.

Shweta Tikoo, Rohit Jain, Florence Tomasetig, Kathy On, Brendon Martinez, Celine Heu, Daniel Stehle, Peyman Obeidy, Dajiang Guo, Jonathan N Vincent, Adam JL Cook, Ben Roediger, Robert Feil, Renee M Whan, Wolfgang Weninger (2021). Amelanotic B16-F10 Melanoma Compatible with Advanced Three-Dimensional Imaging Modalities. Journal of Investigative Dermatology, S0022-202X(21)00156-1. DOI: 10.1016/j.jid.2021.01.025. PMID: 33675788.

Dajiang Guo, Rohit Jain, Jae Sung Hwang, Wolfgang Weninger, Kimberley A. Beaumont and Shweta Tikoo. RAB27A/Melanophilin blocker inhibits melanoma cell motility and invasion (2020). Journal of Investigative Dermatology, 140(7):1470-1473.e3. DOI: 10.1016/j.jid.2019.12.023. PMID: 31978414.

Dajiang Guo, Kimberley A. Beaumont, Goldie Lui, Wolfgang Weninger, Nikolas K. Haass and Shweta Tikoo (2020). Abrogation of RAB27A expression transiently affects melanoma cell proliferation. Pigment cell and melanoma research, 33:889-894. DOI: 10.1111/pcmr.12903. PMID: 32511882.

Dajiang Guo, Shweta Tikoo and Nikolas K. Haass (2019). RAB27A-mediated melanoma exosomes: promoters of invasion and metastasis. Translational cancer research, 8: 732-735. DOI: 10.21037/tcr.2019.04.25. The figure from this article was selected as the cover image for the June 2019 issue of the Journal.

Dajiang Guo, Goldie Y.L. Lui, Siew Li Lai, James S. Wilmott, Shweta Tikoo, Louise A. Jackett, Camelia Quek, Darren L. Brown, Danae M. Sharp, Rain Y.Q. Kwan, Diego Chacon, Jason H. Wong, Dominik Beck, Michelle van Geldermalsen, Jeff Holst, John F. Thompson, Graham J. Mann, Richard A. Scolyer, Jennifer L. Stow, Wolfgang Weninger, Nikolas K. Haass and Kimberley A. Beaumont (2019). RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes. International Journal of Cancer, 144, 3070-3085. DOI: 10.1002/ijc.32064. PMID: 30556600.

Detu Zhu, Zuxianglan Zhao, Guimei Cui, Shiehong Chang, Lingling Hu, Yi Xiang See, Michelle Gek Liang Lim, Dajiang Guo, Xin Chen, Barun Poudel, Paul Robson, Yumei Luo, Edwin Cheung (2018). Single-Cell Transcriptome Analysis Reveals Estrogen Signaling Coordinately Augments One-Carbon, Polyamine, and Purine Synthesis in Breast Cancer. Cell Reports, Nov 20;25(8):2285-2298.e4. DOI: 10.1016/j.celrep.2018.10.093. PMID: 30463022