Dr. Huarong Chen

Research Assistant Professor
Department of Anaesthesia and Intensive Care
The Chinese University of Hong Kong

Research Interests
m6A modification, GI cancer and infectious diseases


Total publication number = 49 (25 with IF > 10 and 7 with IF > 20); Total impact factors (IF) = 630; Total SCI citation = 1,073; h-index = 21 (https://www.webofscience.com/wos/author/record/2154268). Of 49 papers, 18 of them I am the first (co-first#) or senior author*. For details about citations arising from my publications and links to online versions of some of the publications, refer to: https://www.researchgate.net/profile/Huarong_Chen

(*corresponding author, ^co-first author)


  • Wang Y#, Huarong Chen#, Liu W, Yan H, Zhang Y, Cheung AHK, Zhang J, Chen B, Liang L, Zhou Z, Wong CC, Wu WKK, Chan MWY, Cheng ASL, Ma BBY, Yu J, Lo KW, To KF, Kang W. MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target. Theranostics. 2022; 12(15):6509-6526. (IF = 11.6)
  • Wang Y#, Huarong Chen#, Yu J, Kang W, To KF. Recent insight into the role and therapeutic potential of YAP/TAZ in gastrointestinal cancers. Biochim Biophys Acta Rev Cancer. 2022 Aug 28;1877(5):188787. (IF = 11.414)
  • Huarong Chen, Pan Y, Zhou Q, Liang C, Wong CC, Zhou Y, Huang D, Liu W, Zhai J, Gou H, Su H, Zhang X, Xu H, Wang Y, Kang W, Kei Wu WK, Yu J. METTL3 inhibits anti-tumor immunity by targeting m6A-BHLHE41-CXCL1/CXCR2 axis to promote colorectal cancer. Gastroenterology. 2022 Oct;163(4):891-907. (IF = 33.883)
  • Chen H, Zhang X, Su H, Zeng J, Chan H, Li Q, Liu X, Zhang L, Wu WKK, Chan MTV*, Huarong Chen*. Immune dysregulation and RNA N6-methyladenosine modification in sepsis. Wiley Interdiscip Rev RNA. 2022 Sep 23:e1764. (IF = 9.349)
  • Zeng J, Xie C, Zhang L, Liu X, Chan MTV, Wu WKK*, Huarong Chen*. Host cell antimicrobial responses against Helicobacter pylori infection: from biological aspects to therapeutic strategies. Int J Mol Sci. 2022 Sep 19;23(18):10941. (IF = 6.208)
  • Zhang X, Su H, Chen H, Li Q, Liu X, Zhang L, Wu WKK, Chan MTV*, Huarong Chen*. RNA modifications in Gastrointestinal Cancer: Current Status and Future Perspectives. Biomedicines. 2022 Aug 8;10(8):1918. (IF = 4.757)
  • Huarong Chen#*, Wang Y#, Su H, Zhang X, Chen H, Yu J*. RNA N6-Methyladenine Modification, Cellular Reprogramming, and Cancer Stemness. Front Cell Dev Biol. 2022 Jul 4;10:935224. (IF = 6.081)
  • Huang D, Wang X, Huang Z, Liu Y, Liu X, Gin T, Wong SH, Yu J, Zhang L, Chan MTV*, Huarong Chen*, Wu WKK*. 3' Untranslated Regions of Tumor Suppressor Genes Evolved Specific Features to Favor Cancer Resistance. Oncogene. 2022 Jun;41(23):3278-3288. (IF = 8.756)
  • Wang X, Zhang L, Liang Q, Wong CC, Chen H, Gou H, Dong Y, Liu W, Li Z, Ji J, Yu J. DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance. Oncogenesis. 2022 Oct 28;11(1):66. (IF = 7.485)
  • Chan H, Li Q, Wang X, Liu WY, Hu W, Zeng J, Xie C, Kwong TNY, Ho IHT, Liu X, Huarong Chen, Yu J, Ko H, Chan RCY, Ip M, Gin T, Cheng ASL, Zhang L, Chan MTV, Wong SH, Wu WKK. Vitamin D 3 and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome acidification. Autophagy. 2022 Sep;18(9):2050-2067.(IF = 13.391)
  • Wong CC, Wu JL, Ji F, Kang W, Bian X, Huarong Chen, Chan LS, Luk STY, Tong S, Xu J, Zhou Q, Liu D, Su H, Gou H, Cheung AH, To KF, Cai Z, Shay JW, Yu J. The cholesterol uptake regulator PCSK9 promotes and is a therapeutic target in APC/KRAS-mutant colorectal cancer. Nat Commun. 2022 Jul 8;13(1):3971. (IF = 17.694)
  • Wang X, Cheng FTF, Lam TYT, Liu Y, Huang D, Liu X, Huarong Chen, Zhang L, Ali Y, Wang MHT, Yu J, Gin T, Chan MTV, Wu WKK, Wong SH. Cardiovascular and Metabolic Risk - Stress hyperglycemia is associated with an increased risk of subsequent development of diabetes mellitus among bacteremic and non-bacteremic patients. Diabetes Care. 2022 Jun 2;45(6):1438-1444. (IF = 17.152)
  • Sun X, Liu Y, Huang Z, Xu W, Hu W, Yi L, Liu Z, Chan H, Zeng J, Liu X, Huarong Chen, Yu J, Chan FKL, Ng SC, Wong SH, Wang MH, Gin T, Joynt GM, Hui DSC, Zou X, Shu Y, Cheng CHK, Fang S, Luo H, Lu J, Chan MTV, Zhang L, Wu WKK. SARS-CoV-2 Non-Structural Protein 6 Triggers NLRP3-dependent Pyroptosis by Targeting ATP6AP1. Cell Death Differ. 2022 Jun;29(6):1240-1254. (IF = 12.067)
  • Wang X, Hu W, Li X, Huang D, Li Q, Chan H, Zeng J, Xie C, Huarong Chen, Liu X, Gin T, Wang MH, Cheng ASL, Kang W, To KF, Plewczynski D, Zhang Q, Chen X, Chan DCW, Ko H, Wong SH, Yu J, Chan MTV, Zhang L, Wu WKK. Single-Hit Inactivation Drove Tumor Suppressor Genes Out of the X Chromosome during Evolution. Cancer Res. 2022 Apr 15;82(8):1482-1491. (IF = 13.312)
  • Wang S, Gao S, Zeng Y, Zhu L, Mo Y, Wong CC, Bao Y, Su P, Zhai J, Wang L, Soares F, Xu X, Huarong Chen, Hezaveh K, Ci X, He A, McGaha T, O'Brien C, Rottapel R, Kang W, Wu J, Zheng G, Cai Z, Yu J, He HH. N6-methyladenosine reader YTHDF1 promotes ARHGEF2 translation and RhoA signaling in colorectal cancer. Gastroenterology. 2022 Apr;162(4):1183-1196.(IF = 33.883)
  • Bai X, Wong CC, Pan Y, Huarong Chen, Liu W, Zhai J, Kang W, Shi Y, Yamamoto M, Tsukamoto T, Nomura S, Chiu P, Yu J, Kwok-Wai Ng E. Loss of YTHDF1 in gastric tumors restores sensitivity to antitumor immunity by recruiting mature dendritic cells. J Immunother Cancer. 2022 Feb;10(2):e003663. (IF = 12.469)