Prof. William K.K. Wu
BSc (Hons), MMedSc (Distinction), MPhil, PhD, FRCPath, FRCP (Edin, Lond), FRCPS (Glasg)

Associate Professor (Non-clinical)

Department of Anaesthesia and Intensive Care
The Chinese University of Hong Kong

Principal Investigator
State Key Laboratory of Digestive Diseases & Li Ka Shing Institute of Health Sciences
The Chinese University of Hong Kong

Research Interests
Cancer Biology and Genomics; Sepsis and ICU-related Infections; Pain Mechanism; Autophagy; Microbiome; Evolutionary Medicine


For details about citations arising from my publications and links to online versions of some of the publications, refer to: (Researcher ID: A-3277-2009)

(^equal contribution; *corresponding author)

  • Chen H, Zhang X, Su H, Zeng JD, Chan H, Li Q, Liu X, Zhang L, Wu WKK, Chan MTV, Chen H (2023) Immune dysregulation and RNA N6-methyladenosine modification in sepsis. Wiley Interdiscip Rev RNA doi: 10.1002/wrna.1764. [Online ahead of print]
  • Zhang J, Chen B, Li H, Wang Y, Liu X, Wong KY, Chan WN, Chan AKY, Cheung AHK, Leung KT, Dong Y, Pan Y, Ke H, Liang L, Zhou Z, Xiao J, Wong CC, Wu WKK, Cheng ASL, Ma BBY, Yu J, Lo KW, Kang W, To KF (2023) Cancer-associated fibroblasts potentiate colorectal cancer progression by the crosstalk of IGF2-IGF1R and Hippo-YAP1 signaling pathways. J Pathol doi: 10.1002/path.6033. [Online ahead of print]
  • Au-Doung PLW, Chan RH, Wu WKK*, Li Q* (2023) Gut microbiota modulation: Probiotics and prebiotics in GI cancer. In: Microbiome in Gastrointestinal Cancer doi: 10.1007/978-981-19-4492-5. Springer Nature [In press]

  • Chan H, Li Q, Wang X, Liu Y, Hu W, Zeng J, Xie, C, Kwong NYK, Ho IHT, Liu X, Chen H, Yu J, Ko H, Chan RCY, Ip M, Gin T, Cheng ASL, Zhang L, Chan MTV*, Wong SH*, Wu WKK* (2022) Vitamin D3 and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome acidification. Autophagy 18(9):2050-2067.
  • Wang X, Hu W, Li X, Huang D, Li Q, Chan H, Zeng JD, Xie C, Chen H, Liu X, Gin T, Wang MH, Cheng ASL, Kang W, To KF, Plewczynski D, Zhang Q, Chen X, Chan DCW, Ko H, Wong SH, Yu J, Chan MTV*, Zhang L*, Wu WKK* (2022) Single-hit inactivation drove tumor suppressor genes out of the X chromosome during evolution. Cancer Res 82(8):1482-1491.
  • Wang X, Cheng FTF, Lam TYT, Liu Y, Huang D,  Liu X, Chen H, Zhang L, Ali Y, Wang MHT, Yu J, Gin T, Chan MTV*, Wu WKK*, Wong SH (2022) Stress hyperglycemia is associated with an increased risk of subsequent development of diabetes among bacteremic and non-bacteremic patients. Diabetes Care 45(6):1438-1444.
  • Sun X, Liu Y, Huang Z, Xu W, Hu W, Yi L, Liu Z, Chan H, Zeng J, Liu X, Chen H, Yu J, Chan FKL, Ng SC, Wong SH, Wang MH, Gin T, Joynt GM, Hui DSC, Zou X, Shu Y, Cheng CHK, Fang S*, Luo H*, Lu J*, Chan MTV*, Zhang L*, Wu WKK* (2022) SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1. Cell Death Differ 29(6):1240-1254.
  • Huang D, Wang X, Huang Z, Liu Y, Liu X, Gin T, Wong SH, Yu J, Zhang L, Chan MTV*, Chen H*, Wu WKK* (2022) 3'untranslated regions of tumor suppressor genes evolved specific features to favor cancer resistance. Oncogene 41(23):3278-3288.
  • Xu W, Liu Y, Zou X, Luo H, Wu W, Xia J, Chan MTV*, Fang S*, Shu Y*, Wu WKK*, Zhang L* (2022) Hypozincemia in COVID-19 patients correlates with stronger antibody response. Front Immunol 12:785599.
  • Sun X, Yu J, Wong SH, Chan MTV*, Zhang L*, Wu WKK* (2022) SARS-CoV-2 targets the lysosome to mediate airway inflammatory cell death. Autophagy 18(9):2246-2248.
  • Sun R, Wang X, Sun X, Zhao B, Zhang X, Gong X, Wong SH, Chan MTV, Wu WKK (2022) Emerging roles of long non-coding RNAs in ankylosing spondylitis. Front Immunol13:790924.
  • Zeng J, Xie C, Zhang L, Liu X, Chan MTV, Wu WKK*, Chen H* (2022) Host cell antimicrobial responses against Helicobacter pylori infection: from biological aspects to therapeutic strategies. Int J Mol Sci 23(18): 10941.
  • Ma X, Wang X, Ma X, Zhang X, Gong X, Sun R, Wong SH, Chan MTV, Wu WKK (2022) An update on the roles of circular RNAs in spinal cord injury. Mol Neurobiol 59(4):2620-2628.
  • Xu D, Ma X, Sun C, Han J, Zhou C, Chan MTV, Wu WKK (2022) Circular RNAs in intervertebral disc degeneration: An updated review. Front Mol Biosci 8:781424.
  • Devereaux PJ, Marcucci M, Painter TW, Conen D, Lomivorotov V, Sessler DI, Chan MTV, Borges FK, Martínez-Zapata MJ, Wang CY, Xavier D, Ofori SN, Wang MK, Efremov S, Landoni G, Kleinlugtenbelt YV, Szczeklik W, Schmartz D, Garg AX, Short TG, Wittmann M, Meyhoff CS, Amir M, Torres D, Patel A, Duceppe E, Ruetzler K, Parlow JL, Tandon V, Fleischmann E, Polanczyk CA, Lamy A, Astrakov SV, Rao M, Wu WKK, Bhatt K, de Nadal M, Likhvantsev VV, Paniagua P, Aguado HJ, Whitlock RP, McGillion MH, Prystajecky M, Vincent J, Eikelboom J, Copland I, Balasubramanian K, Turan A, Bangdiwala SI, Stillo D, Gross PL, Cafaro T, Alfonsi P, Roshanov PS, Belley-Côté EP, Spence J, Richards T, VanHelder T, McIntyre W, Guyatt G, Yusuf S, Leslie K; POISE-3 Investigators (2022) Tranexamic Acid in Patients Undergoing Noncardiac Surgery. N Engl J Med 386(21):1986-1997.
  • Cao L, Lou J, Zheng H, Zhao S, Mok CKP, Chan SY, Chan RWY, Chong MKC, Wu WKK, Chen Z, Wong ELY, Chan PKS, Zee BCY, Yeoh EK, Wang MH (2022) Rapid evaluation of COVID-19 vaccine effectiveness against symptomatic infection with SARS-CoV-2 variants by analysis of genetic distance.Nat Med 28(8):1715-1722.
  • Lai HM, Tang Y, Lau ZYH, Campbell RAA, Yau JCN, Chan CCY, Chan DCW, Wong TY, Wong HKT, Yan LYC, Wu WKK, Wong SH, Kwok KW, Wing YK, Lam HHN, Ng HK, Mrsic-Flogel TD, Mok VCT, Chan JYK, Ko H (2022) Antibody stabilization for thermally accelerated deep immunostaining. Nat Methods 19(9):1137-1146.
  • Chen H, Pan Y, Zhou Q, Liang C, Wong CC, Zhou Y, Huang D, Liu W, Zhai J, Gou H, Su H, Zhang X, Xu H Wang Y, Kang W, Wu WKK, Yu J (2022) METTL3 inhibits anti-tumor immunity by targeting m6A-BHLHE41-CXCL1/CXCR2 axis to promote colorectal cancer. Gastroenterology 163(4):891-907.
  • Lam S, Zhang J, Yang K, Chu LC, Zhu W, Tang W, Chan FKL, Chan PKS, Wu WKK, Ng SC (2022) Modulation of gut microbiota impacts diet- and drug-induced alopecia in mice. Gut 71(11):2366-2369.
  • Guo CLT, Wong SH, Lau LHS, Lui RNS, Mak JWY, Tang RSY, Yip TCF, Wu WKK, Wong GLH, Chan FKL, Lau JYW, Sung JJY (2022) Timing of endoscopy for acute upper gastrointestinal bleeding: A territory-wide cohort study. Gut 71(8):1544-1550.
  • Sugimura N, Li Q, Chu ESH, Lau HCH, Fong W, Liu W Liang C, Nakatsu G, Su ACY, Coker OO, Wu WKK, Chan FKL, Yu J (2022) Lactobacillus gallinarum modulates the gut microbiota and produces anti-cancer metabolites to protect against colorectal tumorigenesis. Gut 71(10):2011-2021.
  • Coker OO, Liu C, Wu WKK, Wong SH, Jia W, Sung JJY, Yu J (2022) Altered gut metabolites and microbiota interactions are implicated in colorectal carcinogenesis and can be non-invasive diagnostic biomarkers. Microbiome 10(1):35.
  • Yang J, Li Z, Wu WKK, Yu S, Xu Z, Chu Q, Zhang Q (2022) Deep Learning Identifies Explainable Reasoning Paths of Mechanism of Action for Drug Repurposing from Multilayer Biological Network. Brief Bioinform 23(6): bbac469.
  • Wang Y, Chen H, Liu W, Yan H, Zhang Y, Cheung AHK, Zhang J, Chen B, Liang L, Zhou Z, Wong CC, Wu WKK, Chan MWY, Cheng ASL, Ma BBY, Yu J, Lo KW, To KF, Kang W (2022) MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target. Theranostics 12(15): 6509-6526.
  • Zhao L, Zhang X, Zhou Y, Fu K, Lau HCH, Cha TWY, Cheung A, Coker OO, Wei H, Wu WKK, Wong SH, Sung JJY, To KF, Yu J (2022) Parvimonas micra promotes colorectal tumorigenesis and is associated with prognosis of colorectal cancer patients. Oncogene 41(36):4200-4210.
  • Xia X, Zhang Y, Sun R, Wei Y, Li Q, Chong MKC, Wu WKK, Zee BCY, Tang H, Wang MH (2022) A Prism Vote method for individualized risk prediction of traits in genotype data of multi-population. PLoS Genetics 18(10):e1010443.
  • Zhang X, Su H, Chen H, Li Q, Liu X, Zhang L, Wu WKK, Chan MTV, Chen H (2022) RNA modifications in gastrointestinal cancer: Current status and future perspectives. Biomedicines 10(8):1918.
  • Niu JY, Yin IX, Wu WKK, Li QL, Mei ML, Chu CH (2022) Efficacy of the dual-action GA-KR12 peptide for remineralising initial enamel caries: an in vitro study. Clin Oral Investig 26(3):2441-2451.
  • Marcucci M, Painter TW, Conen D, Leslie K, Lomivorotov VV, Sessler D, Chan MTV, Borges FK, Martínez Zapata MJ, Wang CY, Xavier D, Ofori SN, Landoni G, Efremov S, Kleinlugtenbelt YV, Szczeklik W, Schmartz D, Garg AX, Short TG, Wittmann M, Meyhoff CS, Amir M, Torres D, Patel A, Duceppe E, Ruetzler K, Parlow JL, Tandon V, Wang MK, Fleischmann E, Polanczyk CA, Jayaram R, Astrakov SV, Rao M, VanHelder T, Wu WKK, Cheong CC, Ayad S, Abubakirov M, Kirov M, Bhatt K, de Nadal M, Likhvantsev V, Iglesisas PP, Aguado HJ, McGillion M, Lamy A, Whitlock RP, Roshanov P, Stillo D, Copland I, Vincent J, Balasubramanian K, Bangdiwala SI, Biccard B, Kurz A, Srinathan S, Petit S, Eikelboom J, Richards T, Gross PL, Alfonsi P, Guyatt G, Belley-Cote E, Spence J, McIntyre W, Yusuf S, Devereaux PJ (2022) Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery. Trials 23(1):101.