Professor Dennis Lo
Professor Rossa Chiu
Professor Allen K C Chan
Professor Nelson Tang
Professor Chun Kwok Wong
Professor Hao Sun
Professor Kathy Lui
Professor Sung Wing Kin
Professor Peiyong Jiang
Professor Peter Cheung
Professor Hei Ming Lai
Professor Jacky Lam
Professor Guanhua Zhu
Professor Chun Kit Choi
Professor Mingyuan Li
Professor Jason Liao
Professor Qing Zhou
Professor Nirmal Panesar
Professor Chung Shun Ho
Dr Michael H M Chan
Dr Angel Chan
Jason Liao 廖晉粵
Research Assistant Professor 研究助理教授
Dr. Jinyue Liao received his bachelor's degree in Basic Medicine from Fudan University in 2007. During that time, he was trained in biology, biochemistry, genetics and medicine. Afterward, he received his master's degree in Biochemistry from The Hong Kong University of Science and Technology in 2012. Thereafter, he received his Ph.D. in Biomedical Sciences from The Chinese University of Hong Kong in 2017 and had postdoctoral training at the School of Biomedical Sciences, The Chinese University of Hong Kong from 2017 to 2021. His research focused on the analysis of gene regulatory networks that define the identity, development, and function of cells with a particular focus on germ cell development, regeneration and aging. His research integrates both wet (experimental) and dry (computational) components. The tools of his work include RNA-seq for gene expression, ChIP-seq for histone modifications, ATAC-seq for chromatin accessibility, and single-cell RNA-seq and single-cell ATAC-seq for individual transcriptomes and epigenomes from single cells. He is also interested in developing, implementing, and offering methods of single-cell profiling to build a bridge between researchers and single-cell technologies in their quest to understand how cells collectively perform systems-level functions in healthy and diseased states.
Selected publications:
Yang, K. Y., Liao, J., Ma, Z., Tse, H. F., Lu, L., Graca, L., & Lui, K. O. (2023). Single-cell transcriptomics of Treg reveals hallmarks and trajectories of immunological aging. Journal of Leukocyte Biology. [Co-first author]
Suen, H. C., Rao, S., Luk, A. C. S., Zhang, R., Yang, L., Qi, H., So, H. C., Hobbs, R. M., Lee, T.-L., & Liao, J. (2023). The single-cell chromatin accessibility landscape in mouse perinatal testis development. ELife, 12. [Lead contact]
Suen, H. C., Luk, A. C. S., & Liao, J. (2022). scATAC-Seq reveals heterogeneity associated with spermatogonial differentiation in cultured male germline stem cells. Scientific Reports, 12(1), 21482. [Lead contact]
Tang, P.C.-T., Chung, J.Y.-F., Liao, J., Chan, M.K.-K., Chan, A.S.-W., Cheng, G., Li, C., Huang, X.-R., Ng, C.S.-H., Lam, E.W.-F., et al. (2022). Single-cell RNA sequencing uncovers a neuron-like macrophage subset associated with cancer pain. Sci. Adv. 8, eabn5535. 10.1126/sciadv.abn5535.
Rao, Y., Zhu, C., Suen, H.C., Huang, S., Liao, J., Ker, D.F.E., Tuan, R.S., and Wang, D. (2022). Tenogenic induction of human adipose-derived stem cells by soluble tendon extracellular matrix: composition and transcriptomic analyses. Stem Cell Res. Ther. 13, 380. 10.1186/s13287-022-03038-0.
La, H.M., Liao, J., Legrand, J.M.D., Rossello, F.J., Chan, A.-L., Vaghjiani, V., Cain, J.E., Papa, A., Lee, T.L., and Hobbs, R.M. (2022). Distinctive molecular features of regenerative stem cells in the damaged male germline. Nat. Commun. 13, 2500. 10.1038/s41467-022-30130-z.
Liao, J., Suen, H.C., Luk, A.C.S., Yang, L., Lee, A.W.T., Qi, H., and Lee, T.-L. (2021). Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiation. PLoS Genet. 17, e1009369. 10.1371/journal.pgen.1009369.
Lee, A.W.T., Ng, J.K.W., Liao, J., Luk, A.C., Suen, A.H.C., Chan, T.T.H., Cheung, M.Y., Chu, H.T., Tang, N.L.S., Zhao, M.P., et al. (2021). Single-cell RNA sequencing identifies molecular targets associated with poor in vitro maturation performance of oocytes collected from ovarian stimulation. Hum. Reprod. 36, 1907–1921. 10.1093/humrep/deab100.
Liao, J., Suen, H.C., Alfred Chun Shui Luk, Annie Wing Tung Lee, Judy Kin Wing Ng, Ting Hei Thomas Chan, Cheung, M.Y., David Yiu Leung Chan, Li, T.C., Qi, H., et al. (2020). scATAC-Seq reveals epigenetic heterogeneity associated with an EMT-like process in male germline stem cells and its regulation by G9a. bioRxiv.
Suen, H.C., Qian, Y., Liao, J., Luk, C.S., Lee, W.T., Ng, J.K.W., Chan, T.T.H., Hou, H.W., Li, I., Li, K., et al. (2019). Transplantation of Retinal Ganglion Cells Derived from Male Germline Stem Cell as a Potential Treatment to Glaucoma. Stem Cells Dev. 28, 1365–1375. 10.1089/scd.2019.0060.
Meng, C., Liao, J., Zhao, D., Huang, H., Qin, J., Lee, T.-L., Chen, D., Chan, W.-Y., and Xia, Y. (2019). L3MBTL2 regulates chromatin remodeling during spermatogenesis. Cell Death Differ. 26, 2194–2207. 10.1038/s41418-019-0283-z.
Liao, J., Ng, S.H., Luk, A.C., Suen, H.C., Qian, Y., Lee, A.W.T., Tu, J., Fung, J.C.L., Tang, N.L.S., Feng, B., et al. (2019). Revealing cellular and molecular transitions in neonatal germ cell differentiation using single cell RNA sequencing. Development 146. 10.1242/dev.174953.
Tang, P.M.-K., Zhou, S., Li, C.-J., Liao, J., Xiao, J., Wang, Q.-M., Lian, G.-Y., Li, J., Huang, X.-R., To, K.-F., et al. (2018). The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring. Kidney Int. 93, 173–187. 10.1016/j.kint.2017.07.026.
Tu, J., Ng, S.H., Luk, A.C.S., Liao, J., Jiang, X., Feng, B., Lun Mak, K.K., Rennert, O.M., Chan, W.-Y., and Lee, T.-L. (2015). MicroRNA-29b/Tet1 regulatory axis epigenetically modulates mesendoderm differentiation in mouse embryonic stem cells. Nucleic Acids Res. 43, 7805–7822. 10.1093/nar/gkv653.
Ho, V.W.S., Wong, M.-K., An, X., Guan, D., Shao, J., Ng, H.C.K., Ren, X., He, K., Liao, J., Ang, Y., et al. (2015). Systems-level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry. Mol. Syst. Biol. 11, 814. 10.15252/msb.20145857.
The Chinese University of Hong Kong