Margaret IP
Mamie HUI
Zigui CHEN
Christopher KC LAI
Rita WY NG
Siaw Shi BOON
Sishuo WANG
Research, Administrative and Honorary Staff
Elite Alumni Microbiologists
Hospital Staff
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Faculty > Margaret IP
Personal information
Name Margaret IP
Academic / Professional Qualifications BM, MSc, DTM&H, FRCPath, FRCP(Glasg), FRCPA, FHKCPath (Clin Micro and Infection), FHKAM
Academic title & affiliations Professor
Email margaretip@cuhk.edu.hk
Current Appointments
(Including honorary appointments)
  • Chairman, Department of Microbiology, Faculty of Medicine, Chinese University of Hong Kong
  • Honorary Consultant, Dept of Microbiology, Prince of Wales Hospital
ORCID iD iconorcid.org/0000-0003-1291-6537
Research interest
Clinical and molecular epidemiology of Gram positive cocci, including characterization of methicillin-resistant Staphylococcus aureus (MRSA) in Hong Kong, Group B streptococcus (Streptococcus agalactiae) and Streptococcus pneumoniae. Clinical epidemiology of such infections, incl. pneumococcal bacteraemia and meningitis study, colonisation of Group B streptococcus in pregnancy, toxic shock syndrome in streptococci.
Surveillance and study of antibiotic resistance determinants and mechanisms of resistance in Streptococcus pneumoniae and other bacteria.
Assessment and development of the laboratory methods for diagnosis, including molecular methods of diagnosis, evaluations and applications of new methods in the clinical setting.
Microbial Genomics: Whole bacterial genome sequencing and RNA transcriptomes in pathogenic bacteria of importance in Hong Kong and their related disease pathogenesis and antimicrobial resistance.
Our Team
Publications (Representative)
  1. Brueggemann AB, Jansen van Rensburg MJ, Shaw D, McCarthy ND, Jolley KA, Maiden MCJ, van der Linden MPG,.. Ip M,. Zanella RC, Zhou F. Changes in the incidence of invasive disease due to Streptococcus pneumoniaeHaemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and territories in the Invasive Respiratory Infection Surveillance Initiative: a prospective analysis of surveillance data. Lancet Digital Health 2021 Jun;3(6):e360-e370. doi: 10.1016/S2589-7500(21)00077-7
  2. R Subramanian, V Liyanapathirana, N Barua, R Sun, M Wang, R Ng, EAS Nelson, DS Hui, M Ip* Persistence of pneumococcal serotype 3 in adult pneumococcal disease in Hong Kong. Vaccines 2021;9:756. doi.org/10.3390/vaccines9070756
  3. J Ho, Yun-Kit Yeoh, N Barua, Z Chen, G Lui, SH Wong, X Yang, MC Chan, PKS Chan, PM Hawkey, M Ip*. Systematic review of human gut resistome studies revealed variable definitions and approaches. Gut Microbes 2020; 1-12, Jan 16. doi.org/10.1080/19490976.2019.1700755
  4. Ko Kwok, Chan E, Chung PH, Tang A, Wei WI, Riley S, Ip M. Prevalence and associated factors for carriage of Enterobacteriaceae producing ESBLs or carbapenemase and Methicillin-resistant Staphylococcus aureus in Hong Kong community. J of Infection 2020 May21:S0163-4453(20)30309-1. doi: 10.1016/j.jinf.2020.05.033
  5. J Rothen, D Nanayakkara, C Li, N Lo, G Vogel, F Foucault, V Pflüger, JF Pothier, J Blom, C Daubenberger*, M Ip*. Ribosomal subunit protein typing by MALDI-TOF MS on Streptococcus agalactiae: a transferable and rapid alternative for surveillance of clinical and zoonotic strain types. Scientific Report 2020 May29:10(1):8788. doi: 10.1038/s41598-020-65707-5
  6. PJ Dharmaratne, DN Sapugahawatte, Baiyan Wang, CL Chan, VKM Lau, CBS Lau, KP Fung, DKP Ng, M Ip* Contemporary approaches and future perspective of antibacterial photodynamic therapy (aPDT) against methicillin-resistant Staphylococcus aureus (MRSA): A systematic review. Eur J Med Chem 2020 Aug 15;200:112341. doi: 10.1016/j.ejmech.2020.112341
  7. Wyres KL, Nguyen TNT, Lam MMC, Judd LM, van Vinh Chau N, Dance DAB, Ip M, Karkey A, Ling CL, Miliya T, Newton PN, Lan NPH, Sengduangphachanh A, Turner P, Veeraraghavan B, Vinh PV, Vongsouvath M, Thomson NJR, Baker S, Holt KE. Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from South and Southeast Asia. Genome Med. 2020;12(1):11. Published 2020;12;11 (Jan 16.) doi:10.1186/s13073-019-0706-y
  8. Ho J, M Ip* Antibiotic resistant community-acquired bacterial pneumonia. Infect Dis Clin North Am. 2019 Dec;33(4):1087-1103. doi: 10.1016/j.idc.2019.07.002
  9. Kumar N, Browne HP, Viciani E, Forster SC, Clare S, Harcourt K, Stares MD, Dougan G, Fairley DJ, Roberts P, Pirmohamed M, Clokie MRJ, Jensen MBF, Hargreaves KR, Ip M, Wieler LH, Seyboldt C, Norén T, Riley TV, Kuijper EJ, Wren BW, Lawley TD. Adaptation of host transmission cycle during Clostridium difficile speciation. Nature Genetics 2019 Sep;51(9):1315-1320. doi: 10.1038/s41588-019-0478-8
  10. SW Lo*, RA Gladstone*, AJ van Tonder, JA Lees, M du Plessis,…Ip M,…. Yulia Urban. Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era: an international whole-genome sequencing study. Lancet Infectious Disease 2019 Jul;19(7):759-769. doi: 10.1016/S1473-3099(19)30297-X.