Margaret IP
Mamie HUI
Zigui CHEN
Christopher KC LAI
Rita WY NG
Siaw Shi BOON
Sishuo WANG
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Faculty > Xiao YANG
Personal information  
Name Xiao YANG
Academic / Professional Qualifications BSc.(Hons), PhD
Academic title & affiliations Dr.
Department of Microbiology, CUHK
Email xiaoyang@cuhk.edu.hk
Current Appointments
(Including honorary appointments)
Assistant Professor, Department of Microbiology, CUHK
ORCID iD iconhttp://orcid.org/0000-0002-3071-6531  
Research interest
The impact of the gut microbiome on drug metabolism
Bacterial transcriptional regulation
Discovery and development of novel antimicrobial agents
Publications (Representative) *co-first author
  1. Yang X, Luo MJ, Yeung ACM, Lewis PJ, Chan PKS, Ip M, Ma C. First-In-Class Inhibitor of Ribosomal RNA Synthesis with Antimicrobial Activity against Staphylococcus aureus. Biochemistry. 2017; doi: 10.1021/acs.biochem.7b00349.
  2. Wenholz DS, Zeng M, Ma C, Mielczarek M, Yang X, Bhadbhade M, Black DSC, Lewis PJ, Griffith R, Kumar N. Small molecule inhibitors of bacterial transcription complex formation. Bioorganic & Medicinal Chemistry Letters. 2017; pii: S0960-894X(17)30835-1.
  3. Bi Y, Liu XX, Zhang HY, Yang X, Liu ZY, Lu J, Lewis PJ, Wang CZ, Xu JY, Meng QG, Ma C, Yuan CS. Synthesis and Antibacterial Evaluation of Novel 3-Substituted Ocotillol-Type Derivatives as Leads. Molecules 2017; 22(4). pii: E590.
  4. Ma C, Yang X, Lewis PJ. Bacterial Transcription Inhibitor of RNA Polymerase Holoenzyme Formation by Structure-Based Drug Design: From in Silico Screening to Validation. ACS Infectious Disease 2016; 2(1): 39-46.
  5. Ma C, Yang X, Lewis PJ. Bacterial transcription as a target for antibacterial drug development. Microbiology and Molecular Biology Reviews 2016; 80(1): 139-160.
  6. Bi Y*, Yang X*, Zhang T, Yang J, Liu Z, Zhang X, Xu J, Lewis PJ, Bi Y, Meng Q, Ma C. Design, Synthesis, Nitric Oxide Release and Antibacterial Evaluation of Novel Nitrated Ocotilloltype Derivatives. European Journal of Medicinal Chemistry 2015; 101: 71-80.
  7. Ma C*, Mobli M*, Yang X*, Keller AN, King G, Lewis PJ. The Mechanism of Transcription Pause Enhancement By NusA. Nucleic Acid Research 2015; 43(5): 2829-2840.
  8. Keller AN, Yang X, Wiedermannová J, Delumeau O, Krásný L, Lewis PJ. ε, a New Subunit of RNA Polymerase Found in Gram-Positive Bacteria. Journal of Bacteriology 2014; 196: 3622-3632.
  9. Yang X, Lewis PJ. The interaction between bacterial transcription factors and RNA polymerase during the transition from initiation to elongation. Transcription 2010; 1: 66-69.
  10. Yang X, Lewis PJ. The interaction between RNA polymerase and the elongation factor NusA. RNA Biology 2010; 7: 272-275.
  11. Yang X, Molimau S, Doherty GP, Johnston EB, Marles-Wright J, Rothnagel R, Hankamer B, Lewis RJ, Lewis PJ. The structure of bacterial RNA polymerase in complex with the essential transcription elongation factor NusA. EMBO Reports 2009; 10: 997-1002.
  12. Yang X, Lewis PJ. Overproduction and purification of recombinant Bacillus subtilis RNA polymerase. Protein Expression and Purification 2008; 59: 86-93.
  13. Yang X, Doherty GP, Lewis PJ. Tandem affinity purification vectors for use in grampositive bacteria. Plasmid 2008; 59: 54-62.