Dr Jian LIU

• Cheng CK, Shang W, Liu J, Cheang WS, Wang Y, Xiang L, Lau CW, Luo JY, Ng CF, Huang Y, Wang L (2022) Activation of AMPK/miR-181b Axis Alleviates Endothelial Dysfunction and Vascular Inflammation in Diabetic Mice. Antioxidants 11(6):1137 (17 pages).

• Zhao L, Zhang CL, He L, Chen QH, Liu L, Kang L, Liu J, Luo JY, Gou L, Qu D, Song W, Lau CW, Ko H, Mok VCT, Tian XY, Wang L & Huang Y (2022) Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Reducing Mitochondrial ROS-mediated eNOS Monomerization. Diabetes 71(5):1099-1114.

• Liu J, Zhang Y, Qu D, Zhang H, Wang L, Lau CW, Han JY, Pingcuo D, Huang Y & Liu L (2021) Salvianolic acid B ameliorates vascular endothelial dysfunction through the inhibition of bone morphogenetic protein 4 in diabetic mice. Life Sciences 286:120039.

• Zhang H, Liu J, Qu D, Wang L, Wong CM, Lau CW, Huang Y, Wang YF, Huang H, Xia Y, Xiang L, Cai Z, Liu P, Wei Y, Yao X, Ma RCW & *Huang Y (2018) Serum exosomes mediate delivery of arginase 1 as a novel mechanism for endothelial dysfunction in diabetes. Proceedings of the Academy of National Sciences USA 115(29):E6927-E6936. (Co-first author)

• Gou L, Zhao L, Song W, Wang L, Liu J, Zhang H, Huang Y, Lau CW, Yao XQ, Tian XY, Wong WT, Luo JY & Huang Y (2017) Inhibition of miR-92a suppresses oxidative stress and improves endothelial function by upregulating heme oxygenase-1 in db/db mice. Antioxidants & Redox Signaling 28(5):358-370.

• Ling WC, Liu J, Lau CW, Murugan DD, Mustafa MR & Huang Y (2017) Treatment with salvianolic Acid B restores endothelial function in angiotensin II-induced hypertensive mice. Biochemical Pharmacology 136 (2017):76-85.

• Wang L, Luo JY, Li B, Tian XY, Chen LJ, Huang Y, Liu J, Deng D, Lau CW, Wan S, Ai D, Mak KL, Tong KK, Kwan KM, Wang N, Chiu JJ, Zhu Y & Huang Y (2016) Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature (doi:10.1038/nature20602

• Choy KW, Mustafa MR, Lau YS, Liu J, Murugan D, Lau CW, Wang L, Zhao L & Huang Y (2016) Paeonol protects against endoplasmic reticulum stress-induced endothelial dysfunction via AMPK/PPARd signalling pathway. Biochemical Pharmacology 116:51-62.

• Leung FP, Yung LM, Ngai CY, Cheang WS, Tian XY, Lau CW, Zhang Y, Liu J, Chen ZY, Bian ZX, Yao X & Huang Y (2016) Chronic black tea consumption improves endothelial function in ovariectomized rats. European Journal of Nutrition 55(5):1963-1972.

• Tian XY, Wong WT, Lau CW, Wang YX, Cheang WS, Liu J, Lu Y, Huang H, Xia Y, Chen ZY, Mok CSD, Lau CM & Huang Y (2016) Melamine impairs renal and vascular function in rats. Scientific Reports 6:28041

• Zhang H, Liu J, Qu D, Wang L, Luo JY, Lau CW, Liu P, Gao Z, Tipoe, GL, Lee HK, Ng CF, Ma RCW, Yao X & Huang Y (2016) Inhibition of miR-200c restores endothelial function in diabetic mice through suppression of COX-2. Diabetes 65(5):1196-1207 with Commentary Diabetes 65(5):1152-1154.

• Miernisha A, Bi CW, Cheng LK, Xing JG, Liu J, Maiwulanjiang M, Aisa HA, Dong TT, Lin H, Huang Y & Tsim KW (2016) Badiranji Buya Keli, a Traditional Uyghur Medicine, induces vasodilation in rat artery: signaling mediated by nitric oxide production in endothelial cells. Phytotherapy Research 30(1):16-24. doi: 10.1002/ptr.5494.

• Zhang Y, Liu J, Luo JY, Tian XY, Cheang WS, Xu J, Lau CW, Wang L, Wong WT, Wong CM, Lan HY, Yao XQ, Raizada MK & Huang Y (2015) Upregulation of angiotensin (1-7)-mediated signaling preserves endothelial function through reducing oxidative stress in diabetes. Antioxidants & Redox Signaling 23(11):880-892 with Cover Image of the Issue.

• Liu L, Liu J, Gao Y, Ng CF, Yu X, Dou D & Huang Y (2015) Down-regulation of glucagon-like peptide-1 receptor expression is mediated through PKCβ in hypertensive renal arteries. Journal of Hypertension 33(4):784-790. (Co-first author)

• Liu LM, Liu J, Huang Z, Yu X, Zhang X, Dou D, & Huang Y (2015) Berberine improves endothelial function by inhibiting endoplasmic reticulum stress in the carotid arteries of spontaneously hypertensive rats. Biochemical and Biophysical Research Communications 458(4):796-801.

• Liu J, Wang L, Tian XY, Liu LM, Wong WT, Zhang Y, Han Q, Ho HM, Wang N, Wong SL, Chen ZY, Yu J, Ng CF, Yao X & Huang Y (2015) Unconjugated bilirubin mediates heme oxygenase-1-induced vascular benefits in diabetic mice. Diabetes 64(5):1564-1577 with commentary 64(5):1506-1508.

• Liu L, Liu J & Huang Y (2015) Protective effects of glucagon-like peptide-1 on endothelial function in hypertension. Journal of Cardiovascular Pharmacology 65(5):399-405.

• Qu D, Liu J, Lau CW & Huang Y (2014) Differential mechanisms for insulin-induced relaxation in mouse posterior tibial arteries and main mesenteric arteries. Vascular Pharmacology 63(3):173-177.

• Gao Z, Zhang H, Liu J, Lau CW, Liu P, Chen ZY, Lee HK, Tipoe GL, Ho HM, Yao X & Huang Y (2014) Cyclooxygenase-2-dependent oxidative stress mediates palmitate-induced impairment of endothelium-dependent relaxations in mouse arteries. Biochemical Pharmacology 91(4):474-481

• Liu L, Liu J, Tian XY, Wong WT, Lau CW, Xu A, Xu G, Ng CF, Yao X, Gao Y & Huang Y (2014) Uncoupling protein-2 up-regulation and oxidative stress inhibition mediate DPP-4 inhibition-induced restoration of endothelial function in hypertension. Antioxidants & Redox Signaling 21(11):1571-1581

• Qu D, Liu J, Lau CW & Huang Y (2014) Interleukin-6 in diabetes and cardiovascular complications. British Journal of Pharmacology171(15):3595-3603

• Liu L, *Liu J, Gao Y, Yu X, Xu G & Huang Y (2014) Uncoupling protein-2 mediates the protective action of berberine against oxidative stress in rat insulinoma INS-1E cells and in diabetic mouse islets. British Journal of Pharmacology 171(13):3246-3254 (*Co-first author)

• Liu L, *Liu J, Gao Y, Yu X, Dou D & Huang Y (2014) Protein kinase Cδ contributes to phenylephrine-mediated contraction in the aortae of high fat diet-induced obese mice. Biochemical and Biophysical Research Communications 446(4):1179-1183 (*Co-first author)

• Zhang Y, *Liu J, Tian XY, Wong WT, Chen Y, Wang L, Luo JY, Cheang WS, Lau CW, Kwan KM, Wang N, Yao X & Huang Y (2014) Inhibition of bone morphogenic protein-4 restores endothelial function in db/db diabetic mice. Arteriosclerosis, Thrombosis and Vascular Biology 34(1):152-159 (*Co-first author)

• Lau YS, Tian XY, Mustafa MR, Murugan D, Liu J, Zhang Y, Lau CW & Huang Y (2013) Boldine improves endothelial function in diabetic db/db mice through inhibiting angiotensin II-mediated BMP4 oxidative stress cascade. British Journal of Pharmacology 170(6):1190-1198

• Dong J, Wong SL, Lau CW, Liu J, Wang YX, He ZD, Ng CF, Chen ZY, Yao X, Xu A, Ni X, Wang H & Huang Y (2013) Calcitriol restores renovascular function in estrogen-deficient rats through downregulation of cyclooxygenase-2 and the thromboxane-prostanoid receptor. Kidney International 84(1):54-63 with Commentary 2013;84(1):9-11.

• Hu J, *Liu J, Kwok MWT, Wong RHL, Huang Y & Wan S (2013) Bond morphogenic protein-4 contributes to venous endothelial dysfunction in diabetic patients undergoing coronary revascularization. Annals of Thoracic Surgery 95(4):1331-1339. (*Co-first author)

• Yang C, Chen ZY, Wong SL, Liu J, Liang YT, Lau CW, Lee HK, Huang Y & Tsang SY (2013) b-Sitosterol oxidation products attenuate vasorelaxation through increasing reacitive oxygen species and cyclooxygenase-2. Cardiovascular Research 97(3):520-532.

• Bi CWC, Xu L, Tian XY, Liu J, Lau CW, Zheng KYZ, Lau DTW, Choi RCY, Dong TTX, Huang Y, Tsim KWK (2012) Fo Shou San, an ancient Chinese herbal decoction, protects endothelial function through increasing endothelial nitric oxide synthase activity. PLoS One 7(12):e51670.

• Tian XY, Wong WT, Wang N, Lu Y, Cheang WS, Liu J, Liu L, Liu Y, Lee SST, Chen ZY, Cooke JP & Huang Y (2012) PPARδ activation protects endothelial function in diabetic mice. Diabetes 61(12):3285-3293.

• Liu L, Liu J, Wong WT, Tian XY, Lau CW, Wang YX, Xu G, Pu Y, Zhu Z, Xu A, Lam KSL, Chen ZY, Ng CF, Yao X & Huang Y (2012) Dipeptidyl peptidase inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism. Hypertension 60(3):833-841.

• Chen JN, Jiang Y, Liang YT, Tian XY, Peng C, Ma KY, Liu J, Huang Y & Chen ZY (2012) DPA n-3, DPA n-6 and DHA improve lipoprotein profiles and aortic function in hamsters fed a high cholesterol diet. Atherosclerosis 221(2):397-404.

• Tian XY, Yung LH, Wong WT, Liu J, Leung FP, Liu LM, Chen YC, Kong SK, Kwan KM, Ng SM, Lai PB, Yung LM, Yao X & Huang Y (2012) Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway. Journal of Molecular and Cellular Cardiology 52(1):237-244.