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Dr Li WANG

 
SCI-indexed publications
  • Jiang H, Zhao Y, Jin M, Zhang Z, Wang L, Cheng X, Huang Y, Liu Z, Weng J, Xu S (2025) Colchicine Inhibits Smooth Muscle Cell Phenotypic Switch and Aortic Dissection in Mice. Arteriosclerosis, Thrombosis and Vascular Biology (Accepted)
  • Jiang M, Ding H, Huang YH, Lau CW, Guo Y, Luo J, Shih YT, Xia Y, Yao X, Chiu JJ, Wang L, Chien S, Huang Y (2025) Endothelial serotonin receptor 1B acts as a mechanosensor to drive atherosclerosis. Circulation Research (2025 Mar 12. doi: 10.1161/CIRCRESAHA.124.325453. Online ahead of print.
  • Wang Y, Wu Y, Xiang L, Xu C, Lau CW, Zhang C, Deng D, Liu J, Xia Y, Ma RWC, Huang Y, *Wang L (2025) Inhibition of the YAP-E2F2-FGF2 Axis in Renal Tubular Cells Ameliorates Renal Fibrosis in Chronic Kidney Disease. Science China - Life Sciences Accepted: Feb 20, 2025 Available online: Mar 18, 2025 http://engine.scichina.com/doi/10.1007/s11427-024-2880-1
  • Cheng CK, Wang N, *Wang L, *Huang Y (2025) Biophysical and Biochemical Roles of Shear Stress on Endothelium: A Revisit and New Insights. Circulation Research 28;136(7):752-772. (Co-corresponding)
  • Sun L, Leng R, Liu M, Su M, He Q, Zhang Z, Liu Z, Wang Z, Jiang H, Wang L, Guo S, Xu Y, Huo Y, Miller CL, Banach M, Huang Y, Evans PC, Pelisek J, Camici GG, Berk BC, Offermanns S, Ge J, Xu S, Wang J (2025) Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake. Journal of Clinical Investigation (Accepted)
  • Ding H, Jiang M, Chan AM, Xia Y, Ma RCW, Yao X, Wang L, Huang Y (2024) Targeting endothelial Src attenuates disturbed flow-induced inflammation and atherogenesis. British Journal of Pharmacology 2024 Aug 8. doi: 10.1111/bph.17307. Online ahead of print
  • Su M, Zhao W, Jiang H, Zhao Y, Liao Z, Liu Z, Xu M, Jiang S, Wu L, Yang Y, Wang Z, Zeng Z, Fang Y, Tang C, Miller CL, Evans PC, Wang L, Banach M, Jo H, Berk BC, Offermanns S, Huang Y, Ge J, Xu S, Weng J (2025) Endothelial IGFBP6 Suppresses Vascular Inflammation and Atherosclerosis. Nature Cardiovascular Research 4(2):145-162; News & Views by Martin A. Schwartz “IGFBP6 contributes to vascular resilience” 4(2):122-123
  • Xu MY, Xu JJ, Kang LJ, Liu ZH, Su MM, Zhao WQ, Wang ZH, Lu S, Xiao JB, Evans PC, Tian XY, Wang L, Huang Y, Liang XM, Weng JP, Xu SW (2024) Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein E-deficient mice. Acta Pharmacologica Sinica45(11):2277-2289
  • Cheng CK, Yi M, Wang L, Huang Y (2024) Role of gasdermin D in inflammatory diseases: from mechanism to therapeutics. Frontiers in Immunology 15:1456244.
  • Cheng CK, Ye, L, Zuo Y, Wang Y, Wang L, Li F, Chen S, Huang Y (2024) Aged gut microbiome induces metabolic impairment and hallmarks of vascular and intestinal aging in young mice. Antioxidants (Basel) 13(10):1250. doi: 10.3390/antiox13101250.
  • Zhao Y, Wang L, Huang Y, Evans PC, Little PJ, Tian X, Weng J, Xu S (2024) Anthocyanins in vascular health and disease: mechanisms of action and therapeutic potential. Journal of Cardiovascular Pharmacology  84(3):289-303
  • He L, Chen QH, Wang L, Pu YJ, Huang J, Cheng CK, Luo JY, Kang LJ, Lin X, Xiang L, Fang L, He B, Xia Y, Lui KO, Pan Y, Liu J, Zhang CL, Huang Y (2024) Activation of Nrf2 inhibits atherosclerosis in ApoE-/- mice through suppressing endothelial cell inflammation and lipid peroxidation. Redox Biology 74(2024):103229
  • Chen Q, Hao H, Guo Z, Zuo Y, Cheng CK, Zhang CL, Wang L, Lu A, Huang Y, He L (2024) Pien Tze Huang (PZH) Protects Endothelial Function in Diabetic Mice. Life Sciences 349:122723.
  • Xiang L, Wang L, Xia Y, Wang Y, Shui J, Zhang CL, Xie L, Ru Y, Cheng CK, Pu Y, Hu L, Liu J, Xu S, Cai ZW, Huang Y (2024) Exercise Alleviates Diabetic Kidney Disease Through PPARd-CPT1a pathway-dependent Fatty Acid β-oxidation. The Innovation Life 2(2):100065 (10 pages) (Co-first author)
  • Liu Y, Wang Y, Xu C, Zhang Y, Wang Y, Qin J, Lan HY, Wang L, Huang Y, Mak K, Zheng Z, Xia Y (2024) Activation of the YAP/KLF5 transcriptional cascade in renal tubular cells aggravates kidney injury. Molecular Therapy 32(5):1526-1539. doi: 10.1016/j.ymthe.2024.02.031.
  • Huang YH, Wang YF, Ruan XZ, Lau CW, Wang L, Huang Y (2024) The Role of KLF2 in Regulating Hepatic Lipogenesis and Blood Cholesterol Homeostasis via the SCAP/SREBP Pathway. Journal of Lipid Research 65(1):100472.doi: 10.1016/j.jlr.2023.100472
  • Pu Y, Cheng CK, Zhang H, Luo J, Wang L, Tomlinson T, Huang Y (2023) Molecular mechanisms and therapeutic perspectives of peroxisome proliferator-activated receptor α agonists in cardiovascular health and diseases. Medicinal Research Reviews 43(6):2086-2114.
  • Jiang M, Ding H, Huang Y, Cheng CK, Lau CW, Xia Y, Yao X, Wang L, Huang Y (2023) Thioridazine protects against disturbed flow-induced atherosclerosis by inhibiting RhoA/YAP-mediated endothelial inflammation. Acta Pharmacologica Sinica 44(10):1977-1988.
  • Kang L, Yi J, Lau CW, He L, Chen Q, Xu S, Li J, Xia Y, Zhang Y, Huang Y, *Wang L (2023) AMPK-dependent YAP inhibition mediates the protective effect of metformin against obesity-associated endothelial dysfunction and inflammation. Antioxidants 2023,12(9):1681 (16 pages)
  • Luo JY, Cheng CK, Gou L, He L, Zhao L, Zhang Y, Wang L, Lau CW, Chen AF, *Huang Y (2023) Induction of KLF2 by exercise activates eNOS to improve vasodilatation in diabetic mice. Diabetes 72(9):1330-1342
  • Ding H, Jiang M, Lau CW, Luo J, Chan AM, *Wang L, Huang Y (2023) Curaxin CBL0137 inhibits endothelial inflammation and atherogenesis via suppression of Src-YAP signaling axis. British Journal of Pharmacology 180(8):1168-1185.
  • Zhang Y, Huang H, Kong Y, Xu C, Dai L, Geng X, Deng Y, Wang Y, Liu Y, Meng C, Zhang X, Li J, Qin J, Feng B, Mak KK, Wang L, Huang Y, Wang W, Lan HY, Yang B, Lu HAJ, Xia Y (2023) Kidney tubular transcription co-activator, Yes-associated protein 1 (YAP), controls the expression of collecting duct aquaporins and water homeostasis. Kidney International 103(3):501-513
  • Xiang L, Ru Y, Shi J, Wang L, Zhao H, Huang Y, Cai Z (2023) Derivatization of N-Acyl Glycines by 3-Nitrophenylhydrazine for Targeted Metabolomics Analysis and Their Application to the Study of Diabetes Progression in Mice. Analytical Chemistry 95(4):2183-2191.
  • Cheng CK, Lin X, Pu Y, Tse KYJ, Wang Y, Zhang CL, Cao X, Lau CW, Huang J, He L, Luo JY, Shih YT, Wan S, Ng CF, Wang L, Ma CWR, JJ Chiu, Chan TF, Tian XY & Huang Y (2023) SOX4 is a novel phenotypic regulator of endothelial cells in atherosclerosis revealed by single-cell analysis. Journal of Advanced Research 43:187-203. 
  • He L, Zhang CL, Chen QH, Wang L & Huang Y (2022) Endothelial shear stress signal transduction and atherosclerosis: From mechanisms to therapeutics. Pharmacology & Therapeutics 235; (2022) 108152
  • Zhang H, Xiang L, Huo M, Wu Y, Yu M, Lau CW, Tian D, Gou L, Huang Y, Luo JY, Wang L, Song W, Huang J, Cai Z, Chen S, Tian XY & Huang Y (2022)  Branched-chain amino acid supplementation Impairs Insulin Sensitivity and Promotes Lipogenesis During Exercise in Diet-Induced Obese Mice. Obesity (Silver Spring). 30(6):1205-1218.
  • Cheng CK, Shang W, Liu J, Cheang WS, Wang Y, Xiang L, Lau CW, Luo JY, Ng CF, *Huang Y, *Wang L (2022) Activation of AMPK/miR-181b Axis Alleviates Endothelial Dysfunction and Vascular Inflammation in Diabetic Mice. Antioxidants 11(6):1137 (17 pages)
  • Zhao L, Zhang CL, He L, Chen QH, Liu L, Kang L, Liu J, Luo JY, Gou L, Qu D, Song W, Lau CW, Ko H, Mok VCT, Tian XY, Wang L & Huang Y (2022) Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Reducing Mitochondrial ROS-mediated eNOS Monomerization. Diabetes 71(5):1099-1114. doi: 10.2337/db21-0660
  • Wang L, Cheng CK, Yi M, Lui KO, *Huang Y (2022) Targeting endothelial dysfunction and inflammation. Journal of Molecular and Cellular Cardiology 168:58-67.
  • Zhang C, He L, Wang L & *Huang Y (2022) The pathogenesis of endothelial dysfunction (內皮功能障礙的發生機制) SCIENTIA SINICA Vitae (中國科學:生命科學) 52(5):691-698.
  • Liu J, Zhang Y, Qu D, Zhang H, Wang L, Lau CW, Han JY, Pingcuo D, Huang Y & Liu L (2021) Salvianolic acid B ameliorates vascular endothelial dysfunction through the inhibition of bone morphogenetic protein 4 in diabetic mice. Life Sciences 286:120039.
  • Huang J, Pu Y, Zhang H, Xie L, He L, Zhang C, Cheng CK, Huo Y, Wan S, Chen S, Huang Y, Lau CW, Wang L, Huang Y & Luo JY (2021) Endothelial KLF2 mediates the suppressive effect of laminar flow on vascular calcification by inhibiting BMP/SMAD1/5 signaling. Circulation Research 129(4):e87-e100.
  • Xiang L, Nie J, Wang L, Wang Y, Shi J, Wei J, Lau CW, Cai ZW & Huang Y (2021) Integrated metabolomics analysis of the effect of PPARd agonist GW501516 on catabolism of BCAAs and carboxylic acids in diabetic mice. Chinese Chemical Letters 32(7):2197-2202.
  • Cheng CK, Wang C, Shang W, Lau CW, Luo JY, Wang L & Huang Y (2021) A high methionine and low folate diet alters glucose homeostasis and gut microbiome. Biochemistry and Biophysics Reports 24 (March 2021): article 100921
  • Xu C, Wang L, Zhang Y, Li W, Li J, Wang Y, Meng C, Qin J, Zheng ZH, Lan HY, Mak KKL, Huang Y & Xia Y (2020) Tubule-specific Mst1/2 deficiency induces CDK via YAP and non-YAP mechanisms. Journal of the American Society of Nephrology 31(5):946-961 with editorial (Journal of the American Society of Nephrology 2020;31(5):893-894.
  • Qu D, Wang L, Huo M, Song W, Lau CW, Xu J, Xu A, Yao X, Chiu JJ, Tian XY & Huang Y (2020) Focal TLR4 activation mediates disturbed flow-induced endothelial inflammation. Cardiovascular Research 116(1):226-236. doi: 10.1093/cvr/cvz046.
  • Qu D, Huo M, Wang L, Lau CW, Tian XY & Huang Y (2019) Nilotinib activates endothelial TLR4 to exacerbate atherosclerosis. bioRxiv (Cold Spring Harbor Laboratory), doi: https://doi.org/10.1101/2019.12.14.876599
  • Song W, Zhang CL, Gou L, He L, Gong YY, Qu D, Zhao L, Jin N, Chan TF, Wang L, Tian XY, *Luo JY & *Huang Y (2019) Endothelial TFEB (Transcription Factor EB) Restrains IKK (IκB Kinase)-p65 Pathway to Attenuate Vascular Inflammation in Diabetic db/db Mice. Arteriosclerosis, Thrombosis and Vascular Biology 39(4):719-730.
  • Cheang WS, Wong WT, Wang L, Cheng CK, Lau CW, Ma RCW, Xu A, Wang N, Huang Y & Tian XY (2018) Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor δ.Pharmacological Research 139:384-394.
  • Zhang H, Liu J, Qu D, Wang L, Wong CM, Lau CW, Huang Y, Wang YF, Huang H, Xia Y, Xiang L, Cai Z, Liu P, Wei Y, Yao X, Ma RCW & *Huang Y (2018) Serum exosomes mediate delivery of arginase 1 as a novel mechanism for endothelial dysfunction in diabetes. Proceedings of the Academy of National Sciences USA 115(29):E6927-E6936.
  • Gong Y, Luo JY, Wang L & Huang Y (2017) MicroRNAs regulating reactive oxygen species in cardiovascular diseases. Antioxidants & Redox Signaling 29(11):1092-1107

  • Gou L, Zhao L, Song W, Wang L, Liu J, Zhang H, Huang Y, Lau CW, Yao XQ, Tian XY, Wong WT, Luo JY & Huang Y (2018) Inhibition of miR-92a suppresses oxidative stress and improves endothelial function by upregulating heme oxygenase-1 in db/db mice. Antioxidants & Redox Signaling 28(5):358-370.

  • Wang Y, Zhang X, Huang H, Xia Y, Yao Y, Mak AFT, Yung PSH, Chan KM, Wang L, Zhang C, Huang Y & Mak KKL (2017) Osteocalcin expressing cells from tendon sheaths in mice contribute to tendon repair by activating Hedgehog signaling. eLife 2017;6:e30474, DOI: 10.7554/eLife.30474.
  • Cheang WS, Wong WT, Zhao L, Xu J, Wang L, Lau CW, Chen ZY, Ma RCW, Xu A, Wang N, Tian XY & Huang Y (2017) PPARδ Is required for exercise to attenuate endoplasmic reticulum stress and endothelial dysfunction in diabetic mice.Diabetes 66(2):519-528.
  • Wang L, Luo JY, Li B, Tian XY, Chen LJ, Huang Y, Liu J, Deng D, Lau CW, Wan S, Ai D, Mak KL, Tong KK, Kwan KM, Wang N, Chiu JJ, *Zhu Y & Huang Y (2016) Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature 540:579-581. Commented in Nature News and Views, Nature 540:531-532.
  • Choy KW, Mustafa MR, Lau YS, Liu J, Murugan D, Lau CW, Wang L, Zhao L & Huang Y (2016) Paeonol protects against endoplasmic reticulum stress-induced endothelial dysfunction via AMPK/PPARd signalling pathway. Biochemical Pharmacology 116:51-62.
  • Zhang H, Liu J, Qu D, Wang L, Luo JY, Lau CW, Liu P, Gao Z, Tipoe, GL, Lee HK, Ng CF, Ma RCW, Yao X & Huang Y (2016) Inhibition of miR-200c restores endothelial function in diabetic mice through suppression of COX-2. Diabetes 65(5):1196-1207 with Commentary Diabetes 65(5):1152-1154.
  • He L, Liu Q, Hu T, Huang X, Zhang H, Tian X, Yan Y, Wang L, Huang Y, Miquerol L, Wythe JD & Zhou B (2016) Genetic lineage tracing discloses arteriogenesis as the main mechanism for collateral growth in the mouse heart. Cardiovascular Research 109(3):419-430. As Editor’s Choice of the Issue.
  • Hu W, Zhang Y, Wang L, Lau CW, Xu J, Luo JY, Gou L, Yao XY, Chen ZY, Ma RCW, Tian XY & Huang Y (2016) Bone morphogenic protein 4-Smad induced upregulation of platelet-derived growth factor AA impairs endothelial function. Arteriosclerosis, Thrombosis and Vascular Biology 36(3):553-560.
  • Zhang Y, Liu J, Luo JY, Tian XY, Cheang WS, Xu J, Lau CW, Wang L, Wong WT, Wong CM, Lan HY, Yao XQ, Raizada MK & Huang Y (2015) Upregulation of angiotensin (1-7)-mediated signaling preserves endothelial function through reducing oxidative stress in diabetes. Antioxidants & Redox Signaling 23(11):880-892 with Cover Image of the Issue.
  • Xiang L, Cheang WS, Wang L, Lin S, Li Y, *Huang Y & *Cao Z (2015) Plasma metabolic signatures reveal regulatory effect of exercise training in db/db mice. Molecular BioSystems 11(9):2588-2596
  • Luo JY, Zhang Y, Wang L & Huang Y (2015) Regulators and effectors of BMP signaling in the cardiovascular system. The Journal of Physiology 593(14):2995-3011
  • Liu J, Wang L, Tian XY, Liu LM, Wong WT, Zhang Y, Han Q, Ho HM, Wang N, Wong SL, Chen ZY, Yu J, Ng CF, Yao X & Huang Y (2014) Unconjugated bilirubin mediates heme oxygenase-1-induced vascular benefits in diabetic mice. Diabetes 64(5):1564-1577 with commentary 64(5):1506-1508
  • Zhang Y, Liu J, Tian XY, Wong WT, Chen Y, Wang L, Luo JY, Cheang WS, Lau CW, Kwan KM, Wang N, Yao X & Huang Y (2014) Inhibition of bone morphogenic protein-4 restores endothelial function in db/db diabetic mice. Arteriosclerosis, Thrombosis and Vascular Biology 34(1):152-159
  • Tian, XY, Wong WT, Xu A, Lu Y, Zhang Y, Wang L, Cheang WS, Wang Y, Yao X & Huang Y (2012) Uncoupling protein-2 protects endothelial dysfunction in diet-induced obese mice. Circulation Research 110:1211-1216.