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photo of Prof. Sik Lok Lam

Prof. Sik Lok LAM
(Sherlock)

Associate Professor

Education

1992 B.Sc. The Chinese University of Hong Kong
1996 Ph.D. The Chinese University of Hong Kong

Position

Since 2009 Associate Professor,
The Chinese University of Hong Kong
2003-2009 Assistant Professor,
The Chinese University of Hong Kong
1999-2003 Assistant Professor,
(Replacement Teacher)
The Chinese University of Hong Kong
1997-1999 Postdoctoral Fellow,
Oregon State University

Research Interests

  1. Biophysical chemistry of nucleic acids: (i) molecular mechanism of genetic instabilities; (ii) fidelity of DNA replication; (iii) mechanistic pathways of DNA damage and repair
  2. Development of NMR methods for structure determination of nucleic acids
  3. Application of high resolution NMR spectroscopy in biomedical analysis

Representative Publications

  1. Guo, P. and Lam, S.L. (2017). An extraordinarily stable DNA minidumbbell. J Phys Chem Lett 8, 3478-3481.
  2. Guo, P., Chan, H.Y.E. and Lam, S.L. (2017). Conformational flexibility in the RNA stem-loop structures formed by CAG repeats. FEBS Lett 591, 1752-1760.
  3. Liu, Y., Guo, P. and Lam, S.L. (2017). Formation of a DNA mini-dumbbell with a quasi-type II loop. J Phys Chem B 121, 2554-2560.
  4. Guo, P. and Lam, S.L. (2016). Unusual structures of CCTG repeats and their participation in repeat expansion. Biomol Concepts 7, 331-340.
  5. Guo, P. and Lam, S.L. (2016). Minidumbbell: a new form of native DNA structure. J Am Chem Soc 138, 12534-12540.

DSHIFT Web Server

Full Text in PDF: Lam, S.L. (2007) DSHIFT: a web server for predicting DNA chemical shifts. Nucleic Acids Res. 35, W713-717.


Honours and Awards

2010 Wang Tien-Chuan Prize in Spectroscopy (王天眷波譜學獎)