MB ChB (Edin.), MD, FRCPath, FRCPA, FCAP, FFPathRCPI, MIAC, FHKCPath
H.K. Ng is Chair Professor at the Chinese of University of Hong Kong. His interests are in the molecular genetics of brain tumours, both adult and pediatric. He was previously Department Chairman. H.K. Ng is both a neuropathologist and a general pathologist.
H.K. is an Associate Editor of Laboratory Investigation (IF:5.7) and Associate Editor of Neuro-Oncology Advance (IF:3.5) and is also on the Editorial Boards of Acta Neuropathologica (IF:17.1), Brain Pathology (IF:6.5), Glioma, Neuropathology and Applied Neurobiology (IF:8.1), Clinical Neuropathology, and Pathology (IF:5.3).
He was a member of the Consensus Group of the 2007 and 2016 WHO classifications of the brain tumours. For the WHO 2021 Classification, he is one of the only 10 neuropathologists from around the world to have been selected for the Consensus Group.
As an educationalist, H.K. was also Associate Dean (Education) of the Medical School of the Chinese University of Hong Kong for 15 years and was Chair of the Licentiate Examination of the Hong Kong Medical Council, for 10 years.
H.K. Ng was part of the teams who received the 2nd Tier Award of The National Science and Technology Award of China in 2010 and the First Tier Science and Technology Award of Shanghai in 2019. He received the International Academy of Pathology Gold Medal twice in 2006 and 2017, and the HMRF Research Award of the Department of Health in 2021.
Ng HK, Li KKW, Chung NYF, Chan JYT, Poon MFM, Wong QHW, Kwan JSH, Poon WS, Chen H, Chan DTM, Shi ZF, Mao Y. Mutational landscapes of longitudinal NF2/22q and non-NF2/22q meningiomas show different life histories. Brain Pathology 2023, [PMID 36167400]
Liu EM, Shi ZF, Li KK, Malta TM, Chung NY, Chen H, Chan JY, Poon MF, Kwan JS, Chan DT, Noushmehr H, Mao Y, Ng HK. Molecular landscape of adult IDHwt TERTwt glioblastomas. Brain Pathology 2022, [PMID 35815721]
Liu AP, Li KK, Chow C, Chan S, Leung AW, Shing MM, To KF, Chan DT, Chan GC, Ng HK. Expanding the clinical and molecular spectrum of pituitary blastoma. Acta Neuropathologica 2022, [PMID 35129635]
Shi ZF, Li KK, Huang QJ, Wang WW, Kwan JS, Chen H, Liu XZ, Li WC, Chan DT, Zhang ZY, Mao Y, Ng HK. Molecular landscape of IDH-wildtype, H3-wildtype glioblastomas of adolescents and young adults. Neuropathology Applied Neurobiology 2022. [PMID 35191072]
Yang RR, Li KK, Liu AP, Chen H, Chung NY, Chan AK, Li F, Chan DM, Mao Y, Shi ZF, Ng HK. Low-grade BRAF V600E mutant oligodendroglioma-like tumors of children may show EGFR and MET amplification. Brain Pathology 2021, [ PMID 33032379]
Wong QH, Li KK, Wang WW, Mao Y, Zhang ZY, Shi ZF, Ng HK. Molecular landscape of IDH-mutant primary astrocytoma Grade IV/glioblastomas. Modern Pathology 2021, [PMID 33692446]
Wong GC, Li KKY, Wang WW, Mao Y, Zhang ZY, Shi ZF, Ng HK. Clinical and mutational profiles of adult medulloblastoma groups. Acta Neuropathologica Communications 2020, [PMID 33172502]
Yang RR, Shi ZF, Zhang ZY, Liu XZ, Mao Y, Li KK, Ng HK. IDH mutant lower grade astrocytomas can be stratified for risk by CDKNZA, CDK4 and PDGFRA copy number alterations. Brain Pathology 2020, [PMID 31733156]
Yang RR, Aibaidula A, Chan AK, Li KK, Ng HK. Pediatric low-grade gliomas can be molecularly stratified for risk. Acta Neuropathol 2018; 136:641-655, [PMID 29948154]
Chan AKY, Mao Y, Ng HK. TP53 and histone H3.3 mutation in triple-negative adult lower-grade gliomas. New England Journal of Medicine 2016;375: 2206-2208, [PMID 27959765]
Aibaidula A, Chan AK, Shi Z, Li Y, Zhang R, Yang R, Li KK, Chung NY, Yao Y, Zhou L, Wu J, Chen H, Ng HK. Adult IDH wild-type lower-grade gliomas should be further stratified. Neuro-Oncology 2017;19:1327-1337, [PMID 28575485]
Wang L, Yamagnchi S, Burstein MD, Terashima K, Chang K, Ng HK, Wheeler DA, Lau CC. Novel Somatic and germline mutations in intracranial germ cell tumours. Nature 2014; 511: 241-5, [PMID 24896186 ]
Chan AK, Yao Y, Zhang Z, Chung NY, Liu JS, Li KK, Shi Z, Chan DT, Poon WS, Zhou L, Ng HK. TERT promoter mutations contribute to subset prognostication of lower-grade gliomas. Modern Pathology. 2015;28:177-86, [PMID 25081751]
Chang RC, Ho Y S, Wong S, Gentleman SM, Ng HK. Neuropathology of cigarette smoking. Acta Neuropathologica 2014; 127:53-69, [PMID 24240736]
Chan AK, Pang JC, Chung NY, Li KK, Poon WS, Chan DT, Shi Z, Chen L, Zhou L, Ng HK. Loss of CIC and FUBPI expressions are potential markers of shorter time to recurrence in oligodendroglial tumors. Modern Pathology 2014; 27:332-42, [PMID 24030748]
Lau KM, Chan QK, Pang JC, Ma FM, Li KK, Yeung WW, Cheng AS, Feng H, Chung NY, Li HM, Zhou L, Wang Y, Mao Y, Ng HK. Overexpression of HMGA1 deregulates tumor growth via cdc25A and alters migration/invasion through a cdc25A-independent pathway in medulloblastoma. Acta Neuropathologica 2012;123:553-71, [PMID 22249617]
Department of Anatomical and Cellular Pathology, Faculty of Medicine, The Chinese University of Hong Kong
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