Professor Dennis Lo
Professor Rossa Chiu
Professor Nelson Tang
Professor Allen K C Chan
Professor Chun Kwok Wong
Professor Yiu-Loon Chui
Professor Hao Sun
Professor Peiyong Jiang
Professor Kathy Lui
Professor Ping Yuan
Ms Elena Lo
Professor Christopher Lam
Professor Nirmal Panesar
Dr Michael H M Chan
Dr Liz Yuen
 
 
Dennis Lo 盧煜明
Professor 教授
loym@cuhk.edu.hk
Biography
Dennis Lo is the Director of the Li Ka Shing Institute of Health Sciences, the Li Ka Shing Professor of Medicine and Professor of Chemical Pathology of The Chinese University of Hong Kong (CUHK). He is also the Associate Dean (Research) of the Faculty of Medicine of CUHK. Dennis Lo received his Bachelor of Arts degree from the University of Cambridge and the Doctor of Medicine and Doctor of Philosophy degrees from the University of Oxford.
 
Following his training at Oxford, he was appointed as the University Lecturer in Clinical Biochemistry and Honorary Consultant Chemical Pathologist at the John Radcliffe Hospital, the teaching hospital of the University of Oxford Clinical School. He was also a Fellow at Green College, Oxford.
 
Dennis Lo returned to Hong Kong in 1997. In the same year, he discovered the presence of fetal DNA in maternal plasma. His group has since remained at the forefront of this field. His group was the first to report the presence of cell-free fetal RNA and fetal epigenetic markers in maternal plasma and pioneered the use of such markers for noninvasive prenatal diagnosis. Dennis Lo and his colleagues were also the first to show that cell-free fetal nucleic acids in maternal plasma could be used for the noninvasive prenatal diagnosis of fetal trisomy 21 and had devised multiple solutions for this hitherto difficult diagnostic problem, including methods based on plasma RNA-SNP allelic ratios, plasma epigenetic markers, digital PCR and massively parallel DNA sequencing. With the use of massively parallel sequencing and the development of novel bioinformatics strategies, Dennis Lo’s group succeeded at deciphering a genome-wide genetic map of the fetus through the analysis of the small amounts of fragmented DNA floating in the blood of pregnant women. This scientific achievement lays the foundation for developing non-invasive prenatal diagnostic tests for multiple genetic diseases in a non-invasive way.
 

 

In recognition of his work, Dennis Lo has been the recipient of numerous awards, including the 2005 State Natural Science Award from the State Council of China, the 2006 International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) – Abbott Award for Outstanding Contribution to Molecular Diagnostics, the 2006 US National Academy of Clinical Biochemistry Distinguished Scientist Award, a Croucher Senior Medical Research Fellowship, the 2007 Sigi Zeiring Award from the American Association of Clinical Chemistry and Fulbright Distinguished Scholar 2009. He was elected as a Fellow of the Royal Society in 2011 and as a Foreign Associate of the US National Academy of Sciences in 2013.
 
Press conference on December 9, 2010: CUHK researchers decode fetal genomic map from maternal blood
(Lo et al Sci Transl Med 2010;2:61ra91).
 
Selected publications:

Sun, K., Jiang, P., Chan, K. C., Wong, J., Cheng, Y. K., Liang, R. H., Chan, W. K., Ma, E. S., Chan, S. L., Cheng, S. H., Chan, R. W., Tong, Y. K., Ng, S. S., Wong, R. S., Hui, D. S., Leung, T. N., Leung, T. Y., Lai, P. B., Chiu, R. W., & Lo, Y. M. (2015). Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments. Proceedings of the National Academy of Sciences of the United States of America, 112(40), E5503-12.

Jiang, P., Chan, C. W., Chan, K. C., Cheng, S. H., Wong, J., Wong, V. W., Wong, G. L., Chan, S. L., Mok, T. S., Chan, H. L., Lai, P. B., Chiu, R. W., & Lo, Y. M. (2015). Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients. Proceedings of the National Academy of Sciences of the United States of America, 112(11), E1317-25.

Chan, R. W., Jiang, P., Peng, X., Tam, L. S., Liao, G. J., Li, E. K., Wong, P. C., Sun, H., Chan, K. C., Chiu, R. W., & Lo, Y. M. (2014). Plasma DNA aberrations in systemic lupus erythematosus revealed by genomic and methylomic sequencing. Proceedings of the National Academy of Sciences of the United States of America, 111(49), E5302-11.

Yu, S. C., Chan, K. C., Zheng, Y. W., Jiang, P., Liao, G. J., Sun, H., Akolekar, R., Leung, T. Y., Go, A. T., van Vugt, J. M., Minekawa, R., Oudejans, C. B., Nicolaides, K. H., Chiu, R. W., & Lo, Y. M. (2014). Size-based molecular diagnostics using plasma DNA for noninvasive prenatal testing. Proceedings of the National Academy of Sciences of the United States of America, 111(23), 8583-8588.

New, M. I., Tong, Y. K., Yuen, T., Jiang, P., Pina, C., Chan, K. C., Khattab, A., Liao, G. J., Yau, M., Kim, S. M., Chiu, R. W., Sun, L., Zaidi, M., & Lo, Y. M. (2014). Noninvasive prenatal diagnosis of congenital adrenal hyperplasia using cell-free fetal DNA in maternal plasma. The Journal of Clinical Endocrinology and Metabolism, 99(6), E1022-30.

Chan, K. C., Jiang, P., Chan, C. W., Sun, K., Wong, J., Hui, E. P., Chan, S. L., Chan, W. C., Hui, D. S., Ng, S. S., Chan, H. L., Wong, C. S., Ma, B. B., Chan, A. T., Lai, P. B., Sun, H., Chiu, R. W., & Lo, Y. M. (2013). Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing. Proceedings of the National Academy of Sciences of the United States of America, 110(47), 18761-18768.

Lun, F. M., Chiu, R. W., Sun, K., Leung, T. Y., Jiang, P., Chan, K. C., Sun, H., & Lo, Y. M. (2013). Noninvasive prenatal methylomic analysis by genomewide bisulfite sequencing of maternal plasma DNA. Clinical Chemistry, 59(11), 1583-1594.

Chan, K. C., Hung, E. C., Woo, J. K., Chan, P. K., Leung, S. F., Lai, F. P., Cheng, A. S., Yeung, S. W., Chan, Y. W., Tsui, T. K., Kwok, J. S., King, A. D., Chan, A. T., van Hasselt, A. C., & Lo, Y. M. (2013). Early detection of nasopharyngeal carcinoma by plasma epstein-barr virus DNA analysis in a surveillance program. Cancer, 119(10), 1838-1844.

Chan, K. C., Jiang, P., Zheng, Y. W., Liao, G. J., Sun, H., Wong, J., Siu, S. S., Chan, W. C., Chan, S. L., Chan, A. T., Lai, P. B., Chiu, R. W., & Lo, Y. M. (2013). Cancer genome scanning in plasma: Detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing. Clinical Chemistry, 59(1), 211-224.

Lo, Y. M., Corbetta, N., Chamberlain, P. F., Rai, V., Sargent, I. L., Redman, C. W., & Wainscoat, J. S. (1997). Presence of fetal DNA in maternal plasma and serum. Lancet, 350(9076), 485-487.

 
 
 
The Chinese University of Hong Kong