CUHK Huang Yu
Home
Academic Profile
Research Highlights
Publications
Research Team
Honors & Awards
Alumni
Visitors
Albums
Contact

 

The mission of our research programs is to elucidate cellular and molecular events involved in the initiation and progression of endothelial dysfunction in hypertension and diabetes, to uncover novel relevant biomarkers for vascular dysfunction, and develop venues to reverse vascular function and aging in animal models of cardio-metabolic diseases, as well as to train top-quality research students. Our main research focuses on endothelial dysfunction and functional communication between endothelium and other organs such as adipose tissue and bone. The programm is funded by grants from the Hong Kong Research Grants Council, Hong Kong Food and Health Bureau, and Chinese University of Hong Kong Focused Investment Scheme. In recent year, our team has established the positive role of COX-2-derived prostaglandin F2a in impairing endothelial function via acting as a novel endothelium-derived contracting factor in ageing and hypertension. Bone morphogenic protein-4 is among the most important mediators of COX-2 up-regulation and resultant endothelial dysfunction in hypertension. To advance the new concept, namely the ¡§adipose-vascular loop¡¨, Huang¡¦s team has elucidated that PPAR£^-activated adipose tissue-derived adiponectin plays an obligatory role in the improvement of endothelial function in diabetes, thus, the adipose tissue represents a promising target for ameliorating diabetic vasculopathy. Our research platform affiliated with the Institute of Vascular Medicine and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong has provided ample opportunities for closer collaboration with endocrinologists, clinical pharmacologists, and basic scientists in Hong Kong and around the world aiming at deeper understanding of pathophysiological mechanisms and exploring new therapeutic strategies.

2019

2018

2017

2016

2015

2013

2012

2011

2010

2008

2007