CUHK Huang Yu
Academic Profile
Research Highlights
Research Team
Honors & Awards


** Full List of SCI-indexed Publications **

Recent Representative Publications

456 SCI-indexed publications, 27806 citations. H-index: 85


  • Huang J, Pu Y, Zhang H, Xie L, He L, Zhang C, Cheng CK, Huo Y, Wan S, Chen S, Huang Y, Lau CW, Wang L, Xia Yin, *Huang Y & Luo JY (2021) Endothelial KLF2 mediates the suppressive effect of laminar flow on vascular calcification by inhibiting BMP/SMAD1/5 signaling. Circulation Research 129(4):e87-e100.
  • Jiang M, Ding H, *Huang Y & Wang L (2021) Shear Stress and Metabolic Disorders-Two Sides of the Same Plaque. Antioxidants & Redox Signaling (Accepted)
  • Zhao S, Cheng CK, Zhang CL & *Huang Y (2021) Interplay between oxidative stress, cyclooxygenases and prostanoids in cardiovascular diseases. Antioxidants & Redox Signaling 34(10):784-799 with Cover Image.

  • Qu D, Wang L, Huo M, Song W, Lau CW, Xu J, Xu A, Yao X, Chiu JJ, Tian XY & *Huang Y (2020) Focal TLR4 activation mediates disturbed flow-induced endothelial inflammation. Cardiovascular Research 116(1):226-236. doi: 10.1093/cvr/cvz046.

  • Song W, Zhang CL, Gou L, He L, Gong YY, Qu D, Zhao L, Jin N, Chan TF, Wang L, Tian XY, *Luo JY & *Huang Y (2019) Endothelial TFEB (Transcription Factor EB) Restrains IKK (IκB Kinase)-p65 Pathway to Attenuate Vascular Inflammation in Diabetic db/db Mice. Arteriosclerosis, Thrombosis and Vascular Biology 39(4):719-730.

  • Gong Y, Luo JY, Wang L & *Huang Y (2018) MicroRNAs regulating reactive oxygen species in cardiovascular diseases. Antioxidants & Redox Signaling 29(11):1092-1107
  • Zhang H, Liu J, Qu D, Wang L, Wong CM, Lau CW, Huang Y, Wang YF, Huang H, Xia Y, Xiang L, Cai Z, Liu P, Wei Y, Yao X, Ma RCW & *Huang Y (2018) Serum exosomes mediate delivery of arginase 1 as a novel mechanism for endothelial dysfunction in diabetes. Proceedings of the Academy of National Sciences USA 115(29):E6927-E6936.

  • Gou L, Zhao L, Song W, Wang L, Liu J, Zhang H, Huang Y, Lau CW, Yao XQ, Tian XY, Wong WT, Luo JY & *Huang Y (2018) Inhibition of miR-92a suppresses oxidative stress and improves endothelial function by upregulating heme oxygenase-1 in db/db mice. Antioxidants & Redox Signaling 28(5):358-370.

  • Cheang WS, Wong WT, Zhao L, Xu J, Wang L, Lau CW, Chen ZY, Ma RCW, Xu A, Wang N, Tian XY & *Huang Y (2017) PPARδ Is required for exercise to attenuate endoplasmic reticulum stress and endothelial dysfunction in diabetic mice.Diabetes 66(2):519-528.
  • Wang L, Luo JY, Li B, Tian XY, Chen LJ, Huang Y, Liu J, Deng D, Lau CW, Wan S, Ai D, Mak KL, Tong KK, Kwan KM, Wang N, Chiu JJ, *Zhu Y & *Huang Y (2016) Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature 540:579-581. Commented in Nature News and Views, Nature 540:531-532.
  • Zhang H, Liu J, Qu D, Wang L, Luo JY, Lau CW, Liu P, Gao Z, Tipoe, GL, Lee HK, Ng CF, Ma RCW, Yao X & *Huang Y (2016) Inhibition of miR-200c restores endothelial function in diabetic mice through suppression of COX-2. Diabetes 65(5):1196-1207 with Commentary Diabetes 65(5):1152-1154.
  • Hu W, Zhang Y, Wang L, Lau CW, Xu J, Luo JY, Gou L, Yao XY, Chen ZY, Ma RCW, Tian XY & *Huang Y (2016) Bone morphogenic protein 4-Smad induced upregulation of platelet-derived growth factor AA impairs endothelial function. Arteriosclerosis, Thrombosis and Vascular Biology 36(3):553-560.
  • Zhang Y, Liu J, Luo JY, Tian XY, Cheang WS, Xu J, Lau CW, Wang L, Wong WT, Wong CM, Lan HY, Yao XQ, Raizada MK & *Huang Y (2015) Upregulation of angiotensin (1-7)-mediated signaling preserves endothelial function through reducing oxidative stress in diabetes. Antioxidants & Redox Signaling 23(11):880-892 with Cover Image of the Issue.
  • Liu J, Wang L, Tian XY, Liu LM, Wong WT, Zhang Y, Han Q, Ho HM, Wang N, Wong SL, Chen ZY, Yu J, Ng CF, Yao X & *Huang Y (2015) Unconjugated bilirubin mediates heme oxygenase-1-induced vascular benefits in diabetic mice. Diabetes 64(5):1564-1577 with commentary 64(5):1506-1508.
  • LIU L, LIU J, TIAN XY, WONG WT, LAU CW, XU A, XU G, NG CF, YAO X, GAO Y & *HUANG Y (2014) Uncoupling protein-2 up-regulation and oxidative stress inhibition mediate DPP-4 inhibition-induced restoration of endothelial function in hypertension. Antioxidants & Redox Signaling 21(11):1571-1581
  • WONG CM, ZHANG Y & *HUANG Y (2014) Bone morphogenic protein-4-induced oxidant signaling via protein carbonylation for endothelial dysfunction. Free Radical Biology and Medicine 75C:178-190
  • CHEANG WS, TIAN XY, WONG WT, LAU CW, Lee ST; CHEN ZY, YAO X, WANG N & *HUANG Y (2014) Metformin protects endothelial function in diet-Induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor £_ pathway. Arteriosclerosis, Thrombosis and Vascular Biology 34(4):830-6
  • ZHANG Y, LIU J, TIAN XY, WONG WT, CHEN Y, WANG L, LUO JY, CHEANG WS, LAU CW, KWAN KM, WANG N, YAO X &*HUANG Y (2014) Inhibition of bone morphogenic protein-4 restores endothelial function in db/db diabetic mice. Arteriosclerosis, Thrombosis and Vascular Biology 34(1):152-159
  • DONG J, WONG SL, LAU CW, LIU J, HE ZD, NG CF, YAO X, CHEN ZY, NI X, WANG H & *HUANG Y (2013) Calcitriol restores renovascular function in estrogen-deficient rats through the downregulation of cyclooxygenase-2 and thromboxane-prostanoid receptor. Kidney International 84(1):54-63 with commentary 2013;84(1):9-11.
  • TIAN XY, WONG WT, WANG N, LU Y, CHEANG WS, LIU J, LIU L, LIU Y, LEE SST, CHEN ZY, COOKE JP, YAO X & *HUANG Y (2012) PPAR£_ activation protects endothelial function in diabetic mice. Diabetes 61(12):3285-3293.
  • DONG J, WONG SL, LAU CW, LEE, HK, NG CF, ZHANG L, YAO X, CHEN ZY, VANHOUTTE PM & *HUANG Y (2012) Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress. European Heart Journal 33(23):2980-2990.
  • LIU Y, TIAN XY, MAO G, FANG X, FUNG ML, SHYY JYJ, *Huang Y & WANG N (2012) Peroxisome proliferator-activated receptor £^ ameliorates pulmonary arterial hypertension by inhibiting 5-HT2B receptor. Hypertension 60(6):1471-1478.
  • LIU L, LIU J, WONG WT, TIAN XY, LAU CW, WANG YX, XU G, PU Y, ZHU Z, XU A, LAM KS, CHEN ZY, NG CF, YAO X, *HUANG Y (2012) Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism. Hypertension 60(3):833-841.
  • YUEN CY, WONG SL, LAU CW, TSANG SY, XU A, ZHU Z, NG CF, KONG SK, LEE HK, YAO X & *HUANG Y (2012) From skeleton to cytoskeleton: Osteocalcin transforms vascular fibroblasts to myofibroblasts via angiotensin II and Toll-like receptor 4. Circulation Research 111:e55-e66.
  • TIAN XY, WONG WT, XU A, LU Y, ZHANG Y, WANG L, CHEANG WS, WANG Y, YAO X & *HUANG Y (2012) Uncoupling protein-2 protects endothelial function in diet-Induced obese mice. Circulation Research 110(9):1211-1216.
  • TIAN XY, WONG WT, LEUNG FP, ZHANG Y, WANG YX, LEE HK, NG CF, CHEN ZY, YAO X, AU CL, LAU CW, VANHOUTTE PM, COOKE JP & *HUANG Y (2012) Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin F2a impairs endothelial function in renovascular hypertensive rats. Antioxidants & Redox Signaling 16(4):363-373.
  • TIAN XY, YUNG LH, WONG WT, LEUNG FP, LIU L, CHEN YC, KONG SK, KWAN KM, NG SSM, LAI PB, YUNG LM, YAO X & *HUANG Y (2012) Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway. Journal of Molecular and Cellular Cardiology 52(1):237-244.
  • CHEANG WS, WONG WT, TIAN XY, YANG Q, LEE HK, HE GW, YAO X & *HUANG Y (2011) Endothelial nitric oxide synthase enhancer AVE3085 restores endothelial function and reduces oxidative stress in type 2 diabetic db/db mice. Cardiovascular Research 92(2):267-275.
  • WONG WT, TIAN XY, XU A, YU J, LAU CW, HOO RLC, WANG Y, LEE VWY, LAM KSL, VANHOUTEE PM & *HUANG Y (2011) Adiponectin is required for PPARd-mediated improvement of endothelial function in diabetic mice. Cell Metabolism 14(1):104-115.
  • WONG SL, LAU CW, WONG WT, XU A, AU CL, NG CF, NG SSM, YAO X, *HUANG Y (2011) Pivotal role of PKC£_ in angiotensin II-induced endothelial cyclooxygenase-2 expression: A link to vascular inflammation. Arteriosclerosis, Thrombosis and Vascular Biology 31(5):1169-1176.
  • YUEN CY, WONG WT, TIAN XY, WONG SL, LAU CW, YU J, TOMLINSON B, YAO X & *HUANG Y (2011) Telmisartan inhibits vasoconstriction via PPAR£^-dependent expression and activation of endothelial nitric oxide synthase. Cardiovascular Research 90(1):122-129.
  • WONG WT, TIAN XY, CHEN YC, LEUNG FP, LIU L, LEE HK, NG CF, XU A, YAO X, VANHOUTTE PM, TIPOE GL & *HUANG Y (2010) Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: Implications on hypertension. Circulation Research 107(5):984-991.
  • WONG WT, TIAN XY, XU A, NG CF, LEE HK, AU CL, CHEN ZY, YAO X & *HUANG Y (2010) Angiotensin II type 1 receptor-dependent oxidative stress modulates endothelial dysfunction in aortas of diabetes mice and humans. Antioxidants & Redox Signaling 16(3):757-768
  • TIAN J, WONG WT, TIAN XY, ZHANG P, *HUANG Y & WANG N (2010) Rosiglitazone attenuates endothelin-1-induced vasoconstriction by up-regulating endothelial expression of ETB receptor. Hypertension 56(1):129-135. (Co-corresponding author)
  • CHAN YC, LEUNG FP, WONG WT, TIAN XY, YUNG LM, LAU CW, TSANG SY, YAO Y, CHEN ZY, *HUANG Y (2010) Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent eNOS activation. Arteriosclerosis, Thrombosis and Vascular Biology 30(5):992-999.
  • Wong SL, Leung FP, Au CL, Yung LM, Lau CW, Yao X, Chen ZY, Vanhoutte PM & *Huang Y (2009) Cyclooxygenase-2-derived PGF2a mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during ageing. Circulation Research 104(2):228-235 with editorial commentary (104(2):141-143)


Selected Joint Publications with External Collaborators

  • Cui Y, Kassmann M, Nickel S, Zhang C, Alenina N, Anistan YM, Schleifenbaum J, Bader M, Welsh DG, Huang Y & Gollasch M (2021) Myogenic vasoconstriction requires canonical Gq/11 signaling of the angiotensin II type 1 receptor. Journal of American Heart Association (Accepted)

  • Zhong W, Cao X, Pan G, Niu Q, Feng X, Xu M, Li M, Huang Y, Yi Q & Yan D (2021) ORP4L is a prerequisite for the induction of T-cell leukemogenesis associated with human T-cell leukemia virus 1. Blood (Accepted)

  • Yan P, li Z, Xiong J, Geng Z, Wei W, Zhang Y, Wu G, Zhuang T, Tian X, Liu J, Sun K, Chen F, Zhang Y, Zeng C, Huang Y & Zhang B (2021) LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity. Cell Reports (Accepted)
  • Gu P, Hui X, Zheng Q, Gao Y, Jin L, Jiang W, Zhou C, Liu T, Huang Y, Liu Q, Nie T, Wang Y, Wang Y, Zhao J, Xu A (2021) Mitochondrial Uncoupling Protein-1 Antagonizes Atherosclerosis by Blocking NLRP3-Inflammasome-dependent Interleukin-1b production. Science Advances (Accepted)
  • Liang X, Wu S, Geng Z, Liu L, Zhang S, Wang S, Zhang Y, Huang Y & Zhang B (2021) LARP7 suppresses endothelial-to-mesenchymal transition by coupling with the epigenetic repressor TRIM28. Circulation Research 129(9):843-856.

  • Tam CHT, Lim CKP, Luk AOY, Ng ACW, Lee HM, Jiang G, Lau ESH, Fan B, Wan R, Kong AKS, Tam WH, Ozaki R, Chow EYK, Lee KF, Siu SC, Hui G, Tsang CC, Lau KP, Leung JYY, Tsang MW, Kam G, Lau IT, Li JKY, Yeung VTF, Lau E, Lo S, Fung S, Cheng YL, Chow CC, Hu M, Yu W, Tsui SKW, Huang Y, Lan H, Szeto CC, Tang NLS, Ng MCY, So WY, Tomlinson B, Chan JCN, Ma RCW, The Hong Kong Diabetes Register TRS Study Group, The Hong Kong Diabetes Biobank Study Group. (2021) Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidaemia, subclinical atherosclerosis and diabetes cardiovascular complications among East Asians. Genome Medicine 2021 13:29

  • Xiang L, Zhu L, Huang Y & Cai ZW (2020) Application of derivatization in fatty acids and fatty acyls detection: Mass spectrometry-based targeted lipidomics. Small Methods 4(8); 2000160 (19 pages).
  • Fan G, Kaßmann M, Cui Y, Matthaeus C, Kunz S, Zhong C, Zhu S, Xie Y, Tsvetkov D, Daumke O, Huang Y & Gollasch M (2020) Age attenuates the T-type CaV3.2-RyR axis in vascular smooth muscle. Aging Cell 19(4):e13134 (14 pages).
  • Yao L, He J, Li B, Yan M, Wang H, Tan L, Liu M, Lv X, Lv H, Zhang X, Chen C, Wang D, Yu Y, Huang Y, Zhu Y & Ai D (2019) Regulation of Yap by mammalian target of rapamycin complex 1 in endothelial cells controls blood pressure through COX-2/mPGES-1/PGE2 cascade. Hypertension 74(4):936-946
  • Gao P, Li L, Yang L, Gui D, Zhang J, Han J, Wang J, Wang N, Lu J, Chen S, Hou L, Sun H, Xie L, Zhou J, Peng C, Lu Y, Peng X, Wang C, Miao J, Ozcan U, Huang Y, Jia W & Liu J (2019) Yin Yang 1 protein ameliorates diabetic nephropathy pathology through transcriptional repression of TGFβ1. Science Translational Medicine 11(510):eaaw2050 (14 pages). DOI: 10.1126/scitranslmed.aaw2050
  • Kaßmann M, Szijártó IA, García-Prieto CF, Fan G, Schleifenbaum J, Anistan YM, Tabeling C, Shi Y, Noble FL, Witzenrath M, Huang Y, Markó L, Nelson MT & Gollasch M (2019) Role of Ryanodine Type 2 Receptors in Elementary Ca2+ Signaling in Arteries and Vascular Adaptive Responses. Journal of the American Heart Association 8(9):e010090. doi: 10.1161/JAHA.118.010090 (20 pages)
  • Zhu L, Xu C Huo X, Hao H, Wan Q, Chen H, Zhang X, Wang X, Huang Y, Breyer RM, Cao X, Liu DP, FitzGeral GA & Wang M (2019) The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury. Nature Communications 2019 Apr 23;10(1):1888. doi: 10.1038/s41467-019-09492-4 (12 pages)

  • Geng L, Liao B, Jin L, Huang Z, Triggle CR, Ding H, Zhang J, Huang Y, Lin Z & Xu A (2019) Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues. Cell Reports 26(10):2738-2752.
  • Luo H, Guo L, Chen C, Xu Z, Peng X, Wang X, Wang J, Wang N, Li C, Luo X, Wang H, Jose P, Fu C, Huang Y, Shi W & Zeng C (2018) Exposure to maternal diabetes causes renal dopamine D1 receptor dysfunction and hypertension in adult rat offspring. Hypertension 72(4):962-970.
  • Lu Z, Wei X, Sun F, Zhang H, Gao G, Pu Y, Chen J, Tong W, Li Q, Zhou X, Yan Z, Zheng H, Yang G, Huang Y, Liu D & Zhu Z (2018) Non-insulin-determinant pathways maintain glucose homeostasis upon metabolic surgery. Cell Discovery 2018(4):58 (16 pages)
  • Tang TT, Li YY, Li JJ, Wang K, Dong WY, Xia N, Nie SF, Zhang M, Zeng ZP, Lv BJ, Jiao J, Liu H, Xian ZS, Yang XP, Hu Y, Liao YH, Wang Q, Tu X, Mallat Z, Huang Y, Shi GP & Cheng X (2018) Liver-heart crosstalk controls IL22 activity in cardiac protection after myocardial infarction. Theranostics 8(16):4552-4562.
  • Yang J, Wang Y, Zhou T, Wong LY, Tian XY, Hong X, Lai WH, Au KW, Wei R, Liu Y, Cheng LH, Liang G, Huang Z, Fan W, Zhao P, Wang X, Ibanez DP, Luo Z, L\i Y, Chen S, Wang D, Qin B, Siu CW, Huang Y, Esteban MA & Tse HF (2017) Generation of a human liver chimeric mouse model with hepatocytes derived from familiar hypercholesterolemia induced pluripotent stem cells. Stem Cell Reports. 8(3):606-618.
  • Zhao Y, Gao P, Sun F, Li Q, Yu H, Li L, Wei X, Chen J, He H, Liu Z, Wei X, Wang B, Cui Y, Xiong S, Sun Q, Gong L, Ni Y, Shang Q,  Xu A, Huang Y, Liu D & Zhu Z (2016) Sodium intake regulates glucose homeostasis through the PPARδ/adiponectin-mediated SGLT2 pathway. Cell Metabolism 23(4):699-711.
  • Li H, Yao W, Liu Z, Xu A, Huang Y, Ma XL, Irwin MG & Xia Z (2016) Hyperglycemia abrogates ischemic postconditioning cardioprotection by impairing adipoR1/caveolin-3/STAT3 signaling. Diabetes 65(4):942-955. With Commentary Diabetes 65(4):826-828.
  • He L, Liu Q, Hu T, Huang X, Zhang H, Tian X, Yan Y, Wang L, Huang Y, Miquerol L, Wythe JD & Zhou B (2016) Genetic lineage tracing discloses arteriogenesis as the main mechanism for collateral growth in the mouse heart. Cardiovascular Research 109(3):419-430. As Editor’s Choice of the Issue.
  • Xie L, Feng H, Li S, Meng G, Liu S, Tang X, Ma Y, Han Y, Xiao Y, Gu Y, Shao Y, Park CM, Xian M, Huang Y, Ferro A, Wang R, Moore PK, Wang H & Ji Y (2016) SIRT3 mediates the anti-oxidant effect of hydrogen sulfide in endothelial cells. Antioxidants & Redox Signaling 24(6):329-343.
  • Gil-Ortega M, Somoza B, Huang Y, Gollasch M, Femandez-Alfonso MS (2015) Regional differences in perivascular adipose tissue impacting vascular homeostasis. Trends in Endocrinology and Metabolism 26(7):367-375
  • Lin Z, Pan X, Wu F, Ye D, Zhang Y, Wang Y, Jin L, Lian Q, Huang Y, Ding H, Triggle C, Wang K, Li X & Xu A (2015) Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and induction of adiponectin in mice. Circulation 131(21):1861-1871.
  • Chen L, Miao Y, Zhang Y, Dou D, Liu L, Tian XY, Yang G, Pu D, Zhang X, Kang J, Gao Y, Wang S, Breyer MD, Wang N, Zhu Y, Huang Y, Breyer RM & Guan Y (2012) Inactivation of prostaglandin E2 receptor subtype 3 attenuates the angiotensin II pressor response via decreasing arterial contractility. Arteriosclerosis, Thrombosis and Vascular Biology 32(12):3024-3032
  • Luo ZD, Ma LQ, He HB, Yang DC, Feng XL, Ma ST, Chen XP, Cao TB, Liu DY, Nilius B, Huang Y, Yan ZC & Zhu ZM (2012) TRPV1 activation improves exercise endurance and energy metabolism through PGC-1α up-regulation in mice. Cell Research 22(3):551-564
  • Yang D, Luo Z, Ma S, Wong WT, Ma L, Feng X, Hao X, Cao T, Zhao Z, Liu D, Arendshorst WJ, Huang Y, Tepel M & Zhu Z (2010) Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension. Cell Metabolism 12(20:130-141 with CoverArt Image and editorial previews [Sessa WC Cell Metabolism 2010;12(2):109-110]
  • Hercule HC, Schunck W-H, Gross V, Seringer J, Leung FP, Weldon SM, Andrey Ch, Goncalves da C, Huang Y, Luft FC & Gollasch M (2009) Interaction between P450 eicosanoids and nitric oxide in the control of arterial tone in mice. Arteriosclerosis, Thrombosis and Vascular Biology 29(1):54-60