** Recent Selective Representative Publications **

Full List of publications in peer-reviewed SCI-indexed journals

2005

• Tang EHC, Feletou M, Huang Y, Man RYK & Vanhoutte PM (2005) Acetylcholine and sodium nitroprusside causes long-term inhibition of EDCF-mediated contraction. American J ournal of Physiology – Heart & Circulatory Physiology 289: H2434-H2440

• Zhang ZS, James AE, Huang Y, Ho WKK, Sahota DS & Chen ZY (2005) Quantification and characterization of aortic cholesterol in rabbits fed a high-cholesterol diet. International Journal of Food Sciences and Nutrition 56(5):359-366

• Xiao Y, Huang Y & Chen ZY (2005) Distribution, depletion and recovery of docosahexaenoic acid are region-specific in brain. British Journal of Nutrition 94(4):544-550

• Ng CH, Leung KY, Huang Y & Chen ZY (2005) Policosanol has no antioxidant activity in human low-density piloprotein but increases excretion of bile acids in hamsters. Journal of Agricultural and Food Chemistry 53:6289-6293

• Leung FP, Yao X, Lau CW, Ko WH, Lu L & *Huang Y (2005) Raloxifene relaxes rat intrarenal arteries by inhibiting Ca2+ influx. American Journal of Physiology – Renal Physiology 289:F137-F144

• Yang L, Leung KY, Cao Y, Huang Y, Ratnayake WMN & Chen ZY (2005) a-Linolenic acid but not conjugated linolenic acid (CLN) is hypocholesterolemic in hamsters. British Journal of Nutrition 93:433-438

• Chen ZW, Huang Y, Yang Q, Yim AP, & He GW (2005) Urocortin-induced relaxation in human internal mammary arteries. Cardiovascular Research 65(4): 913-920

• Chan YC, Leung FP, Yao X, Lau CW, Vanhoutte PM & *Huang Y (2005) Raloxifene relaxes rat pulmonary arteries and veins: roles of gender, endothelium and antagonism of Ca2+ influx. Journal of Pharmacology and Experimental Therapeutics 312(3): 1266-1271

• Lee CH, Yang L, Xu JZ, Yeung SYV, Huang Y & Chen ZY (2005) Relative antioxidant activity of soybean isoflavones and their glycosides. Food Chemistry 90(4):735-741

2004

• Yip H, Chan 7Y, Leung PC, Kwan HY, Liu C, Huang Y, Michel V, Yew DT & Yao X. (2004) Expression of TRPC homologs in endothelial cells and smooth muscle layers of human arteries. Histochemistry and Cell Biology 122:553-561

• Yue GG, Yip TW, Huang Y & Ko WH. (2004) Cellular mechanism for potentiation of Ca2+-mediated Cl- secretion by the flavonoid baicalein in intestinal epithelia. Journal of Biological Chemistry 279(38):39310-39316

• Verlohren S, Dubrovska G, Tsang SY, Essin K, Luft FC, Huang Y & Gollasch M (2004) Visceral perivascular adipose tissue regulates arterial tone of small mesenteric arteries. Hypertension 44(3):271-276. With Editorial Commentary “Regulation of vascular Tone, The Fat Connection, Hypertension 2004;44:255-256

• Tsang SY, Yao X, Chan FL, Wong CM, Chen ZY, Laher I & *Huang Y (2004) Estrogen and tamoxifen modulate cerebrovascular tone in ovariectomized female rats. Hypertension 44(1):78-82

• Tsang SY, Yao X, Essen K, Wong CM, Chan FL, Gollasch M & *Huang Y. (2004) Raloxifene relaxes rat cerebral arteries in intro and inhibits L-type voltage-sensitive Ca2+ channels. Stroke 35(7):1709-1714

• Zhang RZ, Yang Q, Yim AP, Huang Y & He GW. (2004) Different role of nitric oxide and endothelium-derived hyperpolarizing factor in endothelium-dependent hyperpolarization and relaxation in porcine coronary arterial and venous system. Journal of Cardiovascular Pharmacology 43(6):839-850

• Xu JZ, Yeung SYV, Chang Q, Huang Y & Chen ZY (2004) Comparison of antioxidant activity and bioavailability of tea epicatechins with their epimers. British Journal of Nutrition 91(6):873-881

• Chan YC, Yao X, Lau CW, Chan FL, He GW, Bourreau JP & *Huang Y (2004) The relaxant effect of urocortin in the rat pulmonary resistance artery. Regulatory Peptides 121(1-3):11-18

• Su YL, Xu JZ, Ng CH, Leung LK, Huang Y & Chen ZY (2004) Antioxidant activity of tea theaflavins and methylated catechins in canola oil. Journal of The American Oil Chemists’ Society 81(3):269-274

• Liu C, Mather S, Huang Y, Garland CJ & Yao X. (2004) Extracellular ATP facilitates flow-induced vasodilatation in rat small mesenteric arteries. American Journal of Physiology - Heart & Circulatory Physiology 286(5):H1688-H1695

• Lau CW, Chan YC, Yao XQ, Chan FL, Chen ZY & *Huang Y (2004) Nickel inhibits urocortin-induced relaxation in the rat pulmonary artery. European Journal of Pharmacology 488(1-3):169-172

• Lau CW, Chen ZY, Wong CM, Yao XQ, He DZ, Xu HX & *Huang Y (2004) Attenuation of endothelium-mediated relaxation by acteoside in rat aorta: role of endothelial [Ca2+]i and nitric oxide-cyclic GMP pathway. Life Sciences 75(10):1149-1157

• Tsang SY, Yao X, Wong CW, Chan FL, Chen ZY & *Huang Y (2004) Differential regulation of potassium and calcium channel gene expression by chronic treatment with estrogen and tamoxifen in rat aorta. European Journal of Pharmacology 483(2):155-162

• Kwan HY, Huang Y & X Yao (2004) Regulation of cationic transient receptor potential isoform 3 (TRPC3) channel by protein kinase G. Proceedings of The National Academy of Sciences of The United States of America 101(8):2625-2630

• *Huang Y, Wong CM, Lau CW, Yao, XQ, Tsang SY, Su YL & Chen, Z.Y. (2004) Inhibition of nitric oxide/cyclic GMP-mediated relaxation by purified flavonoids, baicalin and baicalein, in rat aortic rings. Biochemical Pharmacology 67(4):787-794

• *Huang Y, Yao X, Lau CW, Chan YC, Tsang SY & Chan FL (2004) Urocortin and cardiovascular protection. Acta Pharmacologica Sinica 25(3):257-265

2003

• Cheng KT, Chan FL, Huang Y, Chan WY & Yao X. (2003) Expression of olfactory-type cyclic nucleotide-gated channel (CNGA2) in vascular tissues. Histochemistry and Cell Biology 120(6):475-481

• Yang L, Huang Y, Wang HQ & Chen ZY (2003) Isomeric distribution of conjugated linoleic acids (CLA) in the tissues of layer hens fed a CLA diet. Journal of Agricultural and Food Chemistry 51(19):5654-5660

• Xu JZ, Leung LK, Huang Y & Chen ZY. (2003) Epimerization of tea polyphenols in tea drinks. Journal of The Science of Food and Agriculture 83(15):1617-1621

• Ho HM, Leung LK, Chan FL, Huang Y & Chen ZY (2003) Soy leaf lowers the ratio of non-HDL to HDL cholesterol in Hamsters. Journal of Agricultural and Food Chemistry 51(16):4554-4558

• Lau KL, Kong SK, Ko WH, Kwan HY, Huang Y & Yao X (2003) cGMP stimulates endoplasmic reticulum Ca2-ATPase in vascular endothelial cells. Life Sciences 73:2019-2028

• Su YL, Leung LK, Huang Y & Chen ZY. (2003) Stability of tea theaflavins and catechins. Food Chemistry 83(2):189-195

• Cheung SY, Yuen MT, Choi HL, Cheng HK, Huang Y, Chen S & Chan FL. (2003) An expression study of hormone receptors in spontaneously developed, carcinogen-induced and hormone-induced mammary tumors in female Noble rats. International Journal of Oncology 22(6):1383-1395

• Yao X & Huang Y (2003) From nitric oxide to endothelial cytosolic Ca2+: a negative feedback control. Trends in Pharmacological Sciences 24(6):263-266

• Yang Q, Ge ZD, Yang CQ, Huang Y & He GW. (2003) Bioassay of endothelium-derived hyperpolarizing factor with abolishment of nitric oxide and the role of gap junctions in the porcine coronary circulation. Drug Development Research 58(1):99-110

• Kwan HY, Leung PC, Huang Y & Yao X (2003) Depletion of intracellular Ca2+ stores sensitizes the flow-induced Ca2+ influx in rat endothelial cells. Circulation Research 92(3): 286-292

• *Huang Y, Chan FL, Lau CW, Tsang SY, Chen ZY, He GW & Yao XQ. (2003) Role of cAMP and Ca2+-actyivated K+ channels in endothelium-independent relaxation by urocortin in the rat coronary artery. Cardiovascular Research 57(3): 824-833

• Yao X, Kwan HY, Dora KA, Garland CJ & Huang Y. (2003) A mechanosensitive cation channel in endothelial cells and its role in vasoregulation. Biorheology40(1-3):23-30

• Tsang SY, Yao XQ Wong CM, Chen ZY & *Huang Y. (2003) Role of Na+-Ca2+ exchanger in pinacidil-induced relaxation in rat mesenteric artery. British Journal of Pharmacology 138(3):453-460

• Cheung SY, Yuen MT, Choi HL, Cheng HK, Huang Y, Chen S & Chan FL. (2003) Expression status of hormone receptors in spontaneously developed mammary tumors in female Noble rats. International Journal of Oncology 22(2):449-457

• Tsang SY, Yao XQ, Chan HY, Wong CM, Chen ZY, AU CL & *Huang Y. (2003) Contribution of K+ channels to relaxation induced by 17s-estradiol but not by progesterone in rat mesenteric artery rings. Journal of Cardiovascular Pharmacology 41(1):4-13

• Wartenberg M, Budde P, Marees M De, Tsang SY, Huang Y, Chen ZY, Hescheler J & Sauer H. (2003) Inhibition of tumor-induced angiogenesis and matrix-metalloproteinase expression in confrantation cultures of ES cell-derived embryoid bodies and multicellular tumor spheroids by antioxidants and plant ingredients used in traditional Chinese medicine. Laboratory Investigation 83(1):87-98

2002

• Tsang SY, Yao XQ, Chan HY, Cehn ZY, Wong CM & *Huang Y. (2002) Effect of 17s-estradiol exposure on vasorelaxation induced by K+ channel openers and Ca2+ channel blockers. Pharmacology 65(1):26-31

• Chen HY, Yao XQ, Tsang SY, Bourreau JP, Chan FL & *Huang Y. (2002) Isoproterenol amplifies 17s-estradiol-mediated vasorelaxation: role of endothelium/nitric oxide and cyclic AMP. Cardiovascular Research 53(3):627-633. Special Issue “Spotlight on Gender”

• Yao XQ, He GW, Chan FL, Lau CW, Tsang SY, Chen ZY & *Huang Y. (2002) Endothelium-dependent and –independent coronary relaxation induced by urocortin. Journal of Cardiac Surgery 17(4):347-349

• *Huang Y, Tsang SK, Yao XQ, Lau CW, Su YL & Chen ZY. (2002) Baicalin-induced vascular response in rat mesenteric artery: role of endothelial nitric oxide. Clinical and Experimental Pharmacology and Physiology 29(8):721-724

• Ko WH, Law WI, Yin YC, Yue GGL, Lau CW, Chen ZY & Huang Y. (2002) Stimulation of chloride secretion by baicalein in isolated rat distal colon. American Journal of Physiology Gastrointestinal and Liver Physiology 282(3):G508-G518

• Chen ZY, Leung LK & Huang Y. (2002) Reply to K.W. Lee, H.J. Lee and C.Y. Lee. On Antioxidant activity of black tea vs. green tea. Journal of Nutrition 132(4):876

• *Huang Y, Chan FL, Lau CW, Tsang SK, He GW, Chen ZY & Yao XQ. (2002) Urocortin-induced endothelium-dependent relaxation of rat coronary artery: role of nitric oxide and K+ channels. British Journal of Pharmacology 135(6):1467-1476

• Zhang ZS, Ho WKK, Huang Y, James AE, Lam LW & Chen ZY. (2002) Hypolipidemic activity of hawthorn fruit in rabbits fed a high-cholesterol diet. Journal of Nutrition 132(1):5-10

• Zhang ZS, Yeung WK, Huang Y & Chen ZY. (2002) Effect of squalene and shark liver oil on serum cholesterol level in Hamsters. International Journal of Food Science and Nutrition 53(5):411-418

• Lohn M, Muzzulini U, Tsang SY, Conrad H, Kirsch T, Litteral J, Waldron P, Klugbauer N, Hofmann F, Haller H, Luft FC, Huang Y & Gollasch M. (2002) Cilnidipine is a novel slow-acting blocker of vascular L-type calcium channelss that does not target protein kinase C. Journal of Hypertension 20(5):885-894

• Yang L, Yeung SY, Huang Y, Wang HQ & Chen ZY (2002) Preferential incorporation of trans, trans-conjugated linoleic acid isomers in the liver of suckling rats. British Journal of Nutrition 87(3):253-260

• Ho HM, Chen RY, *Huang Y & Chen ZY (2002) Vascular effects of a Soy leaves extract and kaempferol glycoside in rat carotid artery. Planta Medica 68(6):487-491

• Herbst M, Greger R, Sasse P, Huang Y, Hescheler J & Ullrich S. (2002) Membrane potential dependent modulations of calcium oscillations in insulin secreting INS-1 cells. Cell Calcium 31(3):115-126

• Chen ZY, Wong IYF, Leung MWS, He ZD & Huang Y (2002) Characterization of antioxidants present in bitter tea (Ligustrum pedunculare). Journal of Agricultural and Food Chemistry 50(26):7530-7535

• Tam WY, Chen ZY, He ZD, Yao XQ, Lau CW & * Huang Y (2002) Enhancement of contraction of rat mesenteric artery by acteoside: role of endothelial nitric oxide. Journal of Natural Products 65(7):990-995

• Yao X, Kwan, HY & Huang Y (2002) A mechanosensitive cation channel in endothelial cells. Journal of Cardiac Surgery 17(4):340-341

• Ji ZN, Ye WC, Liu GQ & Huang Y (2002) Inhibition of telomerase activity and bcl-2 expression in berbamine-induced apoptosis in HL-60 cells. Planta Medica 68(7):596-600

• Zhang ZS, Ho WKK, Huang Y & Chen ZY (2002) Hypocholesterolemic activity of hawthorn fruit is mediated by regulation of cholesterol-7a-hydroxylase and acyl CoA: cholesterol acyltransferase. Food Research International 35(9):885-891

• Chen ZY, Yao XQ, Chan FL, Lau CW & *Huang Y (2002) (-)Epicatechin induces and modulates endothelium-dependent relaxation in the isolated rat mesenteric artery rings. Acta Pharmacologica Sinica (Invited article) 23(12):1188-1192

• Zhang ZS, Chang Q, Zhu M, Huang Y, Ho WKK & Chen ZY (2002) Characterization of antioxidants present in hawthorn fruits. Journal of Nutritional Biochemistry. 12(3):144-152

• Yang L, Huang Y, Wang HQ & Chen ZY (2002) Production of conjugated linoleic acids through KOH-catalyzed dehydration of ricinoleic acid. Chemistry and Physics of Lipids 119(1-2):23-31

• Yang L, Huang Y, James AE, Lam LW & Chen ZY (2002) Differential incorporation of conjugated linoleic acid isomers into the egg yolk lipids. Journal of Agricultural and Food Chemistry 50(17):4941-4946

• Ho HM, Chen RY, Leung LK, Chan FL, *Huang Y & Chen ZY (2002) Difference in flavonoid and isoflavone profile between soybean and soy leaf. Biomedicine & Pharmacotherapy 56(6):289-295

• Cheng CH, Yew DTW, Kwan HY, Zhou Q, Huang Y, Liu Y, Chan WY & Yao X (2002) An endogenous RNA transcript antisense to CNGα1 cation channel mRNA. Molecular Biology of the Cell. 13(10):3696-3705

2001

• Wong YF, *Huang Y, Hen ZD, Lau CW & Chen ZY (2001) Relaxing effects of Ligustrum purpurascens extract and purified acteoside in rat aortic rings. Planta Medica 67(5):317-321

• *Huang Y, Pai R, Lau CW, Chan FL, Chen ZY & Yao XQ. (2001) Modulatory effect of protein kinase C on contractility of rat vas deferens. Pharmacology 62(1): 2-9

• He ZD, *Huang Y, Yao XQ, Lau CW, Law WI & Chen ZY (2001) Purification of phenylethanoids from Brandisia hancei and the antiproliferative effects on aortic smooth muscle. Planca Medica 67 (6): 520-522

• Chen ZY, Zhu QY, Tsang D & Huang Y (2001) Degradation of green tea catechins in drinks. Journal of Agricultural and Food Chemistry 49(1):477-482

• Chen ZY, Wang S, Lee KMS, Huang Y & Ho WKK (2001) Preparation of flavanol-rich green tea extract by precipitation with AlCl3. Journal of the Science of Food and Agriculture 81(10):1034-1038

• Wang ZT, Lau CW, Chen FL, Yao XQ, Chen ZY, He ZD & *Huang Y (2001) Vasorelaxant effects of alpinetin and cardamonin from Alpinia blepharocalyx K. Schum. Journal of Cardiovascular Pharmacology 37(5):596-606

• Chen ZY, Kwan KY & Huang Y (2001) Accumulation and apparent oxidation of 18.2 c,t isomers relative to linoleic acid in rats. British Journal of Nutrition 86:249-255

• Su JP, Huang Y, Lenka N, Hescheler J & Ullrich S (2001) Expression and regulation of depolarization-activated K+ channels in the insulin secreting cell line INS-1. Pflugers Arch-European Journal of Physiology 442(1):49-56

• Chen HY, Yao XQ, Tsang SY, Chan FL, Lau CW & *Huang Y (2001) Different role of endothelium/nitric oxide in 17s-estradiol and progesterone-induced relaxation in rat arteries. Life Sciences 69(14):1609-1617

• Yao XQ, Kwan HY & Huang Y (2001) Stretch-sensitive switching among different channel sublevels of an endothelial cation channels. Biochimica et Biophysica Acta-Biomembrane 1511:381-390

• Wong IYF, He ZD, Huang Y & Chen ZY (2001) Antioxidative activities of phenylethanoid glycosides from Ligustrum Purpurascens. Journal of Agricultural and Food Chemistry 49(6):3113-3119

• *Huang Y, Bourreau JP, Chan HY, Lau CW, Wong WT & Yao XQ (2001) Inhibitory effect of tetrabutylammonium ions on endothelium/nitric oxide-mediated vasorelaxation. Life Sciences 69(14):1661-1672

• Kwan HY, Huang Y & Yao XQ (2001) cGMP abolishes agonist-induced [Ca2+]i oscillations in human bladder epithelial cells. American Journal of Physiology – Renal Physiology 281(6): F1058-F1066

• Lau CW, Yao XQ, Chen ZY, Ko WH & *Huang Y (2001) Cardiovascular effects of berberine. Cardiovascular Drug Reviews (invited article) 19(3)-234-244

** 2011- **

** 2006-2010 **

** 1996-2000 **

** 1987-1995 **