CUHK Huang Yu
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** Recent Representative Publications **

Full List of publications in peer-reviewed SCI-indexed journals

2021

  • Zhang C, He L, Wang L & *Huang Y (2021) 內皮功能障礙的發生機制 (Meditors of endoyhelial dysfunction) 中國科學:生命科學 (Accepted)
  • Ma Z, Yang K, Huang Y & Lui KO (2021) Endothelial contribution to COVID-19: an update on mechanisms and therapeutic implications. Journal of Molecular and Cellular Cardiology (Accepted)
  • Cui Y, Kassmann M, Nickel S, Zhang C, Alenina N, Anistan YM, Schleifenbaum J, Bader M, Welsh DG, Huang Y & Gollasch M (2021) Myogenic vasoconstriction requires canonical Gq/11 signaling of the angiotensin II type 1 receptor. Journal of American Heart Association (Accepted)
  • Zhong W, Cao X, Pan G, Niu Q, Feng X, Xu M, Li M, Huang Y, Yi Q & Yan D (2021) ORP4L is a prerequisite for the induction of T-cell leukemogenesis associated with human T-cell leukemia virus 1. Blood (Accepted)
  • Yan P, li Z, Xiong J, Geng Z, Wei W, Zhang Y, Wu G, Zhuang T, Tian X, Liu J, Sun K, Chen F, Zhang Y, Zeng C, Huang Y & Zhang B (2021) LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity. Cell Reports (Accepted)
  • Gu P, Hui X, Zheng Q, Gao Y, Jin L, Jiang W, Zhou C, Liu T, Huang Y, Liu Q, Nie T, Wang Y, Wang Y, Zhao J, Xu A (2021) Mitochondrial Uncoupling Protein-1 Antagonizes Atherosclerosis by Blocking NLRP3-Inflammasome-dependent Interleukin-1b production. Science Advances (Accepted)
  • Huo M, Cao X, Zhang H, Lau CW, Hong H, Chen FM, Huang Y, Chawla A & Tian XY (2021) Loss of Myeloid Bmal1 Exacerbates Hypertensive Vascular Remodelling Through Interaction with STAT6 in Mice. Cardiovascular Research 2021 Nov 2:cvab336. doi: 10.1093/cvr/cvab336. Online ahead of print.
  • Liang X, Wu S, Geng Z, Liu L, Zhang S, Wang S, Zhang Y, Huang Y & Zhang B (2021) LARP7 suppresses endothelial-to-mesenchymal transition by coupling with the epigenetic repressor TRIM28. Circulation Research 129(9):843-856.
  • Teoh YCJ, Tian XY, Wong YPC, Lau CW, Cheng CK, Tang WLV, Chan CKR, Huang Y & Ng CF (2021) Endothelial dysfunction after androgen deprivation therapy and the possible underlying mechanisms. Prostate 2021 Sep 27. doi: 10.1002/pros.24244. Online ahead of print.
  • Jiang M, Ding H, *Huang Y & Wang L (2021) Shear Stress and Metabolic Disorders-Two Sides of the Same Plaque. Antioxidants & Redox Signaling 2021 Jul 23. doi: 10.1089/ars.2021.0126. Online ahead of print.
  • Cheng CK & *Huang Y (2021) The gut-cardiovascular connection: new era for cardiovascular therapy. Medical Review (Accepted)
  • Zhang H, Dong J, Lau CW, Wei Y & *Huang Y (2021) Berberine reverses nitroglycerin tolerance through suppressing PKCa activity in vascular smooth muscle cells. Cardiovascular Drugs and Therapy 2021 Jul 28. doi: 10.1007/s10557-021-07193-z. Online ahead of print.
  • Liu J, Zhang Y, Qu D, Zhang H, Wang L, Lau CW, Han JY, Pingcuo D, *Huang Y & Liu L (2021) Salvianolic acid B ameliorates vascular endothelial dysfunction through the inhibition of bone morphogenetic protein 4 in diabetic mice. Life Sciences 286:120039.
  • Lui KO & Huang Y (2021) Chaperon mediated autophagy regulates eNOS uncoupling in cardiovascular events. Circulation Research 129(10):946-948. Editorial
  • Cheng CK, Luo JY, Lau CW, Cho WCS, Ng CF, Ma RCW, Tian XY & *Huang Y (2021) A GLP-1 analog lowers ER stress and enhances protein folding to ameliorate homocysteine-induced endothelial dysfunction. Acta Pharmacological Sinica 42(10):1598-1609.
  • Zhang X, Zhou C, Miao L, Tan Y, Zhou Y, Cheong MS, Huang Y, Wang Y, Yu H & Cheang WS (2021) Panax Notoginseng Protects against Diabetes-associated Endothelial Dysfunction: Comparison between Ethanolic Extract and Total Saponin. Oxidative Medicine and Cellular Longevity Volume 2021, Article ID 4722797, 10 pages.
  • Huang J, Pu Y, Zhang H, Xie L, He L, Zhang C, Cheng CK, Huo Y, Wan S, Chen S, Huang Y, Lau CW, Wang L, Xia Yin, *Huang Y & Luo JY (2021) Endothelial KLF2 mediates the suppressive effect of laminar flow on vascular calcification by inhibiting BMP/SMAD1/5 signaling. Circulation Research 129(4):e87-e100
  • Zhou Y, Murugan DD, Khan H, Huang Y & Cheang WS (2021) Roles and therapeutic implications of endoplasmic reticulum stress and oxidative stress in cardiovascular diseases. Antioxidants 10(8):1167 (17 pages)
  • Xiang L, Nie J, Wang L, Wang Y, Shi J, Wei J, Lau CW, Cai ZW & *Huang Y (2021) Integrated metabolomics analysis of the effect of PPARd agonist GW501516 on catabolism of BCAAs and carboxylic acids in diabetic mice. Chinese Chemical Letters 32(7):2197-2202.
  • Zheng C, Zhang X, Sheridan S, Ho STR, Huang Y & Wong SHS (2021) Effect of sedentary behavior interventions on vascular function in healthy adults: A systematic review and meta-analysis. Scandinavian Journal of Medicine and Science 31(7):1195-1410
  • Zheng CB, Yang W, Gao G, Xie M, Li Z, Ma X, Song W, Luo D, Huang Y, Yang J, Zhang P, Huang Y & Yao XQ (2021) Ang II promotes cardiac autophagy and hypertrophy via Orai1/STIM1. Frontiers in Pharmacology 17 May 2021, Volume: 12; Article: 622774 | https://doi.org/10.3389/fphar.2021.622774
  • Zhao S, Cheng CK, Zhang CL & *Huang Y (2021) Interplay between oxidative stress, cyclooxygenases and prostanoids in cardiovascular diseases. Antioxidants & Redox Signaling 34(10):784-799 with Cover Image.
  • Tam CHT, Lim CKP, Luk AOY, Ng ACW, Lee HM, Jiang G, Lau ESH, Fan B, Wan R, Kong AKS, Tam WH, Ozaki R, Chow EYK, Lee KF, Siu SC, Hui G, Tsang CC, Lau KP, Leung JYY, Tsang MW, Kam G, Lau IT, Li JKY, Yeung VTF, Lau E, Lo S, Fung S, Cheng YL, Chow CC, Hu M, Yu W, Tsui SKW, Huang Y, Lan H, Szeto CC, Tang NLS, Ng MCY, So WY, Tomlinson B, Chan JCN, Ma RCW, The Hong Kong Diabetes Register TRS Study Group, The Hong Kong Diabetes Biobank Study Group. (2021) Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidaemia, subclinical atherosclerosis and diabetes cardiovascular complications among East Asians. Genome Medicine 2021 13:29
  • Cheng CK, Wang C, Shang W, Lau CW, Luo JY, Wang L & *Huang Y (2021) A high methionine and low folate diet alters glucose homeostasis and gut microbiome. Biochemistry and Biophysics Reports 24 (March 2021): article 100921


 
2020

  • Liu J, Xie X, Yan D; Wang Y , Yuan H , Cai Y , Luo J, Xu A, Huang Y, Cheung CW, Irwin MG & Xia Z (2020) Upregulation of FoxO1 contributes to adverse vascular remodeling in type 2 diabetic rat. Journal of Cellular and Molecular Medicine 24(23): 13727-13738.
  • Xiang L, Zhu L, Huang Y & Cai ZW (2020) Application of derivatization in fatty acids and fatty acyls detection: Mass spectrometry-based targeted lipidomics. Small Methods 4(8); 2000160 (19 pages).
  • Zhang Y, Wang S, Huang H, Zeng A, Han Y, Zeng C, Zheng S, Ren H, Wang Y, Huang Y, Jose PA, Ma XL, Zeng C & Chen K (2020) GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension. Clinical Science 134(8):2453-2467.
  • Zhao L, Li Z, Vong JSL, Chen X, Lai HM, Yan LYC, Huang J, Sy SKH, Tian XY, Huang Y, Chan HYE, So HC, Ng WL, Tang Y, Lin WJ, Mok VCT & Ko H (2020) Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain. Nature Communications (2020)11:4413 (15 pages) https://doi.org/10.1038/s41467-020-18249-3.
  • Mohd Farhan M, Silva M, Xingan X, Huang Y & Zheng W (2020) Role of FOXO transcription factors in cancer metabolism and angiogenesis. Cells 9(7), 1586 (18 pages); https://doi.org/10.3390/cells9071586
  • Yang F, Zhang Y, Zhu J, Wang J, Jiang Z, Zhao C, Yang Q, Huang Y, Yao W, Pang W, Han L &  Zhou J (2020) Laminar Flow Protects Vascular Endothelial Tight Junctions and Barrier Function via Maintaining the Expression of Long Non-coding RNA MALAT1. Frontiers in Bioengineering and Biotechnology. June 2020;8:647 (16 pages)
  • Xu C, Wang L, Zhang Y, Li W, Li J, Wang Y, Meng C, Qin J, Zheng ZH, Lan HY, Mak KKL, Huang Y & Xia Y (2020) Tubule-specific Mst1/2 deficiency induces CDK via YAP and non-YAP mechanisms. Journal of the American Society of Nephrology 31(5):946-961 with editorial (Journal of the American Society of Nephrology 2020;31(5):893-894.)
  • Fan G, Kaßmann M, Cui Y, Matthaeus C, Kunz S, Zhong C, Zhu S, Xie Y, Tsvetkov D, Daumke O, Huang Y & Gollasch M (2020) Age attenuates the T-type CaV3.2-RyR axis in vascular smooth muscle. Aging Cell 19(4):e13134 (14 pages).
  • Liang C, Yang KY, Chan VW, Li X, Fung THW, Wu Y, Tian XY, Lau J, Huang Y, Qin L & Lui KO (2020) CD8+ T-cell plasticity regulates vascular regeneration in type-2 diabetes. Theranostics 10(9):4217-4232.
  • Cheng CK, Luo JY, Lau CW, Chen ZY, Tian XY & *Huang Y (2020) Pharmacological Basis and New Insights of Resveratrol Action in the Cardiovascular System. British Journal of Pharmacology 177(6):1258-1277.
  • Qu D, Wang L, Huo M, Song W, Lau CW, Xu J, Xu A, Yao X, Chiu JJ, Tian XY & *Huang Y (2020) Focal TLR4 activation mediates disturbed flow-induced endothelial inflammation. Cardiovascular Research 116(1):226-236. doi: 10.1093/cvr/cvz046.
  • Zou X, Wang J, Chen C, Tan X, Huang Y, Jose PA, Yang J & Zeng C (2020) Secreted monocyte miR-27a, via mesenteric arterial Mas receptor-eNOS pathway, causes hypertension. American Journal of Hypertension 33(1):31-42.

2019

  • Qu D, Huo M, Wang L, Lau CW, Tian XY & *Huang Y (2019) Nilotinib activates endothelial TLR4 to exacerbate atherosclerosis. bioRxiv page 876599 (Cold Spring Harbor Laboratory), doi: https://doi.org/10.1101/2019.12.14.876599
  • Boulanger CM, Baretella O, Blaise G, Bond RA, Cai Y, Chan CKY, Chataigneau T, Chen MJ, Chen H, Cheng Y, Clement DL, Cohen RA, Collis M, Danser AHJ, de Mey J, Detremmerie CMS, Duprez D, Feletou M, Flavahan N, Gao Y, Guo Y, Hoeffner U, Houston DS, Huang IB, Huang Y, Iliano S, Junquero D, Katusic ZS, Komori K, Lee MYK, Leung SWS, Li Z, Liang SC, Liu JTC, Luscher TF, Michel F, Miller VM, Mombouli JV, Morrison K, Muldoon SM, O'Rourke S, Perrault L, Quignard JF, Rusch NJ, Sanchez-Ferrer CF, Schini-Kerth V, Shen K, Shi Y, Song E, Sun KWY, Taddei S, Tang EHC, Tuncer M, van den Ende R, Vedernikov Y, Verbeuren TJ, Webb C, Weigert A, Wong KHK, Xu C, Yang K, Ying F, Zellers T, Zhao Y, Zou Q, Shimokawa H; Professor Paul M. Vanhoutte’s former fellows (2019) Tribute to Paul M. Vanhoutte, MD PhD (1940-2019) Arteriosclerosis, Thrombosis, and Vascular Biology 39(12):2445-2447. doi: 10.1161/ATVBAHA.119.313461
  • Yao L, He J, Li B, Yan M, Wang H, Tan L, Liu M, Lv X, Lv H, Zhang X, Chen C, Wang D, Yu Y, Huang Y, Zhu Y & Ai D (2019) Regulation of Yap by mammalian target of rapamycin complex 1 in endothelial cells controls blood pressure through COX-2/mPGES-1/PGE2 cascade. Hypertension 74(4):936-946

  • Gao P, Li L, Yang L, Gui D, Zhang J, Han J, Wang J, Wang N, Lu J, Chen S, Hou L, Sun H, Xie L, Zhou J, Peng C, Lu Y, Peng X, Wang C, Miao J, Ozcan U, Huang Y, Jia W & Liu J (2019) Yin Yang 1 protein ameliorates diabetic nephropathy pathology through transcriptional repression of TGFβ1. Science Translational Medicine 11(510):eaaw2050 (14 pages). DOI: 10.1126/scitranslmed.aaw2050

  • Kaßmann M, Szijártó IA, García-Prieto CF, Fan G, Schleifenbaum J, Anistan YM, Tabeling C, Shi Y, Noble FL, Witzenrath M, Huang Y, Markó L, Nelson MT & Gollasch M (2019) Role of Ryanodine Type 2 Receptors in Elementary Ca2+ Signaling in Arteries and Vascular Adaptive Responses. Journal of the American Heart Association 8(9):e010090. doi: 10.1161/JAHA.118.010090 (20 pages)
  • Zhu L, Xu C Huo X, Hao H, Wan Q, Chen H, Zhang X, Wang X, Huang Y, Breyer RM, Cao X, Liu DP, FitzGeral GA & Wang M (2019) The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury. Nature Communications2019 Apr 23;10(1):1888. doi: 10.1038/s41467-019-09492-4 (12 pages)
  • Zhang L, Tian XY, Chan C, Bai Q, Cheng CK, Chen F, Cheung M, Yin B, Yang H, Yung WY, Chen Z, Ding F, Leung K, Zhang C, Huang Y, Lau YW & Choi CH (2019) Promoting the delivery of nanoparticles to atherosclerotic plaques by DNA coating. ACS Applied Materials & Interfaces 11(15):13888-13904.
  • Song W, Zhang CL, Gou L, He L, Gong YY, Qu D, Zhao L, Jin N, Chan TF, Wang L, Tian XY, *Luo JY & *Huang Y (2019) Endothelial TFEB (Transcription Factor EB) Restrains IKK (IκB Kinase)-p65 Pathway to Attenuate Vascular Inflammation in Diabetic db/db Mice. Arteriosclerosis, Thrombosis and Vascular Biology 39(4):719-730.
  • Geng L, Liao B, Jin L, Huang Z, Triggle CR, Ding H, Zhang J, Huang Y, Lin Z & Xu A (2019) Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues. Cell Reports 26(10):2738-2752.
  • Guo Y, Xu C, Man AWC, Bai B, Luo C, Huang Y, Xu A, Vanhoutte PM & Wang Y (2019) Endothelial SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase in smooth muscle cells. Cardiovascular Research 115(3):678-690
  • Qin L, Sun FH, Huang Y, Sheridan S, Sit CHP & Wong SHS (2019) Effect of pre-exercise ingestion of alpha-lactalbumin on subsequent endurance exercise performance and mood states. British Journal of Nutrition 121(1):22-29.
  • Cheang WS, Wong WT, Wang L, Cheng CK, Lau CW, Ma RCW, Xu A, Wang N, *Huang Y & *Tian XY (2019) Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor δ. Pharmacological Research 139:384-394.
  • Liang C, Zhang Y, Zhuo D, Lo CY, Yu L, Lau CW, Kwan YW, Tse G, Huang Y & Yao X (2018) Endothelial cell transient receptor potential channel C5 (TRPC5) is essential for endothelium-dependent contraction in mouse carotid arteries. Biochemical Pharmacology 159:11-24.

 

2018

  • Cheng CK, Abu Bakar H, Gollasch M & *Huang Y (2018) Perivascular adipose tissue: the sixth man of the cardiovascular system. Cardiovascular Drugs and Therapy 32(5):481-502.
  • Luo H, Guo L, Chen C, Xu Z, Peng X, Wang X, Wang J, Wang N, Li C, Luo X, Wang H, Jose P, Fu C, Huang Y, Shi W & Zeng C (2018) Exposure to maternal diabetes causes renal dopamine D1 receptor dysfunction and hypertension in adult rat offspring. Hypertension 72(4):962-970.
  • Yang J, Wong LY, Tian XY, Wei R, Lai WH, Au KW, Luo Z, Ward C, Ho WI, Ibañez DP, Liu H, Bao X, Huang Y, Esteban MA & Tse HF  (2018) A familial hypercholesterolemia human liver chimeric mouse model using induced pluripotent stem cell-derived hepatocytes. Journal of Visualized Experiments (139), e57556
  • Lu Z, Wei X, Sun F, Zhang H, Gao G, Pu Y, Chen J, Tong W, Li Q, Zhou X, Yan Z, Zheng H, Yang G, Huang Y, Liu D & Zhu Z (2018) Non-insulin-determinant pathways maintain glucose homeostasis upon metabolic surgery. Cell Discovery 2018(4):58 (16 pages)
  • Xiang L, Zhang H, Wei J, Tian XY, Luan H, Li S, Zhao H, Cao G, Chung ACK, Yang C, *Huang Y & *Cai Z (2018) Metabolomics studies on db/db diabetic mice in skeletal muscle reveal effective clearance of overloaded intermediates by exercise. Analytica Chimica Acta 1037:130-139.
  • Gong Y, Luo JY, Wang L & *Huang Y (2018) MicroRNAs regulating reactive oxygen species in cardiovascular diseases. Antioxidants & Redox Signaling 29(11):1092-1107
  • Tang TT, Li YY, Li JJ, Wang K, Dong WY, Xia N, Nie SF, Zhang M, Zeng ZP, Lv BJ, Jiao J, Liu H, Xian ZS, Yang XP, Hu Y, Liao YH, Wang Q, Tu X, Mallat Z, Huang Y, Shi GP & Cheng X (2018) Liver-heart crosstalk controls IL22 activity in cardiac protection after myocardial infarction. Theranostics 8(16):4552-4562.
  • Amor S, Martín-Carro B, Rubio C, Carrascosa JM, Hu W, Huang Y, Garcia-Villalon A & Granado M (2018) Study of insulin vascular sensitivity in aortic rings and endothelial cells from aged rats subjected to caloric restriction: Role of perivascular adipose tissue. Experimental Gerontology 109(2018):126-136
  • Leung OM, Li J, Li X, Chan V, Yang KY, Ku M, Lu J, Sun H, Waldmann H, Tian X, Huang Y, Lau J, Zhou B & Lui KO (2018) Regulatory T-cells promote apelin-mediated sprouting angiogenesis in type-2 diabetes. Cell Reports 24(6):1610-1626.
  • *Tian XY, Ma S, Tse Ga, Wong WT & *Huang Y (2018) Uncoupling protein 2 in cardiovascular health and disease. Frontiers in Physiology (Vascular Physiology) Volume 9:; Article 1060 (13 pages)
  • Zhang H, Yang F, Guo Y, Wang L, Fang F, Wu H, Nie S, Wang Yifan, Fung ML, Huang Y, Deng H, Qin Y, Ma X & WeI Y (2018) The contribution of chronic intermittent hypoxia to OSAHS: from the perspective of serum extracellular microvesicle proteins. Metabolism – Clinical and Experimental 85(2018):97-108.
  • Zhang H, Liu J, Qu D, Wang L, Wong CM, Lau CW, Huang Y, Wang YF, Huang H, Xia Y, Xiang L, Cai Z, Liu P, Wei Y, Yao X, Ma RCW & *Huang Y (2018) Serum exosomes mediate delivery of arginase 1 as a novel mechanism for endothelial dysfunction in diabetes. Proceedings of the Academy of National Sciences USA. 115(29):E6927-E6936.
  • Wang X, Huang Y & Ji Y (2018) Spotlight on small molecules in cardiovascular diseases. British Journal of Pharmacology 175(8):1111-1113. Editorial,
  • Huang H, Xu C, Wang Y, Meng C, Liu W, Zhao Y, Huang XR, You W, Feng B, Zheng ZH, Huang Y, Lan HY, Qin J & Xia Y (2018) Lethal (3) malignant brain tumor like 2 (L3MBTL2) protects against kidney injury by inhibiting the DNA damage-p53-apoptosis pathway in renal tubular cells. Kidney International 93(4):855-870
  • Mannaa M, Markó L, Balogh A, Vigolo E, N’diaye G, Kaßmann M, Michalik L, Weichelt U, Schmidt–Ott KM, Liedtke WB, Huang Y, Müller DN, Kuebler WM & Gollasch M (2017) The Role of Transient Receptor Potential Vanilloid 4 Channels in Tubular Damage After Acute Renal Ischaemia Reperfusion Injury. Scientific Reports 8(1):4878. doi: 10.1038/s41598-018-23165-0.
  • Liu W, Chen B, Wang Y, Meng C, Huang H, Huang XR, Qin J, Mulay SR, Anders HJ, Qiu A, Yang B, Freeman GJ, Lu HAJ, Lin HY, Zheng Z, Lan HY, Huang Y & Xia Y (2018) RGMb protects against acute kidney injury by inhibiting tubular cell necroptosis via an MLKL-dependent mechanism. Proceedings of the Academy of National Sciences USA 115(7):E1475-E1484.
  • Sun L, Meng Z, Zhu Y, Lu J, Li Z, Zhao Q, Huang Y, Jiang L & Yao X (2018) TM9SF4 is a novel factor promoting autophagic flux under amino acid starvation. Cell Death and Differentiation 25(2):368-379
  • Gou L, Zhao L, Song W, Wang L, Liu J, Zhang H, Huang Y, Lau CW, Yao XQ, Tian XY, Wong WT, Luo JY & *Huang Y (2018) Inhibition of miR-92a suppresses oxidative stress and improves endothelial function by upregulating heme oxygenase-1 in db/db mice. Antioxidants & Redox Signaling 28(5):358-370.
  • Wang L, Zhu H, Zhao Y, Jiao R, Lei L, Chen J, Wang X, Zhang Z, Huang Y, Wang T  & Chen ZY (2018) Cranberry anthocyanin as an herbal medicine lowers plasma cholesterol by increasing excretion of fecal sterols. Phytomedicine. 38:98-106.
  • Chan KW, Zhang L, Cheng CK, Yang H, Huang Y, Tian XY & Choi CH (2018) Recent advances in managing atherosclerosis via nanomedicine. Small 14(4):1702793 (16 pages)
  • Zhu ZM, Gao P & Huang Y (2018) Turning dilatation into constriction: Endothelial TRPV4 (transient receptor potential vanilloid 4) matters. Hypertension 71(1):56-58

2017

  • Wang Y, Zhang X, Huang H, Xia Y, Yao Y, Mak AFT, Yung PSH, Chan KM, Wang L, Zhang C, Huang Y & Mak KKL (2017) Osteocalcin expressing cells from tendon sheaths in mice contribute to tendon repair by activating Hedgehog signaling. eLife 2017;6:e30474, DOI: 10.7554/eLife.30474.

  • Zheng C, Zhong M, Qi Z, Shen F, Zhao Q, Wu L, Huang Y, Tsang SY & Yao X (2017) Histone deacetylase (HDAC) inhibitors relax mouse aorta partly by their inhibitory action on L-type Ca2+ channels. Journal of Pharmacology and Experimental Therapeutics. 363(2):211-220.
  • Xiang L, Wei J, Tian XY, Wang B, Chan W, Li S, Tang Z, Zhang H, Cheang WS, Zhao Q, Zhao H, Yang Z, Hong Y, *Huang Y & *Cai Z. (2017) Comprehensive analysis of acylcarnitine species in db/db mouse using a novel method of high resolution parallel reaction monitoring reveals widespread metabolic dysfunction induced by diabetes. Analytical Chemistry 89(19):10368-10375.
  • Qin L, Wong SH, Sun F-H, Huang Y, Sheridan S & Sit CHP (2017) Effects of alpha-lactalbumin or whey protein isolate on muscle damage, muscle pain and mood states following prolonged strenuous endurance exercise. Frontiers in Physiology – Exercise Physiology Volume 8; Article 754; doi.org/10.3389/fphys.2017.00754
  • Zhou M, Mok MTS, Sun H, Chan AWH, Huang Y, Cheng ASL & Xu G (2017) The anti-diabetic drug exenatide, a glucagon like peptide-1 receptor agonist, counteracts hepatocarcinogenesis through cAMP-PKA-EGFR-STAT3 axis. Oncogene 36(29):4135-4140.
  • Ling WC, Liu J, Lau CW, Murugan DD, Mustafa MR & *Huang Y (2017) Treatment with salvianolic Acid B restores endothelial function in angiotensin II-induced hypertensive mice. Biochemical Pharmacology 136 (2017):76-85.
  • Qin L, Wong SH, Sun F-H, Huang Y, Sheridan S & Sit CHP (2017) The Effect of carbohydrate and protein co-ingestion on energy substrate metabolism, sense of effort, and affective responses during prolonged strenuous endurance exercise. Physiology & Behavior 174 (2017):170-177.
  • Zheng C, Lo C-Y, Li Z, Zhong M, Zhang P, Lu J, Yang Z, Yan F, Zhang Y, Huang Y & Yao X (2017) Gastrodin alleviates cardiac hypertrophy via its action on store-operated Ca2+ entry. Frontiers in Pharmacology - Cardiovascular and Smooth Muscle Pharmacology 8:article 222
  • Yang J, Wang Y, Zhou T, Wong LY, Tian XY, Hong X, Lai WH, Au KW, Wei R, Liu Y, Cheng LH, Liang G, Huang Z, Fan W, Zhao P, Wang X, Ibanez DP, Luo Z, L\i Y, Chen S, Wang D, Qin B, Siu CW, Huang Y, Esteban MA & Tse HF (2017) Generation of a human liver chimeric mouse model with hepatocytes derived from familiar hypercholesterolemia induced pluripotent stem cells. Stem Cell Reports. 8(3):606-618.
  • Huo M, Huang YH, Qu D, Zhang H, Wong WT, Chawla A, Huang Y & Tian XY (2017) Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis. FASEB Journal 31(3):1097-1106.
  • Cheang WS, Wong WT, Zhao L, Xu J, Wang L, Lau CW, Chen ZY, Ma RCW, Xu A, Wang N, *Tian XY & *Huang Y (2017) PPARδ Is required for exercise to attenuate endoplasmic reticulum stress and endothelial dysfunction in diabetic mice. Diabetes 66(2):519-528.
  • Tsvetkov D, Kabmann M, Tano JY, Lan C, Schleifenbaum J, Voelkl J, Lang F, Huang Y & Gollasch M (2017) Do KCNQ1 channels contribute to control of arterial vascular tone? British Journal of Pharmacology 174(2):150-162.

 

2016

  • Wang L, Luo JY, Li B, Tian XY, Chen LJ, Huang Y, Liu J, Deng D, Lau CW, Wan S, Ai D, Mak KL, Tong KK, Kwan KM, Wang N, Chiu JJ, *Zhu Y & *Huang Y (2016) Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature 540:579-581. Commented in Nature News and Views, Nature 540:531-532.

  • Liu C & *Huang Y (2016) Chinese herbal medicine on cardiovascular diseases and the mechanisms of action. Frontiers in Pharmacology 7: Article 469. 01 December 2016 | http://dx.doi.org/10.3389/fphar.2016.00469

  • Choy KW, Mustafa MR, Lau YS, Liu J, Murugan D, Lau CW, Wang L, Zhao L & *Huang Y (2016) Paeonol protects against endoplasmic reticulum stress-induced endothelial dysfunction via AMPK/PPARd signalling pathway. Biochemical Pharmacology 116:51-62.
  • Lau EOC, Lo CY, Yao Y, Mak AFT, Jiang L, Huang Y & Yao X (2016) Aortic baroreceptors display higher mechanosensitivity than carotid baroreceptors. Frontiers in Physiology 7:article 384.
  • *Tse G, Yan BP, Chan YWF, Tian XY & *Huang Y (2016) Reactive oxygen species, endoplasmic reticulum stress and mitochondrial dysfunction: the link with cardiac arrhythmogenesis. Frontiers in Physiology 7:article 313.
  • Leung FP, Yung LM, Ngai CY, Cheang WS, Tian XY, Lau CW, Zhang Y, Liu J, Chen ZY, Bian ZX, Yao X & *Huang Y (2016) Chronic black tea consumption improves endothelial function in ovariectomized rats. European Journal of Nutrition 55(5):1963-1972.
  • Lau OC, Shen B, Wong CO, Tjong YW, Lo CY, Wang HC, Huang Y, Yung WH, Chen Y, Fung ML, Rudd JA & Yao X (2016) TRPC5 channels participate in pressure-sensing in aortic baroreceptors. Nature Communications 2016 Jul 14;7:11947. doi: 10.1038/ncomms11947.
  • Tsvetkov D, Shymanets A, Huang Y, Bucher K, Piekorz R, Hirsch E, Beer-Hammer S, Harteneck C, Gollasch M & Bernd Nürnberg (2016) Better understanding of phosphoinositide 3-kinase (PI3K) pathways in the vasculature: towards precision therapy targeting angiogenesis and tumor blood supply? Biochemistry – Moscow 81(7):691-699.
  • Tian XY, Wong WT, Lau CW, Wang YX, Cheang WS, Liu J, Lu Y, Huang H, Xia Y, Chen ZY, Mok CSD, Lau CM & *Huang Y (2016) Melamine impairs renal and vascular function in rats. Scientific Reports 6:28041
  • Xu A & *Huang Y (2016) A tireless giant in vascular research. Journal of Cardiovascular Pharmacology (Editorial for a special issue on Targeting Vascular Dysfunction) 67(5):359-360.
  • Zhang H, Liu J, Qu D, Wang L, Luo JY, Lau CW, Liu P, Gao Z, Tipoe, GL, Lee HK, Ng CF, Ma RCW, Yao X & *Huang Y (2016) Inhibition of miR-200c restores endothelial function in diabetic mice through suppression of COX-2. Diabetes 65(5):1196-1207 with Commentary Diabetes 65(5):1152-1154.
  • Zhao Y, Gao P, Sun F, Li Q, Yu H, Li L, Wei X, Chen J, He H, Liu Z, Wei X, Wang B, Cui Y, Xiong S, Sun Q, Gong L, Ni Y, Shang Q,  Xu A, Huang Y, Liu D & Zhu Z (2016) Sodium intake regulates glucose homeostasis through the PPARδ/adiponectin-mediated SGLT2 pathway. Cell Metabolism 23(4):699-711.
  • Li H, Yao W, Liu Z, Xu A, Huang Y, Ma XL, Irwin MG & Xia Z (2016) Hyperglycemia abrogates ischemic postconditioning cardioprotection by impairing adipoR1/caveolin-3/STAT3 signaling. Diabetes 65(4):942-955. With Commentary Diabetes 65(4):826-828.
  • Tian XY, Ma S, Huang Y & Wong WT (2016) A revisit of the renin-angiotensin system in cardiovascular biology. Trends in Cardiovascular Medicine 26(3):229-231.
  • Ma S, Tian XY, Zhang Y, Mu C, Shen H, Bismuth J, Pownall HJ, Huang Y & Wong WT (2016) E-selectin-targeting delivery of microRNAs by microparticles ameliorates endothelial inflammation and atherosclerosis. Scientific Reports 2016 Mar 9;6:22910. doi: 10.1038/srep22910.
  • He L, Liu Q, Hu T, Huang X, Zhang H, Tian X, Yan Y, Wang L, Huang Y, Miquerol L, Wythe JD & Zhou B (2016) Genetic lineage tracing discloses arteriogenesis as the main mechanism for collateral growth in the mouse heart. Cardiovascular Research 109(3):419-430. As Editor’s Choice of the Issue.
  • Hu W, Zhang Y, Wang L, Lau CW, Xu J, Luo JY, Gou L, Yao XY, Chen ZY, Ma RCW, Tian XY & *Huang Y (2016) Bone morphogenic protein 4-Smad induced upregulation of platelet-derived growth factor AA impairs endothelial function. Arteriosclerosis, Thrombosis and Vascular Biology 36(3):553-560.
  • Xie L, Feng H, Li S, Meng G, Liu S, Tang X, Ma Y, Han Y, Xiao Y, Gu Y, Shao Y, Park CM, Xian M, Huang Y, Ferro A, Wang R, Moore PK, Wang H & Ji Y (2016) SIRT3 mediates the anti-oxidant effect of hydrogen sulfide in endothelial cells. Antioxidants & Redox Signaling 24(6):329-343.
  • Lei L, Li YM, Wang XB, Liu YW, Ma KY, Wang LJ, Man SW, Zhang CN, Huang Y & Chen ZY (2016) Plasma triacylglycerol-lowering activity of citrus polymethoxylated flavones is mediated by modulating the genes involved in lipid metabolism in hamsters. European Journal of Lipid Science and Technology. 118(2):147-156.

  • Miernisha A, Bi CW, Cheng LK, Xing JG, Liu J, Maiwulanjiang M, Aisa HA, Dong TT, Lin H, Huang Y & Tsim KW (2016) Badiranji Buya Keli, a Traditional Uyghur Medicine, induces vasodilation in rat artery: signaling mediated by nitric oxide production in endothelial cells. Phytotherapy Research 30(1):16-24. doi: 10.1002/ptr.5494.
  • Sun Y, Lau CW, Jia Y, Li Y, Wang W, Ran J, Li F, Huang Y, Zhou H & Yang B (2016) Functional inhibition of urea transporter UT-B enhances endothelial-dependent vasodilation and lowers blood pressure via L-arginine-endothelial nitric oxide synthase-nitric oxide pathway. Scientific Reports 2016 Jan 7;6:18697. doi: 10.1038/srep18697.

2015

  • Dharmani Devi M*, Lau YS, Lau CW, Mohd Rais M & *Huang Y (2015) Angiotensin 1-7 protects against angiotensin II-induced endoplasmic reticulum stress and endothelial dysfunction via Mas receptor. PLoS One 2015 Dec 28;10(12):e0145413.
  • Cheang WS, Tian XY, Wong WT, *Huang Y (2015) Peroxisome proliferator-activated receptors in cardiovascular diseases: experimental benefits and clinical challenges. British Journal of Pharmacology 172(23):5512-5522.
  • Li Y, Zhang M, Xiao H, Fu H, Ho A, Li Cn, Huang Y, Lin G & Bian Z (2015) Addition of berberine to 5-aminosalicylic acid for treatment of dextran sulfate sodium-induced chronic colitis in C57BL/6 mice. PLoS One 10(12):e0144101.
  • Wang X, Cheang WS, Yang H, Xiao L, Lai B, Zhang M, Ni J, Luo Z, Zhang Z, Huang Y & Wang N (2015) Nuciferine relaxes rat mesenteric arteries through endothelium-dependent and -independent mechanisms. British Journal of Pharmacology 172(23):5600-5618.
  • Hu W & *Huang Y (2015) Targeting platelet-derived growth factor signaling in cardiovascular disease. Clinical and Experimental Pharmacology and Physiology 42(12):1221-1224 with Cover Image of the issue.
  • Wang Y, Li ZC, Zhang P, Poon E, Kong CW, Boheler KR, Huang Y, Li RA & Yao X (2015) Nitric oxide-cGMP-PKG pathway acts on orai1 to inhibit the hypertrophy of human embryonic stem cell-derived cardiomyocytes. Stem Cells 33(10):2973-2984.
  • Zhang Y, Liu J, Luo JY, Tian XY, Cheang WS, Xu J, Lau CW, Wang L, Wong WT, Wong CM, Lan HY, Yao XQ, Raizada MK & *Huang Y (2015) Upregulation of angiotensin (1-7)-mediated signaling preserves endothelial function through reducing oxidative stress in diabetes. Antioxidants & Redox Signaling 23(11):880-892 with Cover Image of the Issue.
  • Xiang L, Cheang WS, Wang L, Lin S, Li Y, *Huang Y & *Cao Z (2015) Plasma metabolic signatures reveal regulatory effect of exercise training in db/db mice. Molecular BioSystems 11(9):2588-2596
  • Qi Y, Li Z, Kong CW, Tang NL, Huang Y, Li RA & Yao X (2015) Uniaxial cyclic stretch stimulates TRPV4 to induce realignment of human embryonic stem cell-derived cardiomyocytes. Journal of Molecular and Cellular Cardiology 87:65-73
  • Qi Y, Qi Z, Li Z, Wong CK, So C, Lo IC, Huang Y, Yao X & Tsang SY (2015) Role of TRPV1 in the differentiation of mouse embryonic stem cells into cardiomyocytes. PLoS One 10(7):e0133211
  • Luo JY, Zhang Y, Wang L & *Huang Y (2015) Regulators and effectors of BMP signaling in the cardiovascular system. The Journal of Physiology 593(14):2995-3011
  • Wang X, Guan L, Zhao Y, Lei, L Liu Y, Wang L, Man SW, Wang J, Huang Y & Chen ZY (2015) Plasma cholesterol-lowering activity of dietary dihydrocholesterol in hypercholesterolemia hamsters. Atherosclerosis 242(1):77-86
  • Gil-Ortega M, Somoza B, Huang Y, Gollasch M, Femandez-Alfonso MS (2015) Regional differences in perivascular adipose tissue impacting vascular homeostasis. Trends in Endocrinology and Metabolism 26(7):367-375
  • Ru X, Zheng C, Zhao Q, Lan HY, Huang Y, Wan S, Mori Y & Yao X (2015) Transient receptor potential channel M2 contributes to neointimal hyperplasia in vascular walls. BBA - Molecular Basis of Disease 1852(7):1360-1371.
  • Shao D, Ni J, Shen Y, Liu J, Zhou L, Xue H, Huang Y, Zhang W & Lu L.(2015) CHOP mediates XBP1S-induced renal mesangial cell necrosis following high glucose treatment. European Journal of Pharmacology 758:89-96.
  • Cheang WS, Ngai CY, Tam YY,  Tian XY, Wong WT, Zhang Y, Lau CW, Chen ZY, Bian ZX, *Huang Y & Leung FP (2015) Black tea protects against hypertension-associated endothelial dysfunction through alleviation of endoplasmic reticulum stress. Scientific Reports 5:10340
  • Lin Z, Pan X, Wu F, Ye D, Zhang Y, Wang Y, Jin L, Lian Q, Huang Y, Ding H, Triggle C, Wang K, Li X & Xu A (2015) Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and induction of adiponectin in mice. Circulation 131(21):1861-1871.
  • Cheung SY, Huang Y, Kwan HY, Chung HY, Yao X. Activation of transient receptor potential vanilloid 3 channel (TRPV3) suppresses adipogenesis. Endocrinology 156(6):2074-2086.
  • Liu L, Liu J & *Huang Y (2015) Protective effects of glucagon-like peptide-1 on endothelial function in hypertension. Journal of Cardiovascular Pharmacology 65(5):399-405.
  • Liu J, Wang L, Tian XY, Liu LM, Wong WT, Zhang Y, Han Q, Ho HM, Wang N, Wong SL, Chen ZY, Yu J, Ng CF, Yao X & *Huang Y (2015) Unconjugated bilirubin mediates heme oxygenase-1-induced vascular benefits in diabetic mice. Diabetes 64(5):1564-1577 with commentary 64(5):1506-1508.
  • Shen B, Wong CO, Lau OC, Woo T, Bai S, Huang Y & Yao XQ (2015) Plasma membrane mechanical stress activates TRPC5 channels. PLoS One 10(4):e0122227.
  • Liang YT, Chen J, Jiao R, Peng C, Zuo Y, Lei L, Liu Y, Wang X, Ma KY, Huang Y & Chen ZY (2015) Cholesterol-lowering activity of sesamin Is associated with down-regulation on genes of sterol transporters involved in cholesterol absorption. Journal of Agricultural and Food Chemistry 63(11):2963-2969.
  • Liu L, Liu J, Gao Y, Ng CF, Yu X, Dou D & *Huang Y (2015) Down-regulation of glucagon-like peptide-1 receptor expression is mediated through PKCβ in hypertensive renal arteries. Journal of Hypertension 33(4):784-790.
  • Liu L, Liu J, Huang Z, Yu X, Zhang X, Dou D, & *Huang Y (2015) Berberine improves endothelial function by inhibiting endoplasmic reticulum stress in the carotid arteries of spontaneously hypertensive rats. Biochemical and Biophysical Research Communications 458(4):796-801.
  • Wang X, Huang W, Lei L, Liu Y, Ma KY, Li YM, Wang L, Huang Y & Chen ZY (2015) Blockade of hydroxyl group partially abolishes the cholesterol-lowering activity of b–sitosterol. Journal of Functional Foods, 12:199-207.
  • Liu Y, Lei L, Wang X, Ma KY, Li YM, Wang L, Man SW, Huang Y & Chen ZY (2015) Plasma cholesterol-raising potency of dietary free cholesterol versus cholesteryl ester and effect of β-sitosterol. Food Chemistry 169:277-282.

2014

  • Wu XL, Cheang WS, Zhang DM, Li Y, Lau CW, Wang GC, *Huang Y & Ye WC (2015) Antagonism of Ca2+ influx via L-type Ca2+ channels mediates the vasorelaxant effect of Catharanthus roseus--derived vindorosine in rat renal artery. Planta Medica 80(18)1672-1677.
  • Qu D, Liu J, Lau CW & *Huang Y (2015) Differential mechanisms for insulin-induced relaxation in mouse posterior tibial arteries and main mesenteric arteries. Vascular Pharmacology 63(3):173-177.
  • Du J, Ma X, Shen B, Huang Y, Lutz B & Yao X (2014) Heteromeric coassembly of TRPV4, TRPC1 and TRPP2 to form a flow-sensitive channel. FASEB Journal 28(11):4677-4655.
  • Lei L, Liu Y, Wang X, Jiao R, Ma KY, Li YM, Wang L, Man SW, Sang S, Huang Y & Chen ZY. (2015) Plasma cholesterol-lowering activity of gingerols- and shogaols-riched extract is mediated by increasing sterol excretion. Journal of Agricultural and Food Chemistry 62(43):10515-10521.
  • Zhang P, Ma Y, Wang Y, Ma X, Huang Y, Li RA, Wan S & Yao X (2014) Nitric oxide and protein kinase G act on TRPC1 to inhibit 11,12-EET-induced vascular relaxation. Cardiovascular Research 104(1):138-146

  • Liu L, Liu J, Tian XY, Wong WT, Lau CW, Xu A, Xu G, Ng CF, Yao X, Gao Y & *Huang Y (2014) Uncoupling protein-2 up-regulation and oxidative stress inhibition mediate DPP-4 inhibition-induced restoration of endothelial function in hypertension. Antioxidants & Redox Signaling 21(11):1571-1581

  • Gao Z, Zhang H, Liu J, Lau CW, Liu P, Chen ZY, Lee HK, Tipoe GL, Ho HM, Yao X & *Huang Y (2014) Cyclooxygenase-2-dependent oxidative stress mediates palmitate-induced impairment of endothelium-dependent relaxations in mouse arteries. Biochemical Pharmacology 91(4):474-481

  • Zhu X, Fang C, Jia H, Huang Y, Cheng CHK, Ko CH, Chen Z, Wang J & Wang YX (2014) Cellular uptake behaviour, photothermal therapy performance, and cytotoxicity of gold nanorods with various coatings. Nanoscale 6(19):11462-11472.

  • Ni X, Wong SL, Lau CW, Shi X, Wong CM, Cai Y & *Huang Y (2014) Tetramethylpyrazine protects against hydrogen peroxide-provoked endothelial dysfunction in isolated rat aortic rings: implications for antioxidant therapy of vascular diseases. Evidence-Based Complementary and Alternative Medicine Volume 2014 (2014), Article ID 627181, 10 pages

  • Ni J, Shen Y, Wang Z, Shao DC, Liu J, Kong YL, Fu LJ, Zhou L, Xue H, Huang Y, Zhang W, Yu C & Lu LM (2014) P300-dependent STAT3 acetylation is necessary for angiotensin II-induced pro-fibrotic responses in renal tubular epithelial cells. Acta Pharmacologica Sinica 35(9):1157-1166

  • Wong CM, Zhang Y & *Huang Y (2014) Bone morphogenic protein-4-induced oxidant signaling via protein carbonylation for endothelial dysfunction. Free Radical Biology and Medicine 75C:178-190

  • Huang W, Cheang WS, Wang X, Lei L, Liu Y, Ma KY, Zheng F, Huang Y & Chen ZY (2014) Capsaicinoids but not their analog capsinoids lower plasma cholesterol and possess beneficial vascular activity. Journal of Agricultural and Food Chemistry 62(33):8415-8420

  • Ni J, Shen Y, Wang Z, Shao DC, Liu J, Fu LJ, Kong YL, Zhou L, Xue H, Huang Y, Zhang W, Yu C & Lu LM (2014) STAT3 acetylation is associated with angiotensin II-induced murine renal fibrosis. Acta Pharmacologica Sinica 35(8):1045-1054.

  • Qu D, Liu J, Lau CW & *Huang Y (2014) Interleukin-6 in diabetes and cardiovascular complications. British Journal of Pharmacology 171(15):3595-3603

  • Liu L, Liu J, Gao Y, Yu X, Xu G & *Huang Y (2014) Uncoupling protein-2 mediates the protective action of berberine against oxidative stress in rat insulinoma INS-1E cells and in diabetic mouse islets. British Journal of Pharmacology 171(13):3246-3254

  • Wang Y, Dong J, Liu P, Lau CW, Gao Z, Zhou D, Tang J, Ng CF & *Huang Y (2014) Ginsenoside Rb3 attenuates oxidative stress and preserves endothelial function in hypertension. British Journal of Pharmacology 171(13):3171-3181

  • Liu L, Liu J, Gao Y, Yu X, Dou D & *Huang Y (2014) Protein kinase Cδ contributes to phenylephrine-mediated contraction in the aortae of high fat diet-induced obese mice. Biochemical and Biophysical Research Communications 446(4):1179-1183

  • Peng C, Wang X, Chen J, Jiao R, Wang L, Li YM, Zuo Y, Huang Y & Chen ZY (2014) Biology of ageing and role of dietary antioxidants. BioMed Research International 2014(2014) Article ID 831841

  • Cheang WS, Tian XY, Wong WT, Lau CW, Lee ST; Chen ZY, Yao X, Wang N & *Huang Y (2014) Metformin protects endothelial function in diet-Induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway. Arteriosclerosis, Thrombosis and Vascular Biology 34(4):830-6

  • Shen K, Leung SWS, Huang Y, Hou M, Xu A, Wang Z & Vanhoutte PM (2014) Notoginsenoside Ft1 activates both glucocorticoid and estrogen receptors to induce endothelium-dependent, nitric oxide-mediated relaxations in rat mesenteric artery. Biomedical Pharmacology 88(1):66-74

  • Liu Y, Tian XY, Huang Y & Wang NP (2014) Rosiglitazone attenuated endothelin-1-induced vasoconstriction of pulmonary arteries in the rat model of pulmonary arterial hypertension. PPAR Research 2014(2014):374075

  • Zhang Y, Liu J, Tian XY, Wong WT, Chen Y, Wang L, Luo JY, Cheang WS, Lau CW, Kwan KM, Wang N, Yao X & *Huang Y (2014) Inhibition of bone morphogenic protein-4 restores endothelial function in db/db diabetic mice. Arteriosclerosis, Thrombosis and Vascular Biology 34(1):152-159

2013

  • Liu Y, Zhao B, Mao G, Fang X, Liu Y, Huang Y & Wang N (2013) Epigallocatechin-3-O-gallate, a green tea polyphenol, induces expression of Pim-1 Kinase via PPARγ in human vascular endothelial cells. Cardiovascular Toxicology 13(4):391-395.

  • Jiao R, Chen J, Peng C, Liang Y, Ma KY, Wang X, Liu Y, Lei L, Huang Y & Chen ZY (2013) Cholesteryl ester species differently elevate plasma cholesterol in hamsters. Journal of Agricultural and Food Chemistry 61(46):11041-11047

  • Lau YS, Tian XY, Mustafa MR, Murugan D, Liu J, Zhang Y, Lau CW & *Huang Y (2013) Boldine improves endothelial function in diabetic db/db mice through inhibiting angiotensin II-mediated BMP4 oxidative stress cascade. British Journal of Pharmacology 170(6):1190-1198

  • Zhang M, Zang KH, Luo JL, Leung FP, Huang Y, Lin CY, Yang ZJ, Lu AP, Tang XD, Xu HX, Sung JJ, Bian ZX (2013). Magnolol inhibits colonic motility through down-regulation of voltage-sensitive L-type Ca2+ channels of colonic smooth muscle cells in rats. Phytomedicine 20(14):1272-1279

  • Law SK, Leung CSL, Yau KL, Tse CL, Wing CK, Leung FP, Mascheck L, Huang Y, Sauer H & Tsang SY (2013) Regulatino of multiple transcription factors by reactive oxygen species and effects of pro-inflammatory cytokines released during myocardial infarction on cardiac differentiation of embryonic stem cells. International Journal of Cardiology 168(4):3458-3472

  • Xue H, Yuan P, Ni J, Li C, Shao D, Liu J, Shen Y, Wang Z, Zhou L, Zhang W, Huang Y, Yu C, Wang R & Lu L (2013) H2S inhibits hyperglycemia-induced intrarenal renin-angiotensin system activation via attenuation of reactive oxygen species generation. PLoS One 8(9):e74366

  • Chan GHH, Law BYK, Chu JMT, Yue KKM, Jiang ZH, Lau CW, Huang Y, Chan SW, Yue P & Wong R (2013) Ginseng extracts restore high-glucose induced vascular dysfunctions by altering triglyceride metabolism and down-regulation of atherosclerosis-related genes. Evidence-Based Complementary and Alternative Medicine 2013(2013):797310

  • Dong J, Wong SL, Lau CW, Liu J, Wang YX, He ZD, Ng CF, Chen ZY, Yao X, Xu A, Ni X, Wang H & *Huang Y (2013) Calcitriol restores renovascular function in estrogen-deficient rats through the downregulation of cyclooxygenase-2 and thromboxane-prostanoid receptor. Kidney International 84(1):54-63 with Commentary 2013;84(1):9-11.

  • Huang Y & Vanhoutte PM (2013) Xi’an making history in vascular biology. Journal of Cardiovascular Pharmacology 61(6):453-454

  • Ma X, Du J, Zhang P, Deng J, Liu J, Lam FF, Li RA, Huang Y, Jin J & Yao X. (2012) Functional role of TRPV4-KCa2.3 signaling in vascular endothelial cells in normal and streptozotocin-Induced diabetic rats. Hypertension 62(1):134-139

  • Zuo Y, Peng C, Liang Y, Ma KY, Chan HY, Huang Y & Chen ZY (2013) Sesamin extends the mean lifespan of fruit flies. Biogerontology 14(2):107-119

  • Yung LM, Tian XY, Wong WT, Leung FP, Yung LH, Chen ZY, Lau CW, Yao YX & *Huang Y (2013) Chronic cranberry juice consumption restores cholesterol profiles and improves endothelial function in ovariectomized rats. European Journal of Nutrition 52(3):1145-1155

  • Liang Y, Chen J, Zuo Y, Ma KY, Jiang Y, Huang Y & Chen ZY (2013) Blueberry anthocyanins at doses of 0.5 and 1 % lowered plasma cholesterol by increasing fecal excretion of acidic and neutral sterols in hamsters fed a cholesterol-enriched diet. European Journal of Nutrition 52(3):869-875

  • Leung SB, Zhang H, Lau CW, *Huang Y & Lin Z (2013) Salidroside improves homocysteine induced endothelial dysfunction by reducing oxidative stress. Evidence-Based Complementary and Alternative Medicine 2013(2013):679635

  • Liu Y, Tian XY, Mao G, Fang X, Fung ML, Shyy JYJ, *Huang Y & *Wang N (2013) Letter to the Editor Response: Peroxisome proliferator-activated receptorg ameliorates pulmonary arterial hypertension by inhibiting 5-hydroxytryptamine 2B receptor. Hypertension 61(4):e30

  • Hu J, Liu J, Kwok MWT, Wong RHL, Huang Y & Wan S (2013) Bone morphogenic protein-4 contributes to venous endothelial dysfunction in diabetic patients undergoing coronary revascularization. Annals of Thoracic Surgery 95(4):1331-1339

  • Wong WT, Tian XY & *Huang Y (2013) Endothelial dysfunction in diabetes and hypertension: cross talk in RAS, BMP4 and ROS-dependent COX-2-derived prostanoids. Journal of Cardiovascular Pharmacology (Invited) 61(3):204-214

  • Yang C, Chen ZY, Wong SL, LIU J, Liang YT, Lau CW, Lee HK, Huang Y & Tsang SY (2013) b-Sitosterol oxidation products attenuate vasorelaxation through increasing reacitive oxygen species and cyclooxygenase-2. Cardiovascular Research 97(3):520-532

  • Cheang WS, Lam MY, Wong WT, Tian XY, Zhu Z, Yao X & *Huang Y (2013) Menthol relaxes rat aortae, mesenteric and coronary arteries by inhibiting calcium influx. European Journal of Pharmacology 702(1-3):79-84

  • Wang Z, Ni J, Shao D, Liu J, Shen Y, Zhou L, Huang Y, Yu C, Wang J, Xue H & Lu L (2013) Elevated transcriptional co-activator p102 mediates angiotensin II type 1 receptor up-regulation and extracellular matrix overproduction in the high glucose-treated rat glomerular mesangial cells and isolated glomeruli. European Journal of Pharmacology 702(1-3):208-217

  • Lau YS, Tian XY, Huang Y, Murugan D, Achike FI & Mustafa MR (2013) Boldine protects endothelial function in streptozotocin-induced diabetic rats through inhibition of oxidative stress. Biochemical Pharmacology 85(3):367-375

  • Shao D, Liu J, Ni J, Wang Z, Shen Y, Zhou L, Huang Y, Wang J, Xue H, Zhang W & Lu L (2013) Suppression of XBP1S mediates high glucose-induced oxidative stress and extracellular matrix synthesis in renal mesangial cell and kidney of diabetic rats. PLoS One. 8(2):e56124

  • Liang YT, Tian XY, Peng C, Ma KY, Chen J, Zuo Y, Jiao R, Lu Y, Huang Y & Chen ZY (2013) Capsaicinoids decrease serum cholesterol, increase sterol excretion and improve endothelial function in hamsters fed a high cholesterol diet. European Journal of Nutrition 52(1):379-388

  • Yu S, Jia L, Zhang Y, Wu D, Xu Z, Ng CF, To KK, Huang Y & Chan FL. (2013) Increased expression of activated endothelial nitric oxide synthase contributes to antiandrogen resistance in prostate cancer cells by suppressing androgen receptor transactivation. Cancer Letters 328(1):83-94

2012

  • Bi CWC, Xu L, Tian XY, Liu J, Lau CW, Zheng KYZ, Lau DTW, Choi RCY, Dong TTX, Huang Y & Tsim KWK (2012) Fo Shou San, an ancient Chinese herbal decoction, protects endothelial function through increasing endothelial nitric oxide synthase activity. PLoS One 7(12):e51670

  • Dong J, Wong SL, Lau CW, Lee, HK, Ng CF, Zhang L, Yao X, Chen ZY, Vanhoutte PM & *Huang Y (2012) Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress. European Heart Journal 33(23):2980-2990

  • Tian XY, Wong WT, Wang N, Lu Y, Cheang WS, Liu J, Liu L, Liu Y, Lee SST, Chen ZY, Cooke JP & *Huang Y (2012) PPARδ activation protects endothelial function in diabetic mice. Diabetes 61(12):3285-3293

  • Chen L, Miao Y, Zhang Y, Dou D, Liu L, Tian XY, Yang G, Pu D, Zhang X, Kang J, Gao Y, Wang S, Breyer MD, Wang N, Zhu Y, Huang Y, Breyer RM & Guan Y (2012) Inactivation of prostaglandin E2 receptor subtype 3 attenuates the angiotensin II pressor response via decreasing arterial contractility. Arteriosclerosis, Thrombosis and Vascular Biology 32(12):3024-3032

  • Liu Y, Tian XY, Mao G, Fang X, Fung ML, Shyy JYJ, *Huang Y & Wang N (2012) Peroxisome proliferator-activated receptorg ameliorates pulmonary arterial hypertension by inhibiting 5-HT2B receptor. Hypertension 60(6):1471-1478

  • Zhang DM, Li Y, Cheang WS, Lau CW, Lin SM, Zhang QL, Yao N, Wang Y, Wu X, *Huang Y & Ye WC (2012) Cajaninstilbene acid relaxes rat renal arteries: roles of Ca2+ antagonism and protein kinase C-dependent mechanism. PLoS One 7(10):e47030

  • Yang Q, Shigemura N, Underwood MJ, Hsin M, Xue HM, Huang Y, He GW & Yu CM. (2012) NO and EDHF pathways in pulmonary arteries and veins are impaired in COPD patients. Vascular Pharmacology 57(2-4):113-118

  • Liu L, Liu J, Wong WT, Tian XY, Lau CW, Wang YX, Xu G, Pu Y, Zhu Z, Xu A, Lam KSL, Chen ZY, Ng CF, Yao X & *Huang Y (2012) Dipeptidyl-peptidase inhibition improves endothelial function and reduces blood pressure in spontaneously hypertensive rats. Hypertension 60(3):833-841

  • Ma KY, Liang YT, Chen JN, Jiang Y, Kwan KM, Peng C, Jiao R, Zuo YY, Huang Y & Chen ZY. (2012) Dietary calcium decreases plasma cholesterol level only in female but not in male hamster fed a high cholesterol diet. Biomedical & Environmental Sciences 25(4):392-398

  • Yuen CY, Wong SL, Lau CW, Tsang SY, Xu A, Zhu Z, Ng CF, Kong SK, Lee HK, Yao X & *Huang Y (2012) From skeleton to cytoskeleton: Osteocalcin transforms vascular fibroblasts to myofibroblasts via angiotensin II and Toll-like receptor 4. Circulation Research 111:e55-e66

  • Sun L, Yau HY, Wong WY, Li RA, Huang Y & Yao X (2012) Role of TRPM2 in H2O2-Induced Cell Apoptosis in Endothelial Cells. PLoS One.7(8):e43186

  • Kohn C, Schleifenbaum J, Istvan Szijarto A, Marko L, Dubrovska G, Huang Y & Gollasch M (2012) Differential effects of cystathionine-γ-lyase–dependent vasodilatory H2S in periadventitial vasoregulation of rat and mouse aortas. PLoS One 7(8):e41951

  • Xue H, Zhou L, Yuan P, Wang Z, Ni J, Yao T, Huang Y, Yu C & Lu L (2012) Counteraction between Angiotensin II and Angiotensin-(1–7) via activating angiotensin type I and Mas receptor on rat renal mesangial cells. Regulatory Peptides 177(1-3):12-20

  • Du J, Wong WY, Sun L, Huang Y & Yao X (2012) Protein kinase G inhibits flow-induced Ca2+ entry into collecting duct cells. Journal of American Society of Nephrology 23(7):1172-1180

  • Tian, XY, Wong WT, Xu A, Lu Y, Zhang Y, Wang L, Cheang WS, Wang Y, Yao X & *Huang Y (2012) Uncoupling protein-2 protects endothelial dysfunction in diet-induced obese mice. Circulation Research 110:1211-1216

  • Chen JN, Jiang Y, Liang YT, Tian XY, Peng C, Ma KY, Liu J, Huang Y & Chen ZY (2012) DPA n-3, DPA n-6 and DHA improve lipoprotein profiles and aortic function in hamsters fed a high cholesterol diet. Atherosclerosis 221(2):397-404

  • Wong CK, So WY, Law SK, Leung FP, Yao X, Huang Y, Li X & Tsang SY (2012) Estrogen controls the proliferative characteristic of embryonic stem cells via store-operated calcium entry and the transcription factor nuclear factor of activated T-cells (NFAT). Journal of Cellular Physiology 227(6):2519-2530

  • Zhou L, Xue H, Wang Z, Ni J, Yao T, Huang Y, Yu C & Lu L (2012) Angiotensin-(1-7) attenuates high glucose-induced proximal tubular epithelial-to-mesenchymal transition via inhibiting ERK1/2 and p38 phosphorylation. Life Sciences 90(11-12):454-462

  • Luo ZD, Ma LQ, He HB, Yang DC, Feng XL, Ma ST, Chen XP, Cao TB, Liu DY, Nilius B, Huang Y, Yan ZC & Zhu ZM (2012) TRPV1 activation improves exercise endurance and energy metabolism through PGC-1α up-regulation in mice. Cell Research 22(3):551-564

  • Peng C, Zuo Y, Kwan KM, Liang Y, Ma KY, Chan HY, Huang Y, Yu H & Chen ZY. (2012) Blueberry extract prolongs lifespan of Drosophila melanogaster. Experimental Gerontology 47(2):170-178

  • Chan YC, Leung FP, Tian XY, Yung LM, Lau CW, Chen ZY, Yao X, Laher I & *Huang Y (2012) Raloxifene improves vascular reactivity in pressurized septal coronary arteries of ovariectomized hamsters fed cholesterol diet. Pharmacological Research 65(20):182-188

  • Tian XY, Wong WT, Sayed N, Luo J, Tsang SY, Bian ZX, Lu Y, Cheang WS, Yao X, Chen ZY & *Huang Y (2012) NaHS relaxes rat cerebral artery in vitro via inhibition of L-type voltage-sensitive Ca2+ channel. Pharmacological Research 65(20):239-246

  • Tian XY, Wong WT, Leung FP, Zhang Y, Wang YX, Lee HK, Ng CF, Chen ZY, Yao X, Au CL, Lau CW, Vanhoutte PM, Cooke JP & *Huang Y (2012) Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin F2a impairs endothelial function in renovascular hypertensive rats Antioxidants & Redox Signaling 16(4):363-373

  • Tian XY, Yung LH, Wong WT, Leung FP, Liu LM, Chen YC, Kong SK, Kwan KM, Ng SM, Lai PB, Yung LM, Yao X & *Huang Y (2012) Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway. Journal of Molecular and Cellular Cardiology 52(1):237-244
  • Wang YX, Ko CH, Griffith JF, Deng M, Wong HL, Gu T & Huang Y (2012) Organic nitrate maintains bone marrow blood perfusion in ovariectomized female rats: a dynamic contrast enhanced MRI study. Pharmaceutics. 5(1):23-35.

2011

  • Leung JWC, Wong WT, Koon HW, Mo FFM, Tam S, Huang Y, Vanhoutte PM, Chung SSM & Chung SK (2011) Transgenic mice over-expressing ET-1 in the endothelial cells develop systemic hypertension with altered vascular reactivity. PLoS One 6(11):e26994

  • Wang Y, Cheng KKY, Lam KSL, Wu D, Wang Y, Huang Y, Vanhoutte PM, Sweeney G, Li Y & Xu A (2011) APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by fine-tuning the endothelial production of nitric oxide and endothelin-1 in mice. Diabetes 60(11):3044-3054

  • Liang YT, Wong WT, Guan L, Tian XY, Ma KY, Huang Y & Chen ZY (2011) Effect of phytosterols and their oxidation products on lipoprotein profiles and vascular function in hamster fed a high cholesterol diet. Atherosclerosis 219(1):124-133

  • Cheang WS, Wong WT, Tian XY, Yang Q, Lee HK, He GW, Yao X & *Huang Y (2011) Endothelial nitric oxide synthase enhancer AVE3085 restores endothelial function and reduces oxidative stress in type 2 diabetic db/db mice. Cardiovascular Research 92(2):267-275

  • Feletou M, Huang Y & Vanhoutte PM (2011) Endothelium-mediated control of vascular tone: COX-1 and COX-2 products. British Journal of Pharmacology (Invited) 164(3):894-912

  • Sun L, Yau HY, Lau OC, Huang Y & Yao X. (2011) Effect of hydrogen peroxide and superoxide anions on cytosolic ca: comparison of endothelial cells from large-sized and small-sized arteries. PLoS One. 6(9):e25432

  • Tian XY, Wong WT, Xu A, Chen ZY, Lu Y, Liu L, Lee VWY, Lau CW, Yao X & *Huang Y (2011) Rosuvastatin improves endothelial function of db/db mice: Role of angiotensin II type 1 receptors and oxidative stress. British Journal of Pharmacology 164(b):598-606

  • Ma X, Nilius B, Wong JW, Huang Y & Yao X (2011) Electrophysiological properties of heteromeric TRPV4-C1 channels. Biochim Biophys ActaBiomembranes 1808(12):2789-2797

  • Yuan P, Xue H, Zhou L, Qu L, Li C, Wang Z, Ni J, Yu C, Yao T, Huang Y, Wang R & Lu L (2011) Rescue of mesangial cells from high glucose-induced over-proliferation and extracellular matrix secretion by hydrogen sulfide. Nephrology Dialysis Transplantation 26(7):2119-2126

  • Wong WT, Tian XY, Xu A, Jun Y, Lau CW, Hoo RLC, Wang Y, Lee VWY, Lam KSL, Vanhouttee PM & *Huang Y (2011) Adiponectin is required for PPARg-mediated improvement of endothelial function in diabetic mice. Cell Metabolism 14(1):104-115

  • Yang Q, Xue HM, Wong WT, Tian XY, Huang Y, Tsui SKW, Ng PKS, Wohlfart P, Li H, Xia N, Tobias S, Underwoord MJ & He GW (2011) Endothelial nitric oxide synthase enhancer AVE3085 restores endothelial function and reduces blood pressure in spontaneously hypertensive rats. British Journal of Pharmacology 163(5):1078-1085

  • Shen B, Kwan HY, Ma X, Wong CO, Du J, Huang Y & Yao X. (2011) Cyclic AMP activates TRPC6 channels via PI3K-PKB-MEK-ERK1/2 signaling pathway. Journal of Biological Chemistry 286(22):19439-19445

  • Wong SL & *Huang Y (2011) Targeting soluble epoxide hydrolase via peroxisome proliferator-activated receptorg: a new therapeutic strategy for vascular complications. Clinical and Experimental Pharmacology and Physiology (Invited Editorial) 38(6):356-357

  • Luo J, Qin HY, Wong CK, Tsang SY, Huang Y & Bian ZX (2011) Enhanced excitability and down-regulated voltage-gated potassium channels in colonic DRG neurons from neonatal maternal separation rats. Journal of Pain 12(5):600-609

  • Wong SL, Lau CW, Wong WT, Xu A, Au CL, Ng CF, Ng SSM, Gollasch M, Yao X, *Huang Y (2011) Pivotal role of PKCδ in angiotensin II-induced endothelial cyclooxygenase-2 expression: A link to vascular inflammation. Arteriosclerosis, Thrombosis and Vascular Biology 31(5):1169-1176

  • Kong EKC, Huang Y, Sanderson JE, Chen KB, Yu S & Yu CM (2011) A novel anti-fibrotic agent, baicalein for the treatment of myocardial fibrosis in spontaneously hypertensive rats. European Journal of Pharmacology 658(2-3):175-181

  • Griffith JF, Kumta SM, Huang Y (2011) Hard arteries, weak bones. Skeletal Radiology 40(5):517-521

  • Fan L, Yang Q, Xiao X, Grove KL, Huang Y, Chen ZW, Furnary A & He GW (2011) Dual actions of cilnidipine in human internal thoracic artery: Inhibition of calcium channels and enhancement of endothelial nitric oxide synthase. Journal of Thoracic and Cardiovascular Surgery141(4):1063-1069

  • Yu S, Wong SL, Lau CW, Huang Y, Yu CM (2011) Oxidized LDL at low concentration promotes in vitro angiogenesis and activates nitric oxide synthase through PI3K/Akt/eNOS pathway in human coronary artery endothelial cells Biochemical and Biophysical Research Communications 407(1):44-48

  • Yuen CY, Wong WT, Tian XY, Wong SL, Lau CW, Yu J, Tomlinson B, Yao X & *Huang Y (2011) Telmisartan inhibits vasoconstriction via PPARγ-dependent expression and activation of endothelial nitric oxide synthase. Cardiovascular Research 90(1):122-129

  • Yung LM, Wong WT, Tian XY, Leung FP, Chen ZY, Lau CW, Yao X & *Huang Y (2011) Inhibition of renin-angiotensin system reverses endothelial dysfunction and oxidative stress during estrogen deficiency in ovariectomized rats. PloS One 6(3):e17437

  • Peng C, Chan HY, Huang Y, Yu H & Chen ZY (2011) Apple polyphenols extend the mean lifespan of Drosophila melanogaster. Journal of Agricultural and Food Chemistry 59(5):2097-2106

  • Wong WT, Ng CH, Tsang SY, Huang Y & ZY Chen (2011) Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. Nutrition, Metabolism & Cardiovascular Diseases 21(3):157-164

  • Chu L, Hao H, Luo M, Huang Y, Chen ZY, Lu T, Zhao X, Verfaillie CM, Zweier JL &Liu Z (2011) Ox-LDL modifies the behavior of bone marrow stem cells and impairs their endothelial differentiation via inhibition of Akt phsophosrylation. Journal of Cellular and Molecular Medicine 15(20:247-258

  • Ma KY, Yang N, Jiao R, Peng C, Guan L, Huang Y & Chen ZY (2011) Dietary calcium decreases plasma cholesterol by down-regulation of intestinal Niemann-Pick C1 like 1 and microsomal triacylglycerol transport protein and up-regulation of CYP7A1 and ABCG 5/8 in hamsters. Molecular Nutrition and Food Research 55(2):247-258

  • Jin Zheng, Lee Hui Ching Michelle, Mohamad Mukmin bin Sattar, Yu Huang, Jin-Song Bian (2011) Cardioprotective effects of epigallocatechin-3-gallate against doxorubicin-induced cadiomyocyte injury. European Journal of Pharmacology 652(1-3):82-88

** 2006-2010 **

** 2001-2005 **

** 1996-2000 **

** 1987-1995 **