Margaret IP
Mamie HUI
Zigui CHEN
Christopher KC LAI
Rita WY NG
Siaw Shi BOON
Sishuo WANG
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Faculty > Siaw Shi BOON
Personal information
Name BOON Siaw Shi
Academic / Professional Qualifications Ph.D (Life and Biomolecular Science); MSc (Cancer Molecular Biology); BSc (Biomedical Sciences)
Academic title & affiliations Dr, Department of Microbiology, Faculty of Medicine, CUHK
Email boonss@cuhk.edu.hk
Current Appointments
(Including honorary appointments)
Research Assistant Professor, Department of Microbiology, Faculty of Medicine, CUHK
ORCID iD iconorcid.org/0000-0001-9772-2971
Research interest
  1. Viral pathogenesis
  2. Cancer biology
  3. Cell cycle
  4. Post-translational modification
Publications (Representative)
  1. Boon SS, Xia C, Lim JY, Chen Z, Law PTY, Yeung CMA, Thomas M, Banks L, Chan PKS. Human papillomavirus 58 E7 T20I/G63S variant isolated from East Asian population possesses high oncogenicity. JVI 2020. 94:e00090-20.
  2. Boon SS, Chen Z, Li JT, Ho WCS, Lee YC, Chan PKS. Differential role of HPV18 oncoproteins in esophageal and tongue squamous cell carcinoma cell lines. BMC Cancer 2019. 1211. doi:10.1186/s12885-019-6413-7.
  3. Thatte J, Massimi P, Thomas M, Boon SS, Banks L. The Human Papillomavirus E6 PDZ Binding Motif Links DNA Damage Response Signaling to E6 Inhibition of p53 Transcriptional Activity. J. Virol. 2018;92 (16): e00465-18.
  4. Chen Z, Ho WCS, Boon SS, Law PTY, Chan MCW, DeSalle R, Burk RD, Chan, P.K.S. Ancient Evolution and dispersion of Human Papillomavirus Type 58 variants. J. Virol. 2017;pii: JVI.01285-17.
  5. He L, Law PTY, Boon SS, Zhang C, Ho WC, Banks L, Wong CK, Chan JC, Chan PK. Increased Growth of a Newly Established Mouse Epithelial Cell Line Transformed with HPV-16 E7 in Diabetic Mice. PLoS One. 2016,11(10):e0164490.
  6. Boon SS, Tomaić, V., Roberts, S., Banks, L. Cancer-causing Human Papillomavirus E6 proteins displays major differences in the phospho-regulation of their PDZ interactions. J. Virol. 2015, 89(3):1579-86.
  7. Boon SS and Sim SP. Inhibitor of caspase-activated DNase expression enhances caspase-activated DNase expression and inhibits oxidative stress-induced chromosome breaks at the mixed lineage leukaemia gene in nasopharyngeal carcinoma cells. Cancer Cell International 2015, 15:54.
  8. Boon SS and Banks L. High-risk human papillomavirus E6 oncoproteins interact with 14-3-3ζ in a PDZ binding motif-dependent manner. J. Virol. 2013, 87(3):1586-95.
  9. Pim D, Bergant M, Boon SS, Ganti K, Kranjec C, Massimi P, Subbaiah VK,Thomas M, Tomaic V, Banks L. Human papillomaviruses and the specificity of PDZ domain targeting. FEBS J. 2012, 279(19):3530-7.
  10. Subbaiah VK, Massimi P, Boon SS, Myers MP, Sharek L, Garcia-Mata, R, Banks L. The Invasive Capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity. PLoS Pathogens 2012, 8(2): e1002543