Professor Dennis Lo
Professor Rossa Chiu
Professor Allen K C Chan
Professor Nelson Tang
Professor Chun Kwok Wong
Professor Hao Sun
Professor Kathy Lui
Professor Sung Wing Kin
Professor Peiyong Jiang
Professor Peter Cheung
Professor Hei Ming Lai
Professor Jacky Lam
Professor Guanhua Zhu
Professor Chun Kit Choi
Professor Mingyuan Li
Professor Jason Liao
Professor Qing Zhou
Professor Christopher Lam
Professor Nirmal Panesar
Dr Michael H M Chan
Dr Angel Chan
 
 
 
Guanhua Zhu 朱冠華
Assistant Professor 助理教授
guanhuazhu@cuhk.edu.hk
Biography
Dr. Guanhua Zhu is an Assistant Professor at the Department of Chemical Pathology in The Chinese University of Hong Kong. Prior to joining CUHK, he worked at Genome Institute of Singapore with a research focus on developing data-driven approaches to study cancer and profile circulating tumor DNA to assist in cancer liquid biopsy. Dr. Zhu received his Bachelor's degree from Nanjing Agricultural University, Master’s degree from The University of Edinburgh, and a Doctor of Philosophy degree from Nanyang Technological University. His research interests are using computational approaches to decipher biological data and translate into clinical applications. He developed bioinformatics approaches with artificial intelligence for detecting cancer and quantitatively measuring disease burden in liquid biopsy.

Specialised Research Area(s):

  • Bioinformatics
  • Computational genomics
  • Liquid biopsy
Selected publications:
Zhu G, Guo Y, Ho D, Poon P, Poh ZW, Wong PM, Gan A, Chang MM, Kleftogiannis D, Lau YT, Tay B, Lim WJ, Chua C, Tan T, Koo S, Chong D, Yap YS, Tan I, Ng S, Skanderup AJ. Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden. Nature Communications. 2021;12:2229.
Zhu G, Pan A, Grüber G, Lu L. Conformational states of Zika virus non-structural protein 3 determined by molecular dynamics simulations with small-angle X-Ray scattering data. Progress in Biophysics and Molecular Biology. 2019;143:13-9.
Wang X*, Zhu G*, Liang W, Zhao S, Yuan L, Zhou X, Lu L, Xu H. Design, Synthesis and Docking of Linear and Hairpin‐Like Alpha Helix Mimetics Based on Alkoxylated Oligobenzamide. ChemistrySelect. 2019;4(21):6651-5.
Yang J, Zhu G, Tong D, Lu L, Shen Z. B-spline tight frame based force matching method. Journal of Computational Physics. 2018;362:208-19.
Liu W, Liu X, Zhu G, Lu L, Yang D. A Method for Determining Structure Ensemble of Large Disordered Protein: Application to a Mechanosensing Protein. Journal of the American Chemical Society. 2018;140(36):11276-85.
Zhu G, Liu W, Bao C, Tong D, Ji H, Shen Z, Yang D, Lu L. Investigating energy‐based pool structure selection in the structure ensemble modeling with experimental distance constraints: The example from a multidomain protein P ub1. Proteins: Structure, Function, and Bioinformatics. 2018;86(5):501-14.
Zhu G, Saw WG, Nalaparaju A, Grüber G, Lu L. Coarse-grained molecular modeling of the solution structure ensemble of dengue virus nonstructural protein 5 with small-angle X-ray scattering intensity. The Journal of Physical Chemistry B. 2017;121(10):2252-64.
 
 
 
 
The Chinese University of Hong Kong