Professor Dennis Lo
Professor Rossa Chiu
Professor Allen K C Chan
Professor Nelson Tang
Professor Chun Kwok Wong
Professor Hao Sun
Professor Kathy Lui
Professor Sung Wing Kin
Professor Peiyong Jiang
Professor Peter Cheung
Professor Hei Ming Lai
Professor Jacky Lam
Professor Guanhua Zhu
Professor Chun Kit Choi
Professor Mingyuan Li
Professor Jason Liao
Professor Qing Zhou
Professor Christopher Lam
Professor Nirmal Panesar
Dr Michael H M Chan
Dr Angel Chan
 
 
 
Mingyuan Li 李明圓
Research Assistant Professor 研究助理教授
mingyuanli@cuhk.edu.hk
Biography

Dr. Mingyuan Li is currently a Research Assistant Professor in the Li Ka Shing institute of Health Science, the Department of Chemical Pathology, Faculty of Medicine at the Chinese University of Hong Kong.

She obtained her bachelor’s and master’s degree from Hunan Normal University, China and Xiamen University, China, respectively. She completed her PhD study and postdoctoral training in HKU-Pasteur Research Pole, The University of Hong Kong.

Dr. Li’s interest focuses on the screen and identification of antiviral host targets for further therapeutic treatment replying on the platform for proteome and interactome. The overarching goal of her research is to explore the mechanisms underlying viral manipulation of host cell biology and biochemical underpinnings of host-pathogens interactions.

Dr. Li has published her original research findings in leading international journals. Her works has been supported by the National Key project on Scientific and Technological Innovation and National Natural Science Foundation of China, with which she led to uncover and characterize the broad-spectrum antiviral host targets of pathogenic RNA viruses.

Specialised Research Area(s):

  • Host-pathogen interactions.
  • Mechanism of viral infection and pathogenesis.
  • Anti-viral targets identification and pan anti-viral strategy development.
Selected publications:
Li MY, Cheng X, Qin C. Reverse spillover of SARS-CoV-2 from human to wild animals. Sci China Life Sci. 2022 Sep;65(9):1902-1904. doi: 10.1007/s11427-022-2124-y. Epub 2022 May 30. PMID: 35657469; PMCID: PMC9162899.
Li MY, Naik TS, Siu LYL, Acuto O, Spooner E, Wang P, Yang X, Lin Y, Bruzzone R, Ashour J, Evans MJ, Sanyal S. Lyn kinase regulates egress of flaviviruses in autophagosome-derived organelles. Nat Commun. 2020 Oct 15;11(1):5189. doi: 10.1038/s41467-020-19028-w. PMID: 33060596; PMCID: PMC7564011.
Li MY, Grandadam M, Kwok K, Lagache T, Siu YL, Zhang JS, Sayteng K, Kudelko M, Qin CF, Olivo-Marin JC, Bruzzone R, Wang PG. KDEL Receptors Assist Dengue Virus Exit from the Endoplasmic Reticulum. Cell Rep. 2015 Mar 10;10(9):1496-1507. doi: 10.1016/j.celrep.2015.02.021. Epub 2015 Mar 5. PMID: 25753416.
Li F, Li MY, Ke W, Ji Y, Bian X, Yan X. Identification of the immediate-early genes of white spot syndrome virus. Virology. 2009 Mar 1;385(1):267-74. doi: 10.1016/j.virol.2008.12.007. Epub 2009 Jan 8. PMID: 19135226. (Co-First author)
Lan Y, van Leur SW, Fernando JA, Wong HH, Kampmann M, Siu L, Zhang J, Li MY, Nicholls JM, Sanyal S. Viral subversion of selective autophagy is critical for biogenesis of virus replication organelles. Nat Commun. 2023 May 10;14(1):2698. doi: 10.1038/s41467-023-38377-w. PMID: 37164963; PMCID: PMC10171163.
Cheng L, Zhang X, Chen Y, Wang D, Zhang D, Yan S, Wang H, Xiao M, Liang T, Li H, Xu M, Hou X, Dai J, Wu X, Li MY, Lu M, Wu D, Tian R, Zhao J, Zhang Y, Cao W, Wang J, Yan X, Zhou X, Liu Z, Xu Y, He F, Li Y, Yu X, Zhang S. Dynamic landscape mapping of humoral immunity to SARS-CoV-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients. Signal Transduct Target Ther. 2021 Aug 17;6(1):304. doi: 10.1038/s41392-021-00718-w. PMID: 34404759; PMCID: PMC8368053.
Zhang J, Lan Y, Li MY, Lamers MM, Fusade-Boyer M, Klemm E, Thiele C, Ashour J, Sanyal S. Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger Lipophagy and Drive Virus Production. Cell Host Microbe. 2018 Jun 13;23(6):819-831.e5. doi: 10.1016/j.chom.2018.05.005. PMID: 29902443.
Wang R, Liao X, Fan D, Wang L, Song J, Feng K, Li MY, Wang P, Chen H, An J. Maternal immunization with a DNA vaccine candidate elicits specific passive protection against post-natal Zika virus infection in immunocompetent BALB/c mice. Vaccine. 2018 Jun 7;36(24):3522-3532. doi: 10.1016/j.vaccine.2018.04.051. Epub 2018 May 9. PMID: 29753607.
Hemida MG, Perera RA, Wang P, Alhammadi MA, Siu LY, Li MY, Poon LL, Saif L, Alnaeem A, Peiris M. Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia, 2010 to 2013. Euro Surveill. 2013 Dec 12;18(50):20659. doi: 10.2807/1560-7917.es2013.18.50.20659. PMID: 24342517.
Perera RA, Wang P, Gomaa MR, El-Shesheny R, Kandeil A, Bagato O, Siu LY, Shehata MM, Kayed AS, Moatasim Y, Li MY, Poon LL, Guan Y, Webby RJ, Ali MA, Peiris JS, Kayali G. Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013. Euro Surveill. 2013 Sep 5;18(36):pii=20574. doi: 10.2807/1560-7917.es2013.18.36.20574. PMID: 24079378.
Kudelko M, Brault JB, Kwok K, Li MY, Pardigon N, Peiris JSM, Bruzzone R, Desprès P, Nal B, Wang PG. Class II ADP-ribosylation factors are required for efficient secretion of dengue viruses. J Biol Chem. 2012 Jan 2;287(1):767-777. doi: 10.1074/jbc.M111.270579. Epub 2011 Nov 21. PMID: 22105072; PMCID: PMC3249131.
Ruan L, Bian X, Ji Y, Li MY, Li F, Yan X. Isolation and identification of novel microRNAs from Marsupenaeus japonicus. Fish Shellfish Immunol. 2011 Aug;31(2):334-40. doi: 10.1016/j.fsi.2011.05.023. Epub 2011 May 31. PMID: 21658454.
 
 
 
 
The Chinese University of Hong Kong