Professor Dennis Lo
Professor Rossa Chiu
Professor Allen K C Chan
Professor Nelson Tang
Professor Chun Kwok Wong
Professor Hao Sun
Professor Kathy Lui
Professor Sung Wing Kin
Professor Peiyong Jiang
Professor Peter Cheung
Professor Hei Ming Lai
Professor Jacky Lam
Professor Guanhua Zhu
Professor Chun Kit Choi
Professor Mingyuan Li
Professor Jason Liao
Professor Qing Zhou
Professor Nirmal Panesar
Professor Chung Shun Ho
Dr Michael H M Chan
Dr Angel Chan
 
 
 
Qing Zhou 周晴
Research Assistant Professor 研究助理教授
qingzhou@cuhk.edu.hk
Biography
Dr. Qing Zhou is a Research Assistant Professor at the Department of Chemical Pathology at The Chinese University of Hong Kong. Dr. Zhou received her Bachelor of Medicine degree in Clinical Medicine from Yangzhou University, a Master of Research in Oncology from the University of Manchester, and a Doctor of Philosophy degree in Molecular Medicine from the Medical University of Graz. Her research interests include understanding the biology of cell-free nucleic acid fragmentation and developing non-invasive prenatal and cancer diagnostic testing using cell-free DNA fragmentomics. Dr. Zhou and her colleagues have developed a novel approach to deducing cfDNA methylation based on its fragmentation. This approach has led to the development of new methods for early cancer detection.

Specialised Research Area(s):

  • Non-invasive cancer diagnostic approaches
  • Cell-free DNA fragmentomics
  • Biology of circulating nucleic acids
Selected publications:
Zhou, Z; Ma, ML; Chan, RWY; Lam, WKJ; Peng, W; Gai, W; Hu, X; Ding, SC; Ji, L; Zhou, Q; Cheung, PPH; Yu, SCY; Teoh, JYC; Szeto, CC; Wong, J; Wong, VWS; Wong, GLH; Chan, SL; Hui, EP; Ma, BBY; Chan, ATC; Chiu, RWK; Chan, KCA; Lo, YMD; Jiang, P. Fragmentation landscape of cell‑free DNA revealed by deconvolutional analysis of end motifs. Proceedings of the National Academy of Sciences of the United States of America. 2023;120(17):e2220982120.
Zhou, Q; Kang, G; Jiang, P; Qiao, R; Lam, WKJ; Yu, SCY; Ma, ML; Ji, L; Cheng, SH; Gai, W; Peng, W; Shang, H; Chan, RWY; Chan, SL; Wong, GLH; Hiraki, LT; Volpi, S; Wong, VW; Wong, J; Chiu, RWK; Chan, KCA; Lo, YMD. Epigenetic analysis of cell‑free DNA by fragmentomic profiling. Proceedings of the National Academy of Sciences of the United States of America. 2022;119(44):e2209852119.
Johnson, P; Zhou, Q; Dao, DY; Lo, YMD. Circulating biomarkers in the diagnosis and management of hepatocellular carcinoma. Nature Reviews Gastroenterology & Hepatology. 2022;19(10):670‑681.
Suppan, C; Graf, R; Jahn, S; Zhou, Q; Klocker, EV; Bartsch, R; Terbuch, A; Kashofer, K; Regitnig, P; Lindenmann, J; Posch, F; Gerritsmann, H; Jost, PJ; Heitzer, E; Dandachi, N; Balic, M. Sensitive and robust liquid biopsy‑based detection of PIK3CA mutations in hormone‑receptor‑positive metastatic breast cancer patients. British Journal of Cancer. 2022;126(3):456‑463.
Zhou, Q; Gampenrieder, SP; Frantal, S; Rinnerthaler, G; Singer, CF; Egle, D; Pfeiler, G; Bartsch, R; Wette, V; Pichler, A; Petru, E; Dubsky, PC; Bago‑Horvath, Z; Fesl, C; Rudas, M; Ståhlberg, A; Graf, R; Weber, S; Dandachi, N; Filipits, M; Gnant, M; Balic, M; Heitzer, E. Persistence of ctDNA in Patients with Breast Cancer During Neoadjuvant Treatment Is a Significant Predictor of Poor Tumor Response. Clinical Cancer Research. 2022;28(4):697‑707.
Perakis, SO; Weber, S; Zhou, Q; Graf, R; Hojas, S; Riedl, JM; Gerger, A; Dandachi, N; Balic, M; Hoefler, G; Schuuring, E; Groen, HJM; Geigl, JB; Heitzer, E; Speicher, MR. Comparison of three commercial decision support platforms for matching of next‑generation sequencing results with therapies in patients with cancer. ESMO Open. 2020;5(5):e000872.
Koch, C; Kuske, A; Joosse, SA; Yigit, G; Sflomos, G; Thaler, S; Smit, DJ; Werner, S; Borgmann, K; Gärtner, S; Mossahebi Mohammadi, P; Battista, L; Cayrefourcq, L; Altmüller, J; Salinas‑Riester, G; Raithatha, K; Zibat, A; Goy, Y; Ott, L; Bartkowiak, K; Tan, TZ; Zhou, Q; Speicher, MR; Müller, V; Gorges, TM; Jücker, M; Thiery, JP; Brisken, C; Riethdorf, S; Alix‑Panabières, C; Pantel, K. Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity. EMBO Molecular Medicine. 2020;12(9):e11908.
Zhou, Q; Perakis, S; Ulz, P; Mohan, S; Riedl, JM; Talakic, E; Lax, S; Tötsch, M; Hoefler, G; Bauernhofer, T; Pichler, M; Gerger, A; Geigl, JB; Heitzer, E; Speicher, MR. Cell‑free DNA analysis reveals POLR1D‑mediated resistance to bevacizumab in colorectal cancer. Genome Medicine. 2020;12(1):20.
Ulz, P; Perakis, S; Zhou, Q; Moser, T; Belic, J; Wölfler, A; Zebisch, A; Gerger, A; Pristauz, G; Petru, E; Schimek, MG; Geigl, JB; Bauernhofer, T; Sill, H; Bock, C; Heitzer, E; Speicher, MR. Inference of tumor cell‑specific transcription factor binding from cell‑free DNA. Nature Communications. 2019;10(1):4666.
Zhou, Q; Eldakhakhny, S; Conforti, F; Crosbie, EJ; Melino, G; Sayan, BS. Pir2/Rnf144b is a potential endometrial cancer biomarker that promotes cell proliferation. Cell Death and Disease. 2018;9(5):504‑504.
Zhou, Q; Moser, T; Perakis, S; Heitzer, E. Untargeted profiling of cell‑free circulating DNA. Translational Cancer Research. 2018;7: S140‑S152.
Eldakhakhny, S; Zhou, Q; Crosbie, EJ; Sayan, BS. Human papillomavirus E7 induces p63 expression to modulate DNA damage response. Cell Death and Disease. 2018;9(2):127.
Moser, T; Ulz, P; Zhou, Q; Perakis, S; Geigl, JB; Speicher, MR; Heitzer, E. Single‑Stranded DNA Library Preparation Does Not Preferentially Enrich Circulating Tumor DNA. Clinical Chemistry. 2017;63(10):1656‑1659.
 
 
 
 
The Chinese University of Hong Kong