Professor Dennis Lo
Professor Rossa Chiu
Professor Allen K C Chan
Professor Nelson Tang
Professor Chun Kwok Wong
Professor Hao Sun
Professor Kathy Lui
Professor Peiyong Jiang
Professor Peter Cheung
Professor Jacky Lam
Professor Masashi Yukawa
Professor Chun Kit Choi
Professor Jason Liao
Professor Christopher Lam
Professor Nirmal Panesar
Dr Michael H M Chan
Dr Angel Chan
 
 
 
Nelson Tang 鄧亮生
Professor 教授
nelsontang@cuhk.edu.hk
Biography
Positions Held:
Current
Executive Committee Member, Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics, School of Biomedical Sciences, The Chinese University of Hong Kong
Current
Principal Investigator, Laboratory for Genetics of Disease Susceptibility, Li Ka Shing Institute of Health Sciences, CUHK
Current
Member, The Board of Trustees of United College, CUHK
Current
Principal Investigator, Functional Genomics and Biostatistical Computing Laboratory, CUHK Shenzhen Research Institute, Shenzhen, China
Current
Course coordinator of BMEG 5790 Bioinformatics in MSc porgram in Biomedical Engineering
Current
Member of Preclinical Education Committee
Current
Member, Grant Review Board of Health and Medical Research Fund, Hong Kong SAR Government
Current
Primary Supervisor of training in Genetic Pathology for Royal College of Pathologists of Australasia (RCPA) at Prince of Wales Hospital
Current
Member, Editorial Board of the journal Pathology and Frontiers in Genetics
Current
Member, The Committee of Board Directors for Asian Society of Inherited Metabolic Diseases (ASIMD)
Current
2018
Working Group on Colorectal and Breast Cancer Screening for High Risk Groups, Centre for Health Protection, Department of Health, Hong Kong SAR Government
2009 - 2014
Scientific Editor, Catalogue of Genetic Tests and Laboratories, Royal College of Pathologists of Australasia
2009, 2013
Committee member, Manual Transformation Steering Committee, Royal College of Pathologists of Australasia
2005 - 2012
Member, Advisory Committee of Genetics Pathology in the Royal College of Pathologists of Australasia (RCPA)
2005 - 2010
Panel Coordinator of teaching panel in medical curriculum: Mechanisms of Disease and Therapeutic Approaches
2007
Honorary Professor, Xi'an Jiaotong University, Xi'an China
2006
Overseas Examiner of Genetics Pathology for the Royal College of Pathologists of Australasia (RCPA)
Scholarship and Awards:
2003 / 04
Sir Robert Black Trust Fund Scholarship for a sabbatical to Strangeways Research Laboratory, University of Cambridge
 
Professor Tang graduated MB ChB from The Chinese University of Hong Kong in 1991. He was admitted to Fellow of the Royal College of Pathologists of Australasia (FRCPA) in 1997 after training in both histopathology and chemical pathology in the Departments of Anatomical & Cellular Pathology and Chemical Pathology at the Prince of Wales Hospital. Professor Tang joined the University in 1996. He was then conferred the degree of Doctor of Medicine. In 2003/04, he was awarded a scholarship from the Sir Robert Black Trust Fund for a study leave at the Strangeways Research Laboratory of the University of Cambridge, UK. He is currently serving in the Advisory Committee of Genetic Pathology in the Royal College of Pathologists of Australasia. He has been examiner for RCPA and also serves as editor of RCPA Catalogue of Genetic Tests and Laboratories.
 
Professor Tang started the first metabolic clinic in Hong Kong to take care of patients with various inborn errors of metabolism (IEM, or inherited metabolic diseases) more than 20 years ago. His research team contributed to the discovery of the disease gene causing Primary Carnitine Deficiency (named by him as 卡尼丁缺乏症, which has now become a commonly used Chinese medical term). His discovery facilitated the molecular diagnosis of this disease and today more than 1,000 patients of this rare disease are diagnosed and treated all over China.
 
Professor Tang is also the principal investigator of the Laboratory for Genetics of Disease Susceptibility in the Li Ka Shing Institute of Health Sciences. We investigate the genetic basis of polygenic disease also called complex traits, including many common diseases like diabetes and hypertension. Our long term collaboration with international researchers led to many new insights in various polygenic complex traits, including genetics basis in Scoliosis which inspire new treatment modality. Recently, we develops new analysis algorithms in bioinformatics and genetic statistics which enable determination of gene expression of a single cellular population from bulk data of cell mixtures. This will be useful in development of future blood biomarker tests.
Research interests:
1.
Genetic Susceptibility of common diseases (also known as complex traits), e.g. Scoliosis, Diabetes, etc.
2.
New algorithms in Bioinformatics and genetic statistics: single cell population gene expression and genetic interaction
3.
Inborn errors of metabolism: Carnitine deficiency and Wilson's disease
 
Patent:
Determination of gene expression levels of a cell type, US9589099B2
 
Links to publications:
鄧亮生@全球學者庫
Publons.com/researcher/2047982/nelson-l-tang
Google Scholar
ResearchGate
Pubmed
ORCID ID: 0000-0002-3607-5819
Scopus
 
Book Editor:
Chemical Diagnostics: From Bench to Bedside (in the series of Topics in Current Chemistry, Vol. 336). L.S. Tang, Nelson; Poon, Terence (Eds.) Publisher: Springer; 2014. ISBN-10: 364239941X (Top 25% most downloaded eBooks in the relevant Springer eBook Collection)
 
10 selected publication among > 300 publications
Tang, N. L. S., & Hui, J. (2020). 20 Years After Discovery of the Causative Gene of Primary Carnitine Deficiency, How Much More Have We Known About the Disease? HK J Paediatr (new series), 25:23-29. http://www.hkjpaed.org/pdf/2020;25;23-29.pdf
Styrkarsdottir, U., Stefansson, O. A., Gunnarsdottir, K., et al. (2019). GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures. Nature Communications, 10(1), 2054. https://doi.org/10.1038/s41467-019-09860-0
Styrkarsdottir, U., Helgason, H., Sigurdsson, A., et al. (2017). Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis. Nature Genetics, 49(5), 801–805. https://doi.org/10.1038/ng.3816
Styrkarsdottir, U., Thorleifsson, G., Gudjonsson, S. A., et al. (2016). Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures. Nature Communications, 7, 10129. https://doi.org/10.1038/ncomms10129
Zhu, Z., Tang, N. L.-S., Xu, L., et al. (2015). Genome-wide association study identifies new susceptibility loci for adolescent idiopathic scoliosis in Chinese girls. Nature Communications, 6, 8355. https://doi.org/10.1038/ncomms9355
Estrada, K., Styrkarsdottir, U., Evangelou, E., et al. (2012). Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nature Genetics, 44(5), 491–501. https://doi.org/10.1038/ng.2249
Wan, X., Yang, C., Yang, Q., Xue, H., Fan, X., Tang, N. L. S., & Yu, W. (2010). BOOST: A fast approach to detecting gene-gene interactions in genome-wide case-control studies. American Journal of Human Genetics, 87(3), 325–340. https://doi.org/10.1016/j.ajhg.2010.07.021
Khor, C. C., Vannberg, F. O., Chapman, S. J., et al. (2010). CISH and susceptibility to infectious diseases. The New England Journal of Medicine, 362(22), 2092–2101. https://doi.org/10.1056/NEJMoa0905606
Woo, J., Tang, N., Suen, E., Leung, J., & Wong, M. (2009). Green space, psychological restoration, and telomere length. Lancet (London, England), 373(9660), 299–300. https://doi.org/10.1016/S0140-6736(09)60094-5
Tang, N. L.-S., Chan, P. K.-S., Hui, D. S.-C., To, K.-F., Zhang, W., Chan, F. K. L., Sung, J. J.-Y., & Lo, Y. M. D. (2007). Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection. Nature Genetics, 39(6), 691–692. https://doi.org/10.1038/ng0607-691 
 
 
 
 
The Chinese University of Hong Kong