Professor Dennis Lo
Professor Rossa Chiu
Professor Allen K C Chan
Professor Nelson Tang
Professor Chun Kwok Wong
Professor Hao Sun
Professor Kathy Lui
Professor Peiyong Jiang
Professor Peter Cheung
Professor Jacky Lam
Professor Masashi Yukawa
Professor Chun Kit Choi
Professor Jason Liao
Professor Christopher Lam
Professor Nirmal Panesar
Dr Michael H M Chan
Dr Angel Chan
Nelson Tang 鄧亮生
Professor 教授
Positions Held:
Executive Committee Member, Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics, School of Biomedical Sciences, The Chinese University of Hong Kong
Principal Investigator, Laboratory for Genetics of Disease Susceptibility, Li Ka Shing Institute of Health Sciences, CUHK
Member, The Board of Trustees of United College, CUHK
Principal Investigator, Functional Genomics and Biostatistical Computing Laboratory, CUHK Shenzhen Research Institute, Shenzhen, China
Course coordinator of BMEG 5790 Bioinformatics in MSc porgram in Biomedical Engineering
Member of Preclinical Education Committee
Member, Grant Review Board of Health and Medical Research Fund, Hong Kong SAR Government
Primary Supervisor of training in Genetic Pathology for Royal College of Pathologists of Australasia (RCPA) at Prince of Wales Hospital
Member, Editorial Board of the journal Pathology and Frontiers in Genetics
Member, The Committee of Board Directors for Asian Society of Inherited Metabolic Diseases (ASIMD)
2021 Grant proposal reviewer for 國家自然科學基金委員會
Working Group on Colorectal and Breast Cancer Screening for High Risk Groups, Centre for Health Protection, Department of Health, Hong Kong SAR Government
2009 - 2014
Scientific Editor, Catalogue of Genetic Tests and Laboratories, Royal College of Pathologists of Australasia
2009, 2013
Committee member, Manual Transformation Steering Committee, Royal College of Pathologists of Australasia
2005 - 2012
Member, Advisory Committee of Genetics Pathology in the Royal College of Pathologists of Australasia (RCPA)
2005 - 2010
Panel Coordinator of teaching panel in medical curriculum: Mechanisms of Disease and Therapeutic Approaches
Honorary Professor, Xi'an Jiaotong University, Xi'an China
Overseas Examiner of Genetics Pathology for the Royal College of Pathologists of Australasia (RCPA)
Scholarship and Awards:
2003 / 04
Sir Robert Black Trust Fund Scholarship for a sabbatical to Strangeways Research Laboratory, University of Cambridge
Professor Tang graduated with a MBChB degree from the Chinese University of Hong Kong in 1991. He was admitted to Fellow of the Royal College of Pathologists of Australasia (RCPA) in 1997. Prof. Tang joined CUHK in 1996. He was then conferred the degree of Doctor of Medicine in 2002. He was awarded a scholarship by the Sir Robert Black Trust Fund for a sabbatical leave to the Strangeways Research Laboratory of the University of Cambridge, UK.
Prof. Tang started the first metabolic clinic in Hong Kong to take care of patients with various inborn errors of metabolism, which are rare genetic diseases in children, more than 20 years ago. His research team has contributed to the discovery of the disease gene causing Primary Carnitine Deficiency (named by Prof. Tang as 卡尼丁缺乏症 in Chinese which has become the standard Chinese medical term now). His discovery has facilitated the molecular diagnosis of this disease and more than 1,000 patients of this rare disease have been diagnosed and treated all over Mainland China and Asia.
Professor Tang is also the principal investigator of the Laboratory for Genetics of Disease Susceptibility in the Li Ka Shing Institute of Health Sciences. The team investigates the genetic basis of polygenic diseases, also known as complex traits. Long term collaborations with international researchers have led to many new insights in various complex traits, such as genetics basis in Scoliosis which have inspired new treatment modalities. Recently, he has developed new analysis algorithms in bioinformatics and genetic statistics using cloud computing which enable determination of gene expression of a single cellular population from bulk data of cell mixtures. This invention is instrumental in the development of future blood biomarker tests and has been awarded the Gold Medal in the 2021 Geneva Invention Expo and a Silver Award in a patent portfolio competition in the Greater Bay Area.
Prof. Tang has held various professional and academic positions, for example, serving on the Advisory Committee of Genetic Pathology in the Royal College of Pathologists of Australasia (RCPA), being an editor of RCPA Catalogue of Genetic Tests and Laboratories and Pathology Manual and an examiner in the Fellowship examination for RCPA. Prof. Tang is a member of the Grant Review Board of Health and Medical Research Fund of the Hong Kong SAR Government. He is regularly invited to review grant proposals for Research Grant Council (HK) and various grant bodies in Mainland China, United Kingdom, Singapore, South Africa, Poland etc. He supervised more than 20 postgraduate students at both master and doctorial levels. Prof. Tang has been on the examination boards of graduate schools in many universities to examine PhD students, for example, the University of Hong Kong, The Hong Kong University of Science and Technology, Peking University, University of Sydney etc. He reviewed more than 50 journal manuscripts for various renowned Journals in the past 3 years.
Research interests:
Genetic Susceptibility of common diseases (also known as complex traits), e.g. Scoliosis, Diabetes, etc. Prof. Tang is among the top 10 cited authors in the field of Complex traits according to Google Scholar.
New algorithms in Bioinformatics and genetic statistics: single cell population gene expression and genetic interaction
Inborn errors of metabolism: Carnitine deficiency and Wilson's disease
Determination of gene expression levels of a cell type, US9589099B2
Method to quantify telomere length and genomic motifs, US20210010069A1
Links to publications:
Google Scholar
ORCID ID: 0000-0002-3607-5819
Book Editor:
Chemical Diagnostics: From Bench to Bedside (in the series of Topics in Current Chemistry, Vol. 336). L.S. Tang, Nelson; Poon, Terence (Eds.) Publisher: Springer; 2014. ISBN-10: 364239941X (Top 25% most downloaded eBooks in the relevant Springer eBook Collection)
12 selected publication among > 300 publications
Huang, D., Liu, A. Y. N., Leung, K. S., Tang, N. L. S. (2021) Direct Measurement of B Lymphocyte Gene Expression Biomarkers in Peripheral Blood Transcriptomics Enables Early Prediction of Vaccine Seroconversion. Genes (Basel), 25;12(7):971.
Tang, N. L., Hui, J., Huang, D., Tang, M. F., Wang, X., Wu, J., Chan, I. H. S., Leung, T. F. (2020). Reference intervals of spot urine copper excretion in preschool children and potential application in pre-symptomatic screening of Wilson disease. Pathology, 52(4):439-446. Pre-print available here
Tang, N. L. S., & Hui, J. (2020). 20 Years After Discovery of the Causative Gene of Primary Carnitine Deficiency, How Much More Have We Known About the Disease? HK J Paediatr (new series), 25:23-29.;25;23-29.pdf
Styrkarsdottir, U., Stefansson, O. A., Gunnarsdottir, K., et al. (2019). GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures. Nature Communications, 10(1), 2054.
Styrkarsdottir, U., Helgason, H., Sigurdsson, A., et al. (2017). Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis. Nature Genetics, 49(5), 801–805.
Styrkarsdottir, U., Thorleifsson, G., Gudjonsson, S. A., et al. (2016). Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures. Nature Communications, 7, 10129.
Zhu, Z., Tang, N. L.-S., Xu, L., et al. (2015). Genome-wide association study identifies new susceptibility loci for adolescent idiopathic scoliosis in Chinese girls. Nature Communications, 6, 8355.
Estrada, K., Styrkarsdottir, U., Evangelou, E., et al. (2012). Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nature Genetics, 44(5), 491–501.
Wan, X., Yang, C., Yang, Q., Xue, H., Fan, X., Tang, N. L. S., & Yu, W. (2010). BOOST: A fast approach to detecting gene-gene interactions in genome-wide case-control studies. American Journal of Human Genetics, 87(3), 325–340.
Khor, C. C., Vannberg, F. O., Chapman, S. J., et al. (2010). CISH and susceptibility to infectious diseases. The New England Journal of Medicine, 362(22), 2092–2101.
Woo, J., Tang, N., Suen, E., Leung, J., & Wong, M. (2009). Green space, psychological restoration, and telomere length. Lancet (London, England), 373(9660), 299–300.
Tang, N. L.-S., Chan, P. K.-S., Hui, D. S.-C., To, K.-F., Zhang, W., Chan, F. K. L., Sung, J. J.-Y., & Lo, Y. M. D. (2007). Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection. Nature Genetics, 39(6), 691–692. 
Detailed CV with full publication list of Prof Tang updated in February 2022
The Chinese University of Hong Kong