Department of Chemical Pathology, The Chinese University of Hong Kong

Professor Dennis Lo

Professor Allen K C Chan

Professor Nelson Tang

Professor Chun Kwok Wong

Professor Kathy Lui

Professor Sung Wing Kin

Professor Peiyong Jiang

Professor Peter Cheung

Professor Hei Ming Lai

Professor Jacky Lam

Professor Stephanie Yu

Professor Chun Kit Choi

Professor Mingyuan Li

Professor Qing Zhou

Professor Rossa Chiu

Professor Chung Shun Ho

Dr Michael H M Chan

Dr Jeffrey SS Kwok

Kathy Lui 呂愛蘭
Professor 教授
Research Grants Council Research Fellow

kathyolui@cuhk.edu.hk

Biography

Prof. Kathy Lui is currently the Assistant Dean (Research) for the Faculty of Medicine and a Professor in the Department of Chemical Pathology at the Chinese University of Hong Kong. She leads a research program on disease mechanisms and therapeutic strategies for cardiovascular repair, with a particular focus on the roles of T cells in cardiovascular disease and regeneration. In 2025, she founded the CAS-CUHK Joint Laboratory for Cardiovascular Sciences, funded by the Croucher Foundation, in partnership with Prof. Bin Zhou at the Chinese Academy of Sciences, Shanghai. Prof. Lui established her independent research group in August 2014, and her contributions have been recognized by the Croucher Innovation Award (2017), the NSFC Excellent Young Scientists Fund (2019), and RGC Research Fellowship (2022). A founding member of the Young Academy of Sciences of Hong Kong (2018), she continues to promote science education in the region.

Prof. Lui earned her BSc and MPhil in Biochemistry at CUHK. Supported by the Dorothy Hodgkin Postgraduate Award, she completed her DPhil at the Sir William Dunn School of Pathology, University of Oxford, where she studied stem cell immunology in Prof. Herman Waldmann’s laboratory. During her time at Oxford, she received the Senior Scholarship at Lincoln College and the Peter Beaconsfield Prize in Physiological Sciences. As a Croucher Foundation Fellow, she pursued postdoctoral training at Massachusetts General Hospital in Prof. Kenneth Chien’s laboratory with the focus on cardiovascular regeneration and at the Department of Stem Cell and Regenerative Biology, Harvard University, in Prof. Douglas Melton’s laboratory with the focus on stem cells and regeneration.

The following highlights her current research efforts:

•	Cardiovascular Immunology
•	Cardiovascular Repair and Regeneration
•	Molecular mechanisms driving cardiovascular disease progression

Other official website:

https://www.lihs.cuhk.edu.hk/en-us/research/investigators/luikathy.aspx

Personal lab website:

http://www.cuhk.edu.hk/research/luilab

*Selected Publications ( Correspondence):**
1.	Zhang M, Han M, Hou Y, Liu Z, Wang Y, Huang X, Ho CK, Qu H, Wang QD, Ma X, Lui KO, Zhou B. (2026) Tracing the origins of de novo coronary collateral formation in cardiac repair. Science (in press)
2.	Qu H, Ho CK, Liu J, Cui L, Hou Y, Liang C, Ye W, Wong RHL, Hori S, Zhou B, Lui KO. (2026) CD4+ Tregs drive post-ischemic sprouting angiogenesis via endothelial YY1/MAML1 reactivation. Advanced Science* 20:e18564.
3.	Cui L, Ho CK, Liang P, Gao W, Liu J, Tian XY, Wong R, Zhou B, Lui KO. (2026) METTL14 inhibits atherogenesis by epigenetically activating PPAR-a/g transcription and fatty acid oxidation in VSMCs. Cardiovascular Research* 122:1001-1021.
4.	Hou Y, Ho CK, Lai B, Liu J, Li L, Lin J, Qu H, Wong RHL, Nie Y, Ding Q, Zhou B, Lui KO. (2025) CD4+ Tregs regulate heart growth and regeneration through MRG15/TIP60-mediated epigenomic remodeling in proliferating cardiomyocytes. Circulation* 152:1634-1656.
5.	Ye W, Gao W, Ho CK, Cui L, Lau JYW, Tian XY, Zhou B, Lui KO. (2025) YY1 regulates vascular resistance and blood pressure dynamics through epigenetic control of m6A RNA modifications in VSMCs. Cardiovascular Research. 121:*1898-1916.
6.	Liu D, Yang KY, Chan VW, Ye W, Chong CCN, Wang CC, Wang H, Zhou B, Cheng KKY, Lui KO. (2022) YY1 regulates glucose homeostasis through controlling insulin transcription in pancreatic beta cells. Diabetes.* 71:961-977
7.	Li J, Liang C, Yang KY, Huang X, Han MY, Li X, Chan VW, Chan KS, Liu D, Huang ZP, Zhou B, Lui KO. (2020) Specific ablation of CD4+ T-cells promotes heart regeneration in juvenile mice. Theranostics 10: 8018-8035.
8.	Li J, Li X, Liang C, Ling J, Chen Z, Wong CK, Waldmann H, Lui KO. (2020) Coreceptor blockade targeting CD4 and CD8 allows acceptance of allogeneic human pluripotent stem cell grafts in humanized mice. Biomaterials*. 248: 120013.
9.	Liang C, Yang KY, Chan VW, Li X, Fung THW, Wu Y, Tian XY, Huang Y, Qin L, Lau JYW, Lui KO. (2020) CD8+ T-cell plasticity regulates vascular regeneration in type-2 diabetes. Theranostics*10: 4217-4232.
10.	Li J, Yang KY, Tam RCY, Chan VW, Lan HY, Hori S, Zhou B, Lui KO. (2019) Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner. Theranostics*. 9: 4324-4341.
11.	Leung CS, Yang KY, Li X, Chan VW, Ku M, Waldmann H, Hori S, Tsang JCH, Lo YMD, Lui KO. (2018) Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T-cells. Genome Medicine*. 10: 71.
12.	Leung OM, Li J, Li X, Chan VW, Yang KY, Ku M, Ji L, Sun H, Waldmann H, Tian XY, Huang Y, Lau J, Zhou B, Lui KO. (2018) Regulatory T cells promote apelin mediated sprouting angiogenesis in type 2 diabetes. Cell Reports*. 24: 1610-1626.